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Original Articles
Risk factors for SARS-CoV-2 transmission during a movie theater outbreak in Incheon in the Republic of Korea, November 2021: a retrospective study
Hye Young Lee, Young-Joon Park, Sang-Eun Lee, Han-Na Yoo, Il-Hwan Kim, Jin Sun No, Eun-Jin Kim, Jungyeon Yu, Sanghwan Bae, Mi Yu
Received September 20, 2023  Accepted November 26, 2023  Published online January 31, 2024  
DOI: https://doi.org/10.24171/j.phrp.2023.0269    [Epub ahead of print]
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  • 21 Download
AbstractAbstract PDF
Objectives
We examined factors contributing to the transmission of an acute respiratory virus within multi-use facilities, focusing on an outbreak of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in a movie theater in the Republic of Korea.
Methods
This retrospective cohort study involved a descriptive analysis of 48 confirmed cases. Logistic regression was applied to a cohort of 80 theater attendees to identify risk factors for infection. The infection source and transmission route were determined through gene sequencing data analysis.
Results
Of the 48 confirmed cases, 35 were theater attendees (72.9%), 10 were family members of attendees (20.8%), 2 were friends (4.2%), and 1 was an employee (2.1%). Among the 80 individuals who attended the 3rd to 5th screenings of the day, 35 became infected, representing a 45.0% attack rate. Specifically, 28 of the 33 third-screening attendees developed confirmed SARS-CoV-2, constituting an 84.8% attack rate. Furthermore, 11 of the 12 cases epidemiologically linked to the theater outbreak were clustered monophyletically within the AY.69 lineage. At the time of the screening, 35 individuals (72.9%) had received 2 vaccine doses. However, vaccination status did not significantly influence infection risk. Multivariate analysis revealed that close contacts had a 15.9-fold higher risk of infection (95% confidence interval, 4.37–78.39) than casual contacts.
Conclusion
SARS-CoV-2 transmission occurred within the theater, and extended into the community, via a moviegoer who attended the 3rd screening during the viral incubation period after contracting the virus from a family member. This study emphasizes the importance of adequate ventilation in theaters.
Increased viral load in patients infected with severe acute respiratory syndrome coronavirus 2 Omicron variant in the Republic of Korea
Jeong-Min Kim, Dongju Kim, Nam-Joo Lee, Sang Hee Woo, Jaehee Lee, Hyeokjin Lee, Ae Kyung Park, Jeong-Ah Kim, Chae Young Lee, Il-Hwan Kim, Cheon Kwon Yoo, Eun-Jin Kim
Osong Public Health Res Perspect. 2023;14(4):272-278.   Published online July 27, 2023
DOI: https://doi.org/10.24171/j.phrp.2023.0024
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  • 105 Download
Graphical AbstractGraphical Abstract AbstractAbstract PDF
Objectives
Coronavirus disease 2019 (COVID-19) has been declared a global pandemic owing to the rapid spread of the causative agent, severe acute respiratory syndrome coronavirus 2. Its Delta and Omicron variants are more transmissible and pathogenic than other variants. Some debates have emerged on the mechanism of variants of concern. In the COVID-19 wave that began in December 2021, the Omicron variant, first reported in South Africa, became identifiable in most cases globally. The aim of this study was to provide data to inform effective responses to the transmission of the Omicron variant.
Methods
The Delta variant and the spike protein D614G mutant were compared with the Omicron variant. Viral loads from 5 days after symptom onset were compared using epidemiological data collected at the time of diagnosis.
Results
