Skip Navigation
Skip to contents

PHRP : Osong Public Health and Research Perspectives

OPEN ACCESS
SEARCH
Search

Search

Page Path
HOME > Search
2 "aflatoxin M1"
Filter
Filter
Article category
Keywords
Publication year
Authors
Original Articles
Aflatoxin M1 Contamination Levels in Cheeses Sold in Isfahan Province, Iran
Ali Sharifzadeh, Payam Ghasemi-Dehkordi, Mohsen Foroughi, Elham Mardanpour-Shahrekordi, Shahin Ramazi
Osong Public Health Res Perspect. 2017;8(4):260-263.   Published online August 31, 2017
DOI: https://doi.org/10.24171/j.phrp.2017.8.4.05
  • 4,771 View
  • 31 Download
  • 16 Crossref
AbstractAbstract PDF
Objectives

Aflatoxin M1 (AFM1)-contaminated dairy products pose serious human health risks, causing liver and renal failure if consumed. They are also related to decreased milk and egg production in infected animals. This study investigated the AFM1 contamination levels in cheeses sold in Isfahan province, Iran, by enzyme-linked immunosorbent assay (ELISA).

Methods

A total of 100 white cheese samples were randomly collected from supermarkets in Isfahan province and after extraction using dichloromethane were prepared for the ELISA.

Results

Of the 100 samples, 52 (52%) were contaminated by AFM1, at levels ranging from 50.2 to 424.4 ng/kg. The remaining 48% of the samples had undetectable AFM1 levels (< 50 ng/kg). Based on the standard limit set by the European Commission and Iran, 8% (8/100) of the AFM1-positive samples (with concentrations between 250.2 and 424.4 ng/kg) had levels higher than the permissible value of 250 ng/kg.

Conclusion

Although the percentage of cheese samples in Isfahan province with AFM1 levels exceeding the national permissible limit was low, the examination of cheeses and the milk used for their production is nevertheless important for ensuring public health. Furthermore, optimum storage conditions of animal feed should be ensured, and livestock nutrition must be monitored for the presence of AFM1 and other aflatoxins.

