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Original Articles
Lon Mutant of Brucella abortus Induces Tumor Necrosis Factor-Alpha in Murine J774.A1 Macrophage
Sungdo Park, Young-Sill Choi, Sang-Hee Park, Young-Rok Kim, Hyuk Chu, Kyu-Jam Hwang, Mi-Yeoun Park
Osong Public Health Res Perspect. 2013;4(6):301-307.   Published online December 31, 2013
DOI: https://doi.org/10.1016/j.phrp.2013.10.002
  • 2,027 View
  • 19 Download
  • 5 Citations
AbstractAbstract PDF
Objectives
The objective of this study was to isolate a Brucella lon mutant and to analyze the cytokine response of B. lon mutant during macrophage infection.
Methods
A wild-type Brucella abortus strain was mutagenized by Tn5 transposition. From the mouse macrophage J774.A1 cells, total RNA was isolated at 0 hours, 6 hours, 12 hours, and 24 hours after infection with Brucella. Using mouse cytokine microarrays, we measured transcriptional levels of the cytokine response, and validated our results with a reverse transcriptase-polymerase chain reaction (RT-PCR) assay to confirm the induction of cytokine messenger RNA (mRNA).
Results
In host J774.A1 macrophages, mRNA levels of T helper 1 (Th1)-type cytokines, including tumor necrosis factor-alpha (TNF-α), interferon-gamma (IFN-γ), interleukin-2 (IL-2), and IL-3, were significantly higher in the lon mutant compared to wild-type Brucella and the negative control. TNF-α levels in cell culture media were induced as high as 2 μg/mL after infection with the lon mutant, a greater than sixfold change.
Conclusion
In order to understand the role of the lon protein in virulence, we identified and characterized a novel B. lon mutant. We compared the immune response it generates to the wild-type Brucella response in a mouse macrophage cell line. We demonstrated that the B. lon mutants induce TNF-α expression from the host J774.A1 macrophage.

Citations

Citations to this article as recorded by  
  • Brucella abortus Encodes an Active Rhomboid Protease: Proteome Response after Rhomboid Gene Deletion
    María Inés Marchesini, Ansgar Poetsch, Leticia Soledad Guidolín, Diego J. Comerci
    Microorganisms.2022; 10(1): 114.     CrossRef
  • Proteomics of Brucella
    Ansgar Poetsch, María Inés Marchesini
    Proteomes.2020; 8(2): 8.     CrossRef
  • Outer Membrane Vesicles From Brucella melitensis Modulate Immune Response and Induce Cytoskeleton Rearrangement in Peripheral Blood Mononuclear Cells
    Eric Daniel Avila-Calderón, Olín Medina-Chávez, Leopoldo Flores-Romo, José Manuel Hernández-Hernández, Luis Donis-Maturano, Ahidé López-Merino, Beatriz Arellano-Reynoso, Ma. Guadalupe Aguilera-Arreola, Enrico A. Ruiz, Zulema Gomez-Lunar, Sharon Witonsky,
    Frontiers in Microbiology.2020;[Epub]     CrossRef
  • RNA-seq reveals the critical role of Lon protease in stress response and Brucella virulence
    Yufu Liu, Hao Dong, Xiaowei Peng, Qiang Gao, Hui Jiang, Guanlong Xu, Yuming Qin, Jianrui Niu, Shijing Sun, Peng Li, Jiabo Ding, Ruiai Chen
    Microbial Pathogenesis.2019; 130: 112.     CrossRef
  • Brucella Downregulates Tumor Necrosis Factor-α to Promote Intracellular Survival via Omp25 Regulation of Different MicroRNAs in Porcine and Murine Macrophages
    Xiaomao Luo, Xiujuan Zhang, Xingchen Wu, Xuefeng Yang, Cong Han, Zhengyu Wang, Qian Du, Xiaomin Zhao, Shan-Lu Liu, Dewen Tong, Yong Huang
    Frontiers in Immunology.2018;[Epub]     CrossRef
Evaluation and Selection of Multilocus Variable-Number Tandem-Repeat Analysis Primers for Genotyping Brucella abortus Biovar 1 Isolated from Human Patients
Subok Lee, Kyu-Jam Hwang, Mi-Yeoun Park, Seon-Do Hwang, Hee-Youl Chai, Hyuk Chu, Sang-Hee Park
Osong Public Health Res Perspect. 2013;4(5):265-270.   Published online October 31, 2013
DOI: https://doi.org/10.1016/j.phrp.2013.09.005
  • 1,863 View
  • 15 Download
  • 1 Citations
AbstractAbstract PDF
Objectives
Brucellosis is the most common bacterial zoonosis in the world. Multilocus variable-number tandem-repeat (VNTR) analysis (MLVA) is a molecular method for genotyping bacterial species. Brucella abortus biovar I was isolated from most of the brucellosis-suspected patients in Korea. This study was conducted to investigate the ability of various MLVA primers that are used for molecular typing B. abortus isolates and for analyzing their epidemiological data.
