Objectives
Aflatoxins as a highly toxic group of mycotoxins are present in the environment and foodstuff. These have been reported to cause serious health problems in humans. Since aflatoxin M1 (AFM1) is excreted into breast milk, investigating the exposure of infants to AFM1 is of special concern. Methods
In the present study, breast milk samples were collected from 85 lactating mothers in Ilam province, Iran, and the levels of AFM1 were analyzed using the enzyme-linked immunosorbent assay-based technique. AFM1 was detected in breast milk of all lactating women. The mean contamination level was 5.91 ± 2.031 ng/L, ranging from 2 ng/L to 10 ng/L. Results
Multiple regression analysis indicated no significant associations of consumption of milk and dairy products, meat, fish, legumes, grain products, fruits, and nuts with the concentration of AFM1 in breast milk. Furthermore, no significant association was observed between AFM1 concentration and anthropometric data of infants. Conclusion
In western parts of Iran, lactating mothers and their infants could be at risk of aflatoxin B1 and AFM1 exposure, respectively. Therefore, in Iran, the evaluation of AFM1 in human breast milk as a biomarker for postnatal exposure of infants to this carcinogen requires more attention in different regions and various seasons.
Citations
Citations to this article as recorded by
Determination of aflatoxin M1 and ochratoxin A in breast milk in rural centers of Yazd, Iran: Exposure assessment and risk characterization Zeinab Rezaei, Siavash Hamzeh Pour, Parya Ezati, Fateme Akrami-Mohajeri Mycotoxin Research.2024; 40(2): 211. CrossRef
Evaluation of Aflatoxins Occurrence and Exposure in Cereal-Based Baby Foods: An Update Review Yasemin Açar, Gamze Akbulut Current Nutrition Reports.2024; 13(1): 59. CrossRef
Risk of exposure to aflatoxin M1 through consumption of cow’s milk among children in Magadu, Morogoro Anna Peter Mamiro, Haikael D. Martin, Neema Kassim Mycotoxin Research.2024; 40(2): 245. CrossRef
Assessing Aflatoxin Exposure: Exploring Types of Exposure and Diverse Biomarkers – A Minireview Geethu Mathew, Shubhangi Pingle, Priya S, Ravichandran B Current Fungal Infection Reports.2024; 18(3): 163. CrossRef
Aflatoxin M1 in milk and dairy products: The state of the evidence for child growth impairment Patricia Hsu, Ashish Pokharel, Christian Kelly Scott, Felicia Wu Food and Chemical Toxicology.2024; 193: 115008. CrossRef
Does Bentonite Cause Cytotoxic and Whole-Transcriptomic Adverse Effects in Enterocytes When Used to Reduce Aflatoxin B1 Exposure? Greta Mucignat, Irene Bassan, Mery Giantin, Marianna Pauletto, Anisa Bardhi, Silvia Iori, Rosa Maria Lopparelli, Andrea Barbarossa, Anna Zaghini, Enrico Novelli, Mauro Dacasto Toxins.2022; 14(7): 435. CrossRef
Effects of stem cells and amniotic fluid on uterus and ovaries in a rat model of abdominal adhesions: a controlled study Elif Ganime Aygün, Gamze Tümentemur Journal of the Turkish-German Gynecological Associ.2022; 23(3): 154. CrossRef
Effects of aflatoxin B1 on human breast cancer (MCF-7) cells: cytotoxicity, oxidative damage, metabolic, and immune-modulatory transcriptomic changes Ahmed Aljazzar, Waleed Rizk El-Ghareeb, Wageh Sobhy Darwish, Sherief M. Abdel-Raheem, Abdelazim M. Ibrahim, Eman E. Hegazy, Esraa A. Mohamed Environmental Science and Pollution Research.2022; 30(5): 13132. CrossRef
A promising innovative technique for mycotoxin detoxification from beverages using biofilms of lactic acid bacteria Sahar Nahle, André El Khoury, Jean Claude Assaf, Nicolas Louka, Ali Chokr, Ali Atoui Innovative Food Science & Emerging Technologies.2022; 82: 103165. CrossRef
Human Breast Milk Contamination with Aflatoxins, Impact on Children’s Health, and Possible Control Means: A Review Noreddine Benkerroum, Amir Ismail International Journal of Environmental Research an.2022; 19(24): 16792. CrossRef
