Coronaviruses, which have been known to cause diseases in animals since the 1930s, utilize cellular components during their replication cycle. Lipids play important roles in viral infection, as coronaviruses target cellular lipids and lipid metabolism to modify their host cells to become an optimal environment for viral replication. Therefore, lipids can be considered as potential targets for the development of antiviral agents. This review provides an overview of the roles of cellular lipids in different stages of the life cycle of coronaviruses.
Citations
Citations to this article as recorded by
Orsay Virus Infection of Caenorhabditis elegans Is Modulated by Zinc and Dependent on Lipids Luis Alberto Casorla-Perez, Ranya Guennoun, Ciro Cubillas, Bo Peng, Kerry Kornfeld, David Wang, Rebecca Ellis Dutch Journal of Virology.2022;[Epub] CrossRef
Coronavirus disease 2019 (COVID-19) is caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), which has infected many people around the world. Children are considered an important target group for SARS-CoV-2, as well as other viral infections such as respiratory syncytial virus infection. Both SARS-CoV-2 and respiratory syncytial virus can affect the respiratory tract. Coinfection of SARS-CoV-2 and respiratory syncytial virus can pose significant challenges in terms of diagnosis and treatment in children. This review compares the symptoms, diagnostic methods, and treatment of COVID-19 and respiratory syncytial virus infection in children.
Citations
Citations to this article as recorded by
Results from the second WHO external quality assessment for the molecular detection of respiratory syncytial virus, 2019–2020 Thomas Williams, Sandra Jackson, Ian Barr, Shabana Bi, Jinal Bhiman, Joanna Ellis, Anne von Gottberg, Stephen Lindstrom, Teresa Peret, Sanjiv Rughooputh, Mariana Viegas, Siddhivinayak Hirve, Maria Zambon, Wenqing Zhang Influenza and Other Respiratory Viruses.2023;[Epub] CrossRef
The Impact of Coronavirus Disease 2019 on Viral, Bacterial, and Fungal Respiratory Infections Ashley Losier, Gayatri Gupta, Mario Caldararo, Charles S. Dela Cruz Clinics in Chest Medicine.2023; 44(2): 407. CrossRef
Viral Coinfection of Children Hospitalized with Severe Acute Respiratory Infections during COVID-19 Pandemic Célia Regina Malveste Ito, André Luís Elias Moreira, Paulo Alex Neves da Silva, Mônica de Oliveira Santos, Adailton Pereira dos Santos, Geovana Sôffa Rézio, Pollyanna Neta de Brito, Alana Parreira Costa Rezende, Jakeline Godinho Fonseca, Fernanda Aparecid Biomedicines.2023; 11(5): 1402. CrossRef
Respiratory syncytial virus, recurrent wheeze and asthma: A narrative review of pathophysiology, prevention and future directions Elly Binns, Jane Tuckerman, Paul V Licciardi, Danielle Wurzel Journal of Paediatrics and Child Health.2022; 58(10): 1741. CrossRef
Impact of genetic polymorphisms related to innate immune response on respiratory syncytial virus infection in children Laura Elena Córdova-Dávalos, Alicia Hernández-Mercado, Claudia Berenice Barrón-García, Augusto Rojas-Martínez, Mariela Jiménez, Eva Salinas, Daniel Cervantes-García Virus Genes.2022; 58(6): 501. CrossRef
Clinical and epidemiological characteristics of SARS-CoV-2 virus in ambulatory children under 2 years old Carolina A. Perez, Ivana Ormazabal, Javier Pérez-Valenzuela, Andrea Araya, Rafael A. Medina, Cecilia Perret Frontiers in Pediatrics.2022;[Epub] CrossRef
Objectives We investigated the impact of the coronavirus disease 2019 (COVID-19) pandemic on tuberculosis (TB) management in the Republic of Korea (ROK).
Methods This retrospective cross-sectional study used nationwide ROK TB notification data (98,346 cases) from 2017 to 2020. The median time from the onset of TB symptoms to treatment initiation and the compliance rates with the required timing for notification and individual case investigations were measured and compared across periods and regions affected by the COVID-19 epidemic.
Results TB diagnosis during the COVID-19 pandemic was delayed. The median time to TB treatment initiation (25 days) in 2020 increased by 3 days compared to that of the previous 3 years (22 days) (p<0.0001). In the outbreak in Seoul, Incheon, and Gyeonggi province during August, the time to TB diagnosis was 4 days longer than in the previous 3 years (p=0.0303). In the outbreak in Daegu and Gyeongbuk province from February to March 2020, the compliance rate with the required timing for individual case investigations was 2.2%p points lower than in other areas in 2020 (p=0.0148). For public health centers, the rate was 13%p lower than in other areas (80.3% vs. 93.3%, p=0.0003).
