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Volume 12(5); October 2021
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Editorial
How can we prepare for this autumn and winter?
Jong-Koo Lee
Osong Public Health Res Perspect. 2021;12(5):275-277.   Published online October 26, 2021
DOI: https://doi.org/10.24171/j.phrp.2021.0273
  • 3,608 View
  • 41 Download
PDF
Review Articles
The role of lipids in the pathophysiology of coronavirus infections
Milad Zandi, Parastoo Hosseini, Saber Soltani, Azadeh Rasooli, Mona Moghadami, Sepideh Nasimzadeh, Farzane Behnezhad
Osong Public Health Res Perspect. 2021;12(5):278-285.   Published online October 15, 2021
DOI: https://doi.org/10.24171/j.phrp.2021.0153
  • 3,108 View
  • 148 Download
  • 1 Citations
Graphical AbstractGraphical Abstract AbstractAbstract PDF
Coronaviruses, which have been known to cause diseases in animals since the 1930s, utilize cellular components during their replication cycle. Lipids play important roles in viral infection, as coronaviruses target cellular lipids and lipid metabolism to modify their host cells to become an optimal environment for viral replication. Therefore, lipids can be considered as potential targets for the development of antiviral agents. This review provides an overview of the roles of cellular lipids in different stages of the life cycle of coronaviruses.

Citations

Citations to this article as recorded by  
  • Orsay Virus Infection of Caenorhabditis elegans Is Modulated by Zinc and Dependent on Lipids
    Luis Alberto Casorla-Perez, Ranya Guennoun, Ciro Cubillas, Bo Peng, Kerry Kornfeld, David Wang, Rebecca Ellis Dutch
    Journal of Virology.2022;[Epub]     CrossRef
Severe acute respiratory syndrome coronavirus 2 and respiratory syncytial virus coinfection in children
Milad Zandi, Saber Soltani, Mona Fani, Samaneh Abbasi, Saeedeh Ebrahimi, Ali Ramezani
Osong Public Health Res Perspect. 2021;12(5):286-292.   Published online October 1, 2021
DOI: https://doi.org/10.24171/j.phrp.2021.0140
  • 3,894 View
  • 142 Download
  • 3 Citations
AbstractAbstract PDF
Coronavirus disease 2019 (COVID-19) is caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), which has infected many people around the world. Children are considered an important target group for SARS-CoV-2, as well as other viral infections such as respiratory syncytial virus infection. Both SARS-CoV-2 and respiratory syncytial virus can affect the respiratory tract. Coinfection of SARS-CoV-2 and respiratory syncytial virus can pose significant challenges in terms of diagnosis and treatment in children. This review compares the symptoms, diagnostic methods, and treatment of COVID-19 and respiratory syncytial virus infection in children.

Citations

Citations to this article as recorded by  
  • Respiratory syncytial virus, recurrent wheeze and asthma: A narrative review of pathophysiology, prevention and future directions
    Elly Binns, Jane Tuckerman, Paul V Licciardi, Danielle Wurzel
    Journal of Paediatrics and Child Health.2022; 58(10): 1741.     CrossRef
  • Impact of genetic polymorphisms related to innate immune response on respiratory syncytial virus infection in children
    Laura Elena Córdova-Dávalos, Alicia Hernández-Mercado, Claudia Berenice Barrón-García, Augusto Rojas-Martínez, Mariela Jiménez, Eva Salinas, Daniel Cervantes-García
    Virus Genes.2022; 58(6): 501.     CrossRef
  • Clinical and epidemiological characteristics of SARS-CoV-2 virus in ambulatory children under 2 years old
    Carolina A. Perez, Ivana Ormazabal, Javier Pérez-Valenzuela, Andrea Araya, Rafael A. Medina, Cecilia Perret
    Frontiers in Pediatrics.2022;[Epub]     CrossRef
Original Articles
Delays in the diagnosis and treatment of tuberculosis during the COVID-19 outbreak in the Republic of Korea in 2020
Jiyeon Yang, Yunhyung Kwon, Jaetae Kim, Yoojin Jang, Jiyeon Han, Daae Kim, Hyeran Jeong, Hyekyung Park, Eunhye Shim
Osong Public Health Res Perspect. 2021;12(5):293-303.   Published online September 23, 2021
DOI: https://doi.org/10.24171/j.phrp.2021.0063
  • 4,486 View
  • 146 Download
  • 4 Citations
Graphical AbstractGraphical Abstract AbstractAbstract PDF
Objectives
We investigated the impact of the coronavirus disease 2019 (COVID-19) pandemic on tuberculosis (TB) management in the Republic of Korea (ROK).
Methods
This retrospective cross-sectional study used nationwide ROK TB notification data (98,346 cases) from 2017 to 2020. The median time from the onset of TB symptoms to treatment initiation and the compliance rates with the required timing for notification and individual case investigations were measured and compared across periods and regions affected by the COVID-19 epidemic.
Results
TB diagnosis during the COVID-19 pandemic was delayed. The median time to TB treatment initiation (25 days) in 2020 increased by 3 days compared to that of the previous 3 years (22 days) (p<0.0001). In the outbreak in Seoul, Incheon, and Gyeonggi province during August, the time to TB diagnosis was 4 days longer than in the previous 3 years (p=0.0303). In the outbreak in Daegu and Gyeongbuk province from February to March 2020, the compliance rate with the required timing for individual case investigations was 2.2%p points lower than in other areas in 2020 (p=0.0148). For public health centers, the rate was 13%p lower than in other areas (80.3% vs. 93.3%, p=0.0003).
Conclusion
TB diagnoses during the COVID-19 pandemic in the ROK were delayed nationwide, especially for patients notified by public-private mix TB control hospitals. TB individual case investigations were delayed in regional COVID-19 outbreak areas (Daegu and Gyeongbuk province), especially in public health centers. Developing strategies to address this issue will be helpful for sustainable TB management during future outbreaks.

