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PHRP : Osong Public Health and Research Perspectives

OPEN ACCESS. pISSN: 2210-9099. eISSN: 2233-6052

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"VR Vijay"

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"VR Vijay"

Review Articles
The global prevalence of autism spectrum disorder in children: a systematic review and meta-analysis
Alwin Issac, Kurvatteppa Halemani, Asha Shetty, Latha Thimmappa, VR Vijay, Kiranmayi Koni, Prabhaker Mishra, Vishwas Kapoor
Osong Public Health Res Perspect 2025;16(1):3-27.
Published online February 10, 2025
DOI: https://doi.org/10.24171/j.phrp.2024.0286
The global prevalence of autism spectrum disorder in children: a systematic review and meta-analysis
Objectives
The objective of this review was to analyze quantitative data on autism spectrum disorder (ASD) and to increase the accuracy of estimates of the prevalence of ASD.
Methods
This review, which was reported in accordance with the Preferred Reporting Items for Systematic Reviews and Meta-Analyses statement, included studies conducted from January 2008 to June 2024 on children aged 3 to 18 years that used standardized measurement tools and reported cut-off scores for ASD. The prevalence of ASD was the primary outcome analyzed in this review. The PubMed, Clinical Key, Scopus, Embase, CINAHL, and Web of Science databases were reviewed for relevant studies. The review protocol was registered with PROSPERO and followed the Cochrane collaboration guidelines.
Results
A total of 66 studies reported on the prevalence of ASD, screening 21,313,061 children worldwide. Among these, 25 studies were conducted in Europe, 22 in Asia, and 13 in America. Additionally, 3 studies each were reported from Africa and Australia. According to a meta-analysis, 0.77% of children globally are diagnosed with ASD, with boys comprising 1.14% of this group. Notably, Australia showed the highest prevalence rate, with an effect size of 2.18, highlighting it as a critical area for public health focus.
Conclusion
ASD represents a significant global health burden. Early detection, increased awareness among parents, and prompt intervention are crucial for mitigating developmental problems in children later in life. It is essential for health policymakers to acknowledge the prevalence and growing trends of ASD in order to implement effective interventions.

