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Original Article
- mRNA vaccine effectiveness against SARS-CoV-2 B.1.617.2 (Delta) and B.1.1.529 (Omicron) variant transmission from home care cases to household contacts in South Korea
- Hanul Park, Young Joon Park, Sang Eun Lee, Min Jei Lee, Hyungtae Ahn
- Osong Public Health Res Perspect. 2022;13(6):435-442. Published online November 28, 2022
- DOI: https://doi.org/10.24171/j.phrp.2022.0243
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- 2 Web of Science
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Abstract
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- Objectives
Household contacts of confirmed cases of coronavirus disease 2019 (COVID-19) areexposed to a high risk of viral transmission, and secondary incidence is an important indicatorof community transmission. This study analyzed the secondary attack rate and mRNA vaccineeffectiveness against transmission (VET) for index cases (patients treated at home) confirmedto be infected with the Delta and Omicron variants.Methods: The subjects of the study were 4,450 index cases and 10,382 household contacts.Logistic regression analysis was performed to compare the secondary attack rate byvaccination status, and adjusted relative risk and 95% confidence intervals were identified.Results: The secondary attack rate of the Delta variant was 27.3%, while the secondary attackrate of the Omicron variant was 29.8%. For the Delta variant, groups with less than 90 daysand more than 90 days after 2 doses of mRNA vaccination both showed a VET of 37%. For theOmicron variant, a 64% VET was found among those with less than 90 days after 2 doses ofmRNA vaccination.Conclusion: This study provides useful data on the secondary attack rate and VET of mRNAvaccines for household contacts of COVID-19 cases in South Korea. -
Citations
Citations to this article as recorded by
- Impact of disease severity, age, sex, comorbidity, and vaccination on secondary attack rates of SARS-CoV-2: a global systematic review and meta-analysis
Dewan Md. Sumsuzzman, Yang Ye, Zhen Wang, Abhishek Pandey, Joanne M. Langley, Alison P. Galvani, Seyed M. Moghadas
BMC Infectious Diseases.2025;[Epub] CrossRef - Child Transmission of SARS-CoV-2 Throughout the Pandemic: An Updated Systematic Review and Meta-Analysis
Eugene Kwon, Gabriel Blank, Samantha Starkey, Cassidy Chapman, Conné Lategan, Hennady Shulha, Vanessa Kitchin, Sarah Silverberg, Laura Sauvé, Manish Sadarangani
Pediatric Infectious Disease Journal.2025;[Epub] CrossRef - Household secondary attack rates and risk factors during periods of SARS-CoV-2 Delta and Omicron variant predominance in the Republic of Korea
Jin Lee, Mijeong Ko, Seontae Kim, Dosang Lim, Gemma Park, Sang-Eun Lee
Osong Public Health and Research Perspectives.2023; 14(4): 263. CrossRef
- Impact of disease severity, age, sex, comorbidity, and vaccination on secondary attack rates of SARS-CoV-2: a global systematic review and meta-analysis
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