miR-155 influences cell-mediated immunity in Balb/c mice treated with aflatoxin M1 Kobra Shirani, Bamdad Riahi Zanjani, Soghra Mehri, Kamal Razavi-Azarkhiavi, Ali Badiee, A. Wallace Hayes, John P. Giesy, Gholamreza Karimi Drug and Chemical Toxicology.2021; 44(1): 39. CrossRef
Human milk mycotoxin contamination: smoking exposure and breastfeeding problems Esra Yasemin Memiş, Sıddıka Songül Yalçın The Journal of Maternal-Fetal & Neonatal Medicine.2021; 34(1): 31. CrossRef
Biological Control and Mitigation of Aflatoxin Contamination in Commodities Ferenc Peles, Péter Sipos, Szilvia Kovács, Zoltán Győri, István Pócsi, Tünde Pusztahelyi Toxins.2021; 13(2): 104. CrossRef
Mycotoxin carry-over in breast milk and weight of infant in exclusively-breastfed infants Esra Yasemin Memiş, Sıddıka Songül Yalçın, Suzan Yalçın Archives of Environmental & Occupational Health.2021; 76(6): 313. CrossRef
Physical and Chemical Methods for Reduction in Aflatoxin Content of Feed and Food Péter Sipos, Ferenc Peles, Dóra Lili Brassó, Béla Béri, Tünde Pusztahelyi, István Pócsi, Zoltán Győri Toxins.2021; 13(3): 204. CrossRef
Biocontrol of Aflatoxins Using Non-Aflatoxigenic Aspergillus flavus: A Literature Review Rahim Khan, Farinazleen Mohamad Ghazali, Nor Ainy Mahyudin, Nik Iskandar Putra Samsudin Journal of Fungi.2021; 7(5): 381. CrossRef
Aflatoxin Biosynthesis, Genetic Regulation, Toxicity, and Control Strategies: A Review Rahim Khan, Farinazleen Mohamad Ghazali, Nor Ainy Mahyudin, Nik Iskandar Putra Samsudin Journal of Fungi.2021; 7(8): 606. CrossRef
Aflatoxin M1 contamination level in Iranian milk and dairy products: a systematic review and meta-analysis S. Hamzeh Pour, S. Mahmoudi, S. Masoumi, S. Rezaie, A. Barac, M. Ranjbaran, S. Oliya, F. Mehravar, E. Sasani, F. Noorbakhsh, S. Khodavaisy World Mycotoxin Journal.2020; 13(1): 67. CrossRef
Levels of Aflatoxin M1 and selected heavy metals (Pb, Cd, Cr, Cu, Zn, Fe, As, and Hg) in the breast milk of lactating mothers in South Eastern, Nigeria Chidinma Lynda Ekeanyanwu, Chinwe Sylvanus Alisi, Raphael Chukwuma Ekeanyanwu Food Control.2020; 112: 107150. CrossRef
Dietary mycotoxins exposure and child growth, immune system, morbidity, and mortality: a systematic literature review Kokeb Tesfamariam, Marthe De Boevre, Patrick Kolsteren, Tefera Belachew, Addisalem Mesfin, Sarah De Saeger, Carl Lachat Critical Reviews in Food Science and Nutrition.2020; 60(19): 3321. CrossRef
Occurrence of and Factors Associated With the Presence of Aflatoxin M1 in Breast Milk of Mothers in Fethiye, Turkey Gonca Karayağiz Muslu, Mehmet Özdemir Biological Research For Nursing.2020; 22(3): 362. CrossRef
Aflatoxin exposure among lactating women in southern Ethiopia Bergene Boshe, Samson Gebremedhin, Fikadu Alemayehu, Mesfin Eshete, Mestawet Taye, Barbara J. Stoecker Food Science & Nutrition.2020; 8(12): 6738. CrossRef
An assessment of the occurrence and nutritional factors associated with aflatoxin M1, ochratoxin A, and zearalenone in the breast milk of nursing mothers in Hamadan, Iran Fateme Samiee, Ava Kharazi, Jomana Elaridi, Masoumeh Taravati Javad, Mostafa Leili Toxicon.2020; 187: 209. CrossRef
Aflatoxin, fumonisin, ochratoxin, zearalenone and deoxynivalenol biomarkers in human biological fluids: A systematic literature review, 2001–2018 Belqes Ahmad Al-Jaal, Morana Jaganjac, Andrei Barcaru, Peter Horvatovich, Aishah Latiff Food and Chemical Toxicology.2019; 129: 211. CrossRef
Concentration and Prevalence of Aflatoxin M1 in Human Breast Milk in Iran: Systematic Review, Meta-Analysis, and Carcinogenic Risk Assessment: A Review Yadolah Fakhri, Raheb Ghorbani, Mahmoud Taghavi, Hassan Keramati, Nazak Amanidaz, Bigard Moradi, Simin Hagh Nazari, Nabi Shariatifar, Amin Mousavi Khaneghah Journal of Food Protection.2019; 82(5): 785. CrossRef