Citations

Citations to this article as recorded by  Crossref logo
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    Brain, Behavior, and Immunity.2026; 131: 106162.     CrossRef
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    Maria Grazia Giuliano, Paola Tognini
    Molecular Neurobiology.2026;[Epub]     CrossRef
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    Maria Pia Viscomi, Marta Marlena Ziętek, Silvestre Sampino
    Neuroscience.2026; 593: 18.     CrossRef
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    British Journal of Clinical Psychology.2026; 65(2): 374.     CrossRef
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    Neurobiology of Disease.2026; 218: 107227.     CrossRef
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    Kerim M. Munir
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    Liping Qi, Jing-Wen Ni, Guijun Dong, Tao Sun, Jian-Wei Zhang
    Frontiers in Psychiatry.2026;[Epub]     CrossRef
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    Tian Shu, Kanglong Peng, Qing Liu, Youqi Zhu, Jing Wang, Li Gao
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    Patricia Rannaud-Bartaire, Anni Herranen, Giovanni Levi, Barbara Demeneix, Jean-Baptiste Fini
    Current Opinion in Endocrine and Metabolic Researc.2026; 42: 100597.     CrossRef
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    O. I. Gumenyuk, M. E. Lobanov, Yu. V. Chernenkov, O. S. Groznova, A. V. Vorozhtsova, S. V. Balashova
    Experimental and Clinical Gastroenterology.2026; (6): 46.     CrossRef
  • Machine Learning–Assisted Autism Risk Stratification in Toddlers Using the Vietnamese M-CHAT-R and Perinatal Predictors: A Cross-Sectional Study in Vietnam
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  • Decoding BDNF in neurodevelopmental, neurodegenerative, and neurological disorders: mechanisms and therapeutic perspectives
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    Molecular Biology Reports.2026;[Epub]     CrossRef
  • From Genetic Determinism to Epigenetic Regulation: Paradigm Shifts in the Understanding of Neurodevelopmental Disorders
    Ernesto Burgio, Annamaria Porru, Chiara Pettini, Ilaria Vaglini, Angelo Gemignani, Marco Pettini, Federica Fratini, Daniela Lucangeli
    Current Issues in Molecular Biology.2026; 48(2): 163.     CrossRef
  • E-health interventions for caregivers of autistic children: impacts on caregiver well-being and child development: a systematic review
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  • The Effects of a Sport-Based Training Program on Reaction Time and Fine Motor Coordination in Children with Autism Spectrum Disorder: A Pilot Study
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  • Physical activity and salivary serotonin levels among children with or without autism spectrum disorders: A comparative cross-sectional study
    Sima Dastamooz, Shahzad Tahmasebi Boroujeni, Liye Zou, Mohammad H.D. Farahani, Mina Hasani, Sanaz Dastamouz, Nahid Sarahian, Seyed Ahmad Hosseini, Masoume Kordnayej
    Research in Autism.2026; 133: 202879.     CrossRef
  • Prenatal ultrasound–detected structural anomalies associated with autism spectrum disorder: a narrative review
    Nazyar Khamenehei, Lyudmila V. Tokarskaya
    Consortium PSYCHIATRICUM.2026; 7(1): 24.     CrossRef
  • Effectiveness of a structured physiotherapy intervention on psychomotor and quality of life in children with autism spectrum disorder: A randomised controlled trial protocol
    Nazurah Alwi, Asfarina Zanudin, Mahadir Ahmad, Nor Azizah Mohamad
    MethodsX.2026; 16: 103873.     CrossRef
  • Architects of the Developing Brain: Cytoskeleton-Organizing Molecules in Neurodevelopmental Disorders
    Ksenia A. Achkasova, Pavel V. Subbotin, Vadim V. Zhukov, Anastasia E. Filat’eva, Victor S. Tarabykin, Elena V. Kondakova
    Cells.2026; 15(6): 537.     CrossRef
  • DIAGNÓSTICO TARDIO DO TRANSTORNO DO ESPECTRO AUTISTA EM ADULTOS: Impactos clínicos, psicossociais e na saúde mental
    Hesrom Fernandes Serra Moura, Mara Fernanda Alves Moreira, Daniele Santos Mangabeira, Karolayne Oliveira Santos, Samuel dos Santos da Cruz
    Psicologia e Saúde em debate.2026; 12(1): 662.     CrossRef
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    Meryem Bachir, Mouna Ziani, Khayra Zerrouki, Fawzia Nemar, Rachida Allem, Malika Ahmed Meziane
    Biological Trace Element Research.2026;[Epub]     CrossRef
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  • Socialization of children with autism spectrum disorder complicated by concomitant disorders ‎
    Rymkhanova Ainagul Rymbekovna, Turebayeva Klara Zhamanbaevna, Rakhmetova Anar Muratovna, Olexyuk Zaryana Yaroslavovna, Yakovenko Irina Valeryevna, Zhussupbekova Zamzagul Dostiarovna
    Journal of Advanced Pharmacy Education and Researc.2025; 15(3): 61.     CrossRef
  • Mechanistic Links Between Gut Dysbiosis, Insulin Resistance, and Autism Spectrum Disorder
    Patricia Guevara-Ramírez, Rafael Tamayo-Trujillo, Viviana A. Ruiz-Pozo, Santiago Cadena-Ullauri, Elius Paz-Cruz, Ana Karina Zambrano
    International Journal of Molecular Sciences.2025; 26(13): 6537.     CrossRef
  • Saraswata Churna and Its Potential Effect on Autism Spectrum Disorder in Children: A Comprehensive Review
    Devenda Suman, Ojha N. Kumari
    Journal of Pharmaceutical and BioSciences.2025; 13(1): 1.     CrossRef
  • Autism Spectrum Disorder: From Experimental Models to Probiotic Application with a Special Focus on Lactiplantibacillus plantarum
    Giusi Sabatini, Ilenia Boccadoro, Roberta Prete, Natalia Battista, Aldo Corsetti
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  • Anti-Inflammatory Diet and Probiotic Supplementation as Strategies to Modulate Immune Dysregulation in Autism Spectrum Disorder
