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PHRP : Osong Public Health and Research Perspectives

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Review Articles

Personalized medicine as a novel therapeutic approach for autoimmune diseases: new insights and future prospects
Mahdi Nasiri-Ghiri, Yaghoob Foolad, Shirin Mahmoodi, Abdolmajid Ghasemian
Received October 13, 2025  Accepted February 5, 2026  Published online May 11, 2026  
DOI: https://doi.org/10.24171/j.phrp.2025.0430    [Epub ahead of print]
Autoimmune diseases are caused by dysfunction of the immune system, leading to inappropriate attacks on healthy tissues. Because patients have diverse genetic predispositions and heterogeneous responses to therapy, personalized medicine (PM) offers an opportunity to improve treatment effectiveness. PM uses diagnostic assessments to tailor treatment through individualized medical interventions. PM may improve therapeutic precision beyond traditional trial-and-error approaches, reduce adverse consequences, and improve outcomes by integrating genomic and transcriptomic data. PM considers genetic and molecular landscapes, immunologic factors, epigenetic influences, and environmental exposures to assess treatment response. However, challenges remain related to diagnostic access, the slow pace of biomarker identification, technological limitations, sustained patient engagement, data management, and computational requirements. Nevertheless, continued efforts to improve understanding of disease pathophysiology, gene expression, and immune regulation—together with the application of novel technologies and machine learning—may advance PM-based therapies. Additional opportunities include drug–target modeling and exploratory single-cell–based approaches to clarify patient-specific therapeutic mechanisms. This review briefly introduces the potential of PM for type 1 diabetes, rheumatoid arthritis, and multiple sclerosis.
  • 259 View
  • 12 Download
The effects of resistance training on hemoglobin A1c, body mass index, and muscle strength in patients with diabetes mellitus based on age (middle-aged and older adults): a systematic review and meta-analysis
Objectives
This study aimed to examine the effectiveness of resistance training on hemoglobin A1c (HbA1c) levels and body mass index in patients with diabetes mellitus, categorized by age.
Methods
A comprehensive search of English-language literature published between 1997 and 2025 was performed across 6 databases (Embase, CINAHL, Medline, Cochrane, PubMed, and PEDro). Standardized mean differences and 95% confidence intervals were calculated, and publication bias was assessed using funnel plots and Egger’s test. The Joanna Briggs Institute checklist was applied to evaluate study quality.
Results
Thirty randomized controlled trials met the inclusion criteria, comprising 620 participants in the older (<60 years of age) subgroup and 1,389 in the middle-aged (40–59 years of age) subgroup. In both subgroups, resistance training significantly reduced HbA1c levels and body mass index, while increasing muscle strength (primary outcome). It also significantly increased high-density lipoprotein, improved VO₂ peak, and reduced low-density lipoprotein (secondary outcomes). However, the effects of resistance training were significant only in the older-adult subgroup for total cholesterol and only in the middle-aged subgroup for triglycerides.
Conclusion
Resistance training is a recommended rehabilitation exercise for patients with diabetes mellitus. Routine resistance training has been shown to help maintain optimal HbA1c and body mass index levels and improve muscle strength. In addition, it does not pose a risk of adverse events in either middle-aged or older patients. Nonetheless, patients are advised to monitor blood glucose levels and adhere to a proper diet to achieve optimal outcomes.

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  • Brain glucodynamic variability is an essential feature of the metabolism–cognition relationship
    Hamish A. Deery, Emma Liang, Chris Moran, Gary F. Egan, Sharna D. Jamadar
    Proceedings of the National Academy of Sciences.2026;[Epub]     CrossRef
  • 4,907 View
  • 186 Download
  • 1 Web of Science
  • Crossref

Original Articles

Relationship between diabetes medication self-efficacy and quality of life in older adults with diabetes: a cross-sectional study in Turkey
Nilhan Töyer Şahin, İlayda Kömürcü, Seda Aşcı
Osong Public Health Res Perspect 2025;16(5):498-507.
Published online September 30, 2025
DOI: https://doi.org/10.24171/j.phrp.2025.0218
Relationship between diabetes medication self-efficacy and quality of life in older adults with diabetes: a cross-sectional study in Turkey
Objectives
The aim of this study was to investigate the relationship between diabetes medication self-efficacy and quality of life in older adults with diabetes.
Methods
The study included 192 older adults who attended the diabetes clinic of a public hospital in Istanbul. Data were collected between June and October 2024. Participants were informed about the study and provided both verbal and written consent. Data collection instruments comprised a sociodemographic questionnaire, the diabetes medication self-efficacy scale, and the quality of life scale for older adults.
Results
Of the participants, 98 (51.0%) were women and 105 (54.7%) were aged 65 to 74 years. The mean diabetes medication self-efficacy score was 38.95±10.31, and the mean quality of life score was 18.24±6.37. A weak but statistically significant positive correlation was observed between the autonomy and satisfaction subscale of quality of life and the necessity subscale of self-efficacy (p<0.05).
Conclusion
This study, which examined the relationship between self-efficacy in diabetes management and quality of life in older adults, provides valuable guidance for clinical practice aimed at improving care for this population.
  • 1,264 View
  • 73 Download
Prevalence and determinants of medication adherence in Moroccan patients with type 2 diabetes: a multicenter cross-sectional study
Maryem Arraji, Nadia Al Wachami, Younes Iderdar, Fatima Zahra Bouchachi, Karima Boumendil, Mohamed Chahboune
Osong Public Health Res Perspect 2025;16(4):392-405.
Published online July 9, 2025
DOI: https://doi.org/10.24171/j.phrp.2025.0014
Prevalence and determinants of medication adherence in Moroccan patients with type 2 diabetes: a multicenter cross-sectional study
Objectives
This study was performed to evaluate the prevalence of medication adherence and its determinants among Moroccan patients with type 2 diabetes mellitus. Methods: A multicenter cross-sectional survey was conducted from February to June 2024, involving 584 patients from the Casablanca-Settat and Rabat-Sale-Kenitra regions of Morocco. Medication adherence was assessed using the general medication adherence scale. Associations between independent variables and adherence were analyzed using chi-square tests and multivariate logistic regression. Results: Medication adherence was observed in 96.2% of participants. Multivariate analysis revealed significantly lower medication adherence among patients using 2 or more oral antidiabetic drugs (adjusted odds ratio [aOR], 0.026; 95% confidence interval [CI], 0.001–0.642; p=0.026) and those with a diabetes duration of 11 to 15 years (aOR, 0.037; 95% CI, 0.001–0.956; p=0.047). Conclusion: Despite a high overall adherence rate, patients on dual or polytherapy and those with longer disease duration exhibited lower adherence in multivariate analysis. Targeted interventions are needed to improve adherence in these high-risk groups.
  • 1,984 View
  • 104 Download
Risk of tuberculosis in individuals with type 2 diabetes mellitus based on the tuberculosis predictive index score: a case-control study in Indonesia
Dea P. Audina, Rachel S. Aritonang, Muhammad I. Mokoagow
Osong Public Health Res Perspect 2025;16(4):406-414.
Published online June 11, 2025
DOI: https://doi.org/10.24171/j.phrp.2024.0310
Risk of tuberculosis in individuals with type 2 diabetes mellitus based on the tuberculosis predictive index score: a case-control study in Indonesia
Objectives
The co-occurrence of tuberculosis (TB) and diabetes mellitus presents a significant global health challenge, marked by a bidirectional relationship. This study aims to evaluate the effectiveness of the tuberculosis predictive index (TPI) score, developed by Isfandiari et al., in predicting TB occurrence among individuals living with type 2 diabetes mellitus. Methods: A case-control study was conducted using primary data collected through questionnaires administered to individuals with type 2 diabetes mellitus, with and without pulmonary TB, at the internal medicine outpatient clinic of Fatmawati General Hospital from June to August 2024. The study compared TPI scores between those with type 2 diabetes mellitus who had TB and those who did not. Results: TPI scores were significantly associated with TB risk. Individuals with both type 2 diabetes mellitus and TB had a 6.8-fold higher risk (95% confidence interval [CI], 2.6–17.6; p<0.001) than those without TB. Further chi-square analysis identified three significant risk factors: individuals with type 2 diabetes mellitus exhibiting TB-like symptoms had a 13.3-fold increased TB risk (95% CI, 5.1–34.3; p<0.001); those with a body mass index below 18.5 kg/m² had a 3.3-fold higher risk (95% CI, 1.0–11.0; p=0.039); and those living in poorly ventilated homes (ventilation ≤10%) had a 3.2-fold higher risk (95% CI, 1.0–9.8; p=0.035). Conclusion: This study demonstrates that individuals with type 2 diabetes mellitus who developed TB had significantly higher TPI scores, corresponding to a 6.8-fold increased risk compared to their counterparts without TB. The TPI score may serve as a valuable tool for predicting TB risk among populations living with type 2 diabetes mellitus.