The Omicron variant exhibited a higher viral load than other variants, resulting in greater transmissibility within 5 days of symptom onset.
Conclusion
Future research should focus on vaccine efficacy against the Omicron variant and compare trends in disease severity associated with its high viral load.
Results of contact tracing for SARS-CoV-2 Omicron sub-lineages (BA.4, BA.5, BA.2.75) and the household secondary attack risk
Mi Yu, Sang-Eun Lee, Hye Young Lee, Hye-jin Kim, Yeong-Jun Song, Jian Jeong, Ae Kyung Park, Il-Hwan Kim, Eun-jin Kim, Young-Joon Park
Osong Public Health Res Perspect. 2023;14(3):173-179.   Published online June 22, 2023
DOI: https://doi.org/10.24171/j.phrp.2022.0285
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  • 57 Download
Graphical AbstractGraphical Abstract AbstractAbstract PDF
Objectives
This study aimed to assess the contact tracing outcomes of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) Omicron sub-lineages BA.4, BA.5, and BA.2.75 within Republic of Korea, and to generate foundational data for responding to future novel variants.
Methods
We conducted investigations and contact tracing for 79 confirmed BA.4 cases, 396 confirmed BA.5 cases, and 152 confirmed BA.2.75 cases. These cases were identified through random sampling of both domestically confirmed and imported cases, with the goal of evaluating the pattern of occurrence and transmissibility.
Results
We detected 79 instances of Omicron sub-lineage BA.4 across a span of 46 days, 396 instances of Omicron sub-lineage BA.5 in 46 days, and 152 instances of Omicron sub-lineage BA.2.75 over 62 days. One patient with severe illness was confirmed among the BA.5 cases; however, there were no reports of severe illness in the confirmed BA.4 and BA.2.75 cases. The secondary attack risk among household contacts were 19.6% for BA.4, 27.8% for BA.5, and 24.3% for BA.2.75. No statistically significant difference was found between the Omicron sub-lineages.
Conclusion
BA.2.75 did not demonstrate a higher tendency for transmissibility, disease severity, or secondary attack risk within households when compared to BA.4 and BA.5. We will continue to monitor major SARS-CoV-2 variants, and we plan to enhance the disease control and response systems.
Review Article
Review of the early reports of the epidemiological characteristics of the B.1.1.7 variant of SARS-CoV-2 and its spread worldwide
Yeonju Kim, Eun-Jin Kim, Sang-Won Lee, Donghyok Kwon
Osong Public Health Res Perspect. 2021;12(3):139-148.   Published online June 24, 2021
DOI: https://doi.org/10.24171/j.phrp.2021.0037
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  • 148 Download
  • 8 Web of Science
  • 9 Crossref
AbstractAbstract PDF
The variant B.1.1.7 of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the RNA virus causing the pandemic more than a year worldwide, was reported from United Kingdom (UK) in late December 2020. It was reported that mortality increases by 65% and transmissibility increases by 70%, which may result in an increase of reproduction number to 1.13−1.55 from 0.75−0.85. To analyze the global increasing trend of the variant B.1.1.7, we extracted results of B.1.1.7 from GISAID on May 11 and May 12, 2021, and conducted a doseresponse regression. It took 47 days to reach 20% and 121 days to reach 50% among the sequence submitted from UK. In Korea, cases of B.1.1.7 have increased since the first report of three cases on December 28, 2020. Positive rate of B.1.1.7 in Korea was 21.6% in the week from May 9 to May 15, 2021. Detection rate of the variants is expected to increase further and new variants of SARS-CoV-2 are emerging, so a close monitoring and control would be maintained for months.