Citations

Citations to this article as recorded by  
  • Increased Healthcare Delays in Tuberculosis Patients During the First Wave of COVID-19 Pandemic in Korea: A Nationwide Cross-Sectional Study
    Jinsoo Min, Yousang Ko, Hyung Woo Kim, Hyeon-Kyoung Koo, Jee Youn Oh, Yun-Jeong Jeong, Hyeon Hui Kang, Kwang Joo Park, Yong Il Hwang, Jin Woo Kim, Joong Hyun Ahn, Yangjin Jegal, Ji Young Kang, Sung-Soon Lee, Jae Seuk Park, Ju Sang Kim
    Journal of Korean Medical Science.2022;[Epub]     CrossRef
  • Time trend prediction and spatial–temporal analysis of multidrug-resistant tuberculosis in Guizhou Province, China, during 2014–2020
    Wang Yun, Chen Huijuan, Liao Long, Lu Xiaolong, Zhang Aihua
    BMC Infectious Diseases.2022;[Epub]     CrossRef
  • Real-world association of adherence with outcomes and economic burden in patients with tuberculosis from South Korea claims data
    Sun-Hong Kwon, Jin Hyun Nam, Hye-Lin Kim, Hae-Young Park, Jin-Won Kwon
    Frontiers in Pharmacology.2022;[Epub]     CrossRef
  • The Impact of the COVID-19 Pandemic on Tuberculosis Case Notification and Treatment Outcomes in Eswatini
    Hloniphile Victory Masina, I-Feng Lin, Li-Yin Chien
    International Journal of Public Health.2022;[Epub]     CrossRef
Effects of activities of daily living-based dual-task training on upper extremity function, cognitive function, and quality of life in stroke patients
Hee-Su An, Deok-Ju Kim
Osong Public Health Res Perspect. 2021;12(5):304-313.   Published online September 13, 2021
DOI: https://doi.org/10.24171/j.phrp.2021.0177
  • 7,537 View
  • 183 Download
AbstractAbstract PDFSupplementary Material
Objectives
The aim of this study was to investigate the effect of daily living dual-task training focused on improving attention and executive function of the upper extremities, cognitive function, and quality of life in stroke patients.
Methods
We included 30 stroke patients who were hospitalized between July 2020 and October 2020. They were divided into experimental and control groups through randomization. The experimental group performed 20 minutes of dual-task training and received 10 minutes of conventional occupational therapy, while the control group performed 20 minutes of single-task training and received 10 minutes of conventional occupational therapy. Both groups underwent their respective rehabilitation for 30 minutes per session, 5 times per week for 5 weeks.
Results
Both groups showed significant improvements in upper extremity function, cognitive function, and quality of life; the experimental group showed higher results for all items. A significant between-group difference was observed in the magnitude of the changes.
Conclusion
In stroke patients, dual-task training that combined attention and executive function with daily living activities was found to be meaningful, as it encouraged active participation and motivation. This study is expected to be used as a foundation for future interventions for stroke patients.
Analysis of risk factors affecting suicidal ideation in South Korea by life cycle stage
Ji-Young Hwang, Il-Su Park
Osong Public Health Res Perspect. 2021;12(5):314-323.   Published online October 26, 2021
DOI: https://doi.org/10.24171/j.phrp.2021.0208
  • 2,482 View
  • 95 Download
  • 1 Citations
AbstractAbstract PDF
Objectives
This study analyzed risk factors for suicidal ideation in South Koreans from a life cycle perspective.
Methods
A secondary analysis was conducted of data collected in 2015 as part of the 6th Korea National Health and Nutrition Examination Survey (KNHANES). The participants comprised 5,935 individuals aged 12 years or older. The statistical analysis reflected the complex sampling design of the KNHANES, and the Rao-Scott chi-square test and multiple logistic regression analysis were performed.
Results
The prevalence of suicidal ideation was 5.7% in adolescents, 3.7% in young adults, 5.4% in middle-aged adults, and 7.0% in older adults. Depression and stress were risk factors in every stage of the life cycle. In those aged 12 to 19 years, activity restrictions were significantly associated with suicidal ideation. Education and subjective health status were risk factors in adults aged 20 to 39 years, and education, activity restrictions, and quality of life were the major risk factors in those aged 40 to 64 years. For adults 65 years of age or older, the risk of suicidal ideation was higher among those with inappropriate sleep time.
Conclusion
The risk factors for suicidal ideation were found to be different across stages of the life cycle. This suggests a need for individualized suicide prevention plans and specific government policies that reflect the characteristics of each life cycle stage.