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  • Artificial intelligence and biohealth: the Republic of Korea’s emerging priorities in health care R&D
    Jong-Koo Lee
    Osong Public Health and Research Perspectives.2025; 16(4): 309.     CrossRef
  • 2,198 View
  • 123 Download
  • Crossref

Review Article

The contribution of dietary total antioxidant capacity to type 2 diabetes risk and levels of glycemic biomarkers: a systematic review
Sorayya Kheirouri, Hamed Alizadeh
Osong Public Health Res Perspect 2025;16(2):100-115.
Published online March 27, 2025
DOI: https://doi.org/10.24171/j.phrp.2024.0337
The contribution of dietary total antioxidant capacity to type 2 diabetes risk and levels of glycemic biomarkers: a systematic review
Objectives
This study systematically reviewed and analyzed epidemiological evidence regarding the association between dietary total antioxidant capacity (DTAC) and both the risk of developing diabetes and glycemic biomarker levels.
Methods
We searched the PubMed, Scopus, ScienceDirect, and Google Scholar databases through July 2024 without imposing any date restrictions. Original studies that examined the relationship between DTAC and either the risk of developing diabetes or glycemic biomarker levels—specifically fasting blood glucose (FBG), hemoglobin A1C (HbA1C), insulin, and the homeostatic model assessment for insulin resistance (HOMA-IR)—were eligible for inclusion. After eliminating duplicates and irrelevant records, relevant studies were selected, and data were extracted through rigorous critical analysis.
Results
A total of 32 articles were included in the review. Of the 19 studies that evaluated diabetes risk, 15 reported a lower risk among subjects with higher DTAC values. All 4 studies examining prediabetes risk found lower risk in participants with high DTAC scores. Additionally, significant inverse relationships were observed between DTAC values and FBG (9/15 studies), HbA1C (1/6 studies), insulin (5/6 studies), and HOMA-IR (8/9 studies).
Conclusion
The majority of evidence indicates that high adherence to an antioxidant-rich diet may reduce diabetes risk and improve glycemic biomarkers, including FBG, insulin, and HOMA-IR.
  • 3,554 View
  • 122 Download

Original Articles

Periodontitis and non-communicable diseases in a Brazilian population, a cross-sectional study, Vila Velha-ES, Brazil
Gustavo Vital de Mendonça, Crispim Cerutti Junior, Alfredo Carlos Rodrigues Feitosa, Brígida Franco Sampaio de Mendonça, Lucia Helena Sagrillo Pimassoni
Osong Public Health Res Perspect 2024;15(3):212-220.
Published online June 27, 2024
DOI: https://doi.org/10.24171/j.phrp.2024.0021
Periodontitis and non-communicable diseases in a Brazilian population, a cross-sectional study, Vila Velha-ES, Brazil
Objectives
The objective of this study was to examine the hypothesis that periodontal disease is associated with chronic non-communicable diseases. Methods: In this cross-sectional study, we evaluated the periodontal health condition of the population, based on the community periodontal index, as well as the number of missing teeth and the presence of systemic health conditions. We quantified the association between oral health and the presence of chronic diseases using simple logistic regression, adjusting for confounding factors including age, smoking, and overweight. Results: The study population consisted of 334 volunteers, aged between 19 and 81 years. In patients over 45 years old, periodontal disease was found to be significantly associated with hypertension and diabetes. Furthermore, in female patients, periodontal disease was significantly associated with hypertension, diabetes, and cancer. Conclusion: Our findings indicate that periodontal disease is positively and significantly associated with both arterial hypertension and diabetes, independent of potential confounding factors.

Citations

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  • Comparative Antimicrobial and Antibiofilm Activity of Antiseptics and Commercial Mouthwashes Against Porphyromonas gingivalis ATCC 33277
    Marzena Korbecka-Paczkowska, Tomasz M. Karpiński, Marcin Ożarowski
    Journal of Clinical Medicine.2025; 14(24): 8909.     CrossRef
  • 4,230 View
  • 89 Download
  • 1 Web of Science
  • Crossref
Estimation of the onset time of diabetic complications in type 2 diabetes patients in Thailand: a survival analysis
Natthanicha Sauenram, Jutatip Sillabutra, Chukiat Viwatwongkasem, Pratana Satitvipawee
Osong Public Health Res Perspect 2023;14(6):508-519.
Published online November 23, 2023
DOI: https://doi.org/10.24171/j.phrp.2023.0084
Estimation of the onset time of diabetic complications in type 2 diabetes patients in Thailand: a survival analysis
Objectives
This study aimed to identify factors associated with the onset time of diabetic complications in patients with type 2 diabetes mellitus (T2DM) and determine the best-fitted survival model. Methods: A retrospective cohort study was conducted among T2DM patients enrolled from October 1, 2016 to July 15, 2020 at the National Health Security Office (NHSO). In total, 388 T2DM patients were included. Cox proportional-hazard and parametric models were used to identify factors related to the onset time of diabetic complications. The Akaike information criterion, Bayesian information criterion, and Cox-Snell residual were compared to determine the best-fitted survival model. Results: Thirty diabetic complication events were detected among the 388 patients (7.7%). A 90% survival rate for the onset time of diabetic complications was found at 33 months after the first T2DM diagnosis. According to multivariate analysis, a duration of T2DM ≥42 months (time ratio [TR], 0.56; 95% confidence interval [CI], 0.33–0.96; p=0.034), comorbid hypertension (TR, 0.30; 95% CI, 0.15–0.60; p=0.001), mildly to moderately reduced levels of the estimated glomerular filtration rate (eGFR) (TR, 0.43; 95% CI, 0.24–0.75; p=0.003) and an eGFR that was severely reduced or indicative of kidney failure (TR, 0.38; 95% CI, 0.16–0.88; p=0.025) were significantly associated with the onset time of diabetic complications (p<0.05). Conclusion: Patients with T2DM durations of more than 42 months, comorbid hypertension, and decreased eGFR were at risk of developing diabetic complications. The NHSO should be aware of these factors to establish a policy to prevent diabetic complications after the diagnosis of T2DM.

Citations

Citations to this article as recorded by  Crossref logo
  • Survival and predictors of mortality among adults with type 2 diabetes at a teaching hospital in Ghana: a retrospective cohort study
    Issah Haruna, Abdul-Rauf Sulemana, Emmanuel Kweku Nakua, Daniel Boateng
    BMC Public Health.2026;[Epub]     CrossRef
  • An elevated level of one-hour postprandial plasma glucose is an independent risk factor for developing chronic complications of type 2 diabetes mellitus
    Yanyan Jin, Jing Wei, Jie Yang, Hongxia Qian, Yan Wu, Mengmeng Liu
    Archives of Physiology and Biochemistry.2025; 131(6): 1025.     CrossRef
  • Advanced age and elevated cholesterol predict diabetic neuropathy in patients with type II diabetes mellitus in Southern Ethiopia
    Fasika Merid, Habtamu Esubalew, Tamirat Gezahegn Guyo, Firdawek Getahun
    Cardiovascular Diabetology – Endocrinology Reports.2025;[Epub]     CrossRef
  • 6,809 View
  • 219 Download
  • 4 Web of Science
  • Crossref
The risk associated with psychiatric disturbances in patients with diabetes in Indonesia (2018): a cross-sectional observational study video
Siti Isfandari, Betty Roosihermiatie, Sulistyowati Tuminah, Laurentia Konadi Mihardja
Osong Public Health Res Perspect 2023;14(5):368-378.
Published online October 18, 2023
DOI: https://doi.org/10.24171/j.phrp.2023.0144
The risk associated with psychiatric disturbances in patients with diabetes in Indonesia (2018): a cross-sectional observational study
Objectives
The global prevalence of psychiatric disturbances is rising, detrimentally affecting the quality of care and treatment outcomes for individuals, particularly those with diabetes.This study investigated the association of risk factors for psychiatric disturbances among productive-age patients with diabetes (ages 30−59 years), considering sociodemographic characteristics and co-existing diseases. The risk factors considered included sociodemographic factors (e.g., residence, age, sex, marital status, education, and occupation) and co-existing diseases (e.g., hypertension, heart disease, stroke, renal failure, rheumatism, asthma, and cancer). Methods: This cross-sectional study utilized data from the 2018 Indonesian National Health Survey (Riskesdas). The study population comprised respondents aged between 30 and 59 years who had diabetes and had completed the 20-question self-reporting questionnaire (SRQ-20). After the exclusion of incomplete SRQ-20 data, the sample included 8,917 respondents. Data were analyzed using logistic regression. Results: Approximately 18.29% of individuals with diabetes displayed symptoms indicative of psychiatric disturbances. After adjusting for sociodemographic factors such as age, sex, education level, occupation, marital status, and place of residence, patients with diabetes who had co-existing conditions such as hypertension, heart diseases, rheumatic disorders, asthma, or cancer had a higher risk for developing psychiatric disturbances than those with diabetes alone (adjusted odds ratio, 6.67; 95% confidence interval, 4.481−9.928; p<0.001). Conclusion: The elevated risk of psychiatric disturbances among patients with diabetes who had comorbidities underscores the importance of addressing mental health issues in the management of diabetes, especially in patients with concurrent disease conditions.