Citations

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  • Mutations in SARS-CoV-2: Insights on structure, variants, vaccines, and biomedical interventions
    Ahmed I. Abulsoud, Hussein M. El-Husseiny, Ahmed A. El-Husseiny, Hesham A. El-Mahdy, Ahmed Ismail, Samy Y. Elkhawaga, Emad Gamil Khidr, Doaa Fathi, Eman A. Mady, Agnieszka Najda, Mohammad Algahtani, Abdulrahman Theyab, Khalaf F. Alsharif, Ashraf Albrakati
    Biomedicine & Pharmacotherapy.2023; 157: 113977.     CrossRef
  • Structural implications of SARS-CoV-2 Surface Glycoprotein N501Y mutation within receptor-binding domain [499-505] – computational analysis of the most frequent Asn501 polar uncharged amino acid mutations
    Done Stojanov
    Biotechnology & Biotechnological Equipment.2023;[Epub]     CrossRef
  • Molecular and Clinical Epidemiology of SARS-CoV-2 Infection among Vaccinated and Unvaccinated Individuals in a Large Healthcare Organization from New Jersey
    José R. Mediavilla, Tara Lozy, Annie Lee, Justine Kim, Veronica W. Kan, Elizabeth Titova, Ashish Amin, Michael C. Zody, André Corvelo, Dayna M. Oschwald, Amy Baldwin, Samantha Fennessey, Jerry M. Zuckerman, Thomas Kirn, Liang Chen, Yanan Zhao, Kar Fai Cho
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  • Incidence Evaluation of SARS-CoV-2 Variants in the Ulsan Area, Korea, Using PowerChek SARS-CoV-2 S-gene Mutation Detection Kit: A Pilot Study
    Sang Hyuk Park, Hyun-Ki Kim, Hang Kang, Jung Heon Kim, Jaeseung Lee, Ji-Hun Lim, Seon-Ho Lee, Joseph Jeong
    Annals of Laboratory Medicine.2022; 42(3): 363.     CrossRef
  • Biological Properties of SARS-CoV-2 Variants: Epidemiological Impact and Clinical Consequences
    Reem Hoteit, Hadi M. Yassine
    Vaccines.2022; 10(6): 919.     CrossRef
  • Virtual recruitment and participant engagement for substance use research during a pandemic
    Carolin C. Hoeflich, Anna Wang, Ayodeji Otufowora, Linda B. Cottler, Catherine W. Striley
    Current Opinion in Psychiatry.2022; 35(4): 252.     CrossRef
  • Display of receptor-binding domain of SARS-CoV-2 Spike protein variants on the Saccharomyces cerevisiae cell surface
    Hongguan Xing, Liyan Zhu, Pingping Wang, Guoping Zhao, Zhihua Zhou, Yi Yang, Hong Zou, Xing Yan
    Frontiers in Immunology.2022;[Epub]     CrossRef
  • Mutations in SARS-CoV-2 nucleocapsid in variants of concern impair the sensitivity of SARS-CoV-2 detection by rapid antigen tests
    Ibrahim T. Hagag, Krzysztof Pyrc, Saskia Weber, Anne Balkema-Buschmann, Martin H. Groschup, Markus Keller
    Frontiers in Virology.2022;[Epub]     CrossRef
  • The Disease Severity and Clinical Outcomes of the SARS-CoV-2 Variants of Concern
    Lixin Lin, Ying Liu, Xiujuan Tang, Daihai He
    Frontiers in Public Health.2021;[Epub]     CrossRef
Brief Report
Genomic Surveillance of SARS-CoV-2: Distribution of Clades in the Republic of Korea in 2020
Ae Kyung Park, Il-Hwan Kim, Junyoung Kim, Jeong-Min Kim, Heui Man Kim, Chae young Lee, Myung-Guk Han, Gi-Eun Rhie, Donghyok Kwon, Jeong-Gu Nam, Young-Joon Park, Jin Gwack, Nam-Joo Lee, SangHee Woo, Jin Sun No, Jaehee Lee, Jeemin Ha, JeeEun Rhee, Cheon-Kwon Yoo, Eun-Jin Kim
Osong Public Health Res Perspect. 2021;12(1):37-43.   Published online February 23, 2021
DOI: https://doi.org/10.24171/j.phrp.2021.12.1.06
  • 8,740 View
  • 221 Download
  • 20 Web of Science
  • 22 Crossref
AbstractAbstract PDF

Since a novel beta-coronavirus, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) was first reported in December 2019, there has been a rapid global spread of the virus. Genomic surveillance was conducted on samples isolated from infected individuals to monitor the spread of genetic variants of SARS-CoV-2 in Korea. The Korea Disease Control and Prevention Agency performed whole genome sequencing of SARS-CoV-2 in Korea for 1 year (January 2020 to January 2021). A total of 2,488 SARS-CoV-2 cases were sequenced (including 648 cases from abroad). Initially, the prevalent clades of SARS-CoV-2 were the S and V clades, however, by March 2020, GH clade was the most dominant. Only international travelers were identified as having G or GR clades, and since the first variant 501Y.V1 was identified (from a traveler from the United Kingdom on December 22nd, 2020), a total of 27 variants of 501Y.V1, 501Y.V2, and 484K.V2 have been classified (as of January 25th, 2021). The results in this study indicated that quarantining of travelers entering Korea successfully prevented dissemination of the SARS-CoV-2 variants in Korea.