Methods
A total of 80 human isolates of B. abortus biovar I isolated from human patients and the reference strain were used for MLVA. Genetic diversity was determined by calculating the Simpson's diversity index (DI) of each VNTR locus. The Brucella strains were subcultured 30 times to determine the stability of each locus. The DNA of the strains cultivated in each passage was extracted and subjected to MLVA for further investigation.
Results
The 15 VNTR loci were selected based on high DI values. The DIs of the 15 VNTR loci showed considerable discrimination power ranging from 59% for Bruce 43 to 87% for Bruce 22. Bruce 09, Bruce 11, Bruce 16, Bruce 42, and Bruce 43 were confirmed to remain stable in vitro among the 15 VNTR loci selected.
Conclusion
The results of this study suggest that the five loci subsets may be a useful epidemiological tool for investigating B. abortus biovar 1 outbreak.

Citations

Citations to this article as recorded by  
  • Brucella abortus: Current Research and Future Trends
    Tariq Jamil, Falk Melzer, John Njeru, Hosny El-Adawy, Heinrich Neubauer, Gamal Wareth
    Current Clinical Microbiology Reports.2017; 4(1): 1.     CrossRef
Epidemiological Characteristics of Serologically Confirmed Q Fever Cases in South Korea, 2006–2011
Wooseok Kwak, Hyuk Chu, Seondo Hwang, Ji-Hyuk Park, Kyu Jam Hwang, Jin Gwack, Young-Sil Choi, Seung-Ki Youn, Mi-Yeoun Park
Osong Public Health Res Perspect. 2013;4(1):34-38.   Published online February 28, 2013
DOI: https://doi.org/10.1016/j.phrp.2012.12.006
  • 2,271 View
  • 15 Download
  • 22 Citations
AbstractAbstract PDF
Objectives
Q fever has been reported worldwide; however, there was almost no official report of Q fever in Korea. In this study, we describe the current status of human Q fever occurrence in Korea.
Methods
Demographic data of Q fever patients were collected from the National Notifiable Diseases Surveillance System from 2006 to 2011. Case investigation reports from regional public health departments were used for additional information, like risk factors and clinical manifestation, of the patients since 2008.
Results
There were 65 serologically confirmed cases during the study period. The annual notification rate of Q fever was 0.22 cases per million persons. The majority of cases were men (87.7%), adults (98.5%), and urban inhabitants (67.7%). Relevant exposures to risk factors were identified in 45.7% of patients. The most common symptoms of acute Q fever were fever (89.3%), myalgia (67.9%) and asthenia (53.6%). Two cases with endocarditis were identified in chronic Q fever.
Conclusion
This study suggests that Q fever has a low endemicity in Korea. However, management and research at national level is required for prevention of a future epidemic.