Citations

Citations to this article as recorded by  Crossref logo
  • The impact of dietary consumption on hypertension in indonesia: An analysis of indonesian health survey 2023
    Cici A. Yanti, Ratna Djuwita, Evi Martha, Besral, Debby Ratno Kustanto, Noor Mastura Mohd Mujar
    Journal of Education and Health Promotion.2025;[Epub]     CrossRef
  • Investigating the association between physical fitness and blood pressure among healthcare workers in Indonesia
    Wahyu Sulistiadi, Riswandy Wasir, Astriana, Badra Al Aufa, Sri Rahayu, Wasir Thalib, Fadilah Aulia Rahma
    Discover Social Science and Health.2024;[Epub]     CrossRef
  • Correction to “The risk associated with psychiatric disturbances in patients with diabetes in Indonesia (2018): a cross-sectional observational study” [Osong Public Health Res Perspect 2023;14(5):368–78]
    Siti Isfandari, Betty Roosihermiatie, Sulistyowati Tuminah, Laurentia Konadi Mihardja
    Osong Public Health and Research Perspectives.2023; 14(6): 530.     CrossRef
  • 5,237 View
  • 120 Download
  • 4 Web of Science
  • Crossref
Chronic kidney disease in Indonesia: evidence from a national health survey
Puti Sari Hidayangsih, Dwi Hapsari Tjandrarini, Noor Edi Widya Sukoco, Nikson Sitorus, Ika Dharmayanti, Feri Ahmadi
Osong Public Health Res Perspect 2023;14(1):23-30.
Published online February 14, 2023
DOI: https://doi.org/10.24171/j.phrp.2022.0290
Chronic kidney disease in Indonesia: evidence from a national health survey
Objectives
Several previous studies have stated that consuming certain foods and beverages might increase the risk of chronic kidney disease (CKD). This study aimed to examine the relationships of food and beverage consumption with other risk factors for CKD. Methods: Data sources included the 2018 Basic Health Research (Riskesdas) and the National Socio-Economic Survey (Susenas), which were analyzed using a cross-sectional design. The study samples were households from 34 provinces in Indonesia, and the analysis was performed with provincial aggregates. Data were analyzed using risk factor analysis followed by linear regression to identify relationships with CKD. Results: The prevalence of CKD in Indonesia was 0.38%. The province with the highest prevalence was North Kalimantan (0.64%), while the lowest was found in West Sulawesi (0.18%). Five major groups were formed from 15 identified risk factors using factor analysis. A linear regression model presented 1 significant selected factor (p=0.006, R2 =31%). The final model of risk factors included water quality, consumption of fatty foods, and a history of diabetes. Conclusion: Drinking water quality, fatty food consumption, and diabetes are associated with CKD. There is a need to monitor drinking water, as well as to promote health education and provide comprehensive services for people with diabetes, to prevent CKD.

Citations

Citations to this article as recorded by  Crossref logo
  • Syndemic analysis of stroke in Indonesia
    Andi Alfian Zainuddin, Rais Reskiawan A. Kadir, Nurul Qalby, Hedi Kuswanto, Andi Afdal Abdullah, Takuro Furusawa, Haerani Rasyid, Irawan Yusuf
    The Lancet Regional Health - Western Pacific.2026; 69: 101849.     CrossRef
  • Integrating Spirituality and Self-Transcendence in Chronic Kidney Disease Management: A Structural Equation Modeling Approach
    Siti Nurkholifah, Yurika Fauzia Wardhani, Minarti Minarti, Asep Hermawan, Eka Denis Machfutra, Doni Lasut
    Journal of Holistic Nursing.2026;[Epub]     CrossRef
  • Clinical characteristics, medication use, and mortality outcomes in pediatric chronic kidney disease: A retrospective study at national hospital in Jakarta
    Aprilita Rina Yanti Eff, Selvia Yuliana, Nadiya Nurul Afifah, Ade Heryana
    Journal of Advanced Pharmaceutical Technology & Re.2026; 17(2): 108.     CrossRef
  • Enhanced detection of albumin-creatinine ratio in urine using gold nanoparticle-integrated 3D-connector microfluidic paper-based analytical devices for early diagnosis of chronic kidney disease
    Akhmad Sabarudin, Saidun Fiddaroini, Ahmad Luthfi Fahmi, Abdul Munir Roja’i, Isadora Evani Salsabila, Aulanni’am, Setyawan Purnomo Sakti, Hani Susianti
    Microchemical Journal.2025; 211: 113071.     CrossRef
  • The Effect of Intravenous Oxyhydrogen Nanobubble on Chronic Kidney Disease: Case Series
    Olly Indrajani, Aditya T. Hernowo, Christyanita P. Ekasari, Ricki Yudhanata, Sutiman B. Sumitro
    Clinical Therapeutics.2025; 47(9): e13.     CrossRef
  • Association between low-carbohydrate diet and chronic kidney disease in population with gestational diabetes mellitus history: based on the National Health and Nutrition Examination Survey database
    Junli Zhang, Youlian Dong
    Food & Nutrition Research.2025;[Epub]     CrossRef
  • Hubungan Lama Hemodialisa dengan Kualitas Hidup Pasien Chronic Kidney Disease yang Menjalani Hemodialisa di Rumah Sakit TK II
    Kadek Dheana Novitayani W, Ni Putu Dita Wulandari, I Made Dwie Pradnya Susila, I Nyoman Sutresna
    Journal Center of Research Publication in Midwifer.2025; 9(2): 85.     CrossRef
  • 13,647 View
  • 917 Download
  • 6 Web of Science
  • Crossref
Insufficient weight management in pregnant women with gestational diabetes mellitus
Kyunghee Han, Dong Wook Kwak, Hyun Mee Ryu, Hyun-Young Park
Osong Public Health Res Perspect 2022;13(4):242-251.
Published online August 31, 2022
DOI: https://doi.org/10.24171/j.phrp.2022.0182
Insufficient weight management in pregnant women with gestational diabetes mellitus
Objectives
This study investigated whether weight was managed appropriately in pregnant women with gestational diabetes mellitus (GDM) and examined the association between insufficient gestational weight gain (GWG) and adverse pregnancy outcomes.
Methods
The study included 235 pregnant women with GDM from the Korean Pregnancy Outcome Study. GWG from the second to the third trimester (kg/wk) and total GWG (kg) were classified as insufficient, appropriate, or excessive according to the 2009 Institute of Medicine guidelines. Adverse pregnancy outcomes included maternal (hypertensive disorders of pregnancy, preterm birth, cesarean delivery, and delivery complications) and infant (low birth weight, high birth weight, neonatal intensive care unit admission, and congenital anomalies) outcomes.
Results
The proportion of pregnant women with GDM who had insufficient GWG from the second to the third trimester was 52.3%, and that of participants with total insufficient GWG was 48.1%. There were no significant associations between insufficient GWG from the second to the third trimester and adverse pregnancy outcomes. Participants with total insufficient GWG had a significantly lower risk of preterm birth (odds ratio [OR], 0.17; 95% confidence interval [CI], 0.05–0.60) and high birth weight (OR, 0.23; 95% CI, 0.07–0.80).
Conclusion
Our findings suggest the importance of appropriate weight management and the need for GWG guidelines for pregnant women with GDM.

