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Azadeh Rezazadeh 1 Article
Comparing Two Methods of Cryotherapy and Intense Pulsed Light with Triamcinolone Injection in the Treatment of Keloid and Hypertrophic Scars: A Clinical Trial
Simin Shamsi Meymandi, Mahmood Moosazadeh, Azadeh Rezazadeh
Osong Public Health Res Perspect. 2016;7(5):313-319.   Published online October 31, 2016
DOI: https://doi.org/10.1016/j.phrp.2016.08.005
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  • 11 Citations
AbstractAbstract PDF
Objectives
Keloid and hypertrophic scars are abnormal manifestations of wounds that occur following skin injuries in the form of local proliferation of fibroblasts and increased production of collagen. There are several ways to cure these scars; treatment must be selected based on the nature of the scars. In this clinical trial, two methods—cryotherapy and intense pulsed light (IPL)—are compared in the treatment of scars, and the results are presented in terms of improvement level, complications, and patient satisfaction.
Methods
This clinical trial was conducted in southeastern Iran. The intervention group included scars that underwent the IPL method and the control group, which consisted of scars that were subjected to cryotherapy. In both methods, intralesional corticosteroid injection was administered. To select samples, the easy sampling method was used. To determine the expected outcomes, the criteria determined in the Vancouver scar scale were used. Data were analyzed using the Mix Model, chi-square test, and t test.
Results
In this study, 166 samples of keloid and hypertrophic scars were cured using two methods (Cryotherapy, 83; IPL, 83). The recovery rate was higher in the Cryotherapy group than in the IPL group (p > 0.05), and the incidence of complications was also higher in the Cryotherapy group (14.5% vs. 12%). Moreover, patients were more satisfied, although not significantly so, with the cryotherapy method (p = 0.09).
Conclusion
Both methods were highly successful in curing scars; participants were totally satisfied with both methods.

Citations

Citations to this article as recorded by  
  • A systematic review of randomised controlled trials investigating laser assisted drug delivery for the treatment of keloid and hypertrophic scars
    Kelvin Truong, Ines Prasidha, Tevi Wain
    Lasers in Medical Science.2022; 37(1): 47.     CrossRef
  • Diagnosis, Treatment, and Management of Painful Scar: A Narrative Review
    Alaa Abd-Elsayed, Jason Pope, Derick A Mundey, Konstantin V Slavin, Steven Falowski, Ahish Chitneni, Stephen R Popielarski, Jarod John, Samuel Grodofsky, Tony Vanetesse, Michael A Fishman, Philip Kim
    Journal of Pain Research.2022; Volume 15: 925.     CrossRef
  • Traditional Chinese medicine for hypertrophic scars—A review of the therapeutic methods and potential effects
    Daqin Chen, Qiannan Li, Huimin Zhang, Fang Kou, Qiang Li, Chunming Lyu, Hai Wei
    Frontiers in Pharmacology.2022;[Epub]     CrossRef
  • Cryotherapy: treatment spectrum and setting up the service
    Paul Charlson
    Journal of Aesthetic Nursing.2021; 10(1): 6.     CrossRef
  • Intense pulsed light versus cryotherapy in the treatment of hypertrophic scars: A clinical and histopathological study
    Samar A.M. Salem, Sharief M. Abdel Hameed, Azza E. Mostafa
    Journal of Cosmetic Dermatology.2021; 20(9): 2775.     CrossRef
  • Comparative Efficacy and Safety of Common Therapies in Keloids and Hypertrophic Scars: A Systematic Review and Meta-analysis
    Yawei Bao, Shanshan Xu, Zhipeng Pan, Jixiang Deng, Xinyi Li, Faming Pan, Xiaojing Li
    Aesthetic Plastic Surgery.2020; 44(1): 207.     CrossRef
  • Comparison of Nd:YAG Laser and Combined Intense Pulsed Light and Radiofrequency in the Treatment of Hypertrophic Scars
    Mohamed M. Khedr, Wael Hussein Mahmoud, Fersan A. Sallam, Nader Elmelegy
    Annals of Plastic Surgery.2020; 84(5): 518.     CrossRef
  • Monoclonal Antibodies Addressed to Factors of Signalization in Keloid Scars: Opportunities and Areas of Action
    Erick Moreno Pizarro, Eduardo Morales Valencia, Arturo Pérez Cuéllar, Camilo Acuña Pinzon, Aarón Emanuel Serrano Padilla
    Cureus.2020;[Epub]     CrossRef
  • Treatment of hypertrophic scars and keloids using an intralesional 1470 nm bare-fibre diode laser: a novel efficient minimally-invasive technique
    Ke Li, Fabio Nicoli, Chunxiao Cui, Wen Jing Xi, Ahmed Al-Mousawi, Zheng Zhang, Alberto Balzani, Lindsay Neill, Roberto Sorge, Yun Tong, Yixin Zhang
    Scientific Reports.2020;[Epub]     CrossRef
  • Topical cryoanesthesia for the relief of pain caused by steroid injections used to treat hypertrophic scars and keloids
    Xiuxia Wang, Xiaoli Wu, Ke Liu, Lingling Xia, Xunxun Lin, Wei Liu, Zhen Gao
    Medicine.2017; 96(43): e8353.     CrossRef
  • Comparing Efficacy and Tolerability of Triamcinolone and Verapamil in Treatment of Hypertrophic Scars and Keloids
    Abbas Zamanian, Maryam Nokandeh, Elham Behrangi, Zeynab Fazel, Zahra Azizian
    Journal of Skin and Stem Cell.2017;[Epub]     CrossRef

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