Aflatoxin M1 in human breast milk: A global systematic review, meta-analysis, and risk assessment study (Monte Carlo simulation) Yadolah Fakhri, Jamal Rahmani, Carlos Augusto Fernandes Oliveira, Larissa Tuanny Franco, Carlos Humberto Corassin, Sumbal Saba, Jamal Rafique, Amin Mousavi Khaneghah Trends in Food Science & Technology.2019; 88: 333. CrossRef
The occurrence of mycotoxins in breast milk, fruit products and cereal-based infant formula: A review Carolina Fernanda Sengling Cebin Coppa, Amin Mousavi Khaneghah, Paula Alvito, Ricardo Assunção, Carla Martins, Ismail Eş, Bruna Leonel Gonçalves, Diane Valganon de Neeff, Anderson S. Sant'Ana, Carlos Humberto Corassin, Carlos Augusto Fernandes Oliveira Trends in Food Science & Technology.2019; 92: 81. CrossRef
Exposure assessment of Portuguese infants to Aflatoxin M1 in breast milk and maternal social-demographical and food consumption determinants Fernando Bogalho, Sofia Duarte, Maria Cardoso, Anabela Almeida, Ricardo Cabeças, Celeste Lino, Angelina Pena Food Control.2018; 90: 140. CrossRef
Occurrence and dietary factors associated with the presence of aflatoxin B1 and M1 in breast milk of nursing mothers in Iran Manizheh Azarikia, Reza Mahdavi, Leila Nikniaz Food Control.2018; 86: 207. CrossRef
Concentration of Aflatoxin M 1 and selected heavy metals in mother milk samples from Pakistan Sarah Khan, Amir Ismail, Yun Yun Gong, Saeed Akhtar, Majid Hussain Food Control.2018; 91: 344. CrossRef
Immunotoxicity of aflatoxin M1: as a potent suppressor of innate and acquired immune systems in a subacute study Kobra Shirani, Bamdad R Zanjani, Mahmoud Mahmoudi, Amir H Jafarian, Faezeh V Hassani, John P Giesy, Gholamreza Karimi Journal of the Science of Food and Agriculture.2018; 98(15): 5884. CrossRef
Natural occurrence of aflatoxin M 1 in fresh cow milk and human milk in Penang, Malaysia Nor Shifa Shuib, Ahmad Makahleh, Salizawati Muhamad Salhimi, Bahruddin Saad Food Control.2017; 73: 966. CrossRef
Aflatoxin M1in human breast milk in Shahrekord, Iran and association with dietary factors Tina Jafari, Aziz A. Fallah, Soleiman Kheiri, Abdolmajid Fadaei, Sayed Asadollah Amini Food Additives & Contaminants: Part B.2017; 10(2): 128. CrossRef
Biomonitoring of Mycotoxins in Human Breast Milk: Current State and Future Perspectives Benedikt Warth, Dominik Braun, Chibundu N. Ezekiel, Paul C. Turner, Gisela H. Degen, Doris Marko Chemical Research in Toxicology.2016; 29(7): 1087. CrossRef
Objectives
Tumor necrosis factor-α (TNF-α) plays roles in the development of obesity, insulin resistance, and possibility of Type 2 diabetes mellitus (T2DM). The objective of the current study was to evaluate the association of TNF-α promoter−308 G/A polymorphism with T2DM. Methods
In all, 1038 patients with T2DM and 1023 normoglycemic controls were included in this study. All participants were genotyped using the polymerase chain reaction-restriction fragment length polymorphism method. Genotypic and allelic frequencies were then analyzed in each group. Serum lipids, fasting glucose, fasting serum insulin, homeostatic model assessment of insulin resistance, and hemoglogin A1c levels were determined by conventional methods. Results
The allelic frequency of the A allele was significantly different between case and control participants (p = 0.006). Genotypes GA and AA were found to be significantly associated with 2.24- and 3.18-fold increased risk for T2DM, respectively. Similarly, the dominant model of -308 G/A polymorphism was found to have a higher risk for T2DM (odds ratio = 2.34, p = 0.001). Individuals with T2DM carrying the GA + AA genotypes of -308 G/A variation had significantly lower fasting plasma insulin than those carrying GG genotype. Conclusion
Our findings revealed that there is an association between the TNF-α promoter -308 G/A polymorphism and T2DM in this population.