Citations

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  • Impact of gestational weight gain on adverse pregnancy outcomes in women with gestational diabetes: a retrospective cohort study
    Amin Moradi, Mehdi Norouzi, Ehsan Mosa Farkhani
    BMC Pediatrics.2026;[Epub]     CrossRef
  • Risk factors and prediction model for low-birth-weight infants born to women with gestational diabetes mellitus
    Yu-qing Pan, Xin-xin Huang, Xiu-min Jiang
    Frontiers in Public Health.2024;[Epub]     CrossRef
  • 5,468 View
  • 125 Download
  • 2 Web of Science
  • Crossref
Educational Needs Associated with the Level of Complication and Comparative Risk Perceptions in People with Type 2 Diabetes
Youngji Hwang, Dongsuk Lee, Yeon Sook Kim
Osong Public Health Res Perspect 2020;11(4):170-176.
Published online August 31, 2020
DOI: https://doi.org/10.24171/j.phrp.2020.11.4.05
<sec> <title>Objectives</title> <p>This study aimed to identify the educational needs of people with type 2 diabetes according to risk perceptions and the level of severity of complications.</p></sec> <sec> <title>Methods</title> <p>There were 177 study participants who were outpatients of the internal medicine department at a university hospital located in the Republic of Korea, who consented to participate in the survey from December 10, 2016 to February 10, 2017. The data were analyzed using descriptive statistics, Pearson correlation, ANOVA with post-hoc comparison, and multiple regression analysis. Type 2 diabetes complications were classified into 3 groups: no complications, common complications, and severe complications.</p></sec> <sec> <title>Results</title> <p>There were statistically significant positive correlations between educational needs and comparative risk perceptions, and the level of complication and comparative risk perception. Multiple regression analysis revealed that the factor predicting educational needs of type 2 diabetes people was their comparative risk perceptions, rather than the severity of diabetes complications or sociodemographic variables.</p></sec> <sec> <title>Conclusion</title> <p>Since risk perception is the factor that indicates the educational needs of people with type 2 diabetes, there is a need to explore factors which increase risk perception, in order to meet educational needs. The findings suggest that a more specific and individualized educational program, which focuses on each person's risk perceptions, should be developed.</p></sec>

Citations

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  • Fear of Complications Among Patients with Type 2 Diabetes: A Latent Profile Analysis
    Yuqing Liang, Ya’ning Yang, Xingruo Zhang, Lili Chen, Dan Su
    Patient Preference and Adherence.2026; Volume 20: 1.     CrossRef
  • Added value of an online education intervention among patients with type 2 diabetes mellitus in Acapulco, Mexico: a non-randomised parallel group comparison
    Guadalupe Aguilar-Hernández, Sergio Paredes-Juárez, Baltazar Joanico-Morales, Janet Saldaña-Almazán, Claudia Erika Rios-Rivera, Miguel Flores-Moreno, Sergio Paredes-Solís, Neil Andersson
    IJQHC Communications.2026;[Epub]     CrossRef
  • Associations between Diabetes Self-Management and Microvascular Complications among Patients Living in Rural Areas, in Kenya
    Rachael Ireri, Gideon Kikuvi, Susan Mambo, Betsy C. Rono Cheriro
    Open Journal of Epidemiology.2025; 15(01): 88.     CrossRef
  • Determinants of Complications of Diabetic Among Adult with Type 2 Diabetic Patients at Hubaal Specialist Hospital and Libaan Hospital in Mogadishu: Case Control Study
    Ahmed Mohamed, Ali Mohamed, Ahmed Guled, Mohamed Fuji, Abdullahi Qoryoley, Abdirahman Hassan
    American Journal of Internal Medicine.2024; 12(5): 82.     CrossRef
  • 9,030 View
  • 191 Download
  • 1 Web of Science
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The Association Between Lung Function and Type 2 Diabetes in Koreans
Do-Youn Lee, Seung-min Nam
Osong Public Health Res Perspect 2020;11(1):27-33.
Published online February 28, 2020
DOI: https://doi.org/10.24171/j.phrp.2020.11.1.05
<sec> <title>Objectives</title> <p>This study was performed to test the association between lung function and type 2 diabetes mellitus (T2DM) in Korean patients.</p></sec> <sec> <title>Methods</title> <p>Data from the 6<sup>th</sup> Korea National Health and Nutrition Examination Survey (2013 to 2015) was used in this study. There were 3,466 individuals aged between 40 and 80 years, with T2DM, who had a smoking and alcohol status listed, and blood analysis (including blood pressure), were included in this study. Lung function, measured by spirometer ventilatory dysfunction was categorized into 3 patterns: normal, restrictive ventilatory dysfunction, and obstructive ventilatory dysfunction (OVD).</p></sec> <sec> <title>Results</title> <p>Based on multivariate logistic regression analysis, individuals with restrictive ventilatory dysfunction had an increased odds ratio (OR 1.615, 95% CI 1.137–2.294) for T2DM compared with individuals with normal ventilatory function, whereas OVD had no increase in the odds ratio (OR 1.169, 95 % CI 0.857–1.594). Model 1, which adjusted for age and gender, showed that the probability of having restrictive disorder was 1.559 times (95% CI 1.617–2.082) higher for prediabetes patients, and 2.320 times (95% CI 1.611–3.343) higher for T2DM patients, compared to normal individuals. For Model 4, which was fully adjusted for variables, the probability of having a restrictive disorder was 1.837 times higher for T2DM patients (95% CI 1.260–2.679).</p></sec> <sec> <title>Conclusion</title> <p>Restrictive ventilatory dysfunction, but not OVD, was associated independently with T2DM.</p></sec>

Citations

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  • The role of obesity and Type 2 diabetes in lung health: A systematic review (2024)
    Roanne Lecky, Svitlana Grogan, Priyank Shukla, Sarah Atkinson, Paula L. McClean, Catriona Kelly, Hidetaka Hamasaki
    PLOS One.2026; 21(1): e0340692.     CrossRef
  • Association between the estimated glucose disposal rate and new-onset chronic obstructive pulmonary disease in United States adults
    Kai Cheng, Sodiq Fakorede, Guodong Hu, Rongjun Wan, Nianxin Fang, Zhijian Wu, Quan Zhang
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    Sohini Raje, G Arun Maiya, Padmakumar R, Mukund A. Prabhu, Krishnananda Nayak, Shivashankara KN, BA Shastry, Megha Nataraj
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Enrolment Phase Results of the Tabari Cohort Study: Comparing Family History, Lipids and Anthropometric Profiles Among Diabetic Patients
Mahmood Moosazadeh, Mahdi Afshari, Kaveh Jafari, Motahareh Kheradmand, Zahra Kashi, Mohsen Aarabi, Adeleh Bahar, Mohammad Khademloo
Osong Public Health Res Perspect 2019;10(5):289-294.
Published online October 31, 2019
DOI: https://doi.org/10.24171/j.phrp.2019.10.5.05
<sec> <title>Objectives</title> <p>Different factors are responsible for the silent epidemic of diabetes mellitus in developing and developed countries. This study aimed to determine the role of demographic factors, lipid profile, family history (the estimation of genetic association) and anthropometric factors on diabetes onset.</p></sec> <sec> <title>Methods</title> <p>Data from the enrolment phase of the Tabari Cohort study was applied for this study and included 10,255 participants aged between 35–70 years. Anthropometric variables were measured by trained staff using standard tools. Blood specimens were collected for lipid profile and blood glucose measurements. Data analyses were performed using SPSS version 24, with univariate and multivariate logistic regression.</p></sec> <sec> <title>Results</title> <p>The prevalence of diabetes mellitus was estimated to be 17.2% in the cohort population, 15.6% in men, and 18.3% in women. The adjusted odds ratios (95% confidence intervals) for age groups 40–49, 50–59 and over 60 were 2.58 (2.20–3.69), 5.80 (4.51–7.48) and 8.72 (6.67–11.39), respectively. In addition, the odds ratios (95% confidence intervals) for 2 (or more), and 1 affected family member were 4.12 (3.55–4.90) and 2.34 (2.07–2.65), respectively. Triglyceride concentrations more than 500, and abnormal high-density lipoprotein levels increased the odds of diabetes mellitus by 3.29- and 1.18-fold, respectively.</p></sec> <sec> <title>Conclusion</title> <p>The current study showed that old age and a family history were strong predictors for diabetes mellitus.</p></sec>

