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Original Articles
A Healthcare-Associated Outbreak of HCV Genotype 2a at a Clinic in Seoul
Siwon Choi, Hyerim Lee, Hyungmin Lee, Yoon-Seok Chung
Osong Public Health Res Perspect. 2021;12(1):3-12.   Published online February 23, 2021
DOI: https://doi.org/10.24171/j.phrp.2021.12.1.02
  • 3,791 View
  • 211 Download
AbstractAbstract PDF
Objectives

An epidemiological investigation was conducted into a hepatitis C virus (HCV) outbreak at an outpatients clinic in Seoul (2011–2012). The aim of the study was to analyze the scale of infection, identify the source of infection, and route of transmission to prevent hepatitis C transmission in the future.

Methods

A retrospective study of the outpatients and health care workers (n = 7,285) in the target outpatient clinic during 2011–2012 was conducted. The history of the study population infection with hepatitis C, electronic medical records, field visits, and health care worker interviews were examined for the period between March 1st, 2006 and March 25th, 2016. The blood samples were collected and tested for anti-HCV antibodies, HCV RNA and HCV gene in 2016.

Results

The rate of anti-HCV positive results was 4.4% in the study population. The risk factors associated with an anti-HCV positive result were ≥ 10 clinic visits, and receiving an invasive procedure including a nerve block and a block of the peripheral branch of the spinal nerve (p < 0.05). There were 112 HCV RNA positive cases out of 320 anti-HCV positive test result cases, amongst which 100 cases had the dominant HCV genotype 2a which formed either 1 cluster (n = 56) or 2 clusters (n = 25). This result indicated exposure to a high-association infection source.

Conclusion

Anti-HCV antibodies and genotypic analysis showed an epidemiological association between the outbreak of HCV and invasive procedures performed (2011–2012) at an outpatients clinic in Seoul.

Treatment with Sofosbuvir and Daclatasvir (with or without Ribavirin) Improves Patient Reported Outcomes in Hepatitis C
Lucas Pereira Jorge de Medeiros, Mario Barreto Correa Lima, Marcia Maria Amêndola Pires, Alessandra Mendonça Almeida Maciel, Renata Barboza Vianna Medeiros, Mariana Dermínio Donadel, Isabela Martins Becattini Pereira, Fábio Marchon Leão, Luiz Eduardo Amorim Correa Lima Pires, Helio Rzetelna, Carlos Eduardo Brandão-Mello
Osong Public Health Res Perspect. 2018;9(2):50-58.   Published online April 30, 2018
DOI: https://doi.org/10.24171/j.phrp.2018.9.2.03
  • 3,452 View
  • 35 Download
  • 4 Citations
AbstractAbstract PDF
Objectives

To evaluate the impact of 3 treatment regimens upon health-related quality of life and work productivity using patient-reported outcomes (PROs) in chronic hepatitis C infected patients: sofosbuvir (SOF) + daclatasvir (DCV); SOF + DCV + ribavirin (RBV); SOF + simeprevir (SMV).

Methods

4 questionnaires were used to evaluate PROs before, during and after treatment: Short Form-36 (SF-36), Chronic Liver Disease Questionnaire (CLDQ) - hepatitis C virus (HCV), Work Productivity and Activity Index, Functional Assessment of Chronic Illness Therapy-Fatigue (FACIT-F).

Results

Of the global sample of 55 patients included in this study; SOF + DCV (n = 10); SOF + DCV + RBV (n = 29); SOF + SMV (n = 16) all had a statistically significant improvement in SF-36, CLDQ and FACIT-F scores during and post-treatment. No statistically significant differences in the PRO questionnaire values were observed between the distinct treatment regimens. The SOF and SMV patient groups presented higher mean PRO variations during and post-treatment, compared to the other groups: SF-36 functional capacity (16.1); SF-36 mental health (21.4); CLDQ activity (1.8); CLDQ emotional function (1.2); FACIT-F physical well-being (8.0); Total FACIT-F (21.6).

Conclusion

Treatment with SOF + DCV, with or without RBV, results in an improved PRO similar to treatment with SOF + SMV in chronic hepatitis C patients.