Citations
Citations to this article as recorded by
Effects of tumor necrosis factor-α rs1800629 and interleukin-10 rs1800872 genetic variants on type 2 diabetes mellitus susceptibility and metabolic parameters among Jordanians Lana Nasrallah Mousa, Yazun Jarrar, Munir Gharaibeh, Hussam Alhawari Drug Metabolism and Personalized Therapy.2024; 39(2): 81. CrossRef
Comparative analysis of TNF-α (-308) gene polymorphism in Turkish patients with type 2 diabetes developing nephropathy and/or neuropathy Venhar Gurbuz Can, Ozlem Cesur Gunay, Sinem Cesur Scientific Reports.2024;[Epub] CrossRef
Estimating the role of single-nucleotide polymorphism (rs1800629)-308 G/A of TNF-alpha gene as genetic marker associated with angina pectoris in a sample of Iraqi patients Shaimaa Y. Abdulfattah, Farah Thamer Samawi Journal of Genetic Engineering and Biotechnology.2023; 21(1): 2. CrossRef
Oral Supplementation with Three Vegetable Oils Differing in Fatty Acid Composition Alleviates High-Fat Diet-Induced Obesity in Mice by Regulating Inflammation and Lipid Metabolism Waleed Aldamarany, Huang Taocui, Deng Liling, Yang Wanfu, Geng Zhong Polish Journal of Food and Nutrition Sciences.2023; : 80. CrossRef
Diabetes as one of the long-term COVID-19 complications: from the potential reason of more diabetic patients’ susceptibility to COVID-19 to the possible caution of future global diabetes tsunami Yasamin Sharbatdar, Ronak Mousavian, Seyed Mostafa Noorbakhsh Varnosfaderani, Fatemeh Aziziyan, Mahsa Liaghat, Payam Baziyar, Ali Yousefi Rad, Chanour Tavakol, Amir Mansour Moeini, Mohsen Nabi-Afjadi, Hamidreza Zalpoor, Fatemeh Kazemi-Lomedasht Inflammopharmacology.2023; 31(3): 1029. CrossRef
Single-nucleotide polymorphisms as important risk factors of diabetes among Middle East population Iman Akhlaghipour, Amir Reza Bina, Mohammad Reza Mogharrabi, Ali Fanoodi, Amir Reza Ebrahimian, Soroush Khojasteh Kaffash, Atefeh Babazadeh Baghan, Mohammad Erfan Khorashadizadeh, Negin Taghehchian, Meysam Moghbeli Human Genomics.2022;[Epub] CrossRef
Glucose-Related Traits and Risk of Migraine—A Potential Mechanism and Treatment Consideration Md Rafiqul Islam, Dale R. Nyholt Genes.2022; 13(5): 730. CrossRef
A meta-analysis on the association of the -308 G/A polymorphism of the TNF-alpha gene with the development of malaria Raphael Enrique Tiongco, Ivy Cayabyab, Benjie Clemente, Chastene Christopher Flake, Dianne Dizon, Joey Kyle Mallari, Maria Ruth Pineda-Cortel Gene Reports.2022; 27: 101626. CrossRef
Exploring the Relationship between TNF-α Gene Expression in Non Diabetic Nephropathy Type 2 Diabetes Patients Muhammad Roman, Samra Anees, Saima Sharif, Shah Jahan Futuristic Biotechnology.2022; : 07. CrossRef
Association between ABCC8 Ala1369Ser Polymorphism (rs757110 T/G) and Type 2 Diabetes Risk in an Iranian Population: A Case-Control Study Amin Bakhtiyari, Karimeh Haghani, Salar Bakhtiyari, Mohammad A. Zaimy, Ali Noori-Zadeh, Ali Gheysarzadeh, Shahram Darabi, Ali Seidkhani-Nahal, Mansour Amraei, Iraj Alipourfard Endocrine, Metabolic & Immune Disorders - Drug Tar.2021; 21(3): 441. CrossRef