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  • Free-fatty acid receptor-4 gene polymorphism (rs61866610) and colorectal cancer risk
    Ramin Shekarriz, Maryam Hasanian, Mohadeseh Ahmadi, Versa Omrani-Nava, Reza Alizadeh-Navaei
    Nucleosides, Nucleotides & Nucleic Acids.2025; 44(9): 717.     CrossRef
  • The association between smoking profile, leukocyte count, and inflammatory indices in males: a cross-sectional analysis of the TABARI cohort study at enrollment phase
    Erfan Ghadirzadeh, Mahmood Moosazadeh, Motahareh Kheradmand, Masoumeh Bagheri-Nesami, Sajad Ghafari-Cherati, Mobina Gheibi, Amirsaeed Hosseini
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  • The prevalence and determinants of diabetes mellitus and thyroid disorder comorbidity in Tabari cohort population
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  • The relationship between spiritual intelligence and self-management in patients with diabetes type 1
    Sima Rafiei, Saber Souri, Zahra Nejatifar, Mohammad Amerzadeh
    BMC Endocrine Disorders.2023;[Epub]     CrossRef
  • Prevalence and determinants of diabetes and prediabetes in southwestern Iran: the Khuzestan comprehensive health study (KCHS)
    Sanam Hariri, Zahra Rahimi, Nahid Hashemi-Madani, Seyyed Ali Mard, Farnaz Hashemi, Zahra Mohammadi, Leila Danehchin, Farhad Abolnezhadian, Aliasghar Valipour, Yousef Paridar, Mohammad Mahdi Mir-Nasseri, Alireza Khajavi, Sahar Masoudi, Saba Alvand, Bahman
    BMC Endocrine Disorders.2021;[Epub]     CrossRef
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<sec> <title>Objectives</title> <p>To describe the distribution of social factors, lifestyle habits and anthropometric measurements according to hypertension and Type-2 diabetes.</p></sec> <sec> <title>Methods</title> <p>A cross-sectional study was conducted in Gaza City, Palestine that included 379 patients (20–60 years) who had hypertension and/or diabetes. Three groups of patients were involved; 106 hypertensive (HT), 109 diabetic (T2DM) and 164 hypertensive diabetics (HT + T2DM).</p></sec> <sec> <title>Results</title> <p>The HT + T2DM group were older and had a higher body mass index compared to HT and T2DM groups. There were 62.3% patients who were female, 49.2% were highly educated HT patients, and 49.3% patients had a low level of education and were HT + T2DM. There were 55.8% patients who lived in large families. Patients who were passive smokers or never smoked before were mostly HT + T2DM, while active smokers and past smokers had T2DM. There were 48.2% patients who were highly physically active who had HT, 40.9% whom were moderately active had T2DM, and 53.8% of patients who had a low level of activity were HT + T2DM. Multivariate linear regression showed that having a diseased mother, living in a large family, being a past or passive smoker, or never having smoked, having a low or moderate level of activity, and having HT or HT + T2DM, were significantly associated with an increased body mass index.</p></sec> <sec> <title>Conclusion</title> <p>Parental health/disease conditions and environmental factors (social network and lifestyle habits) played the greatest role in the development of obesity and disease.</p></sec>

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  • Barriers and facilitators of lifestyle management among diabetic patients in palestine: a qualitative exploration of physician perspectives
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    Mohd Sharique Katchhi, Long Chiau Ming
    Journal of Epidemiology and Global Health.2025;[Epub]     CrossRef
  • Factors associated with physical inactivity among Palestinians with type 2 diabetes mellitus treated in resource-limited settings
    Ramzi Shawahna, Mohammad Jaber, Arob Zmiro, Sewar Kashkoush
    Scientific Reports.2024;[Epub]     CrossRef
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    Simeng Sun, Ting Zhang, Hao Yu, Ting Xia, Yunan Yao, Mengting Sun, Hongmei Liang, Qiaoyu Huang, Weiwei Wang, Huafeng Yang, Xin Hong
    Frontiers in Aging Neuroscience.2024;[Epub]     CrossRef
  • Prevalence of hypertension and its associated factors among healthcare workers in the Gaza Strip, Palestine: a cross-sectional study
    Joma Younis, Lina Wang, Kejing Zhang, Majed Jebril, Hong Jiang, Yahui Fan, Zhaofang Li, Mei Ma, Le Ma, Zhaozhao Hui, Mao Ma, Wei Zhang
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    Enas A. Assaf, Haleama Al Sabbah, Ayoub Al-Jawadleh
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Public Awareness of Early and Late Complications of Type 2 Diabetes - Application of Latent Profile Analysis in Determining Questionnaire Cut-Off Points
Nasrin Shirmohammadi, Ali Reza Soltanian, Shiva Borzouei
Osong Public Health Res Perspect 2018;9(5):261-268.
Published online October 31, 2018
DOI: https://doi.org/10.24171/j.phrp.2018.9.5.08
<sec> <title>Objectives</title> <p>A questionnaire was designed to determine public understanding of early and late complications of Type 2 diabetes mellitus (T2DM).</p></sec> <sec> <title>Methods</title> <p>A cross-sectional study was performed in participants who were selected using a multi-stage sampling method and a standard questionnaire of 67 questions was proposed. An expert panel selected 53 closed-ended questions for content validity to be included in the questionnaire. The reliability of the questionnaire was tested using Cronbach’s alpha coefficient giving a score of 0.84.</p></sec> <sec> <title>Results</title> <p>Of the 825 participants, 443 (57.6%) were male, and 322 (41.87%) were 40 years or more. The proportion of low-, moderate- and high- awareness about T2DM and its complications was 29.26%, 62.68%, and 8.06%, respectively. Friends (56.31%) and internet and social networks (20.55%) were the 2 major sources of awareness, respectively. The medical staff (e.g., physicians) had the lowest share in the level of public awareness (3.64%) compared to other sources.</p></sec> <sec> <title>Conclusion</title> <p>These results present data that shows the general population awareness of T2DM is low. Healthcare policymakers need to be effective at raising awarenes of diabetes and it should be through improved education.</p></sec>

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  • Psychosomatic symptom profiles identified by latent profile analysis and their psychosocial and clinical correlates in patients with type 2 diabetes mellitus: A cross-sectional study
    He Yin, Haixia Ma, Xiaoju Zhang, Chao Li, Chunguang Wang, Qingqing Li
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    Hong-Dong Ma, Lei Shi, Hai-Tian Li, Xin-Dong Wang, Mao-Wei Yang
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  • Global burden of type 2 diabetes mellitus from 1990 to 2021, with projections of prevalence to 2044: a systematic analysis across SDI levels for the global burden of disease study 2021
    Ke-Jie He, Haitao Wang, Jianguang Xu, Guoyu Gong, Xu Liu, Huiting Guan
    Frontiers in Endocrinology.2024;[Epub]     CrossRef
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    Nikhil Tandon, Piya Ballani Thakkar, Jubbin Jacob, Pramila Kalra, Nanditha Arun, Alok Kanungo, Ashish Birla, Ashish Prasad, Mayuri Talathi
    Cureus.2023;[Epub]     CrossRef
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    Hanlin Fu, Lulu Si, Ruixia Guo
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    Journal of Behavioral Addictions.2020; 9(3): 698.     CrossRef
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Factors that Correlate with Poor Glycemic Control in Type 2 Diabetes Mellitus Patients with Complications
Mohammad Haghighatpanah, Amir Sasan Mozaffari Nejad, Maryam Haghighatpanah, Girish Thunga, Surulivelrajan Mallayasamy
Osong Public Health Res Perspect 2018;9(4):167-174.
Published online August 31, 2018
DOI: https://doi.org/10.24171/j.phrp.2018.9.4.05
<sec> <title>Objectives</title> <p>Inadequate glycemic control amongst patients with Type 2 diabetes mellitus (T2DM) indicates a major public health problem and a significant risk factor for the progression and complications caused by diabetes. Glycemic control is the main therapeutic objective for the prevention of organ damage and other complications arising from diabetes.</p></sec> <sec> <title>Methods</title> <p>This was a retrospective observational study of T2DM patients with complications, who were aged 40 years and older. The study was conducted retrospectively on medical records (in-patient and out-patient) obtained from a South Indian teaching hospital, Manipal, India. The patients included in the study had fasting blood sugar, postprandial blood sugar and HbA1c measured at least twice during follow-ups the previous year. Patients’ HbA1c levels were categorized into good control ≤7% (≤53mmol/mol), and poor control >7% (>53mmol/mol), and patients’ characteristics were analyzed.</p></sec> <sec> <title>Results</title> <p>A total of 657 patients were included in the study. The mean age was 59.67 (SD = 9.617) years, with 152 (23.1%) females and 505 (76.9%) males, and 514 (78.2%) patients had poor glycemic control. Most of the patients were on insulin mono-therapy [<italic>n</italic> = 271 (42.1%)], about a third of the patients were on combination therapy that included an oral hypoglycemic agent and insulin [<italic>n</italic> = 236 (36.6%)]. Patients with a history of more than 10 years of diabetes [<italic>n</italic> = 293 (44.6%)], had a family history of diabetes [<italic>n</italic> = 256 (39%)] and obesity [<italic>n</italic> = 95 (14.5%)], all had poor glycemic control.</p></sec> <sec> <title>Conclusion</title> <p>This present study indicated a significant association of gender (female), age, high-density lipoprotein level, duration of diabetes and type of medication, with poor glycemic control in T2DM patients that had secondary medical complications.</p></sec>