Citations

Citations to this article as recorded by  
  • Health-related quality of life in people receiving opioid agonist treatment and treatment for hepatitis C virus infection
    Olav Dalgard, Alain H. Litwin, Oren Shibolet, Jason Grebely, Ronald Nahass, Frederick L. Altice, Brian Conway, Edward J. Gane, Anne F. Luetkemeyer, Cheng-Yuan Peng, David Iser, Isaias Noel Gendrano, Michelle M. Kelly, Barbara A. Haber, Heather Platt, Amy
    Journal of Addictive Diseases.2022; : 1.     CrossRef
  • Impact of sofosbuvir and daclastavir on health-related quality of life in patients co-infected with hepatitis C and human immunodeficiency virus
    Evy Yunihastuti, Fhadilla Amelia, Arini Ika Hapsari, Bramantya Wicaksana, Veritea Natali, Alvina Widhani, Andri Sanityoso Sulaiman, Teguh Harjono Karjadi
    Health and Quality of Life Outcomes.2021;[Epub]     CrossRef
  • Health-related quality of life and fatigue in patients with chronic hepatitis C with therapy with direct-acting antivirals agents interferon-free
    Raíssa Neves Fagundes, Lincoln Eduardo Villela Vieira de Castro Ferreira, Fábio Heleno de Lima Pace, Yury E. Khudyakov
    PLOS ONE.2020; 15(8): e0237005.     CrossRef
  • Efficacy and safety of sofosbuvir-based pangenotypic direct-acting antiviral agents for chronic hepatitis C patients without genotype determination
    Juan Li, Dong-Bo Wu, Wei Jiang, Xue-Bin Chen, Gui-Bao Xiao, Yong-Hong Wang, Meng-Lan Wang, Ya-Chao Tao, En-Qiang Chen
    Medicine.2020; 99(43): e22726.     CrossRef
Quality of Life of Chronic Hepatitis C Patients and Its Associated Factors
Hoo Jeung Cho, Euna Park
Osong Public Health Res Perspect. 2017;8(2):124-129.   Published online April 30, 2017
DOI: https://doi.org/10.24171/j.phrp.2017.8.2.04
  • 3,059 View
  • 27 Download
  • 7 Citations
AbstractAbstract PDF
Objectives

This study aimed to investigate the factors affecting the health-related quality of life (HRQOL) of patients with chronic hepatitis C (CHC).

Methods

This study is based on a descriptive survey and involved 125 gastroenterology outpatients visiting a university hospital in South Korea as the participants. HRQOL was assessed using the Liver Disease Quality of Life 1.0, which consisted of Short Form-36 (SF-36) and the Liver Disease Targeted Scale. Data were collected from December 2015 to April 2016, which were then analyzed through multiple regression analysis.

Results

HRQOL had a statistically significant correlation with age, sex, educational level, living type, employment status, monthly income level, and comorbidity status. This study showed that age > 51 years, female sex, high educational level, living alone, unemployment status, low monthly income, and presence of comorbidity had negative effects on the HRQOL of patients with CHC (R2 = 8.7%–34.6%).

Conclusion

Based on the result of this study, intervention for patients with CHC needs to be developed to enhance their HRQOL. The findings can serve as a useful reference for nursing personnel in the development of therapeutic plans to upgrade the care of CHC patients.