Conclusion TB diagnoses during the COVID-19 pandemic in the ROK were delayed nationwide, especially for patients notified by public-private mix TB control hospitals. TB individual case investigations were delayed in regional COVID-19 outbreak areas (Daegu and Gyeongbuk province), especially in public health centers. Developing strategies to address this issue will be helpful for sustainable TB management during future outbreaks.
Citations
Citations to this article as recorded by
Tuberculosis: Republic of Korea, 2021 Jinsoo Min, Hyung Woo Kim, Ju Sang Kim Tuberculosis and Respiratory Diseases.2023; 86(1): 67. CrossRef
Prevalence and associated factors of diabetes mellitus among patients with tuberculosis in South Korea from 2011 to 2018: a nationwide cohort study Dawoon Jeong, Jeongha Mok, Doosoo Jeon, Hee-Yeon Kang, Hee Jin Kim, Hee-Sun Kim, Jeong Mi Seo, Hongjo Choi, Young Ae Kang BMJ Open.2023; 13(3): e069642. CrossRef
Increased Healthcare Delays in Tuberculosis Patients During the First Wave of COVID-19 Pandemic in Korea: A Nationwide Cross-Sectional Study Jinsoo Min, Yousang Ko, Hyung Woo Kim, Hyeon-Kyoung Koo, Jee Youn Oh, Yun-Jeong Jeong, Hyeon Hui Kang, Kwang Joo Park, Yong Il Hwang, Jin Woo Kim, Joong Hyun Ahn, Yangjin Jegal, Ji Young Kang, Sung-Soon Lee, Jae Seuk Park, Ju Sang Kim Journal of Korean Medical Science.2022;[Epub] CrossRef
Time trend prediction and spatial–temporal analysis of multidrug-resistant tuberculosis in Guizhou Province, China, during 2014–2020 Wang Yun, Chen Huijuan, Liao Long, Lu Xiaolong, Zhang Aihua BMC Infectious Diseases.2022;[Epub] CrossRef
Real-world association of adherence with outcomes and economic burden in patients with tuberculosis from South Korea claims data Sun-Hong Kwon, Jin Hyun Nam, Hye-Lin Kim, Hae-Young Park, Jin-Won Kwon Frontiers in Pharmacology.2022;[Epub] CrossRef
The Impact of the COVID-19 Pandemic on Tuberculosis Case Notification and Treatment Outcomes in Eswatini Hloniphile Victory Masina, I-Feng Lin, Li-Yin Chien International Journal of Public Health.2022;[Epub] CrossRef
Trends in incidences of newly notified tuberculosis in Jeju Province, Korea, 2017-2021 Jinhee Kim, Nam-Hun Kang, Jong-Myon Bae Journal of Medicine and Life Science.2022; 19(3): 103. CrossRef
Objectives The aim of this study was to investigate the effect of daily living dual-task training focused on improving attention and executive function of the upper extremities, cognitive function, and quality of life in stroke patients.
Methods We included 30 stroke patients who were hospitalized between July 2020 and October 2020. They were divided into experimental and control groups through randomization. The experimental group performed 20 minutes of dual-task training and received 10 minutes of conventional occupational therapy, while the control group performed 20 minutes of single-task training and received 10 minutes of conventional occupational therapy. Both groups underwent their respective rehabilitation for 30 minutes per session, 5 times per week for 5 weeks.
Results Both groups showed significant improvements in upper extremity function, cognitive function, and quality of life; the experimental group showed higher results for all items. A significant between-group difference was observed in the magnitude of the changes.
Conclusion In stroke patients, dual-task training that combined attention and executive function with daily living activities was found to be meaningful, as it encouraged active participation and motivation. This study is expected to be used as a foundation for future interventions for stroke patients.
Citations
Citations to this article as recorded by
Occupation-based interventions to improve occupational performance and participation in the hospital setting: a systematic review Gemma Wall, Stephen Isbel, Louise Gustafsson, Claire Pearce Disability and Rehabilitation.2023; : 1. CrossRef
Effect of Upper Limb Motor Rehabilitation on Cognition in Parkinson’s Disease: An Observational Study Valentina Varalta, Elisa Evangelista, Anna Righetti, Giovanni Morone, Stefano Tamburin, Alessandro Picelli, Cristina Fonte, Michele Tinazzi, Ilaria Antonella Di Vico, Andreas Waldner, Mirko Filippetti, Nicola Smania Brain Sciences.2022; 12(12): 1684. CrossRef
Objectives This study analyzed risk factors for suicidal ideation in South Koreans from a life cycle perspective.