Citations

Citations to this article as recorded by  
  • Increased viral load in patients infected with severe acute respiratory syndrome coronavirus 2 Omicron variant in the Republic of Korea
    Jeong-Min Kim, Dongju Kim, Nam-Joo Lee, Sang Hee Woo, Jaehee Lee, Hyeokjin Lee, Ae Kyung Park, Jeong-Ah Kim, Chae Young Lee, Il-Hwan Kim, Cheon Kwon Yoo, Eun-Jin Kim
    Osong Public Health and Research Perspectives.2023; 14(4): 272.     CrossRef
  • Rapid Emergence of the Omicron Variant of Severe Acute Respiratory Syndrome Coronavirus 2 in Korea
    Ae Kyung Park, Il-Hwan Kim, Chae Young Lee, Jeong-Ah Kim, Hyeokjin Lee, Heui Man Kim, Nam-Joo Lee, SangHee Woo, Jaehee Lee, JeeEun Rhee, Cheon-Kwon Yoo, Eun-Jin Kim
    Annals of Laboratory Medicine.2023; 43(2): 211.     CrossRef
  • A Seroprevalence Study on Residents in a Senior Care Facility with Breakthrough SARS-CoV-2 Omicron Infection
    Heui Man Kim, Eun Ju Lee, Sang Won O, Yong Jun Choi, Hyeokjin Lee, Sae Jin Oh, Jeong-Min Kim, Ae Kyung Park, Jeong-Ah Kim, Chae young Lee, Jong Mu Kim, Hanul Park, Young Joon Park, Jeong-Hee Yu, Eun-Young Kim, Hwa-Pyeong Ko, Eun-Jin Kim
    Viral Immunology.2023; 36(3): 203.     CrossRef
  • COVID-19 Cases and Deaths among Healthcare Personnel with the Progression of the Pandemic in Korea from March 2020 to February 2022
    Yeonju Kim, Sung-Chan Yang, Jinhwa Jang, Shin Young Park, Seong Sun Kim, Chansoo Kim, Donghyok Kwon, Sang-Won Lee
    Tropical Medicine and Infectious Disease.2023; 8(6): 308.     CrossRef
  • The COVID-19 pandemic and healthcare utilization in Iran: evidence from an interrupted time series analysis
    Monireh Mahmoodpour-Azari, Satar Rezaei, Nasim Badiee, Mohammad Hajizadeh, Ali Mohammadi, Ali Kazemi-Karyani, Shahin Soltani, Mehdi Khezeli
    Osong Public Health and Research Perspectives.2023; 14(3): 180.     CrossRef
  • Online Phylogenetics with matOptimize Produces Equivalent Trees and is Dramatically More Efficient for Large SARS-CoV-2 Phylogenies than de novo and Maximum-Likelihood Implementations
    Alexander M Kramer, Bryan Thornlow, Cheng Ye, Nicola De Maio, Jakob McBroome, Angie S Hinrichs, Robert Lanfear, Yatish Turakhia, Russell Corbett-Detig, Olivier Gascuel
    Systematic Biology.2023; 72(5): 1039.     CrossRef
  • Genomic epidemiology of SARS-CoV-2 variants in South Korea between January 2020 and February 2023
    Il-Hwan Kim, Jin Sun No, Jeong-Ah Kim, Ae Kyung Park, HyeokJin Lee, Jeong-Min Kim, Nam-Joo Lee, Chi-Kyeong Kim, Chae Young Lee, SangHee Woo, Jaehee Lee, JeeEun Rhee, Eun-Jin Kim
    Virology.2023; 587: 109869.     CrossRef
  • Genomic evidence of SARS‐CoV‐2 reinfection in the Republic of Korea
    Ae Kyung Park, Jee Eun Rhee, Il‐Hwan Kim, Heui Man Kim, Hyeokjin Lee, Jeong‐Ah Kim, Chae Young Lee, Nam‐Joo Lee, SangHee Woo, Jaehee Lee, Jin Sun No, Gi‐Eun Rhie, Seong Jin Wang, Sang‐Eun Lee, Young Joon Park, Gemma Park, Jung Yeon Kim, Jin Gwack, Cheon‐K
    Journal of Medical Virology.2022; 94(4): 1717.     CrossRef
  • SARS-CoV-2 B.1.619 and B.1.620 Lineages, South Korea, 2021
    Ae Kyung Park, Il-Hwan Kim, Heui Man Kim, Hyeokjin Lee, Nam-Joo Lee, Jeong-Ah Kim, SangHee Woo, Chae young Lee, Jaehee Lee, Sae Jin Oh, JeeEun Rhee, Cheon-Kwon Yoo, Eun-Jin Kim
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  • Humoral and Cellular Responses to COVID-19 Vaccines in SARS-CoV-2 Infection-Naïve and -Recovered Korean Individuals
    Ji-Young Hwang, Yunhwa Kim, Kyung-Min Lee, Eun-Jeong Jang, Chang-Hoon Woo, Chang-Ui Hong, Seok-Tae Choi, Sivilay Xayaheuang, Jong-Geol Jang, June-Hong Ahn, Hosun Park
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  • Increase in Viral Load in Patients With SARS-CoV-2 Delta Variant Infection in the Republic of Korea
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  • Molecular Dynamics Studies on the Structural Stability Prediction of SARS-CoV-2 Variants Including Multiple Mutants