Citations

Citations to this article as recorded by  
  • Novel genotypes of Coxiella burnetii circulating in rats in Yunnan Province, China
    Mengjiao Fu, Peisheng He, Xuan OuYang, Yonghui Yu, Bohai Wen, Dongsheng Zhou, Xiaolu Xiong, Qinghong Yuan, Jun Jiao
    BMC Veterinary Research.2022;[Epub]     CrossRef
  • Toxoplasma gondii and Rickettsia spp. in ticks collected from migratory birds in the Republic of Korea
    A.-Tai Truong, Mi-Sun Yoo, Subin Min, Ji-Yeon Lim, Hyun-Ji Seo, Heung-Chul Kim, Sung-Tae Chong, Terry A. Klein, Chang-uk Park, Sook-Young Cho, Chang-Yong Choi, Young-Soo Kwon, Miran Kim, Soon-Seek Yoon, Yun Sang Cho
    Scientific Reports.2022;[Epub]     CrossRef
  • Real-time PCR biochip for on-site detection of Coxiella burnetii in ticks
    A.-Tai Truong, Bo-Ram Yun, Jiyeon Lim, Subin Min, Mi-Sun Yoo, Soon-Seek Yoon, Young-Min Yun, Jong-Taek Kim, Yun Sang Cho
    Parasites & Vectors.2021;[Epub]     CrossRef
  • Epidemiological investigation and physician awareness regarding the diagnosis and management of Q fever in South Korea, 2011 to 2017
    Yong Chan Kim, Hye Won Jeong, Dong-Min Kim, Kyungmin Huh, Sang-Ho Choi, Hee Young Lee, Yunjung Jung, Yeol Jung Seong, Eun Jin Kim, Young Hwa Choi, Jung Yeon Heo, Julie Arsenault
    PLOS Neglected Tropical Diseases.2021; 15(6): e0009467.     CrossRef
  • Comparing Treatment Outcomes of Ampicillin-Sulbactam, Other β-Lactams, and Vancomycin in Blood Culture-Negative Infective Endocarditis
    Se Ju Lee, Jung Ho Kim, Hi Jae Lee, Ki Hyun Lee, Eun Hwa Lee, Yae Jee Baek, Jin Nam Kim, Jin Young Ahn, Su Jin Jeong, Nam Su Ku, Seung Hyun Lee, Jun Yong Choi, Joon Sup Yeom, Young Goo Song
    Antibiotics.2021; 10(12): 1476.     CrossRef
  • Q fever in Greece: Findings of a 13 years surveillance study
    Iosif Vranakis, Sofia Kokkini, Emmanouil Yachnakis, Yannis Tselentis, Dimosthenis Chochlakis, Anna Psaroulaki
    Comparative Immunology, Microbiology and Infectiou.2020; 69: 101340.     CrossRef
  • Isolation of Coxiella burnetii in patients with nonspecific febrile illness in South Korea
    Seung Hun Lee, Jae Hoon Lee, Sungdo Park, Hae Kyung Lee, Seon Do Hwang, Hye Won Jeong, Jung Yeon Heo, Yeong Seon Lee
    BMC Infectious Diseases.2020;[Epub]     CrossRef
  • Current Status of Tick-Borne Diseases in South Korea
    Jae Hyoung Im, JiHyeon Baek, Areum Durey, Hea Yoon Kwon, Moon-Hyun Chung, Jin-Soo Lee
    Vector-Borne and Zoonotic Diseases.2019; 19(4): 225.     CrossRef
  • Diagnostic usefulness of molecular detection of Coxiella burnetii from blood of patients with suspected acute Q fever
    Moonsuk Bae, Choong Eun Jin, Joung Ha Park, Min Jae Kim, Yong Pil Chong, Sang-Oh Lee, Sang-Ho Choi, Yang Soo Kim, Jun Hee Woo, Yong Shin, Sung-Han Kim
    Medicine.2019; 98(23): e15724.     CrossRef
  • Clinical characteristics of acute Q fever patients in South Korea and time from symptom onset to serologic diagnosis
    Jung Yeon Heo, Young Wha Choi, Eun Jin Kim, Seung Hun Lee, Seung Kwan Lim, Seon Do Hwang, Ju Young Lee, Hye Won Jeong
    BMC Infectious Diseases.2019;[Epub]     CrossRef
  • Serologic Survey and Risk Factors forCoxiella burnetiiInfection among Dairy Cattle Farmers in Korea
    Ji-Hyuk Park, Hyuk Chu, Seok-Ju Yoo, Kyu-Jam Hwang, Hyun-Sul Lim
    Journal of Korean Medical Science.2018;[Epub]     CrossRef
  • Molecular detection of Coxiella burnetii in heart valve tissue from patients with culture-negative infective endocarditis