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Effects of Physical Activity on Depression in Adults with Diabetes
Deok-Ju Kim
Osong Public Health Res Perspect 2018;9(4):143-149.
Published online August 31, 2018
DOI: https://doi.org/10.24171/j.phrp.2018.9.4.02
<sec> <title>Objectives</title> <p>The purpose of this study was to identify the current state of physical activity in adults with diabetes and to investigate the effect of physical activity on depression.</p></sec> <sec> <title>Methods</title> <p>The present study was conducted using data from the 2<sup>nd</sup> year of the 6<sup>th</sup> Korea National Health and Nutritional Examination Survey. From the total of 7,550 individuals, 418 adults diagnosed with diabetes were selected as participants, and their physical activity and depression levels were examined.</p></sec> <sec> <title>Results</title> <p>The physical activity status of the participants showed that they did not usually engage in physical activities at work, and only a few participants were involved in moderate intensity physical leisure activity. Apart from walking for 10 minutes each day, which accounted for 1/3 of the participants, most of the participants did not engage in specific forms of exercise. An examination of the effects of physical activity on depression revealed that moderate intensity physical activity at work and leisure influenced depression. In terms of demographic characteristics, gender, occupation, income quintile, and subjective health status were all found to affect depression.</p></sec> <sec> <title>Conclusion</title> <p>For elderly (60 years or older) patients with diabetes, which accounted for the majority of the diabetic population, a systematic leisure program and professional education are necessary to help them to manage stress and depression in daily life. Additionally, provision of community and family support should encourage regular, moderate intensity exercise and promote lifestyle changes to encourage increased physical activity.</p></sec>

Citations

Citations to this article as recorded by  Crossref logo
  • Physical activity is associated with depression and depressive symptoms in US adults with diabetes: a cross-sectional study
    Damián Pereira-Payo, Carmen Galán-Arroyo, Jorge Pérez-Gómez, Marco Batista
    Psychology, Health & Medicine.2026; : 1.     CrossRef
  • A cross-sectional study on the effects of physical activity on hand grip strength in type 2 diabetes mellitus patients
    Praveena Meyyazhagan, Thamaraiselvi Kanagaraj, Nachal Annamalai
    Journal of Basic and Clinical Physiology and Pharm.2025; 36(1): 27.     CrossRef
  • The Effect of Leisure-Time Exercise on Mental Health Among Adults: A Bibliometric Analysis of Randomized Controlled Trials
    Karuppasamy Govindasamy, Masilamani Elayaraja, Abderraouf Ben Abderrahman, Koulla Parpa, Borko Katanic, Urs Granacher
    Healthcare.2025; 13(5): 575.     CrossRef
  • Optimizing Physical Activity Strategies for Older Adults with Diabetes
    Hyeon-Jin Yu, Doyoun Hong, Kyuho Kim, Ji Hye Heo, Dong-Hyeok Cho, Yoshitaka Hashimoto, Jae-Seung Yun
    Diabetes & Metabolism Journal.2025; 49(6): 1178.     CrossRef
  • Association of Physical Activity and Sleep Metrics with Depression in People with Type 1 Diabetes
    Abdullah Al-Ozairi, Mohammad Irshad, Husain Alsaraf, Jumana AlKandari, Ebaa Al-Ozairi, Stuart Gray
    Psychology Research and Behavior Management.2024; Volume 17: 2717.     CrossRef
  • The mediating role of depression on the link between physical activity and health-related quality of life among people with diabetes: A cross-sectional study
    Djoko Priyono, Sanghee Kim, Md. Feroz Kabir
    PLOS ONE.2024; 19(12): e0312774.     CrossRef
  • Influence of Depression on Health Behavior (Daily Smoking, Binge Drinking, Walking, Skipping Breakfast) among Korean Adults: Based on the KNHANES
    Su Yeon Jeong
    Journal of Health Informatics and Statistics.2024; 49(4): 325.     CrossRef
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    Rehanguli Maimaitituerxun, Wenhang Chen, Jingsha Xiang, Atipatsa C. Kaminga, Xin Yin Wu, Letao Chen, Jianzhou Yang, Aizhong Liu, Wenjie Dai
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    Aatik Arsh, Saima Afaq, Claire Carswell, Karen Coales, Najma Siddiqi
    Mental Health and Physical Activity.2023; 25: 100542.     CrossRef
  • Moderating Effect of Grip Strength in the Association between Diabetes Mellitus and Depressive Symptomatology
    Diogo Veiga, Miguel Peralta, Élvio R. Gouveia, Laura Carvalho, Jorge Encantado, Pedro J. Teixeira, Adilson Marques
    Sports.2023; 12(1): 3.     CrossRef
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    Bhina Patria
    BMC Public Health.2022;[Epub]     CrossRef
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Brief Report

Imported Melioidosis in South Korea: A Case Series with a Literature Review
Seung Woo Kim, Geun-Yong Kwon, Bongyoung Kim, Donghyok Kwon, Jaeseung Shin, Geun-Ryang Bae
Osong Public Health Res Perspect 2015;6(6):363-368.
Published online December 31, 2015
DOI: https://doi.org/10.1016/j.phrp.2015.10.014
Objectives
Melioidosis is a potentially fatal infectious disease caused by the environmental anaerobic Gram-negative bacillus <i>Burkholderia pseudomallei</i>. Melioidosis is endemic to areas of northern Australia and Southeast Asia. With increasing international travel and migration, imported cases of melioidosis are being reported regularly. Here, we summarize the 11 cases of melioidosis reported in South Korea from 2003 to 2014.
Methods
Tracing epidemiological investigations were performed on every patient reported to the National Surveillance System since 2011. A systematic literature search was performed to identify melioidosis cases that occurred prior to 2011.
Results
The overall fatality rate was 36.4%. All the patients had visited Southeast Asia where melioidosis is endemic. The stay in the endemic region ranged from 4 days to 20 years. Of the seven patients who developed initial symptoms after returning to South Korea, the time interval between returning to South Korea and symptom onset ranged from 1 day to 3 years. The remaining four patients developed symptoms during their stay in the endemic region and were diagnosed with melioidosis in South Korea. Seven (63.6%) patients possessed at least one risk factor, all of whom were diabetic. Pneumonia was the most frequent clinical manifestation, but the patients showed a wide spectrum of clinical features, including internal organ abscesses, a mycotic aneurysm of the aorta, and coinfection with tuberculosis.
Conclusion
An early diagnosis and initiation of the appropriate antibiotics can reduce the mortality of melioidosis. Consequently, increased awareness of the risk factors and clinical features of melioidosis is required.