Citations

Citations to this article as recorded by  
  • Risk factors of severe hepatotoxicity among HIV-1 infected individuals initiated on highly active antiretroviral therapy in the Northwest Region of Cameroon
    Lem Edith Abongwa, Anthony Kebira Nyamache, Fokunang Charles, Judith Torimiro, Nshom Emmanuel, Irénée Domkam, Mbu Eyongetah, Beriyuy Jude, Fung Holgar Mua, Sama Bella, Tankou Colman Tamboh, Erna Charlene Moungang, Victorine Ngum, Paul Okemo
    BMC Gastroenterology.2022;[Epub]     CrossRef
  • Cathepsin B and Plasma Kallikrein Are Reliable Biomarkers to Discriminate Clinically Significant Hepatic Fibrosis in Patients with Chronic Hepatitis-C Infection
    Alexia de Cassia Oliveira Zanelatto, Gilmar de Souza Lacerda, Camila de Melo Accardo, Natalia Fonseca do Rosário, Andréa Alice da Silva, Guacyara Motta, Ivarne Luis dos Santos Tersariol, Analucia Rampazzo Xavier
    Microorganisms.2022; 10(9): 1769.     CrossRef
  • Impact of newer direct-acting antiviral drugs based on quality-adjusted life years: A prospective pharmacoeconomic study in hepatitis C patientsImpact of newer direct-acting antiviral drugs based on quality-adjusted life years: A prospective pharmacoecono
    BhavyaH Vyas, NishitaH Darji, DevangA Rana, KaushalY Vyas, SupriyaD Malhotra
    Perspectives in Clinical Research.2021; 12(2): 76.     CrossRef
  • Exploring Perception of Chronic Hepatitis C: An Idiographic Case Study
    Hana Arshad, Subha Malik
    Pakistan Journal of Psychological Research.2020; 34(4): 735.     CrossRef
  • Changes in Quality of Life of Chronic Hepatitis C Patients Participating in Clinical Trial
    Hoo-Jeung CHO, Euna PARK
    JOURNAL OF FISHRIES AND MARINE SCIENCES EDUCATION.2018; 30(5): 1725.     CrossRef
  • Treatment with Sofosbuvir and Daclatasvir (with or without Ribavirin) Improves Patient Reported Outcomes in Hepatitis C
    Lucas Pereira Jorge de Medeiros, Mario Barreto Correa Lima, Marcia Maria Amêndola Pires, Alessandra Mendonça Almeida Maciel, Renata Barboza Vianna Medeiros, Mariana Dermínio Donadel, Isabela Martins Becattini Pereira, Fábio Marchon Leão, Luiz Eduardo Amor
    Osong Public Health and Research Perspectives.2018; 9(2): 50.     CrossRef
  • Quality of life in Brazilian patients with treated or untreated chronic hepatitis C
    Cássio Marques Perlin, Vinicius Lins Ferreira, Helena Hiemisch Lobo Borba, Astrid Wiens, Cláudia Alexandra Pontes Ivantes, Luana Lenzi, Roberto Pontarolo
    Revista do Instituto de Medicina Tropical de São P.2017;[Epub]     CrossRef
Illness Experience of Patients with Chronic Hepatitis C Participating in Clinical Trials
Hoo-Jeung Cho, Euna Park
Osong Public Health Res Perspect. 2016;7(6):394-399.   Published online December 31, 2016
DOI: https://doi.org/10.1016/j.phrp.2016.11.001
  • 2,154 View
  • 18 Download
  • 5 Citations
AbstractAbstract PDF
Objectives
To understand the illness experience of patients with chronic hepatitis C participating in clinical trials in the sociocultural context of Korea in an in-depth and comprehensive manner.
Methods
A focused ethnography approach was used to discover the pattern of illness experience of patients with chronic hepatitis C in the cultural background of Korea. Interviews were conducted with 11 patients with chronic hepatitis C participating in clinical trials and the collected data were analyzed with the domain analysis, taxonomical analysis, componential analysis, and theme analysis proposed by Spradley.
Results
With the cultural theme of “less-known illness, less-familiar illness,” four categories were derived: “my illness discovered by accident,” “shaken life,” “scary but inevitable treatment method,” and “precious life that can't be wasted,” along with 12 properties.
Conclusion
Public campaigns or education programs are needed to meet the needs for information on the disease for patients with chronic hepatitis C participating in clinical trials and help the general public acquire knowledge or change view on this disease.