    Young-Rock Jang, Joon Seon Song, Choong Eun Jin, Byung-Han Ryu, Se Yoon Park, Sang-Oh Lee, Sang-Ho Choi, Yang Soo Kim, Jun Hee Woo, Jae-Kwan Song, Yong Shin, Sung-Han Kim
    Medicine.2018; 97(34): e11881.     CrossRef
  • The Epidemiology and Characteristics of Q fever and Co-infections with Scrub Typhus, Murine Typhus or Leptospirosis in Taiwan: A Nationwide Database Study
    C.-H. Lai, W. Sun, C.-H. Lee, J.-N. Lin, M.-H. Liao, S.-S. Liu, T.-Y. Chang, K.-F. Tsai, Y.-C. Chang, H.-H. Lin, Y.-H. Chen
    Zoonoses and Public Health.2017; 64(7): 517.     CrossRef
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    Saber Esmaeili, Farhad Golzar, Erfan Ayubi, Behrooz Naghili, Ehsan Mostafavi, Joseph M. Vinetz
    PLOS Neglected Tropical Diseases.2017; 11(4): e0005535.     CrossRef
  • Clinical and Genetic Features ofCoxiella burnetiiin a Patient with an Acute Febrile Illness in Korea
    Seung Hun Lee, Jung Yeon Heo, Hae Kyung Lee, Yeong Seon Lee, Hye Won Jeong, Seon Do Hwang
    Journal of Korean Medical Science.2017; 32(6): 1038.     CrossRef
  • Seroreactivity to Q Fever Among Slaughterhouse Workers in South Korea
    Hyuk Chu, Seok-Ju Yoo, Kyu-Jam Hwang, Hyun-Sul Lim, Kwan Lee, Mi-Yeoun Park
    Journal of Preventive Medicine and Public Health.2017; 50(3): 195.     CrossRef
  • Prevalence of bovine tuberculosis, brucellosis and Q fever in Korean black goats
    Hyobi Kim, Seongjoon Kim, Kina Kim, Byeol Kim, Byungjoon Chang, Nong-Hoon Choe
    Korean Journal of Veterinary Research.2016; 56(4): 249.     CrossRef
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    Wenping Gong, Pengcheng Wang, Xiaolu Xiong, Jun Jiao, Xiaomei Yang, Bohai Wen, James E Samuel
    PLOS ONE.2015; 10(4): e0124664.     CrossRef
  • Cultural drivers and health-seeking behaviours that impact on the transmission of pig-associated zoonoses in Lao People’s Democratic Republic
    Stephanie Burniston, Anna L Okello, Boualam Khamlome, Phouth Inthavong, Jeffrey Gilbert, Stuart D Blacksell, John Allen, Susan C Welburn
    Infectious Diseases of Poverty.2015;[Epub]     CrossRef
  • Clinical Characteristics of Q Fever and Etiology of Community-Acquired Pneumonia in a Tropical Region of Southern Taiwan: A Prospective Observational Study
    Chung-Hsu Lai, Lin-Li Chang, Jiun-Nong Lin, Wei-Fang Chen, Yu-Feng Wei, Chien-Tung Chiu, Jiun-Ting Wu, Chi-Kuei Hsu, Jung-Yueh Chen, Ho-Sheng Lee, Hsi-Hsun Lin, Yen-Hsu Chen, Daniel E. Voth
    PLoS ONE.2014; 9(7): e102808.     CrossRef
  • Seroprevalence of Q-fever in Korean native cattle
    Ji-Yeon Kim, So-Ra Sung, Ji-In Pyun, Moon Her, Sung-Il Kang, Hyang-Keun Lee, Suk Chan Jung
    Korean Journal of Veterinary Research.2014; 54(3): 147.     CrossRef
  • Serological characterization of surface-exposed proteins of Coxiella burnetii
    Jun Jiao, Xiaolu Xiong, Yong Qi, Wenping Gong, Changsong Duan, Xiaomei Yang, Bohai Wen
    Microbiology .2014; 160(12): 2718.     CrossRef
Articles
Application of the Microagglutination Test for Serologic Diagnosis of Human Brucellosis
Sang-Hee Park, Yoo-Hoon Lee, Hyuk Chu, Seon-Do Hwang, Kyu-Jam Hwang, Hee-Yeol Choi, Mi-Yeoun Park
Osong Public Health Res Perspect. 2012;3(1):19-23.   Published online December 31, 2011
DOI: https://doi.org/10.1016/j.phrp.2012.01.003
  • 1,897 View
  • 14 Download
  • 13 Citations
AbstractAbstract PDF
Objectives