Citations

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    Pakpoom Wongyikul, Wiyada Kwanhian Klangbud, Moragot Chatatikun, Phichayut Phinyo
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    Kamaruddin Mardhiah, Othman Nursyahiyatul-Anis
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  • Epidemiological Aspects of Imported Melioidosis in Korea and Japan, 2011 to 2020
    Myeong-Jin Lee, Kyu Sung Kim, Won-Chang Lee, Young Hwan Kwon
    The Korean Journal of Aerospace and Environmental .2023; 33(1): 32.     CrossRef
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    Kamaruddin Mardhiah, Nadiah Wan-Arfah, Nyi Nyi Naing, Muhammad Radzi Abu Hassan, Huan-Keat Chan
    Medicine.2021; 100(25): e26160.     CrossRef
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    Seow Yen Tan
    Case Reports in Infectious Diseases.2020; 2020: 1.     CrossRef
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    Chee-Hoo Yip, Ahmad-Kamal Ghazali, Sheila Nathan
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    Hua Wu, Xuming Wang, Xiaojun Zhou, Zhicheng Wu, Yanyan Wang, Mengjie Pan, Binghuai Lu, Susanna Jane Dunachie
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    Hua Wu, Dongliang Huang, Biao Wu, Mengjie Pan, Binghuai Lu
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    Myung Hyun Kim, Tong Jin Chun
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    Genome Announcements.2018;[Epub]     CrossRef
  • ACTUAL ISSUES OF MODERN EPIDEMIOLOGY OF MELIOIDOSIS: A LITERATURE REVIEW AND ANALYSIS OF IMPORTED CASES TO NON-ENDEMIC REGIONS
    Irina B. Zakharova
    Epidemiology and Infectious Diseases.2018; 23(3): 126.     CrossRef
  • Accidental Occupational Exposure to Burkholderia pseudomallei in South Korea Did Not Result in Melioidosis
    Jae-Bum Jun, Taehoon Lee, Joseph Jeong, Jeong-Hoon Chun, Yong-Woo Shin, Jiwon Jung
    Infection Control & Hospital Epidemiology.2017; 38(7): 886.     CrossRef
  • Molecular detection of leptospirosis and melioidosis co-infection: A case report
    Mohammad R. Mohd Ali, Amira W. Mohamad Safiee, Padmaloseni Thangarajah, Mohd H. Fauzi, Alwi Muhd Besari, Nabilah Ismail, Chan Yean Yean
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Original Articles
Depression among Korean Adults with Type 2 Diabetes Mellitus: Ansan-Community-Based Epidemiological Study
Chan Young Park, So Young Kim, Jong Won Gil, Min Hee Park, Jong-Hyock Park, Yeonjung Kim
Osong Public Health Res Perspect 2015;6(4):224-232.
Published online August 31, 2015
DOI: https://doi.org/10.1016/j.phrp.2015.05.004
Objectives
There are an increasing number of studies being carried out on depression in patients with diabetes. Individuals with diabetes have been reported as having a higher prevalence of depression compared to those without diabetes. However, only a few studies involving Korean patients have been conducted. The aims of this study were to examine the prevalence of depression and to find various risk factors according to the degree of depression among Korean patients with Type 2 diabetes mellitus (T2DM).
Methods
An Ansan-community-based epidemiological study was conducted from 2005 to 2012. The total number of participants in this study was 3,540, from which patients with diabetes (<i>n</i> = 753) have been selected. The presence of depression was evaluated using the Beck Depression Inventory total score.
Results
The prevalence of depression was 28.8%. The mean age of participants was 55.5 ± 8.2 years. We divided the participants into three groups (without-depression, moderate-depression, and severe-depression groups) to examine the depression prevalence among Korean T2DM patients. The unemployed participants had 2.40 [95% confidence interval (CI) 1.21–4.76], the low-income participants had 2.57 (95% CI 1.52–4.35), the participants using an oral diabetes medicine or insulin had 2.03 (95% CI 1.25–3.32), the participants who are currently smoking had 2.03 (95% CI 1.10–3.73), and those without regular exercise had 1.91 (95% CI 1.17–3.14) times higher odds of depression in the severe-depression group, compared with the without-depression group.
Conclusion
There was a significant association between depression prevalence and diabetes, and we found various risk factors according to the degree of depression in Korean patients with T2DM.

Citations

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Association of TNF-α 308 G/A Polymorphism With Type 2 Diabetes: A Case–Control Study in the Iranian Kurdish Ethnic Group
Hasan Golshani, Karimeh Haghani, Majid Dousti, Salar Bakhtiyari
Osong Public Health Res Perspect 2015;6(2):94-99.
Published online April 30, 2015
DOI: https://doi.org/10.1016/j.phrp.2015.01.003
Objectives
Tumor necrosis factor-α (TNF-α) plays roles in the development of obesity, insulin resistance, and possibility of Type 2 diabetes mellitus (T2DM). The objective of the current study was to evaluate the association of TNF-α promoter−308 G/A polymorphism with T2DM.
Methods
In all, 1038 patients with T2DM and 1023 normoglycemic controls were included in this study. All participants were genotyped using the polymerase chain reaction-restriction fragment length polymorphism method. Genotypic and allelic frequencies were then analyzed in each group. Serum lipids, fasting glucose, fasting serum insulin, homeostatic model assessment of insulin resistance, and hemoglogin A1c levels were determined by conventional methods.
Results
The allelic frequency of the A allele was significantly different between case and control participants (<i>p</i> = 0.006). Genotypes GA and AA were found to be significantly associated with 2.24- and 3.18-fold increased risk for T2DM, respectively. Similarly, the dominant model of -308 G/A polymorphism was found to have a higher risk for T2DM (odds ratio = 2.34, <i>p</i> = 0.001). Individuals with T2DM carrying the GA + AA genotypes of -308 G/A variation had significantly lower fasting plasma insulin than those carrying GG genotype.
Conclusion
Our findings revealed that there is an association between the TNF-α promoter -308 G/A polymorphism and T2DM in this population.

Citations

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    Hamideh Moravvej, Pardis-Sadat Tabatabaei-Panah, Elaheh Ebrahimi, Nafiseh Esmaeili, Sayyed Mohammad Hossein Ghaderian, Ralf J. Ludwig, Reza Akbarzadeh
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  • IL-6, TNF-α, and IL-10 levels/polymorphisms and their association with type 2 diabetes mellitus and obesity in Brazilian individuals
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Effects of Fenugreek Seed Extract and Swimming Endurance Training on Plasma Glucose and Cardiac Antioxidant Enzymes Activity in Streptozotocin-induced Diabetic Rats
Sajad Arshadi, Salar Bakhtiyari, Karimeh Haghani, Ahmad Valizadeh
Osong Public Health Res Perspect 2015;6(2):87-93.
Published online April 30, 2015
DOI: https://doi.org/10.1016/j.phrp.2014.12.007
Objective
Diabetes mellitus is a group of metabolic diseases characterized by chronic hyperglycemia condition resulting from defective insulin secretion or resistance insulin action, or both. The purpose of this study was to evaluate the effect of 6 weeks swimming training and <i>Trigonella foenum-graecum</i> seed (fenugreek) extract, alone and in combination, on plasma glucose and cardiac antioxidant enzyme activity of streptozotocin-induced diabetic rats.
Methods
Fifty male Wistar rats were divided into five groups: diabetic control (DC, <i>n</i> = 8); healthy control (HC, <i>n</i> = 11); swimming training (S, <i>n</i> = 11); swimming training + fenugreek seed extract (1.74 g/kg body weight; SF1, <i>n</i> = 11); and swimming training + fenugreek seed extract (0.87 g/kg body weight; SF2, <i>n</i> = 9). Streptozotocin was used for the induction of diabetes. Results were analyzed using one-way analysis of variance followed by Tukey test.
Results
In comparison with the DC group, all groups exhibited a significant decrease in body weight (<i>p</i> < 0.05), except for the HC group. SF1 and HC groups showed significant decreases in plasma glucose levels compared with the DC group (<i>p</i> < 0.05). S, SF1, SF2, and HC groups showed significant elevations in cardiac antioxidant enzymes activity in comparison with the DC group.
Conclusion
The results indicated that the combination of endurance swimming training and fenugreek seed extract can significantly reduce the plasma glucose levels and increase cardiac antioxidant enzymes activity in diabetic rats. Our findings suggest that this combination could be useful for the treatment of hyperglycemia and cardiac oxidative stress induced by diabetes mellitus.

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  • Anti-inflammatory effects of sericin and swimming exercise in treating experimental Achilles tendinopathy in rat
    Koksal Gundogdu, Ozgen Kılıc Erkek, Gulsah Gundogdu, Dilek Sayin, Gulcin Abban Mete
    Applied Physiology, Nutrition, and Metabolism.2024; 49(4): 501.     CrossRef
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    Koji Nonaka, Junichi Akiyama, Satsuki Une
    Medicina.2024; 60(3): 480.     CrossRef
  • Fabrication and characterization of gold nanoparticles using alginate: In vitro and in vivo assessment of its administration effects with swimming exercise on diabetic rats
    Vahideh Hashemzadeh, Alireza Hashemzadeh, Reza Mohebbati, Reza Gharari Arefi, Mohammad Ehsan Taghavizadeh Yazdi
    Open Life Sciences.2024;[Epub]     CrossRef
  • Antidiabetic potential of fenugreek (Trigonella foenum‐graecum): A magic herb for diabetes mellitus
    Dipto Kumer Sarker, Pallobi Ray, Ashit Kumar Dutta, Razina Rouf, Shaikh Jamal Uddin
    Food Science & Nutrition.2024; 12(10): 7108.     CrossRef
  • Safety and Efficacy of Furosap®, a Patented Trigonella foenum-graecum Seed Extract, in Boosting Testosterone Level, Reproductive Health and Mood Alleviation in Male Volunteers
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    Waleed I. Albaker
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    Adnan Fatahi, Ebrahim Zarrinkalam, Kamal Azizbeigi, Kamal Ranjbar
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    Sadegh Shabab, Zahra Gholamnezhad, Maryam Mahmoudabady
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    Maryam Mohammad-Sadeghipour, Mehdi Afsharinasab, Maryam Mohamadi, Mehdi Mahmoodi, Soudeh Khanamani Falahati-pour, Mohammad Reza Hajizadeh
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Evidence Gap on the Prevalence of Non-conventional Risk Factors for Type 2 Diabetes in Iran
Abdolreza Shaghaghi, Ali Ahmadi
Osong Public Health Res Perspect 2014;5(5):292-297.
Published online October 31, 2014
DOI: https://doi.org/10.1016/j.phrp.2014.08.002
Objectives
Robust scientific evidence exists about the role of non-conventional risk factors in type 2 diabetes worldwide. The current epidemiological pattern of the disease in Iran suggests a precipitating role for these non-conventional risk factors. This review was performed to examine the research evidence suggesting a higher prevalence of non-conventional type 2 diabetes risk factors in Iran.
Methods
MeSH keywords were applied to search several databases, including PUBMED, MEDLINE, AMED, EMBASE, Iran DOC, and the Scientific Information Database without a time limit from inception to September 2011. The quality of the non-interventional and population-based studies on Iranians included in these databases was assessed by the authors and any disagreement was resolved with consensus.
Results
The literature search yielded 1847 publications, of which 62 were included in this study after eliminating non-relevant and overlapping papers. No study was found that verified a higher prevalence of the non-conventional type 2 diabetes risk factors in the Iranian population.
Conclusion
The identified evidence gap about the role of prominent non-conventional risk factors of type 2 diabetes in the Iranian population could be a major caveat in the application of an evidence-based approach to endorse or reject existing hypothesis about these risk factors. Studies on the prevalence of non-conventional biomarkers of type 2 diabetes among Iranians could be a promising area of research.