Citations

Citations to this article as recorded by  
  • Prevalence and concentration of aflatoxin M1 and ochratoxin A in cheese: a global systematic review and meta-analysis and probabilistic risk assessment
    Trias Mahmudiono, Yeganeh Mazaheri, Parisa Sadighara, Zeynab Akbarlou, Somayeh Hoseinvandtabar, Yadolah Fakhri
    Reviews on Environmental Health.2024; 39(4): 801.     CrossRef
  • Human health risk assessment of aflatoxin M1 in various dairy products in Iran: A literature review
    Tooraj Massahi, Abdullah Khalid Omer, Mohammad Hossein Habibollahi, Borhan Mansouri, Gholamreza Ebrahimzadeh, Kimya Parnoon, Hamed Soleimani, Kiomars Sharafi
    Journal of Food Composition and Analysis.2024; 129: 106124.     CrossRef
  • An overview of regional mycotoxin contamination in Iranian food
    Kousar Aghebatbinyeganeh, Mohamed F. Abdallah
    Food and Humanity.2024; 3: 100370.     CrossRef
  • Current Status of Major Mycotoxins Contamination in Food and Feed in Asia─A Review
    Lu Sun, Runyan Li, Bowen Tai, Sarfaraz Hussain, Gang Wang, Xiumin Liu, Fuguo Xing
    ACS Food Science & Technology.2023; 3(2): 231.     CrossRef
  • A national systematic literature review for aflatoxin M1 in commonly consumed cheese brands in Iran: Human health risk assessment by Monte Carlo simulation
    Tooraj Massahi, Amir Kiani, Kiomars Sharafi, Abdullah Khalid Omer, Gholamreza Ebrahimzadeh, Jalil Jaafari, Nazir Fattahi, Kimya Parnoon
    Heliyon.2023; 9(9): e19679.     CrossRef
  • Aflatoxin M1 in milk and dairy products: global occurrence and potential decontamination strategies
    Khurram Muaz, Muhammad Riaz, Carlos Augusto Fernandes de Oliveira, Saeed Akhtar, Shinawar Waseem Ali, Habibullah Nadeem, Sungkwon Park, Balamuralikrishnan Balasubramanian
    Toxin Reviews.2022; 41(2): 588.     CrossRef
  • The prevalence of aflatoxin M1 (AFM1) in conventional and industrial dairy products (yogurt, cheese, kashk and dough) of Iran: a systematic review and meta-analysis
    Pouran Makhdoumi, Hooshyar Hossini, Reza Mohammadi, Mojtaba Limoee
    Reviews on Environmental Health.2022; 37(1): 123.     CrossRef
  • Aflatoxin‐M1 contamination in cheese of six countries in the West Asia region: A systematic review and meta‐analysis
    Salman Mohammadi, Majid Keshavarzi, Asma Kazemi, Samane Rahmdel, Mehran Nouri, Ayoob Rastegar, Ali Ghaffarian‐Bahraman
    International Journal of Dairy Technology.2022; 75(3): 653.     CrossRef
  • Aflatoxin M1 Contamination of Ghanaian Traditional Soft Cottage Cheese (Wagashie) and Health Risks Associated with Its Consumption
    Nii Korley Kortei, Theophilus Annan, Parise Adadi
    Journal of Food Quality.2022; 2022: 1.     CrossRef
  • Aflatoxin M1 contamination in different Iranian cheese types: A systematic review and meta-analysis
    Salman Mohammadi, Khosro Behmaram, Majid Keshavarzi, Somayeh Saboori, Abbas Jafari, Ali Ghaffarian-Bahraman
    International Dairy Journal.2022; 133: 105437.     CrossRef
  • Occurrence of aflatoxin M1 in milk and Minas Frescal cheese manufactured in Brazilian dairy plants
    Bruna L Gonçalves, Rômulo D Ulliana, Gustavo L P A Ramos, Adriano G Cruz, Carlos A F Oliveira, Eliana S Kamimura, Carlos H Corassin
    International Journal of Dairy Technology.2021; 74(2): 431.     CrossRef
  • Physical and Chemical Methods for Reduction in Aflatoxin Content of Feed and Food
    Péter Sipos, Ferenc Peles, Dóra Lili Brassó, Béla Béri, Tünde Pusztahelyi, István Pócsi, Zoltán Győri
    Toxins.2021; 13(3): 204.     CrossRef
  • Aflatoxin M1 contamination level in Iranian milk and dairy products: a systematic review and meta-analysis
    S. Hamzeh Pour, S. Mahmoudi, S. Masoumi, S. Rezaie, A. Barac, M. Ranjbaran, S. Oliya, F. Mehravar, E. Sasani, F. Noorbakhsh, S. Khodavaisy
    World Mycotoxin Journal.2020; 13(1): 67.     CrossRef
  • Microbial quality and safety of milk and milk products in the 21st century
    Vincenzina Fusco, Daniele Chieffi, Francesca Fanelli, Antonio F. Logrieco, Gyu‐Sung Cho, Jan Kabisch, Christina Böhnlein, Charles M. A. P. Franz
    Comprehensive Reviews in Food Science and Food Saf.2020; 19(4): 2013.     CrossRef
  • Aflatoxin M1 in Nicaraguan and locally made hard white cheeses marketed in El Salvador
    Oscar Peña-Rodas, Roxana Martinez-Lopez, Mario Pineda-Rivas, Roberto Hernandez-Rauda
    Toxicology Reports.2020; 7: 1157.     CrossRef
  • Incidence of aflatoxin M1 contamination in milk, white cheese, kashar and butter from Sakarya, Turkey
    Suzan ÖZTÜRK YILMAZ, Alev ALTINCI
    Food Science and Technology.2019; 39( suppl 1): 190.     CrossRef
Exposure of Infants to Aflatoxin M1 from Mother's Breast Milk in Ilam, Western Iran
Farajollah Maleki, Soghra Abdi, Elaham Davodian, Karimeh Haghani, Salar Bakhtiyari
Osong Public Health Res Perspect. 2015;6(5):283-287.   Published online October 31, 2015
DOI: https://doi.org/10.1016/j.phrp.2015.10.001
  • 3,769 View
  • 22 Download
  • 35 Crossref
AbstractAbstract PDF
Objectives
Aflatoxins as a highly toxic group of mycotoxins are present in the environment and foodstuff. These have been reported to cause serious health problems in humans. Since aflatoxin M1 (AFM1) is excreted into breast milk, investigating the exposure of infants to AFM1 is of special concern.
Methods
In the present study, breast milk samples were collected from 85 lactating mothers in Ilam province, Iran, and the levels of AFM1 were analyzed using the enzyme-linked immunosorbent assay-based technique. AFM1 was detected in breast milk of all lactating women. The mean contamination level was 5.91 ± 2.031 ng/L, ranging from 2 ng/L to 10 ng/L.
Results
Multiple regression analysis indicated no significant associations of consumption of milk and dairy products, meat, fish, legumes, grain products, fruits, and nuts with the concentration of AFM1 in breast milk. Furthermore, no significant association was observed between AFM1 concentration and anthropometric data of infants.
Conclusion
In western parts of Iran, lactating mothers and their infants could be at risk of aflatoxin B1 and AFM1 exposure, respectively. Therefore, in Iran, the evaluation of AFM1 in human breast milk as a biomarker for postnatal exposure of infants to this carcinogen requires more attention in different regions and various seasons.

