Skip Navigation
Skip to contents

PHRP : Osong Public Health and Research Perspectives



Page Path
HOME > Search
2 "Injun Cha"
Article category
Publication year
Original Article
Surveillance of Bacillus cereus Isolates in Korea from 2012 to 2014
Su-Mi Jung, Nan-Ok Kim, Injun Cha, Hae-young Na, Gyung Tae Chung, Hyo Sun Kawk, Sahyun Hong
Osong Public Health Res Perspect. 2017;8(1):71-77.   Published online February 28, 2017
  • 4,514 View
  • 41 Download
  • 5 Crossref
AbstractAbstract PDF

To investigate the prevalence and toxin production characteristics of non-emetic and emetic Bacillus cereus strains isolated via the laboratory surveillance system in Korea.


A total of 667 B. cereus strains were collected by the Korea National Research Institute of Health laboratory surveillance system from 2012 to 2014. The collected strains were analyzed by geographical region, season, patient age, and patient sex. Additionally, the prevalence rates of enterotoxin and emetic toxin genes were evaluated.


The isolation rate of B. cereus strains increased during the summer, but the isolation rate was evenly distributed among patient age groups. Emetic toxin was produced by 20.2% of the isolated strains. The prevalence rates of five enterotoxin genes (entFM, nheA, cytK2, hblC, and bceT) were 85.0, 78.6, 44.5, 36.6, and 29.7%, respectively, among non-emetic strains and 77.8, 59.3, 17.8, 11.9 and 12.6%, respectively, among emetic strains. Thus, the prevalence rates of all five enterotoxin genes were lower in emetic B. cereus.


The prevalence of enterotoxin genes differed between non-emetic and emetic B. cereus strains. Among emetic B. cereus strains, the prevalence rates of two enterotoxin genes (cytK2 and hblC) were lower than those among the non-emetic strains. In both the emetic and non-emetic strains isolated in Korea, nheA and entFM were the most prevalent enterotoxin genes.


Citations to this article as recorded by  
  • Toxigenic diversity of Bacillus cereus isolated from fresh produce and effects of various factors on the growth and the cytotoxicity of B. cereus
    Areum Han, Jae-Hyun Yoon, Yun-Sun Choi, Yujin Bong, Gyusuck Jung, Sung-Kwon Moon, Sun-Young Lee
    Food Science and Biotechnology.2024; 33(1): 219.     CrossRef
  • Bacillus cereus containing nheA, hblC and cytk enterotoxin genes is associated with acute childhood gastroenteritis in Nigeria
    Ebuka E. David, Ikechuku O. Igwenyi, Ifeanyichukwu R. Iroha, Layla F. Martins, Guillermo Uceda-Campos, Aline M. da Silva
    Indian Journal of Medical Microbiology.2024; 51: 100666.     CrossRef
  • A study on toxin genes and cytotoxicity levels of Bacillus cereus in various ready-to-eat foods and pastry products in Turkey
    Başak Gökçe ÇÖL, Harun AKSU
    Journal of Istanbul Veterinary Sciences.2022; 6(3): 152.     CrossRef
  • Autoinducer-2 Could Affect Biofilm Formation by Food-Derived Bacillus cereus
    Nari Lee, Myo-Deok Kim, Min-Cheol Lim
    Indian Journal of Microbiology.2021; 61(1): 66.     CrossRef
  • Effects of Low-Temperature Drying with Intermittent Gaseous Chlorine Dioxide Treatment on Texture and Shelf-Life of Rice Cakes
    Timilehin Martins Oyinloye, Won Byong Yoon
    Processes.2020; 8(3): 375.     CrossRef
Enhanced Type III Secretion System Expression of Atypical Shigella flexneri II:(3)4,7(8)
Sahyun Hong, Injun Cha, Nan-Ok Kim, Seong-Han Kim, Kyung-Tae Jung, Je-Hee Lee, Dong-Wook Kim, Mi-Sun Park, Yeon-Ho Kang
Osong Public Health Res Perspect. 2012;3(4):222-228.   Published online December 31, 2012
  • 2,585 View
  • 19 Download
AbstractAbstract PDF
We aimed at evaluating the virulence of atypical Shigella flexneri II:(3)4,7(8) by DNA microarray and invasion assay.
We used a customized S. flexneri DNA microarray to analyze an atypical S. flexneri II:(3)4,7(8) gene expression profile and compared it with that of the S. flexneri 2b strain.
Approximately one-quarter of the atypical S. flexneri II:(3)4,7(8) strain genes showed significantly altered expression profiles; 344 genes were more than two-fold upregulated, and 442 genes were more than 0.5-fold downregulated. The upregulated genes were divided into the category of 21 clusters of orthologous groups (COGs), and the “not in COGs” category included 170 genes. This category had virulence plasmid genes, including the ipa-mxi-spa genes required for invasion of colorectal epithelium (type III secretion system). Quantitative reverse-transcription polymerase chain reaction results also showed the same pattern in two more atypical S. flexneri II:(3)4,7(8) strains. Atypical S. flexneri II:(3)4,7(8) showed four times increased invasion activity in Caco-2 cells than that of typical strains.
Our results provide the intracellularly regulated genes that may be important for adaptation and growth strategies of this atypical S. flexneri.

PHRP : Osong Public Health and Research Perspectives