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  • Application of Pender’s health promotion model for type 2 diabetes treatment adherence: protocol for a mixed methods study in southern Iran
    Nahid Shahabi, Zahra Hosseini, Teamur Aghamolaei, Amin Ghanbarnejad, Ahmad Behzad
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    Sanam Hariri, Zahra Rahimi, Nahid Hashemi-Madani, Seyyed Ali Mard, Farnaz Hashemi, Zahra Mohammadi, Leila Danehchin, Farhad Abolnezhadian, Aliasghar Valipour, Yousef Paridar, Mohammad Mahdi Mir-Nasseri, Alireza Khajavi, Sahar Masoudi, Saba Alvand, Bahman
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Knowledge of Diabetes Mellitus: Does Gender Make a Difference?
Patrício Fernando Lemes dos Santos, Poliana Rodrigues dos Santos, Graziele Souza Lira Ferrari, Gisele Almeida Amaral Fonseca, Carlos Kusano Bucalen Ferrari
Osong Public Health Res Perspect 2014;5(4):199-203.
Published online August 31, 2014
DOI: https://doi.org/10.1016/j.phrp.2014.06.004
Objective
Diabetes mellitus (DM) is a chronic disease considered an important public health problem. In recent years, its prevalence has been exponentially rising in many developing countries. Chronic complications of DM are important causes of morbidity and mortality among patients, which impair their health and quality of life. Knowledge on disease prevention, etiology, and management is essential to deal with parents, patients, and caregivers. The aim of this study was to evaluate the knowledge regarding DM in an adult population from a Middle-western Brazilian city.
Methods
This was a cross-sectional study covering 178 adults, aged 18–64 years, who answered a diabetes knowledge questionnaire. In order to identify the difference between groups, analysis of variance was used.
Results
Higher knowledge scores were found regarding the role of sugars on DM causality, diabetic foot care, and the effects of DM on patients (blindness, impaired wound healing, and male sexual dysfunction). However, lower scores were found amongst types of DM, hyperglycemic symptoms, and normal blood glucose levels. Females tended to achieve better knowledge scores than males.
Conclusion
Women had better knowledge regarding types of DM, normal blood glucose values, and consequences of hyperglycemia revealed that diabetes education should be improved.

Citations

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  • Public Awareness of Type 1 Diabetes and the New Italian Childhood Screening Program: Results From a Cross-Sectional Survey in Italy
    Ilen Lucia Guerrero Almeida, Alice Fachin, Eulalia Catamo, Antonietta Robino, Paolo Dalena, Gianluca Tamaro, Cinzia Braida, Gianluca Tornese
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    Noor Albawab, Batol Junbolat, Aya Almohamad, Kefah Albawab, Sedra Mando, Rama Asaad, Shahd Alhayek, Adel Habib, Mohammed Ahmed Albakoush, Mosa Shibani, Yaser Abas, Abdullah Alhouri
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    Burçin AKÇAY, Tuğba KURU ÇOLAK, Sultan İĞREK, Bahar ÖZGÜL, Adnan APTI
    Bandırma Onyedi Eylül Üniversitesi Sağlık Bilimler.2023; 5(2): 162.     CrossRef
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    Tariq M Shaqran, Saud N Alqahtani, Abdullah F Alhalafi , Norah M Alsabeelah, Rafaa A Algethmi, Ammar S Azhari, Abdulrahman Y Alhashmi, Abdullah N Almaghrabi, Hibah A Alshammari, Mohammed Saeed Alshahrani
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Prevalence of Dyslipidemia and Hypertension in Indian Type 2 Diabetic Patients with Metabolic Syndrome and its Clinical Significance
Dhananjay Yadav, Meerambika Mishra, Arvind Tiwari, Prakash Singh Bisen, Hari Mohan Goswamy, G.B.K.S. Prasad
Osong Public Health Res Perspect 2014;5(3):169-175.
Published online June 30, 2014
DOI: https://doi.org/10.1016/j.phrp.2014.04.009
Objectives
The present study was designed to estimate the prevalence of dyslipidemia and hypertension based on the National Cholesterol Educational Programme Adult Treatment Panel III definition of metabolic syndrome (MetS). The study also focuses on prevalence for MetS with respect to the duration of disease in Gwalior–Chambal region of Madhya Pradesh, India.
Methods
Type 2 diabetic patients (<i>n</i> = 700) were selected from a cross-sectional study that is regularly being conducted in the School of Studies in Biochemistry, Jiwaji University Gwalior, India. The period of our study was from January 2007 to October 2009. Dyslipidemia and hypertension were determined in type 2 diabetic patients with MetS as per National Cholesterol Educational Programme Adult Treatment Panel III criteria.
Results
The mean age of the study population was 54 ± 9.3 years with 504 (72%) males and 196 (28%) females. The prevalence of MetS increased with increased duration of diabetes in females; however, almost constant prevalence was seen in the males. Notable increase in the dyslipidemia (64.1%) and hypertension (49%) in type 2 diabetic patients were seen. The steep increase in dyslipidemia and hypertension could be the reason for the growing prevalence of diabetes worldwide. The study also noted a close association between age and occurrence of MetS.
Conclusion
Individual variable of MetS appears to be highly rampant in diabetic population. Despite treatment, almost half of patients still met the criteria for MetS. Effective treatment of MetS components is required to reduce cardiovascular risk in diabetes mellitus hence accurate and early diagnosis to induce effective treatment of MetS in Indian population will be pivotal in the prevention of cardiovascular disease and type 2 diabetes.

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Development of a Predictive Model for Type 2 Diabetes Mellitus Using Genetic and Clinical Data
Juyoung Lee, Bhumsuk Keam, Eun Jung Jang, Mi Sun Park, Ji Young Lee, Dan Bi Kim, Chang-Hoon Lee, Tak Kim, Bermseok Oh, Heon Jin Park, Kyu-Bum Kwack, Chaeshin Chu, Hyung-Lae Kim
Osong Public Health Res Perspect 2011;2(2):75-82.
Published online June 30, 2011
DOI: https://doi.org/10.1016/j.phrp.2011.07.005
Objectives
Recent genetic association studies have provided convincing evidence that several novel loci and single nucleotide polymorphisms (SNPs) are associated with the risk of developing type 2 diabetes mellitus (T2DM). The aims of this study were: 1) to develop a predictive model of T2DM using genetic and clinical data; and 2) to compare misclassification rates of different models.
Methods
We selected 212 individuals with newly diagnosed T2DM and 472 controls aged in their 60s from the Korean Genome and Epidemiology Study. A total of 499 known SNPs from 87 T2DM-related genes were genotyped using germline DNA. SNPs were analyzed for significant association with T2DM using various classification algorithms including Quest (Quick, Unbiased, Efficient, Statistical tree), Support Vector Machine, C4.5, logistic regression, and K-nearest neighbor.
Results
We tested these models using the complete Korean Genome and Epidemiology Study cohort (<i>n</i> = 10,038) and computed the T2DM misclassification rates for each model. Average misclassification rates ranged at 28.2–52.7%. The misclassification rates for the logistic and machine-learning algorithms were lower than the statistical tree algorithms. Using 1-to-1 matched data, the misclassification rate of the statistical tree QUEST algorithm using body mass index and SNP variables was the lowest, but overall the logistic regression performed best.
Conclusions
The K-nearest neighbor method exhibited more robust results than other algorithms. For clinical and genetic data, our “multistage adjustment” model outperformed other models in yielding lower rates of misclassification. To improve the performance of these models, further studies using warranted, strategies to estimate better classifiers for the quantification of SNPs need to be developed.

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