    Kwang-Eun Choi, Jeong-Min Kim, Jee Eun Rhee, Ae Kyung Park, Eun-Jin Kim, Cheon Kwon Yoo, Nam Sook Kang
    International Journal of Molecular Sciences.2022; 23(9): 4956.     CrossRef
  • SARS-CoV-2 shedding dynamics and transmission in immunosuppressed patients
    Jee-Soo Lee, Ki Wook Yun, Hyeonju Jeong, Boram Kim, Man Jin Kim, Jae Hyeon Park, Ho Seob Shin, Hyeon Sae Oh, Hobin Sung, Myung Gi Song, Sung Im Cho, So Yeon Kim, Chang Kyung Kang, Pyoeng Gyun Choe, Wan Beom Park, Nam Joong Kim, Myoung-Don Oh, Eun Hwa Choi
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    Sunhee Lee, Gun Young Yoon, Su Jin Lee, Young-Chan Kwon, Hyun Woo Moon, Yu-Jin Kim, Haesoo Kim, Wooseong Lee, Gi Uk Jeong, Chonsaeng Kim, Kyun-Do Kim, Seong-Jun Kim, Dae-Gyun Ahn, Miguel Angel Martinez
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    Sung Woon Kang, Heedo Park, Ji Yeun Kim, Sunghee Park, So Yun Lim, Sohyun Lee, Joon-Yong Bae, Jeonghun Kim, Seongman Bae, Jiwon Jung, Min Jae Kim, Yong Pil Chong, Sang-Oh Lee, Sang-Ho Choi, Yang Soo Kim, Sung-Cheol Yun, Man-Seong Park, Sung-Han Kim
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  • Comparative analysis of mutational hotspots in the spike protein of SARS-CoV-2 isolates from different geographic origins
    Sanghoo Lee, Mi-Kyeong Lee, Hyeongkyun Na, Jinwoo Ahn, Gayeon Hong, Youngkee Lee, Jimyeong Park, Yejin Kim, Yun-Tae Kim, Chang-Ki Kim, Hwan-Sub Lim, Kyoung-Ryul Lee
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  • Review of Current COVID-19 Diagnostics and Opportunities for Further Development
    Yan Mardian, Herman Kosasih, Muhammad Karyana, Aaron Neal, Chuen-Yen Lau
    Frontiers in Medicine.2021;[Epub]     CrossRef
  • Locally harvested Covid-19 convalescent plasma could probably help combat the geographically determined SARS-CoV-2 viral variants
    Manish Raturi, Anuradha Kusum, Mansi Kala, Garima Mittal, Anita Sharma, Naveen Bansal
    Transfusion Clinique et Biologique.2021; 28(3): 300.     CrossRef
  • Molecular Dynamics Studies on the Structural Characteristics for the Stability Prediction of SARS-CoV-2
    Kwang-Eun Choi, Jeong-Min Kim, JeeEun Rhee, Ae Kyung Park, Eun-Jin Kim, Nam Sook Kang
    International Journal of Molecular Sciences.2021; 22(16): 8714.     CrossRef
  • Management following the first confirmed case of SARS-CoV-2 in a domestic cat associated with a massive outbreak in South Korea
    Taewon Han, Boyeong Ryu, Suyeon Lee, Yugyeong Song, Yoongje Jeong, Ilhwan Kim, Jeongmin Kim, Eunjin Kim, Wonjun Lee, Hyunju Lee, Haekyoung Hwang
    One Health.2021; 13: 100328.     CrossRef
  • Genomic epidemiology reveals the reduction of the introduction and spread of SARS-CoV-2 after implementing control strategies in Republic of Korea, 2020
    Jung-Hoon Kwon, Jeong-Min Kim, Dong-hun Lee, Ae Kyung Park, Il-Hwan Kim, Da-Won Kim, Ji-Yun Kim, Noori Lim, Kyeong-Yeon Cho, Heui Man Kim, Nam-Joo Lee, SangHee Woo, Chae Young Lee, Jin Sun No, Junyoung Kim, JeeEun Rhee, Myung-Guk Han, Gi-Eun Rhie, Cheon K
    Virus Evolution.2021;[Epub]     CrossRef
Original Articles
2019 Tabletop Exercise for Laboratory Diagnosis and Analyses of Unknown Disease Outbreaks by the Korea Centers for Disease Control and Prevention
Il-Hwan Kim, Jun Hyeong Jang, Su-Kyoung Jo, Jin Sun No, Seung-Hee Seo, Jun-Young Kim, Sang-Oun Jung, Jeong-Min Kim, Sang-Eun Lee, Hye-Kyung Park, Eun-Jin Kim, Jun Ho Jeon, Myung-Min Choi, Boyeong Ryu, Yoon Suk Jang, Hwami Kim, Jin Lee, Seung-Hwan Shin, Hee Kyoung Kim, Eun-Kyoung Kim, Ye Eun Park, Cheon-Kwon Yoo, Sang-Won Lee, Myung-Guk Han, Gi-Eun Rhie, Byung Hak Kang
Osong Public Health Res Perspect. 2020;11(5):280-285.   Published online October 22, 2020
DOI: https://doi.org/10.24171/j.phrp.2020.11.5.03
  • 5,595 View
  • 105 Download
AbstractAbstract PDF
Objectives