Association of TNF-α 308G/A and LEPR Gln223Arg Polymorphisms with the Risk of Type 2 Diabetes Mellitus Maria Trapali, Dimitra Houhoula, Anthimia Batrinou, Anastasia Kanellou, Irini F. Strati, Argyris Siatelis, Panagiotis Halvatsiotis Genes.2021; 13(1): 59. CrossRef
Biological and Clinical Implications of TNF-α Promoter and CYP1B1
Gene Variations in Coronary Artery Disease Susceptibility Rashid Mir, Imadeldin Elfaki, Chandan K. Jha, Jamsheed Javid, Abdullatif T. Babakr, Shaheena Banu, Mohammad M. Mir, Dheeraj Jamwal, Naina Khullar, Khalid J Alzahrani, Sukh M.S. Chahal Cardiovascular & Hematological Disorders-Drug Targ.2021; 21(4): 266. CrossRef
TNF-α gene polymorphism in Iranian Azeri population Mohammad Asgharzadeh, Manouchehr Fadaee, Hamed Ebrahimzadeh Leylabadlo, Behroz Mahdavi Poor, Jalil Rashedi, Vahid Asgharzadeh, Ali Vegari, Behrooz Shokouhi, Nima Najafi Ghalelou, Hossein Samadi Kafil Gene Reports.2020; 19: 100651. CrossRef
The association of TNF-α −308G/A and −238G/A polymorphisms with type 2 diabetes mellitus: a meta-analysis Xiaoliang Guo, Chenxi Li, Jiawei Wu, Qingbu Mei, Chang Liu, Wenjing Sun, Lidan Xu, Songbin Fu Bioscience Reports.2019;[Epub] CrossRef
Association of polymorphisms at −174 in IL-6, and −308 and −238 in TNF-α, in the development of tuberculosis and type 2 diabetes mellitus in the Mexican population Ruth Elizabeth Lara-Gómez, María Luisa Moreno-Cortes, Raquel Muñiz-Salazar, Roberto Zenteno-Cuevas Gene.2019; 702: 1. CrossRef
A Review of Type 2 Diabetes Mellitus Predisposing Genes Tajudeen O. Yahaya, Titilola F. Salisu Current Diabetes Reviews.2019; 16(1): 52. CrossRef
TNF-alpha G/A308 polymorphism association with nasal polyposis in North part of Iran Masoumeh Faghani, Parvaneh Keshavars, Alireza Sharafshah, Babak Pourgholamali, Farshad Moharami, Shadman Nemati European Archives of Oto-Rhino-Laryngology.2018; 275(9): 2253. CrossRef
TNF-α -308G/A gene polymorphism in bullous pemphigoid and alopecia areata Hamideh Moravvej, Pardis-Sadat Tabatabaei-Panah, Elaheh Ebrahimi, Nafiseh Esmaeili, Sayyed Mohammad Hossein Ghaderian, Ralf J. Ludwig, Reza Akbarzadeh Human Antibodies.2018; 26(4): 201. CrossRef
Infliximab ameliorates tumor necrosis factor‐alpha‐induced insulin resistance by attenuating PTP1B activation in 3T3L1 adipocytes in vitro Lucia A. Méndez‐García, Fernanda Trejo‐Millán, Camilo P. Martínez‐Reyes, Aarón N. Manjarrez‐Reyna, Marcela Esquivel‐Velázquez, Guillermo Melendez‐Mier, Sergio Islas‐Andrade, Araceli Rojas‐Bernabé, Julia Kzhyshkowska, Galileo Escobedo Scandinavian Journal of Immunology.2018;[Epub] CrossRef
Study of the associations between polymorphic markers rs1800629 TNFa, rs909253 Lta, rs767455 TNFR1, rs1061624 TNFR2 and the development of type 2 diabetes Mikhail I. Churnosov, Oksana N. Belousova, Svetlana Sergeyevna Sirotina Diabetes mellitus.2017; 20(3): 166. CrossRef
IL-6, TNF-α, and IL-10 levels/polymorphisms and their association with type 2 diabetes mellitus and obesity in Brazilian individuals Kathryna Fontana Rodrigues, Nathalia Teixeira Pietrani, Adriana Aparecida Bosco, Fernanda Magalhães Freire Campos, Valéria Cristina Sandrim, Karina Braga Gomes Archives of Endocrinology and Metabolism.2017; 61(5): 438. CrossRef