    Carlos Andrés Naranjo-Galvis, Diana María Trejos-Gallego, Cristina Correa-Salazar, Jessica Triviño-Valencia, Marysol Valencia-Buitrago, Andrés Felipe Ruiz-Pulecio, Luisa Fernanda Méndez-Ramírez, Jovanny Zabaleta, Miguel Andres Meñaca-Puentes, Carlos Alber
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  • TRENING NA TRAMPOLINIE JAKO PRZYKŁAD AKTYWNOŚCI FIZYCZNEJ O CHARAKTERZE TERAPEUTYCZNYM PRZEZNACZONEJ DLA DZIECI I MŁODZIEŻY ZE SPEKTRUM AUTYZMU
    Amanda Błaszczak
    Szkoła Specjalna.2025;[Epub]     CrossRef
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    ADEL M ZEGLAM, NAJAH S WAHRA
    Innovare Journal of Medical Sciences.2025; : 8.     CrossRef
  • Sleep disorders in children with neurodevelopmental disorders: Comparative actigraphy and questionnaire assessment in ASD, ADHD, and controls
    Sara Pinghini, Lucio Giordano, Francesca Banditelli, Rossana Bucci, Anna Eusebi, Elena Filippini, Michela Gritti, Paola Mattei, Davide Nocita, Elisa Maria Fazzi, Giuseppe Milito
    Sleep Medicine.2025; 136: 106794.     CrossRef
  • The Evidence-Based Instrument for the Nutritional Assessment of Individuals with Autism Spectrum Disorder
    Cristiane Vasconcelos, Kamila Castro, Rudimar dos Santos Riesgo
    Dietetics.2025; 4(3): 37.     CrossRef
  • Otizmin Semptom Öncesi Dönemde Tespiti: Göz İzleme Teknolojileri ve Görsel Dikkat Biyobelirteçleri
    Işık Akın Bülbül
    Turkish Journal of Special Education Research and .2025; 7(1): 1.     CrossRef
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    Sara Močnik, Hojka Gregorič Kumperščak, Ajda Demšar
    Frontiers in Psychiatry.2025;[Epub]     CrossRef
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    Manuel Airoldi, Veronica Remori, Mauro Fasano
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  • Resilient narratives of a single mother raising a child with autism spectrum disorder: A neurodiversity perspective
    Nettie N. Ndou-Chikwena, Maximus M. Sefotho, Nausheen Ameen
    African Journal of Disability.2025;[Epub]     CrossRef
  • The use of digital technologies by children with learning difficulties in inclusive primary schools: a literature synthesis
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    International Journal of Inclusive Education.2025; : 1.     CrossRef
  • Association Between Prenatal Air Pollution Exposure and Autism in Children: EPINED Study
    Sharanpreet Kaur, Paula Morales-Hidalgo, Mònica Guxens, Núria Voltas, Sami Petricola, Josefa Canals-Sans
    Journal of Autism and Developmental Disorders.2025;[Epub]     CrossRef
  • A Network Analysis of ADHD and ASD Symptoms in Chinese Children: Insights on Age and Gender Differences
    Jie Luo, Wen Shao, Yuanzhen Wu, Huanhuan Huang, Gaoyang Xu, Yanjie Qi, Paul Overton, Yi Zheng, Fan He
    International Journal of Methods in Psychiatric Re.2025;[Epub]     CrossRef
  • Therapeutic timing limitations of postnatal darbepoetin in a valproic acid rat model of Autism Spectrum Disorder
    Ömer Yusuf İpek, Tuğba Kirboğa, Ercan Babur, Nurcan Dursun, Cem Süer, Anna-Leena Sirén
    PLOS One.2025; 20(11): e0337294.     CrossRef
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    Indumathi Ravichandran, R.T. Kannapiran, Ajeethkumar Ramadass, J. Reuben, B. Sujeetha, Pagadpally Srinivas
    Indian Journal of Psychological Medicine.2025;[Epub]     CrossRef
  • Burden and risk factors of autism spectrum disorder: global study and analysis
    Lin Lin, Yunge Zhang, Dongyue Zhou, Qi Wang, Xixi Wang, Jin Sun, Huanjie Li, Fengyu Cong
    Pediatric Research.2025;[Epub]     CrossRef
  • Long-Term Outcomes of Early Autism Spectrum Disorder Screening: Prevalence and Diagnostic Stability in a Decade-Long Cohort from Türkiye
    İbrahim Selçuk Esin, Esen Yıldırım Demirdöğen, Mehmet Akif Akıncı, Bahadır Turan, Gülsüm Tuğba Korkmaz Ürük, İlknur İbili Ucuz, Onur Burak Dursun
    Brain Sciences.2025; 16(1): 62.     CrossRef
  • 40,577 View
  • 1,314 Download
  • 45 Web of Science
  • Crossref
Scrutiny of COVID-19 response strategies among severely affected European nations
Shine Stephen, Alwin Issac, Rakesh Vadakkethil Radhakrishnan, Jaison Jacob, VR Vijay, Sam Jose, SM Azhar, Anoop S. Nair, Nadiya Krishnan, Rakesh Sharma, Manju Dhandapani
Osong Public Health Res Perspect 2021;12(4):203-214.
Published online July 29, 2021
DOI: https://doi.org/10.24171/j.phrp.2021.0068
Scrutiny of COVID-19 response strategies among severely affected European nations
Although the health care systems in Europe are considered the global benchmark, European nations were severely affected by the coronavirus disease 2019 (COVID-19) pandemic. This manuscript aimed to examine the strategies implemented to combat the COVID-19 pandemic by France, the United Kingdom, Spain, Italy, Germany, and Russia and their outcomes in terms of the number of cases, testing, and deaths. This is the first review of its kind that extensively analyzes the preparedness, mitigation, and response strategies against the COVID-19 pandemic adopted by these nations. This paper further suggests a strategic preparedness model for future pandemics. From the analysis, we found that a decentralized approach, prompt decision-making and timely execution, coordination between local health authorities, and public participation in the implementation of strategies could substantially reduce the case fatality rate. Nations with a high percentage of gross domestic product invested in the health sector, as well as more nurses, physicians, hospital beds, intensive care unit beds, and ventilators, better managed the pandemic. Instead, nations that postponed their pandemic response by delaying tracking, tracing, testing, quarantine, and lockdown were badly affected. The lessons learned from the present pandemic could be used as a guide to prepare for further pandemics.

