<sec><b>Objectives</b><p>Integrons are thought to play an important role in the spread of antibiotic resistance. This study investigates class 1 and 2 integron-positive methicillin-resistant coagulase-negative staphylococci strains isolated in Iran and characterizes their patterns of antimicrobial resistance.</p></sec><sec><b>Methods</b><p>Hundred clinical isolates of coagulase-negative staphylococci were characterized for integron content and staphylococcal cassette chromosome <italic>mec</italic> (SCCmec) type.</p></sec><sec><b>Results</b><p>Sixteen isolates carried class 1 (<italic>intI1</italic>) integrons and four isolates carried class 2 (<italic>intI2</italic>) integrons. One resistance gene array was identified among the class 1 integrons (<italic>aadA1</italic> cassette). The distribution of SCCmec types in 50 methicillin-resistant coagulase-negative staphylococci strains showed that SCCmec types III and V dominated among the tested strains.</p></sec><sec><b>Conclusion</b><p>This is the first report of methicillin-resistant coagulase-negative staphylococci strains that carry two mobile genetic elements, including class 1 and 2 integrons and SCCmec, in Iran.</p></sec>