Methods A secondary analysis was conducted of data collected in 2015 as part of the 6th Korea National Health and Nutrition Examination Survey (KNHANES). The participants comprised 5,935 individuals aged 12 years or older. The statistical analysis reflected the complex sampling design of the KNHANES, and the Rao-Scott chi-square test and multiple logistic regression analysis were performed.
Results The prevalence of suicidal ideation was 5.7% in adolescents, 3.7% in young adults, 5.4% in middle-aged adults, and 7.0% in older adults. Depression and stress were risk factors in every stage of the life cycle. In those aged 12 to 19 years, activity restrictions were significantly associated with suicidal ideation. Education and subjective health status were risk factors in adults aged 20 to 39 years, and education, activity restrictions, and quality of life were the major risk factors in those aged 40 to 64 years. For adults 65 years of age or older, the risk of suicidal ideation was higher among those with inappropriate sleep time.
Conclusion The risk factors for suicidal ideation were found to be different across stages of the life cycle. This suggests a need for individualized suicide prevention plans and specific government policies that reflect the characteristics of each life cycle stage.
Citations
Citations to this article as recorded by
Alcohol Consumption and Quality of Life in Middle-aged Men Jeong-Sook Lee International Journal of High Risk Behaviors and A.2023;[Epub] CrossRef
Association between Sleep Duration and Symptoms of Depression Aged between 18 and 49: The Korea National Health and Nutrition Examination Survey (KNHANES Ⅶ) from 2016 to 2018 Sung-Yong Choi, Ji-Eun Han, Jiae Choi, Minjung Park, Soo-Hyun Sung, Angela Dong-Min Sung Healthcare.2022; 10(11): 2324. CrossRef
Objectives The aims of this study were to investigate the expression of Yes-associated protein 1 (YAP1), its prognostic significance, and the correlation between YAP1 and telomerase in various cancers.
Methods The Gene Expression Profiling Interactive Analysis database was used to analyze RNA sequencing data and the survival rate of patients with various cancers in The Cancer Genome Atlas (TCGA) database. PrognoScan was used to analyze the prognostic value of YAP1 expression in various cancers. Tumor Immune Estimation Resource was used to determine the correlation between YAP1 expression and telomerase in various cancer types based on TCGA data.
Results The analysis suggested that YAP1 was differentially expressed between tissues of various cancers and non-tumor tissues. High YAP1 expression was also related to a poor prognosis in adrenocortical carcinoma, bladder urothelial carcinoma, and pancreatic adenocarcinoma. Moreover, YAP1 expression was correlated with the expression of telomerase reverse transcriptase and telomerase RNA component in various cancer types.
Conclusion These results suggest that YAP1 is a potential biomarker with prognostic significance and relevance for oncogene research in various cancer types. The correlation between the expression of YAP1 and telomere-associated genes will help to understand their cancer-promoting mechanisms and interactions.
Objectives The aim of this study was to compare the rate of parasitism and intestinal parasitism profiles of children who live in relatively proximal communities across the 5 municipalities of the Barranquilla metropolitan area, Colombia.
Methods In total, 986 fecal samples from children aged 1 to 10 were analyzed using a direct method (physiological saline and lugol) and the zinc sulfate flotation technique. A comparative analysis of the parasitism profiles between sampling locations (7 schools and 3 health centers providing growth and development services) was conducted using principal component analysis (PCA). The presence of Taenia solium antibodies was evaluated by the enzyme-linked immunosorbent assay method in 269 serum samples from the same group of children.
Results The overall prevalence of intestinal parasitism was 57.6% (range, 42.1%–77.6%) across the sampling areas. The prevalence of helminthiasis was between 4.1% and 23.7%, and that of intestinal protozoa was between 38.2% and 73.5%. PCA showed that the parasite profiles of each sampling location shared no common characteristics. A total of 3.0% of the serum samples were positive for T. solium antibodies.
Conclusion The intestinal parasitism profiles between relatively proximal sampling locations with similar geographic conditions were vastly different, indicating the need to study each small ecological niche on a localized scale to develop more cost-effective interventions for controlling intestinal parasitism.
Citations
Citations to this article as recorded by
An update on the distribution of Blastocystis subtypes in the Americas Paula Jiménez, Marina Muñoz, Juan David Ramírez Heliyon.2022; 8(12): e12592. CrossRef
Frecuencia de parasitosis intestinal en escuelas primarias en Veracruz, México Vanessa Oceguera-Segovia, Gabriel Obed Martínez-Rodríguez, Janet Michelle Villafuerte-Ordaz, Xóchitl Magnolia Alanís-Reyes, Angel Alberto Puig-Lagunes Revista Mexicana de Pediatría.2022; 89(4): 146. CrossRef