Objective
Diabetes mellitus is a group of metabolic diseases characterized by chronic hyperglycemia condition resulting from defective insulin secretion or resistance insulin action, or both. The purpose of this study was to evaluate the effect of 6 weeks swimming training and Trigonella foenum-graecum seed (fenugreek) extract, alone and in combination, on plasma glucose and cardiac antioxidant enzyme activity of streptozotocin-induced diabetic rats. Methods
Fifty male Wistar rats were divided into five groups: diabetic control (DC, n = 8); healthy control (HC, n = 11); swimming training (S, n = 11); swimming training + fenugreek seed extract (1.74 g/kg body weight; SF1, n = 11); and swimming training + fenugreek seed extract (0.87 g/kg body weight; SF2, n = 9). Streptozotocin was used for the induction of diabetes. Results were analyzed using one-way analysis of variance followed by Tukey test. Results
In comparison with the DC group, all groups exhibited a significant decrease in body weight (p < 0.05), except for the HC group. SF1 and HC groups showed significant decreases in plasma glucose levels compared with the DC group (p < 0.05). S, SF1, SF2, and HC groups showed significant elevations in cardiac antioxidant enzymes activity in comparison with the DC group. Conclusion
The results indicated that the combination of endurance swimming training and fenugreek seed extract can significantly reduce the plasma glucose levels and increase cardiac antioxidant enzymes activity in diabetic rats. Our findings suggest that this combination could be useful for the treatment of hyperglycemia and cardiac oxidative stress induced by diabetes mellitus.
Citations
Citations to this article as recorded by
Anti-inflammatory effects of sericin and swimming exercise in treating experimental Achilles tendinopathy in rat Koksal Gundogdu, Ozgen Kılıc Erkek, Gulsah Gundogdu, Dilek Sayin, Gulcin Abban Mete Applied Physiology, Nutrition, and Metabolism.2024; 49(4): 501. CrossRef
Exercise May Increase Oxidative Stress in the Sciatic Nerve in Streptozotocin-Induced Diabetic Rats Koji Nonaka, Junichi Akiyama, Satsuki Une Medicina.2024; 60(3): 480. CrossRef
Fabrication and characterization of gold nanoparticles using alginate: In vitro and in vivo assessment of its administration effects with swimming exercise on diabetic rats Vahideh Hashemzadeh, Alireza Hashemzadeh, Reza Mohebbati, Reza Gharari Arefi, Mohammad Ehsan Taghavizadeh Yazdi Open Life Sciences.2024;[Epub] CrossRef
Antidiabetic potential of fenugreek (Trigonella foenum‐graecum): A magic herb for diabetes mellitus Dipto Kumer Sarker, Pallobi Ray, Ashit Kumar Dutta, Razina Rouf, Shaikh Jamal Uddin Food Science & Nutrition.2024; 12(10): 7108. CrossRef
Safety and Efficacy of Furosap®, a Patented Trigonella foenum-graecum Seed Extract, in Boosting Testosterone Level, Reproductive Health and Mood Alleviation in Male Volunteers S. N. Sankhwar, Pawan Kumar, Manashi Bagchi, Mehul Rungta, Debasis Bagchi Journal of the American Nutrition Association.2023; 42(1): 27. CrossRef