Brucellosis is one of the most common zoonoses in the world, and occurs mainly in farmers, slaughterhouse workers, and veterinarians via direct or indirect contact with infected animals or their products. The clinical symptoms of human brucellosis are nonspecific, such as fever, headache, chills, and sweating. Diagnosis and treatment of brucellosis requires laboratory tests. Although the serum tube agglutination test (SAT) is the standardized gold method, it is laborious, time consuming, and requires a number of reagents. A microagglutination test (MAT) variant of the SAT or enzyme-linked immunosorbent assay (ELISA) is recommended for serological diagnoses. For the simple and rapid diagnosis of brucellosis, the MAT was standardized using samples for the SAT to define positive and negative categories, and we then compared the sensitivity and specificity of the MAT and ELISA.
Methods
Thirty SAT-positive sera and 60 SAT-negative sera were used in this study. Antibody titers of ≥1:160 were considered positive readings in both the SAT and MAT. Brucella abortus antigens and Brucella-positive control antiserum were used in the SAT and MAT. ELISAs of IgM and IgG were performed according to the manufacturers’ instructions.
Results
The titers of the MAT differed according to antigen concentration. The optimal concentration of B abortus antigen was determined to compare the sensitivity and specificity between the MAT and SAT. The sensitivity and specificity of the MAT were 93.3% and 96.7%, respectively, for IgG with reference to ELISA, and 96.7% and 98.3%, respectively, for IgM.
Conclusions
The optimal concentration of antigen for the MAT was 1:10. The MAT is less time consuming and requires less antigen and serum than the SAT. The results of the MAT showed good agreement with those of ELISA. The results of this study suggest that the MAT could be useful for diagnosis of brucellosis.

Citations

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  • Bovine brucellosis – a comprehensive review
    Sandip Kumar Khurana, Anju Sehrawat, Ruchi Tiwari, Minakshi Prasad, Baldev Gulati, Muhammad Zubair Shabbir, Rajesh Chhabra, Kumaragurubaran Karthik, Shailesh Kumar Patel, Mamta Pathak, Mohd. Iqbal Yatoo, Vivek Kumar Gupta, Kuldeep Dhama, Ranjit Sah, Wanpe
    Veterinary Quarterly.2021; 41(1): 61.     CrossRef
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    Giovanni Di Bonaventura, Silvia Angeletti, Andrea Ianni, Tommasangelo Petitti, Giovanni Gherardi
    Pathogens.2021; 10(12): 1623.     CrossRef
  • The spatiotemporal distribution of human brucellosis in mainland China from 2007-2016
    Peifeng Liang, Yuan Zhao, Jianhua Zhao, Dongfeng Pan, Zhongqin Guo
    BMC Infectious Diseases.2020;[Epub]     CrossRef
  • Brucellar spondylodiscitis: A case series with focus on histopathological features
    Soumaya Rammeh, Emna Romdhane, Hend Riahi, Meriem Ksentini, Mouna Chelli Bouaziz, Rahma Ayadi, Aida Berriche, Yosra Chebbi, Mohamed Fethi Ladeb
    Journal of Clinical Neuroscience.2020; 78: 360.     CrossRef
  • A case report of neurobrucellosis mimicking Guillain–Barré syndrome
    Parastoo Paydarnia, Soroush Moradi, Arman Habibi, Ladan Abbasian, Mojdeh Ghabaee
    Neurology, Psychiatry and Brain Research.2019; 31: 27.     CrossRef
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    A. Gorey, S. Shukla, J.G. Prasad, S. Verma, A. Sharma, S. Vasudevan
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    Pablo Yagupsky, Pilar Morata, Juan D. Colmenero
    Clinical Microbiology Reviews.2019;[Epub]     CrossRef