Citations

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  • 165 Download
  • 2 Web of Science
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COVID-19: Weighing the Endeavors of Nations, with Time to Event Analysis
Shine Stephen, Alwin Issac, Jaison Jacob, VR Vijay, Rakesh Vadakkethil Radhakrishnan, Nadiya Krishnan
Osong Public Health Res Perspect 2020;11(4):149-157.
Published online August 31, 2020
DOI: https://doi.org/10.24171/j.phrp.2020.11.4.02
<p>The cataclysmic COVID-19 pandemic erupted silently causing colossal impact worldwide, the repercussions of which indicated a lackadaisical vigilance in preparation for such a pandemic. This review assessed the measures taken by nations to contain this pandemic. A literature review was conducted using Medline, Google Scholar, Science Direct, Scopus, and WHO website. There were 8 nations (selected from the GHS index list) appraised for containment strategies. This was achieved by using mortality rate (per million) as the primary endpoint. The nations which were proactive, initiated scientific strategies earlier with rigor, appeared to have succeeded in containing the pandemic, although it is still too early to arbitrate a verdict. The so called “pandemic war” mandates international, interdisciplinary, and interdepartmental collaboration. Furthermore, building trust and confidence between the government and the public, having transparent communication, information sharing, use of advanced research-technology, and plentiful resources are required in the fight against COVID-19.</p>

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  • An evidence-based nursing care guide for critically ill patients with COVID-19: A scoping Review
    Manju Dhandapani, Vijay VR, Nadiya Krishnan, Lakshmanan Gopichandran, Alwin Issac, Shine Stephen, Jaison Jacob, Thilaka Thilaka, Lakshmi Narayana Yaddanapudi, Sivashanmugam Dhandapani
    Asian Journal of Nursing Education and Research.2022; : 144.     CrossRef
  • An examination of Thailand’s health care system and strategies during the management of the COVID-19 pandemic
    Alwin Issac, Rakesh Vadakkethil Radhakrishnan, VR Vijay, Shine Stephen, Nadiya Krishnan, Jaison Jacob, Sam Jose, SM Azhar, Anoop S Nair
    Journal of Global Health.2021;[Epub]     CrossRef
  • Somatoform Symptoms among Frontline Health-Care Providers during the COVID-19 Pandemic
    Jaison Jacob, VR Vijay, Alwin Issac, Shine Stephen, Manju Dhandapani, Nadiya Krishnan, VR Rakesh, Sam Jose, Anoop S. Nair, SM Azhar
    Indian Journal of Psychological Medicine.2021; 43(3): 272.     CrossRef
  • How the nations should gear up for future pandemics?
    Alwin Issac, VR Vijay, Nadiya Krishnan, Jaison Jacob, Shine Stephen, Rakesh Vadakkethil Radhakrishnan, Manju Dhandapani
    Journal of Global Health.2021;[Epub]     CrossRef
  • Determinants of Willingness for COVID-19 Vaccine: Implications for Enhancing the Proportion of Vaccination Among Indians
    Jaison Jacob, Shine Stephen, Alwin Issac, Nadiya Krishnan, Rakesh Vadakkethil Radhakrishnan, Vijay V R, Manju Dhandapani, Sam Jose, Azhar SM, Anoop S Nair
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  • Scrutiny of COVID-19 response strategies among severely affected European nations
    Shine Stephen, Alwin Issac, Rakesh Vadakkethil Radhakrishnan, Jaison Jacob, VR Vijay, Sam Jose, SM Azhar, Anoop S. Nair, Nadiya Krishnan, Rakesh Sharma, Manju Dhandapani
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  • 13,979 View
  • 139 Download
  • 8 Web of Science
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