Citations

Citations to this article as recorded by  
  • Determination of aflatoxin M1 and ochratoxin A in breast milk in rural centers of Yazd, Iran: Exposure assessment and risk characterization
    Zeinab Rezaei, Siavash Hamzeh Pour, Parya Ezati, Fateme Akrami-Mohajeri
    Mycotoxin Research.2024; 40(2): 211.     CrossRef
  • Evaluation of Aflatoxins Occurrence and Exposure in Cereal-Based Baby Foods: An Update Review
    Yasemin Açar, Gamze Akbulut
    Current Nutrition Reports.2024; 13(1): 59.     CrossRef
  • Risk of exposure to aflatoxin M1 through consumption of cow’s milk among children in Magadu, Morogoro
    Anna Peter Mamiro, Haikael D. Martin, Neema Kassim
    Mycotoxin Research.2024; 40(2): 245.     CrossRef
  • Assessing Aflatoxin Exposure: Exploring Types of Exposure and Diverse Biomarkers – A Minireview
    Geethu Mathew, Shubhangi Pingle, Priya S, Ravichandran B
    Current Fungal Infection Reports.2024; 18(3): 163.     CrossRef
  • Aflatoxin M1 in milk and dairy products: The state of the evidence for child growth impairment
    Patricia Hsu, Ashish Pokharel, Christian Kelly Scott, Felicia Wu
    Food and Chemical Toxicology.2024; 193: 115008.     CrossRef
  • Aflatoxins: Source, Detection, Clinical Features and Prevention
    Solomon Abrehame, Valsa Remony Manoj, Merry Hailu, Yu-Yi Chen, Yu-Chun Lin, Yen-Po Chen
    Processes.2023; 11(1): 204.     CrossRef
  • Does Bentonite Cause Cytotoxic and Whole-Transcriptomic Adverse Effects in Enterocytes When Used to Reduce Aflatoxin B1 Exposure?
    Greta Mucignat, Irene Bassan, Mery Giantin, Marianna Pauletto, Anisa Bardhi, Silvia Iori, Rosa Maria Lopparelli, Andrea Barbarossa, Anna Zaghini, Enrico Novelli, Mauro Dacasto
    Toxins.2022; 14(7): 435.     CrossRef
  • Effects of stem cells and amniotic fluid on uterus and ovaries in a rat model of abdominal adhesions: a controlled study
    Elif Ganime Aygün, Gamze Tümentemur
    Journal of the Turkish-German Gynecological Associ.2022; 23(3): 154.     CrossRef
  • Effects of aflatoxin B1 on human breast cancer (MCF-7) cells: cytotoxicity, oxidative damage, metabolic, and immune-modulatory transcriptomic changes
    Ahmed Aljazzar, Waleed Rizk El-Ghareeb, Wageh Sobhy Darwish, Sherief M. Abdel-Raheem, Abdelazim M. Ibrahim, Eman E. Hegazy, Esraa A. Mohamed
    Environmental Science and Pollution Research.2022; 30(5): 13132.     CrossRef
  • A promising innovative technique for mycotoxin detoxification from beverages using biofilms of lactic acid bacteria
    Sahar Nahle, André El Khoury, Jean Claude Assaf, Nicolas Louka, Ali Chokr, Ali Atoui
    Innovative Food Science & Emerging Technologies.2022; 82: 103165.     CrossRef
  • Human Breast Milk Contamination with Aflatoxins, Impact on Children’s Health, and Possible Control Means: A Review
    Noreddine Benkerroum, Amir Ismail
    International Journal of Environmental Research an.2022; 19(24): 16792.     CrossRef
  • miR-155 influences cell-mediated immunity in Balb/c mice treated with aflatoxin M1
    Kobra Shirani, Bamdad Riahi Zanjani, Soghra Mehri, Kamal Razavi-Azarkhiavi, Ali Badiee, A. Wallace Hayes, John P. Giesy, Gholamreza Karimi
    Drug and Chemical Toxicology.2021; 44(1): 39.     CrossRef
