Osong Public Health and Research Perspectives

Original Articles

The effect of photodynamic therapy using Radachlorin on biofilm-forming multidrug-resistant bacteria: Choong-Won Seo, Young-Kwon Kim, Jeong-Lib An, Jong-Sook Kim, Pil-Seung Kwon, Young-Bin Yu; Osong Public Health Res Perspect. 2022;13(4):290-297. Published online August 10, 2022; DOI: https://doi.org/10.24171/j.phrp.2022.0150

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Objectives
This study aimed to test the effect of photodynamic therapy (PDT) on the inhibition and removal of biofilms containing multidrug-resistant Acinetobacter baumannii.
Methods
Using multidrug-resistant A. baumannii strains, an antibiotic susceptibility test was performed using the Gram-negative identification card of the Vitek 2 system (bioMérieux Inc., France), as well as an analysis of resistance genes, the effects of treatment with a light-emitting diode (LED) array using Radachlorin (RADA-PHARMA Co., Ltd., Russia), and transmission and scanning electron microscopy to confirm the biofilm-inhibitory effect of PDT.
Results
The antibiotic susceptibility test revealed multiple resistance to the antibiotics imipenem and meropenem in the carbapenem class. A class-D–type β-lactamase was found, and OXA-23 and OXA-51 were found in 100% of 15 A. baumannii strains. After PDT using Radachlorin, morphological observations revealed an abnormal structure due to the loss of the cell membrane and extensive morphological changes, including low intracellular visibility and small vacuoles attached to the cell membrane.
Conclusion
PDT involving a combination of LED and Radachlorin significantly eliminated the biofilm of multidrug-resistant A. baumannii. Observations made using electron microscopy showed that PDT combining LED and Radachlorin was effective. Additional studies on the effective elimination of biofilms containing multidrug-resistant bacteria are necessary, and we hope that a treatment method superior to sterilization with antibiotics will be developed in the future.

Citations

Citations to this article as recorded by

Photophysical properties of Radachlorin photosensitizer in solutions of different pH, viscosity and polarity
A.V. Belashov, A.A. Zhikhoreva, I.A. Gorbunova, M.E. Sasin, Sh.S. Shayakhmedov, I.V. Semenova
Spectrochimica Acta Part A: Molecular and Biomolec.2024; 305: 123480. CrossRef
Applications of Antimicrobial Photodynamic Therapy in Aquaculture: Effect on Fish Pathogenic Bacteria
Edith Dube, Grace Emily Okuthe
Fishes.2024; 9(3): 99. CrossRef
Understanding the biofilm development of Acinetobacter baumannii and novel strategies to combat infection
Naji Naseef Pathoor, Akshaya Viswanathan, Gulshan Wadhwa, Pitchaipillai Sankar Ganesh
APMIS.2024; 132(5): 317. CrossRef
PDT-Induced Variations of Radachlorin Fluorescence Lifetime in Living Cells In Vitro
Andrey V. Belashov, Anna A. Zhikhoreva, Anna V. Salova, Tatiana N. Belyaeva, Ilia K. Litvinov, Elena S. Kornilova, Irina V. Semenova
Photonics.2023; 10(11): 1262. CrossRef

Impact of fatigue on quality of life among breast cancer patients receiving chemotherapy: Fares Mohammed Saeed Muthanna, Mahmathi Karuppannan, Bassam Abdul Rasool Hassan, Ali Haider Mohammed; Osong Public Health Res Perspect. 2021;12(2):115-125. Published online April 29, 2021; DOI: https://doi.org/10.24171/j.phrp.2021.12.2.09

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Abstract PDF

Objectives
Fatigue is the most frequently reported symptom experienced by cancer patients and has a profound effect on their quality of life (QOL). The study aimed to determine the impact of fatigue on QOL among breast cancer patients receiving chemotherapy and to identify the risk factors associated with severe fatigue incidence.
Methods
This was an observational prospective study carried out at multiple centers. In total, 172 breast cancer patients were included. The Functional Assessment of Chronic Illness Therapy-Fatigue Questionnaire was used to measure QOL, while the Brief Fatigue Inventory (BFI) was used to assess the severity of fatigue.
Results
The total average mean and standard deviation of QOL were 84.58±18.07 and 4.65±1.14 for BFI scores, respectively. A significant association between fatigue and QOL was found in linear and multiple regression analyses. The relationships between fatigue severity and cancer stage, chemotherapy dose delay, dose reduction, chemotherapy regimen, and ethnicity were determined using binary logistic regression analysis.
Conclusion
The findings of this study are believed to be useful for helping oncologists effectively evaluate, monitor, and treat fatigue related to QOL changes.

Citations

Citations to this article as recorded by

Effectiveness of Therapeutic Exercise Models on Cancer-Related Fatigue in Patients With Cancer Undergoing Chemotherapy: A Systematic Review and Network Meta-analysis
Aida Herranz-Gómez, Ferran Cuenca-Martínez, Luis Suso-Martí, Clovis Varangot-Reille, Miriam Prades-Monfort, Joaquín Calatayud, Jose Casaña
Archives of Physical Medicine and Rehabilitation.2023; 104(8): 1331. CrossRef
Anatomical Sites OF Superficial Basal Cell Cancers Demonstrate Higher Rates of Mixed Histology
Zahid Sarfaraz Khan, Asim Muhammad, Muhammad Ataullah, Syeda Gulrukh Saba Shah, Tehmina Naushin, Hina Mir, Nabiha Naeem, Ziyad Ahmad, Sudhair Abbas Bangash, Irfan Ullah
Pakistan BioMedical Journal.2022; : 44. CrossRef
Glycated Albumin's Clinical Effectiveness in The Diabetes Diagnosis
Summeira Jabeen Shah, Hajira Ishaq, Hina Hakeem, Saima Shaheen, Sikandar Ali Khan, Sosan Rauf, Hina Mir, Sudhair Abbas Bangash, Muhammad Ali, Irfan Ullah
Pakistan BioMedical Journal.2022; : 176. CrossRef
Post stroke intervention trial in fatigue (POSITIF): Randomised multicentre feasibility trial
Gillian Mead, David Gillespie, Mark Barber, Allan House, Steff Lewis, Hannah Ensor, Simiao Wu, Trudie Chalder
Clinical Rehabilitation.2022; 36(12): 1578. CrossRef
Quality of Life and Its Associated Factors Among Cancer Patients Receiving Chemotherapy at Oncology Hospitals in Vietnam After the Third Wave of the COVID-19 Pandemic
Hanh TH Nguyen, Khanh Linh Duong, Son T Nguyen, Quy Trinh, Hao TL Hoang, Toan Q Phung, Hsiang-Wen Lin, Huong TL Nguyen
Cancer Management and Research.2022; Volume 14: 2429. CrossRef
Effects of traditional Chinese medicine exercise therapy on cancer-related fatigue, anxiety and sleep quality in cancer patients
Lihao Jiang, Ju Ouyang, Xianfeng Du
Medicine.2021; 100(44): e27681. CrossRef

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