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2 "immune response"
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Original Articles
Role of Active and Inactive Cytotoxic Immune Response in Human Immunodeficiency Virus Dynamics
Hernan Dario Toro Zapata, Angelica Graciela Caicedo Casso, Derdei Bichara, Sunmi Lee
Osong Public Health Res Perspect. 2014;5(1):3-8.   Published online February 28, 2014
DOI: https://doi.org/10.1016/j.phrp.2014.01.001
  • 1,954 View
  • 25 Download
  • 8 Citations
AbstractAbstract PDF
Objectives
Mathematical models can be helpful to understand the complex dynamics of human immunodeficiency virus infection within a host. Most of work has studied the interactions of host responses and virus in the presence of active cytotoxic immune cells, which decay to zero when there is no virus. However, recent research highlights that cytotoxic immune cells can be inactive but never be depleted.
Methods
We propose a mathematical model to investigate the human immunodeficiency virus dynamics in the presence of both active and inactive cytotoxic immune cells within a host. We explore the impact of the immune responses on the dynamics of human immunodeficiency virus infection under different disease stages.
Results
Standard mathematical and numerical analyses are presented for this new model. Specifically, the basic reproduction number is computed and local and global stability analyses are discussed.
Conclusion
Our results can give helpful insights when designing more effective drug schedules in the presence of active and inactive immune responses.

Citations

Citations to this article as recorded by  
  • A Multi-Scale Model for the Spread of HIV in a Population Considering the Immune Status of People
    Sol de Amor Vásquez-Quintero, Hernán Darío Toro-Zapata, Dennis Alexánder Prieto-Medellín
    Processes.2021; 9(11): 1924.     CrossRef
  • Qualitative investigation of cytolytic and noncytolytic immune response in an HBV model
    John G. Alford, Stephen A. McCoy
    Involve, a Journal of Mathematics.2020; 13(3): 455.     CrossRef
  • Mathematical Model Describing HIV Infection with Time-Delayed CD4 T-Cell Activation
    Hernán Darío Toro-Zapata, Carlos Andrés Trujillo-Salazar, Edwin Mauricio Carranza-Mayorga
    Processes.2020; 8(7): 782.     CrossRef
  • The Role of Immune Response in Optimal HIV Treatment Interventions
    Hernán Toro-Zapata, Angélica Caicedo-Casso, Sunmi Lee
    Processes.2018; 6(8): 102.     CrossRef
  • Evaluación teórica de estrategias óptimas y sub-óptimas de terapia antirretroviral para el control de la infección por VIH
    Hernán Darío Toro-Zapata, Carlos Andrés Trujillo-Salazar, Dennis Alexánder Prieto-Medellín
    Revista de Salud Pública.2018; 20(1): 117.     CrossRef
  • Summing Up Again
    Hae-Wol Cho, Chaeshin Chu
    Osong Public Health and Research Perspectives.2014; 5(4): 177.     CrossRef
  • Roll the Dice
    Hae-Wol Cho, Chaeshin Chu
    Osong Public Health and Research Perspectives.2014; 5(5): 243.     CrossRef
  • Journal Publishing: Never Ending Saga
    Hae-Wol Cho, Chaeshin Chu
    Osong Public Health and Research Perspectives.2014; 5(1): 1.     CrossRef
Lon Mutant of Brucella abortus Induces Tumor Necrosis Factor-Alpha in Murine J774.A1 Macrophage
Sungdo Park, Young-Sill Choi, Sang-Hee Park, Young-Rok Kim, Hyuk Chu, Kyu-Jam Hwang, Mi-Yeoun Park
Osong Public Health Res Perspect. 2013;4(6):301-307.   Published online December 31, 2013
DOI: https://doi.org/10.1016/j.phrp.2013.10.002
  • 2,012 View
  • 19 Download
  • 5 Citations
AbstractAbstract PDF
Objectives
The objective of this study was to isolate a Brucella lon mutant and to analyze the cytokine response of B. lon mutant during macrophage infection.
Methods
A wild-type Brucella abortus strain was mutagenized by Tn5 transposition. From the mouse macrophage J774.A1 cells, total RNA was isolated at 0 hours, 6 hours, 12 hours, and 24 hours after infection with Brucella. Using mouse cytokine microarrays, we measured transcriptional levels of the cytokine response, and validated our results with a reverse transcriptase-polymerase chain reaction (RT-PCR) assay to confirm the induction of cytokine messenger RNA (mRNA).
Results
In host J774.A1 macrophages, mRNA levels of T helper 1 (Th1)-type cytokines, including tumor necrosis factor-alpha (TNF-α), interferon-gamma (IFN-γ), interleukin-2 (IL-2), and IL-3, were significantly higher in the lon mutant compared to wild-type Brucella and the negative control. TNF-α levels in cell culture media were induced as high as 2 μg/mL after infection with the lon mutant, a greater than sixfold change.
Conclusion
In order to understand the role of the lon protein in virulence, we identified and characterized a novel B. lon mutant. We compared the immune response it generates to the wild-type Brucella response in a mouse macrophage cell line. We demonstrated that the B. lon mutants induce TNF-α expression from the host J774.A1 macrophage.

Citations

Citations to this article as recorded by  
  • Brucella abortus Encodes an Active Rhomboid Protease: Proteome Response after Rhomboid Gene Deletion
    María Inés Marchesini, Ansgar Poetsch, Leticia Soledad Guidolín, Diego J. Comerci
    Microorganisms.2022; 10(1): 114.     CrossRef
  • Proteomics of Brucella
    Ansgar Poetsch, María Inés Marchesini
    Proteomes.2020; 8(2): 8.     CrossRef
  • Outer Membrane Vesicles From Brucella melitensis Modulate Immune Response and Induce Cytoskeleton Rearrangement in Peripheral Blood Mononuclear Cells
    Eric Daniel Avila-Calderón, Olín Medina-Chávez, Leopoldo Flores-Romo, José Manuel Hernández-Hernández, Luis Donis-Maturano, Ahidé López-Merino, Beatriz Arellano-Reynoso, Ma. Guadalupe Aguilera-Arreola, Enrico A. Ruiz, Zulema Gomez-Lunar, Sharon Witonsky,
    Frontiers in Microbiology.2020;[Epub]     CrossRef
  • RNA-seq reveals the critical role of Lon protease in stress response and Brucella virulence
    Yufu Liu, Hao Dong, Xiaowei Peng, Qiang Gao, Hui Jiang, Guanlong Xu, Yuming Qin, Jianrui Niu, Shijing Sun, Peng Li, Jiabo Ding, Ruiai Chen
    Microbial Pathogenesis.2019; 130: 112.     CrossRef
  • Brucella Downregulates Tumor Necrosis Factor-α to Promote Intracellular Survival via Omp25 Regulation of Different MicroRNAs in Porcine and Murine Macrophages
    Xiaomao Luo, Xiujuan Zhang, Xingchen Wu, Xuefeng Yang, Cong Han, Zhengyu Wang, Qian Du, Xiaomin Zhao, Shan-Lu Liu, Dewen Tong, Yong Huang
    Frontiers in Immunology.2018;[Epub]     CrossRef

PHRP : Osong Public Health and Research Perspectives