Skip Navigation
Skip to contents

PHRP : Osong Public Health and Research Perspectives

OPEN ACCESS
SEARCH
Search

Author index

Page Path
HOME > Articles and issues > Author index
Search
Bo-Eun Kwon 1 Article
Complete Sequence Analysis and Antiviral Screening of Medicinal Plants for Human Coxsackievirus A16 Isolated in Korea
Jae-Hyoung Song, Kwisung Park, Aeri Shim, Bo-Eun Kwon, Jae-Hee Ahn, Young Jin Choi, Jae Kyung Kim, Sang-Gu Yeo, Kyungah Yoon, Hyun-Jeong Ko
Osong Public Health Res Perspect. 2015;6(1):52-58.   Published online February 28, 2015
DOI: https://doi.org/10.1016/j.phrp.2014.12.004
  • 1,850 View
  • 16 Download
  • 14 Citations
AbstractAbstract PDF
Objectives
Coxsackievirus A group 16 strain (CVA16) is one of the predominant causative agents of hand, foot, and mouth disease (HFMD).
Methods
Using a specimen from a male patient with HFMD, we isolated and performed sequencing of the Korean CVA16 strain and compared it with a G10 reference strain. Also, we were investigated the effects of medicinal plant extract on the cytopathic effects (CPE) by CPE reduction assay against Korean CVA16.
Results
Phylogenetic analysis showed that the Korean CVA16 isolate belonged to cluster B-1 and was closely related to the strain PM-15765-00 isolated in Malaysia in 2000. The Korean CVA16 isolate showed 73.2% nucleotide identity to the G10 prototype strain and 98.7% nucleotide identity to PM-15765-00. Next, we assessed whether the Korean CVA16 isolate could be used for in vitro screening of antiviral agents to treat HFMD infection. Vero cells infected with the Korean CVA16 isolate showed a cytopathic effect 2 days after the infection, and the treatment of cells with Cornus officinalis, Acer triflorum, Pulsatilla koreana, and Clematis heracleifolia var. davidiana Hemsl extracts exhibited strong antiviral activity against CVA16.
Conclusion
Collectively, our work provides potential candidates for the development of vaccine and novel drugs to treat the CVA16 strain isolated from a Korean patient.

Citations

Citations to this article as recorded by  
  • A Review with Updated Perspectives on the Antiviral Potentials of Traditional Medicinal Plants and Their Prospects in Antiviral Therapy
    Nur Fadlin Saifulazmi, Emelda Rosseleena Rohani, Sarahani Harun, Hamidun Bunawan, Hamizah Shahirah Hamezah, Nor Azlan Nor Muhammad, Kamalrul Azlan Azizan, Qamar Uddin Ahmed, Sharida Fakurazi, Ahmed Mediani, Murni Nazira Sarian
    Life.2022; 12(8): 1287.     CrossRef
  • Medicinal plants: Treasure for antiviral drug discovery
    Sofi Imtiyaz Ali, Wajid Mohammad Sheikh, Muzafar Ahmad Rather, Venugopalan Venkatesalu, Showkeen Muzamil Bashir, Showkat Ul Nabi
    Phytotherapy Research.2021; 35(7): 3447.     CrossRef
  • Seasonal Distribution and Meteorological Factors Associated with Hand, Foot, and Mouth Disease among Children in Xi’an, Northwestern China
    Tianci Guo, Jifeng Liu, Junjiang Chen, Yao Bai, Yong Long, Baozhong Chen, Shuxuan Song, Zhongjun Shao, Kun Liu
    The American Journal of Tropical Medicine and Hyg.2020; 102(6): 1253.     CrossRef
  • Short-term effects of meteorological factors and air pollution on childhood hand-foot-mouth disease in Guilin, China
    Guoqi Yu, Yonghong Li, Jiansheng Cai, Dongmei Yu, Jiexia Tang, Wenwen Zhai, Yi Wei, Shiyi Chen, Quanhui Chen, Jian Qin
    Science of The Total Environment.2019; 646: 460.     CrossRef
  • The effect of temperature on childhood hand, foot and mouth disease in Guangdong Province, China, 2010–2013: a multicity study
    Zece Xu, Wenqi Hu, Kedi Jiao, Ci Ren, Baofa Jiang, Wei Ma
    BMC Infectious Diseases.2019;[Epub]     CrossRef
  • Surveillance, epidemiology, and pathogen spectrum of hand, foot, and mouth disease in mainland of China from 2008 to 2017
    Tianjiao Ji, Taoli Han, Xiaojuan Tan, Shuangli Zhu, Dongmei Yan, Qian Yang, Yang Song, Aili Cui, Yan Zhang, Naiying Mao, Songtao Xu, Zhen Zhu, Dandan Niu, Yong Zhang, Wenbo Xu
    Biosafety and Health.2019; 1(1): 32.     CrossRef
  • A potential therapeutic neutralization monoclonal antibody specifically against multi-coxsackievirus A16 strains challenge
    Ruixiao Du, Qunying Mao, Yalin Hu, Shuhui Lang, Shiyang Sun, Kelei Li, Fan Gao, Lianlian Bian, Ce Yang, Bopei Cui, Longfa Xu, Tong Cheng, Zhenglun Liang
    Human Vaccines & Immunotherapeutics.2019; 15(10): 2343.     CrossRef
  • Corni Fructus: a review of chemical constituents and pharmacological activities
    Yu Dong, Zhe-Ling Feng, Hu-Biao Chen, Fu-Sheng Wang, Jia-Hong Lu
    Chinese Medicine.2018;[Epub]     CrossRef
  • Inhibition of Murine Norovirus and Feline Calicivirus by Edible Herbal Extracts
    Dong Joo Seo, Changsun Choi
    Food and Environmental Virology.2017; 9(1): 35.     CrossRef
  • Antiviral activity of herbal extracts against the hepatitis A virus
    Dong Joo Seo, Minhwa Lee, Su Been Jeon, Hyunkyung Park, Suntak Jeong, Bog-Hieu Lee, Changsun Choi
    Food Control.2017; 72: 9.     CrossRef
  • A novel Enterovirus 96 circulating in China causes hand, foot, and mouth disease
    Yi Xu, Yisuo Sun, Jinmin Ma, Shuru Zhou, Wei Fang, Jiawei Ye, Limei Tan, Jingkai Ji, Dan Luo, Liqiang Li, Jiandong Li, Chunxiao Fang, Na Pei, Shuo Shi, Xin Liu, Hui Jiang, Sitang Gong, Xun Xu
    Virus Genes.2017; 53(3): 352.     CrossRef
  • Characterization of VP1 sequence of Coxsackievirus A16 isolates by Bayesian evolutionary method
    Guolian Zhao, Xun Zhang, Changmin Wang, Guoqing Wang, Fan Li
    Virology Journal.2016;[Epub]     CrossRef
  • Traditional uses, phytochemistry, and pharmacology of the genus Acer (maple): A review
    Wu Bi, Ying Gao, Jie Shen, Chunnian He, Haibo Liu, Yong Peng, Chunhong Zhang, Peigen Xiao
    Journal of Ethnopharmacology.2016; 189: 31.     CrossRef
  • Epidemiological Research on Hand, Foot, and Mouth Disease in Mainland China
    Zhi-Chao Zhuang, Zeng-Qiang Kou, Yong-Juan Bai, Xiang Cong, Li-Hong Wang, Chun Li, Li Zhao, Xue-Jie Yu, Zhi-Yu Wang, Hong-Ling Wen
    Viruses.2015; 7(12): 6400.     CrossRef

PHRP : Osong Public Health and Research Perspectives