The toxic effects of anabolic steroids “nandrolone decanoate” on cardiac and skeletal muscles with the potential ameliorative effects of silymarin and fenugreek seeds extract in adult male albino rats Dalia Abd Elwahab Hassan, Sherien S. Ghaleb, Amr reda Zaki, Ahmed Abdelmenem, Shimaa Nabil, Mostafa Abdallah Abdel Alim BMC Pharmacology and Toxicology.2023;[Epub] CrossRef
Fenugreek and Its Effects on Muscle Performance: A Systematic Review Waleed I. Albaker Journal of Personalized Medicine.2023; 13(3): 427. CrossRef
The Impact of Chronic Stress on Behavior and Body Mass in New Animal Models Anisia Iuliana Alexa, Carmen Lăcrămioara Zamfir, Camelia Margareta Bogdănici, Andra Oancea, Alexandra Maștaleru, Irina Mihaela Abdulan, Daniel Constantin Brănișteanu, Alin Ciobîcă, Miruna Balmuș, Teodora Stratulat-Alexa, Roxana Elena Ciuntu, Florentina Se Brain Sciences.2023; 13(10): 1492. CrossRef
Cardioprotective effects of exercise preconditioning on ischemia-reperfusion injury and ventricular ectopy in young and senescent rats Adnan Fatahi, Ebrahim Zarrinkalam, Kamal Azizbeigi, Kamal Ranjbar Experimental Gerontology.2022; 162: 111758. CrossRef
Protective effects of medicinal plant against diabetes induced cardiac disorder: A review Sadegh Shabab, Zahra Gholamnezhad, Maryam Mahmoudabady Journal of Ethnopharmacology.2021; 265: 113328. CrossRef
The Effects of Hydro-Alcoholic Extract of Fenugreek Seeds on the Lipid Profile and Oxidative Stress in Fructose-Fed Rats Maryam Mohammad-Sadeghipour, Mehdi Afsharinasab, Maryam Mohamadi, Mehdi Mahmoodi, Soudeh Khanamani Falahati-pour, Mohammad Reza Hajizadeh Journal of Obesity & Metabolic Syndrome.2020; 29(3): 198. CrossRef
Dose-dependent effects of fenugreek seed extract on the biochemical and haematological parameters in high-fat diet-fed rats Takkella Nagamma, Anjaneyulu Konuri, Chandrika D. Nayak, Shobha U. Kamath, Padmanabha E.G. Udupa, Yogendra Nayak Journal of Taibah University Medical Sciences.2019; 14(4): 383. CrossRef
A small plant with big benefits: Fenugreek (Trigonella foenum‐graecum Linn.) for disease prevention and health promotion Kalyan C. Nagulapalli Venkata, Anand Swaroop, Debasis Bagchi, Anupam Bishayee Molecular Nutrition & Food Research.2017;[Epub] CrossRef
Amelioration of Hyperglycemia and Associated Health Hazards Using Two Dietary Formulas Composed of Multiple Ingredients F.A. El-Shobaki, Amal S. Abdel-Azee, Amany M. Hegazy, Hassan Z. Hassouna, I.H. Badawy American Journal of Food Technology.2017; 12(4): 227. CrossRef
State of hyperglycemic animals during consumption of high-calorie diet with the bionanocomposite supplement Ie. Goloborodko, V. Konopelniuk, L. Ostapchenko Bulletin of Taras Shevchenko National University o.2017; 22(1): 43. CrossRef
In Vivo Effects of Quercetin in Association with Moderate Exercise Training in Improving Streptozotocin-Induced Aortic Tissue Injuries Irina Chis, Andrei Coseriu, Ramona Simedrea, Adrian Oros, Andras Nagy, Simona Clichici Molecules.2015; 20(12): 21770. CrossRef
Effectiveness of phytotherapy in supportive treatment of type 2 diabetes mellitus. II. Fenugreek (Trigonella foenum-graecum) David Koupý, Hana Kotolová, Jana Rudá Kučerová Česká a slovenská farmacie.2015; 64(3): 67. CrossRef