  • Human milk mycotoxin contamination: smoking exposure and breastfeeding problems
    Esra Yasemin Memiş, Sıddıka Songül Yalçın
    The Journal of Maternal-Fetal & Neonatal Medicine.2021; 34(1): 31.     CrossRef
  • Biological Control and Mitigation of Aflatoxin Contamination in Commodities
    Ferenc Peles, Péter Sipos, Szilvia Kovács, Zoltán Győri, István Pócsi, Tünde Pusztahelyi
    Toxins.2021; 13(2): 104.     CrossRef
  • Mycotoxin carry-over in breast milk and weight of infant in exclusively-breastfed infants
    Esra Yasemin Memiş, Sıddıka Songül Yalçın, Suzan Yalçın
    Archives of Environmental & Occupational Health.2021; 76(6): 313.     CrossRef
  • Physical and Chemical Methods for Reduction in Aflatoxin Content of Feed and Food
    Péter Sipos, Ferenc Peles, Dóra Lili Brassó, Béla Béri, Tünde Pusztahelyi, István Pócsi, Zoltán Győri
    Toxins.2021; 13(3): 204.     CrossRef
  • Biocontrol of Aflatoxins Using Non-Aflatoxigenic Aspergillus flavus: A Literature Review
    Rahim Khan, Farinazleen Mohamad Ghazali, Nor Ainy Mahyudin, Nik Iskandar Putra Samsudin
    Journal of Fungi.2021; 7(5): 381.     CrossRef
  • Aflatoxin Biosynthesis, Genetic Regulation, Toxicity, and Control Strategies: A Review
    Rahim Khan, Farinazleen Mohamad Ghazali, Nor Ainy Mahyudin, Nik Iskandar Putra Samsudin
    Journal of Fungi.2021; 7(8): 606.     CrossRef
  • Aflatoxin M1 contamination level in Iranian milk and dairy products: a systematic review and meta-analysis
    S. Hamzeh Pour, S. Mahmoudi, S. Masoumi, S. Rezaie, A. Barac, M. Ranjbaran, S. Oliya, F. Mehravar, E. Sasani, F. Noorbakhsh, S. Khodavaisy
    World Mycotoxin Journal.2020; 13(1): 67.     CrossRef
  • Levels of Aflatoxin M1 and selected heavy metals (Pb, Cd, Cr, Cu, Zn, Fe, As, and Hg) in the breast milk of lactating mothers in South Eastern, Nigeria
    Chidinma Lynda Ekeanyanwu, Chinwe Sylvanus Alisi, Raphael Chukwuma Ekeanyanwu
    Food Control.2020; 112: 107150.     CrossRef
  • Dietary mycotoxins exposure and child growth, immune system, morbidity, and mortality: a systematic literature review
    Kokeb Tesfamariam, Marthe De Boevre, Patrick Kolsteren, Tefera Belachew, Addisalem Mesfin, Sarah De Saeger, Carl Lachat
    Critical Reviews in Food Science and Nutrition.2020; 60(19): 3321.     CrossRef
  • Occurrence of and Factors Associated With the Presence of Aflatoxin M1 in Breast Milk of Mothers in Fethiye, Turkey
    Gonca Karayağiz Muslu, Mehmet Özdemir
    Biological Research For Nursing.2020; 22(3): 362.     CrossRef
  • Aflatoxin exposure among lactating women in southern Ethiopia
    Bergene Boshe, Samson Gebremedhin, Fikadu Alemayehu, Mesfin Eshete, Mestawet Taye, Barbara J. Stoecker
    Food Science & Nutrition.2020; 8(12): 6738.     CrossRef
  • An assessment of the occurrence and nutritional factors associated with aflatoxin M1, ochratoxin A, and zearalenone in the breast milk of nursing mothers in Hamadan, Iran
    Fateme Samiee, Ava Kharazi, Jomana Elaridi, Masoumeh Taravati Javad, Mostafa Leili
    Toxicon.2020; 187: 209.     CrossRef
  • Aflatoxin, fumonisin, ochratoxin, zearalenone and deoxynivalenol biomarkers in human biological fluids: A systematic literature review, 2001–2018
