- A Case–control Study on the Relationship between Mycoplasma genitalium Infection in Women with Normal Pregnancy and Spontaneous Abortion using Polymerase Chain Reaction
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Rashid Ramazanzadeh, Mazaher Khodabandehloo, Fariba Farhadifar, Samaneh Rouhi, Amjad Ahmadi, Shaho Menbari, Fariba Fallahi, Reza Mirnejad
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Osong Public Health Res Perspect. 2016;7(5):334-338. Published online October 31, 2016
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DOI: https://doi.org/10.1016/j.phrp.2016.07.001
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 Abstract
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- Objectives
Mycoplasma genitalium infections are suggested as causes of a number of pathological outcomes in pregnant women. The aim of this study was to evaluate the frequency of M. genitalium infections among pregnant women and its association with spontaneous abortion.
Methods
In this case–control study we included 109 women with spontaneous abortion with a gestational age of 10–20 weeks (patients), and 109 women with normal pregnancy with a gestational age of 20–37 weeks (controls) in Sanandaj, Iran. Using specific primers and extracted DNA from endocervical swabs, a polymerase chain reaction was conducted for the detection of M. genitalium infection in both groups.
Results
The frequency of M. genitalium infection in patient and control groups was one (0.91%) and three (2.75%), respectively. In both control and patient groups using Fisher test, no association between mycoplasma infection and spontaneous abortion was seen.
Conclusion
M. genitalium may be positive in the genital tract of some pregnant women but was not associated with spontaneous abortion. Further powerful studies with larger sample sizes are needed for the determination of a possible role of M. genitalium in pregnancy outcomes and spontaneous abortion.
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Citations
Citations to this article as recorded by  - The association between genital mycoplasma infection and spontaneous abortion: A systematic review and meta-analysis
Wei Chen, Shimin Xiong, Xubo Shen, Ting Qiu, Caidie He, Songlin An, Yuanzhong Zhou
Reproductive Toxicology.2023; 116: 108334. CrossRef - Latest Advances in Laboratory Detection of Mycoplasma genitalium
Ken B. Waites, Donna M. Crabb, Amy E. Ratliff, William M. Geisler, T. Prescott Atkinson, Li Xiao, Romney M. Humphries
Journal of Clinical Microbiology.2023;[Epub] CrossRef - Weighing Potential Benefits and Harms of Mycoplasma genitalium Testing and Treatment Approaches
Lisa E. Manhart, William M. Geisler, Catriona S. Bradshaw, Jørgen S. Jensen, David H. Martin
Emerging Infectious Diseases.2022;[Epub] CrossRef - The Associations of Genital Mycoplasmas with Female Infertility and Adverse Pregnancy Outcomes: a Systematic Review and Meta-analysis
Caifeng Ma, Jikun Du, Yuhong Dou, Rui Chen, Yuxia Li, Lijun Zhao, Helu Liu, Kebin Zhang
Reproductive Sciences.2021; 28(11): 3013. CrossRef - Mollicutes antibiotic resistance profile and presence of genital abnormalities in couples attending an infertility clinic
Brenda Maldonado-Arriaga, Noé Escobar-Escamilla, Juan Carlos Pérez-Razo, Sofia Lizeth Alcaráz-Estrada, Ignacio Flores-Sánchez, Daniel Moreno-García, Rebeca Pérez-Cabeza de Vaca, Paul Mondragón-Terán, Jonathan Shaw, Cecilia Hernandez-Cortez, Graciela Castr
Journal of International Medical Research.2020; 48(1): 030006051982894. CrossRef - Association of spontaneous abortion and Ureaplasma parvum detected in placental tissue
C. N. T. Oliveira, M. T. S. Oliveira, H. B. M. Oliveira, L. S. C. Silva, R. S. Freire, M. N. Santos Júnior, M. V. Oliveira, J. Timenetsky, G. B. Campos, L. M. Marques
Epidemiology and Infection.2020;[Epub] CrossRef - Epidemiology of genital infections caused by Mycoplasma hominis, M. genitalium and Ureaplasma urealyticum in Iran; a systematic review and meta-analysis study (2000–2019)
Khadijeh Moridi, Mohammad Hemmaty, Amir Azimian, Mohammad Hosein Fallah, Hamid Khaneghahi Abyaneh, Kiarash Ghazvini
BMC Public Health.2020;[Epub] CrossRef - Prevalence and incidence of Mycoplasma genitalium in a cohort of HIV-infected and HIV-uninfected pregnant women in Cape Town, South Africa
Carolyn P Smullin, Hunter Green, Remco Peters, Dorothy Nyemba, Yamkela Qayiya, Landon Myer, Jeffrey Klausner, Dvora Joseph Davey
Sexually Transmitted Infections.2020; 96(7): 501. CrossRef - Frequency of Chlamydia trachomatis, Mycoplasma genitalium, and Ureaplasma urealyticum Isolated From Vaginal Samples of Women in Kerman, Iran
Zahra Zahirnia, Shahla Mansouri, Fereshteh Saffari, Ghazal Mansouri
Archives of Clinical Infectious Diseases.2018;[Epub] CrossRef - High Prevalence of Leptotrichia amnionii, Atopobium vaginae, Sneathia sanguinegens, and Factor 1 Microbes and Association of Spontaneous Abortion among Korean Women
Sang Soo Seo, Selvaraj Arokiyaraj, Mi Kyung Kim, Hea Young Oh, Minji Kwon, Ji Sook Kong, Moon Kyung Shin, Ye Lee Yu, Jae Kwan Lee
BioMed Research International.2017; 2017: 1. CrossRef
- High Prevalence of AmpC β-Lactamases in Clinical Isolates of Escherichia coli in Ilam, Iran
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Abbas Maleki, Afra Khosravi, Sobhan Ghafourian, Iraj Pakzad, Shiva Hosseini, Rashid Ramazanzadeh, Nourkhoda Sadeghifard
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Osong Public Health Res Perspect. 2015;6(3):201-204. Published online June 30, 2015
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DOI: https://doi.org/10.1016/j.phrp.2015.02.001
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2,357
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24
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8
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Abstract
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- Objectives
Widespread use of β-lactam antibiotics could cause resistance to this group of antibiotics in pathogenic bacteria through the production of the enzyme β-lactamases. The aim of this study is to determine the molecular detection of AmpC β-lactamases among clinical Escherichia coli isolated from Ilam hospitals in Ilam, Iran.
Methods
One hundred and twelve clinical isolates of E. coli were collected from hospitalized patients and were identified by biochemical tests. They were evaluated for extended spectrum beta-lactamases (ESBLs) production, and the positive strains were subjected to AmpC enzymes; for detection of AmpC cluster genes, multiplex polymerase chain reaction was applied.
Results
The analysis showed 62.5% of isolates were ESBLs positive and that five strains revealed the AmpC cluster genes. This is the first report of FOXM cluster genes in E. coli in Iran.
Conclusion
Based on our results, the prevalence of AmpC β-lactamases is increasing in Iran, which caused failure in antibiotic therapy. So, the current study recommended the revision of antibiotic policy in Iranian hospitals.
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