Skip Navigation
Skip to contents

PHRP : Osong Public Health and Research Perspectives



Page Path
HOME > Search
1 "Hye-Ran Jeong"
Article category
Publication year
Original Article
Evaluation and Comparison of Molecular and Conventional Diagnostic Tests for Detecting Tuberculosis in Korea, 2013
Sang-Hee Park, Chang-Ki Kim, Hye-Ran Jeong, Hyunjin Son, Seong-Han Kim, Mi-Sun Park
Osong Public Health Res Perspect. 2014;5(Suppl):S3-S7.   Published online December 31, 2014
  • 2,986 View
  • 21 Download
  • 7 Crossref
AbstractAbstract PDF
A fast and accurate diagnosis is necessary to control and eliminate tuberculosis (TB). In Korea, TB continues to be a serious public health problem. In this study, diagnostic tests on clinical samples from patients suspected to have TB were performed and the sensitivity and specificity of the various techniques were compared. The main objective of the study was to compare various diagnostic tests and evaluate their sensitivity and specificity for detecting tuberculosis.
From January 2013 to December 2013, 170,240 clinical samples from patients suspected to have TB were tested with smear microscopy, acid-fast bacilli culture, and real-time polymerase chain reaction (PCR). The test results were compared and data were analyzed.
A total of 8216 cultures tested positive for TB (positive detection rate, 4.8%). The contamination rate in the culture was 0.6% and the isolation rate of nontuberculous mycobacteria was 1.0%. The sensitivity and specificity of smear microscopy were 56.8% and 99.6%, respectively. The concordance rate between the solid and liquid cultures was 92.8%. Mycobacterium isolates were not detected in 0.4% of the cases in the liquid culture, whereas no Mycobacterium isolates were detected in 6.8% of the cases in the solid culture. The sensitivity and specificity of real-time PCR for the solid culture were 97.2% and 72.4%, respectively, whereas the corresponding data for the liquid culture were 93.5% and 97.2%.
The study results can be used to improve existing TB diagnosis procedure as well as for comparing the effectiveness of the assay tests used for detecting Mycobacterium tuberculosis isolates.


Citations to this article as recorded by  
  • The Xpert® MTB/RIF diagnostic test for pulmonary and extrapulmonary tuberculosis in immunocompetent and immunocompromised patients: Benefits and experiences over 2 years in different clinical contexts
    Ana Paula de Oliveira Tomaz, Sonia Mara Raboni, Gislene Maria Botão Kussen, Keite da Silva Nogueira, Clea Elisa Lopes Ribeiro, Libera Maria Dalla Costa, Padmapriya P. Banada
    PLOS ONE.2021; 16(3): e0247185.     CrossRef
  • Comparative performance of the laboratory assays used by a Diagnostic Laboratory Hub for opportunistic infections in people living with HIV
    Narda Medina, Ana Alastruey-Izquierdo, Danicela Mercado, Oscar Bonilla, Juan C. Pérez, Luis Aguirre, Blanca Samayoa, Eduardo Arathoon, David W. Denning, Juan Luis Rodriguez-Tudela
    AIDS.2020; 34(11): 1625.     CrossRef
  • Multiplex PCR is a Rapid, Simple and Cheap Method for Direct Diagnosis of M. tuberculosis from Sputum Samples
    Tarig M.S. Alnour, Faisel Abuduhier , Mohammed Khatatneh , Fahad Albalawi , Khalid Alfifi , Bernard Silvala
    Infectious Disorders - Drug Targets .2020; 20(4): 495.     CrossRef
  • Naked eye detection of the Mycobacterium tuberculosis complex by recombinase polymerase amplification—SYBR green I assays
    Nuntita Singpanomchai, Yukihiro Akeda, Kazunori Tomono, Aki Tamaru, Pitak Santanirand, Panan Ratthawongjirakul
    Journal of Clinical Laboratory Analysis.2019;[Epub]     CrossRef
  • Retropharyngeal SOL: An unusual presentation of a multifaceted entity
    Poojan Agarwal, Manju Kaushal, Shruti Dogra, Ankur Gupta, Nishi Sharma
    CytoJournal.2018; 15: 12.     CrossRef
  • Rapid Detection of Rifampicin- and Isoniazid-Resistant Mycobacterium tuberculosis using TaqMan Allelic Discrimination
    Davood Darban-Sarokhalil, Mohammad J. Nasiri, Abbas A.I. Fooladi, Parvin Heidarieh, Mohammad M. Feizabadi
    Osong Public Health and Research Perspectives.2016; 7(2): 127.     CrossRef
  • Port site infection in laparoscopic surgery: A review of its management
    Prakash K Sasmal
    World Journal of Clinical Cases.2015; 3(10): 864.     CrossRef

PHRP : Osong Public Health and Research Perspectives