Citations

Citations to this article as recorded by  
  • Association between Sleep Duration and Symptoms of Depression Aged between 18 and 49: The Korea National Health and Nutrition Examination Survey (KNHANES Ⅶ) from 2016 to 2018
    Sung-Yong Choi, Ji-Eun Han, Jiae Choi, Minjung Park, Soo-Hyun Sung, Angela Dong-Min Sung
    Healthcare.2022; 10(11): 2324.     CrossRef
Yes-associated protein 1 as a prognostic biomarker and its correlation with telomerase in various cancers
Hye-Ran Kim, Choong-Won Seo, Keunje Yoo, Sang Jun Han, Jongwan Kim
Osong Public Health Res Perspect. 2021;12(5):324-332.   Published online September 17, 2021
DOI: https://doi.org/10.24171/j.phrp.2021.0207
  • 2,780 View
  • 78 Download
AbstractAbstract PDFSupplementary Material
Objectives
The aims of this study were to investigate the expression of Yes-associated protein 1 (YAP1), its prognostic significance, and the correlation between YAP1 and telomerase in various cancers.
Methods
The Gene Expression Profiling Interactive Analysis database was used to analyze RNA sequencing data and the survival rate of patients with various cancers in The Cancer Genome Atlas (TCGA) database. PrognoScan was used to analyze the prognostic value of YAP1 expression in various cancers. Tumor Immune Estimation Resource was used to determine the correlation between YAP1 expression and telomerase in various cancer types based on TCGA data.
Results
The analysis suggested that YAP1 was differentially expressed between tissues of various cancers and non-tumor tissues. High YAP1 expression was also related to a poor prognosis in adrenocortical carcinoma, bladder urothelial carcinoma, and pancreatic adenocarcinoma. Moreover, YAP1 expression was correlated with the expression of telomerase reverse transcriptase and telomerase RNA component in various cancer types.
Conclusion
These results suggest that YAP1 is a potential biomarker with prognostic significance and relevance for oncogene research in various cancer types. The correlation between the expression of YAP1 and telomere-associated genes will help to understand their cancer-promoting mechanisms and interactions.
Comparative study of the intestinal parasitism profiles between communities across the 5 municipalities of the Barranquilla metropolitan area, Colombia
Luz A. Sarmiento-Rubiano, Margarita Filott, Lucila Gómez, Marianella Suarez-Marenco, María C. Sarmiento, Jimmy E. Becerra
Osong Public Health Res Perspect. 2021;12(5):333-341.   Published online October 20, 2021
DOI: https://doi.org/10.24171/j.phrp.2021.0181
  • 2,543 View
  • 84 Download
AbstractAbstract PDF
Objectives
The aim of this study was to compare the rate of parasitism and intestinal parasitism profiles of children who live in relatively proximal communities across the 5 municipalities of the Barranquilla metropolitan area, Colombia.
Methods
In total, 986 fecal samples from children aged 1 to 10 were analyzed using a direct method (physiological saline and lugol) and the zinc sulfate flotation technique. A comparative analysis of the parasitism profiles between sampling locations (7 schools and 3 health centers providing growth and development services) was conducted using principal component analysis (PCA). The presence of Taenia solium antibodies was evaluated by the enzyme-linked immunosorbent assay method in 269 serum samples from the same group of children.
Results
The overall prevalence of intestinal parasitism was 57.6% (range, 42.1%–77.6%) across the sampling areas. The prevalence of helminthiasis was between 4.1% and 23.7%, and that of intestinal protozoa was between 38.2% and 73.5%. PCA showed that the parasite profiles of each sampling location shared no common characteristics. A total of 3.0% of the serum samples were positive for T. solium antibodies.
Conclusion
The intestinal parasitism profiles between relatively proximal sampling locations with similar geographic conditions were vastly different, indicating the need to study each small ecological niche on a localized scale to develop more cost-effective interventions for controlling intestinal parasitism.

PHRP : Osong Public Health and Research Perspectives