    Belqes Ahmad Al-Jaal, Morana Jaganjac, Andrei Barcaru, Peter Horvatovich, Aishah Latiff
    Food and Chemical Toxicology.2019; 129: 211.     CrossRef
  • Concentration and Prevalence of Aflatoxin M1 in Human Breast Milk in Iran: Systematic Review, Meta-Analysis, and Carcinogenic Risk Assessment: A Review
    Yadolah Fakhri, Raheb Ghorbani, Mahmoud Taghavi, Hassan Keramati, Nazak Amanidaz, Bigard Moradi, Simin Hagh Nazari, Nabi Shariatifar, Amin Mousavi Khaneghah
    Journal of Food Protection.2019; 82(5): 785.     CrossRef
  • Aflatoxin M1 in human breast milk: A global systematic review, meta-analysis, and risk assessment study (Monte Carlo simulation)
    Yadolah Fakhri, Jamal Rahmani, Carlos Augusto Fernandes Oliveira, Larissa Tuanny Franco, Carlos Humberto Corassin, Sumbal Saba, Jamal Rafique, Amin Mousavi Khaneghah
    Trends in Food Science & Technology.2019; 88: 333.     CrossRef
  • The occurrence of mycotoxins in breast milk, fruit products and cereal-based infant formula: A review
    Carolina Fernanda Sengling Cebin Coppa, Amin Mousavi Khaneghah, Paula Alvito, Ricardo Assunção, Carla Martins, Ismail Eş, Bruna Leonel Gonçalves, Diane Valganon de Neeff, Anderson S. Sant'Ana, Carlos Humberto Corassin, Carlos Augusto Fernandes Oliveira
    Trends in Food Science & Technology.2019; 92: 81.     CrossRef
  • Exposure assessment of Portuguese infants to Aflatoxin M1 in breast milk and maternal social-demographical and food consumption determinants
    Fernando Bogalho, Sofia Duarte, Maria Cardoso, Anabela Almeida, Ricardo Cabeças, Celeste Lino, Angelina Pena
    Food Control.2018; 90: 140.     CrossRef
  • Occurrence and dietary factors associated with the presence of aflatoxin B1 and M1 in breast milk of nursing mothers in Iran
    Manizheh Azarikia, Reza Mahdavi, Leila Nikniaz
    Food Control.2018; 86: 207.     CrossRef
  • Concentration of Aflatoxin M 1 and selected heavy metals in mother milk samples from Pakistan
    Sarah Khan, Amir Ismail, Yun Yun Gong, Saeed Akhtar, Majid Hussain
    Food Control.2018; 91: 344.     CrossRef
  • Immunotoxicity of aflatoxin M1: as a potent suppressor of innate and acquired immune systems in a subacute study
    Kobra Shirani, Bamdad R Zanjani, Mahmoud Mahmoudi, Amir H Jafarian, Faezeh V Hassani, John P Giesy, Gholamreza Karimi
    Journal of the Science of Food and Agriculture.2018; 98(15): 5884.     CrossRef
  • Natural occurrence of aflatoxin M 1 in fresh cow milk and human milk in Penang, Malaysia
    Nor Shifa Shuib, Ahmad Makahleh, Salizawati Muhamad Salhimi, Bahruddin Saad
    Food Control.2017; 73: 966.     CrossRef
  • Aflatoxin M1in human breast milk in Shahrekord, Iran and association with dietary factors
    Tina Jafari, Aziz A. Fallah, Soleiman Kheiri, Abdolmajid Fadaei, Sayed Asadollah Amini
    Food Additives & Contaminants: Part B.2017; 10(2): 128.     CrossRef
  • Biomonitoring of Mycotoxins in Human Breast Milk: Current State and Future Perspectives
    Benedikt Warth, Dominik Braun, Chibundu N. Ezekiel, Paul C. Turner, Gisela H. Degen, Doris Marko
    Chemical Research in Toxicology.2016; 29(7): 1087.     CrossRef

PHRP : Osong Public Health and Research Perspectives
TOP