The Korea Centers for Disease Control and Prevention has published “A Guideline for Unknown Disease Outbreaks (UDO).” The aim of this report was to introduce tabletop exercises (TTX) to prepare for UDO in the future.

Methods

The UDO Laboratory Analyses Task Force in Korea Centers for Disease Control and Prevention in April 2018, assigned unknown diseases into 5 syndromes, designed an algorithm for diagnosis, and made a panel list for diagnosis by exclusion. Using the guidelines and laboratory analyses for UDO, TTX were introduced.

Results

Since September 9th, 2018, the UDO Laboratory Analyses Task Force has been preparing TTX based on a scenario of an outbreak caused by a novel coronavirus. In December 2019, through TTX, individual missions, epidemiological investigations, sample treatments, diagnosis by exclusions, and next generation sequencing analysis were discussed, and a novel coronavirus was identified as the causal pathogen.

Conclusion

Guideline and laboratory analyses for UDO successfully applied in TTX. Conclusions drawn from TTX could be applied effectively in the analyses for the initial response to COVID-19, an ongoing epidemic of 2019 – 2020. Therefore, TTX should continuously be conducted for the response and preparation against UDO.

Infectivity of Homologous Recombinant HIV-1 Pseudo-virus with Reverse Transcriptase Inhibitor-related Mutations from Highly Active Antiretroviral Therapy Experienced Patients
Oh-Kyung Kwon, Ju-yeon Choi, Eun-Jin Kim, Sung Soon Kim
Osong Public Health Res Perspect. 2011;2(1):23-28.   Published online June 30, 2011
DOI: https://doi.org/10.1016/j.phrp.2011.04.006
  • 2,656 View
  • 13 Download
  • 3 Crossref
AbstractAbstract PDF
Objectives
In this study, the viral fitness of pseudo-viruses with a drug-resistant site in the reverse transcriptase (RT) region of the genome was investigated. The pseudo-viruses were derived from highly active antiretroviral therapy (HAART)-experienced HIV/AIDS patients.
Methods
HIV-1 RNA was extracted from the plasma of HAART-experienced (KRB9149, KRB7021, KRC1097) and HAART-naïve (KRC5180, KRC5123) HIV-1 patients. The RT gene from the extracted viral RNA was amplified and the polymerase chain reaction product was cloned from the pHXB2Δ2-261 RT vector. C8166 and TZM-bl cell lines were used as the HIV-1 replication capacity measurement system. To quantify the infectivity of homologous recombinant HIV-1, the infectivity derived from each pseudo-virus was compared with the infectivity of the reference strain HXB2.
Results
Patient-derived HIV-1 was cotransfected into C8166 cells and the expression level of the p24 antigen was measured. The expression was high in the HIV-1 isolates from patients KRC5180 and KRB9149 and low in patients KRB7021, KRC5123, and KRC1097, when compared with the reference strain. The infectivity of the pseudo-virus measured in TZM-bl cells decreased in the order, reference strain HXB2 > KRC5180 > KRC5123 > KRB9149 > KRB7021 > KRC1097.
Conclusion
In this study, HIV-1 infectivity of the drug-resistant strain isolated from HAART-experienced patients with HIV/AIDS was found to be lower than the infectivity of the reference strain HXB2. This study provides useful data for the phenotypic susceptibility assay in HAART-experienced patients infected with HIV-1.

Citations

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PHRP : Osong Public Health and Research Perspectives