Citations

Citations to this article as recorded by  
  • “There are many fevers”: Communities’ perception and management of Febrile illness and its relationship with human animal interactions in South-Western Uganda
    Michael Wandanje Mahero, Katherine M. Pelican, Jacinta M. Waila, Shamilah Namusisi, Innocent B. Rwego, Charles Kajura, Christopher Nyatuna, David R. Boulware, Joel Hartter, Lawrence Mugisha, Cheryl Robertson, Dominic A. Travis, Kate Zinszer
    PLOS Neglected Tropical Diseases.2022; 16(2): e0010125.     CrossRef
  • Effect of Disease-related Knowledge and Health Enhancement Lifestyle on Self-management Behavior among Chronic Hepatitis C Patients
    Hoo Jeung CHO, Euna PARK
    THE JOURNAL OF FISHERIES AND MARINE SCIENCES EDUCA.2022; 34(2): 219.     CrossRef
  • Impact of Hepatitis C Virus Cure on Depressive Symptoms in the Human Immunodeficiency Virus-Hepatitis C Virus Coinfected Population in Canada
    Gayatri Marathe, Erica EM Moodie, Marie Josée Brouillette, Charlotte Lanièce Delaunay, Joseph Cox, Valérie Martel-Laferrière, John Gill, Curtis Cooper, Neora Pick, Marie Louise Vachon, Sharon Walmsley, Marina B Klein, Lisa Barrett, Jeff Cohen, Brian Conwa
    Clinical Infectious Diseases.2022;[Epub]     CrossRef
  • Assessing potential cures: are there distinctive elements of value beyond health gain?
    Saskia Hendriks, Steven D Pearson
    Journal of Comparative Effectiveness Research.2021; 10(4): 255.     CrossRef
  • Depression in patients with chronic hepatitis-C treated with direct-acting antivirals: A real-world prospective observational study
    Mohamed A. Khalil, Hend Ibrahim Shousha, Saeed M. El-Nahaas, Mohamed Ibrahim Negm, Kariman Kamal, Nagwan Mohamed Madbouly
    Journal of Affective Disorders.2021; 282: 126.     CrossRef
Comparison of Three Different Methods for Detection of IL28 rs12979860 Polymorphisms as a Predictor of Treatment Outcome in Patients with Hepatitis C Virus
Abolfazl Fateh, Mohammadreza Aghasadeghi, Seyed D. Siadat, Farzam Vaziri, Farzin Sadeghi, Roohollah Fateh, Hossein Keyvani, Alireza H. Tasbiti, Shamsi Yari, Angila Ataei-Pirkooh, Seyed H. Monavari
Osong Public Health Res Perspect. 2016;7(2):83-89.   Published online April 30, 2016
DOI: https://doi.org/10.1016/j.phrp.2015.11.004
  • 2,206 View
  • 17 Download
  • 17 Citations
AbstractAbstract PDF
Objectives
This study aimed to evaluate the specificity, sensitivity, cost, and turn-around time of three methods of gene polymorphism analysis and to study the relationship between IL28B rs12979860 and SVR rate to pegIFN-α/RVB therapy among patients with chronic hepatitis C.
Methods
A total of 100 samples from chronic hepatitis C patients were analyzed in parallel using the three methods: direct sequencing, real-time polymerase chain reaction (PCR), amplification refractory mutation system (ARMS)-PCR.
Results
The different profiles for IL28B rs12979860 alleles (CC, CT, and TT) obtained with PCR-RFLP, ARMS-PCR, and direct sequencing were consistent among the three methods. Prevalence of rs12979860 genotypes CC, CT and TT in HCV genotype 1a was 10(19.6%), 35(68.6%), and six (11.8%), respectively, and in HCV genotype 31, it was 13(26.5%), 31(63.3%), and five (10.2%), respectively. No significant difference was seen between rs12979860 genotype and HCV genotype (p = 0.710).
Conclusion
Screening by ARMS – PCR SNOP detection represents the most efficient and reliable method to determine HCV polymorphisms in routine clinical practice.

Citations

Citations to this article as recorded by  
  • MicroRNAs Profiling in HIV, HCV, and HIV/HCV Co-Infected Patients
    Mohsen Moghoofei, Sohrab Najafipour, Shayan Mostafaei , Ahmad Tavakoli , Farah Bokharaei-Salim , Saied Ghorbani, Davod Javanmard, Hadi Ghaffari , Seyed Hamidreza Monavari
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    Amir Hossein Nafari, Ahmad Ayadi, Zahra Noormohamadi, Fatemeh Sakhaee, Farzam Vaziri, Seyed Davar Siadat, Abolfazl Fateh
    Infection, Genetics and Evolution.2020; 79: 104144.     CrossRef
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    Ataollah Moshirabadi, Mohammad Razi, Peyman Arasteh, Mohammad Mahdi Sarzaeem, Saman Ghaffari, Saied Aminiafshar, Kami Hosseinian Khosroshahy, Fatemeh Maryam Sheikholeslami
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  • Evaluation of TRIM5 and TRIM22 polymorphisms on treatment responses in Iranian patients with chronic hepatitis C virus infection
    Setareh Mobasheri, Nazanin Irani, Abbas Akhavan Sepahi, Fatemeh Sakhaee, Fatemeh Rahimi Jamnani, Farzam Vaziri, Seyed Davar Siadat, Abolfazl Fateh
    Gene.2018; 676: 95.     CrossRef
  • Data Mining and Machine Learning Algorithms Using IL28B Genotype and Biochemical Markers Best Predicted Advanced Liver Fibrosis in Chronic Hepatitis C
    Hend Ibrahim Shousha, Abubakr Hussein Awad, Dalia Abdelhamid Omran, Mayada Mohamed Elnegouly, Mahasen Mabrouk
    Japanese Journal of Infectious Diseases.2018; 71(1): 51.     CrossRef
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  • A comparative study of various methods for detection of IL28B rs12979860 in chronic hepatitis C
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    Jundishapur Journal of Microbiology.2016;[Epub]     CrossRef

PHRP : Osong Public Health and Research Perspectives