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    Man Li, Xingang Zhou, Jingjing Li, Lei Sun, Xiangmei Chen, Peng Wang
    Medicine.2018; 97(9): e0062.     CrossRef
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    Manuela Carugati, Holly M Biggs, Michael J Maze, Robyn A Stoddard, Shama Cash-Goldwasser, Julian T Hertz, Jo E B Halliday, Wilbrod Saganda, Bingileki F Lwezaula, Rudovick R Kazwala, Sarah Cleaveland, Venance P Maro, Matthew P Rubach, John A Crump
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  • Seroreactivity and Risk Factors Associated with Human Brucellosis among Cattle Slaughterhouse Workers in South Korea
    Dilaram Acharya, Seon Hwang, Ji-Hyuk Park
    International Journal of Environmental Research an.2018; 15(11): 2396.     CrossRef
  • Outbreak of human brucellosis in Southern Brazil and historical review of data from 2009 to 2018
    Tamilly Silva Lemos, Juliana Clelia Cequinel, Tania Portela Costa, Amanda Boni Navarro, Andressa Sprada, Flávia Kazumi Shibata, Regina Gondolfo, Felipe Francisco Tuon, Stephen Baker
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    KA Al-Anazi, AM Al-Jasser
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  • Evaluation and Selection of Multilocus Variable-Number Tandem-Repeat Analysis Primers for Genotyping Brucella abortus Biovar 1 Isolated from Human Patients
    Subok Lee, Kyu-Jam Hwang, Mi-Yeoun Park, Seon-Do Hwang, Hee-Youl Chai, Hyuk Chu, Sang-Hee Park
    Osong Public Health and Research Perspectives.2013; 4(5): 265.     CrossRef
Original Article
Serological Detection of Lyme Borreliosis Agents in Patients From Korea, 2005–2009
Sang-Hee Park, Kyu-Jam Hwang, Hyuk Chu, Mi-Yeoun Park
Osong Public Health Res Perspect. 2011;2(1):29-33.   Published online June 30, 2011
DOI: https://doi.org/10.1016/j.phrp.2011.04.004
  • 1,836 View
  • 13 Download
  • 13 Citations
AbstractAbstract PDF
Objectives
Laboratory tests are now being used to identify seropositive cases in patients suspected of having a Lyme borreliosis (LB) infection. From 2005 to 2009, we analyzed the serological and epidemiological characteristics of 53 LB positive cases in Korea using immunoblot assay.
Methods
During the five-year study period, a total of 1897 serum samples from suspected LB cases were referred to us for further laboratory diagnosis. The bacterial strains Borrelia afzeli pKo, Borrelia garinii 935T and Borrelia burgdorferi B31 were used for indirect immunofluorescent antibody assay. Immunoblot assay was performed using the recomBlot Borrelia.
Results
Based on the information from the clinicians, the main symptoms of LB infection were rash and fever (66.0%), neurological symptoms (30.2%), and arthritis (5.7%). Of the 53 cases, 16 (30.2%) were infected abroad and the remaining 37 cases (69.8%) were suspected to have been infected in Korea. Immunoblot assays detected high levels of the antigens p41 (FlaB) of B. burgdorferi and OspC of B. garinii in infected samples.
Conclusions
The causative bacteria of LB were not isolated from humans yet but from vector ticks and rodents in Korea, and a few cases were reported with serological diagnosis. Our results suggest that LB is present in all areas of Korea and indicate that B. garinii and B. burgdorferi may be the predominant bacteria in patients with LB. However, further studies are needed to isolate and identify the causative bacteria for LB in patients.

Citations

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PHRP : Osong Public Health and Research Perspectives