The remarkable efforts that are made on molecular imaging technologies demonstrate its potential importance and range of applications. The generation of disease-specific animal models, and the developments of target-specific probes and genetically encoded reporters are another important component. Continued improvements in the instrumentation, the identification of novel targets and genes, and the availability of improved imaging probes should be made. Multimodal imaging probes should provide easier transitions between laboratory studies, including small animal studies and clinical applications. Here, we reviewed basic strategies of noninvasive in vivo imaging methods in small animals to introducing the concept of molecular imaging.
Citations
Citations to this article as recorded by
Exploring the Interplay of Wavelength, Quantum Yield, and Penetration Depth in In Vivo Fluorescence Imaging Meital Harel, Rinat Ankri Journal of Fluorescence.2024;[Epub] CrossRef
Advances in NK cell therapy for brain tumors Jawad Fares, Zachary B. Davis, Julian S. Rechberger, Stephanie A. Toll, Jonathan D. Schwartz, David J. Daniels, Jeffrey S. Miller, Soumen Khatua npj Precision Oncology.2023;[Epub] CrossRef
Novel Biophotonic Techniques for Phototherapy Enhancement: Cerenkov Radiation as a Bridge between Ionizing and Non-Ionizing Radiation Treatment Ellas Spyratou, Kyriakos Kokkinogoulis, Georgios Tsigaridas, Georgios Kareliotis, Kalliopi Platoni, Mersini Makropoulou, Efstathios P. Efstathopoulos Journal of Nanotheranostics.2023; 4(1): 86. CrossRef
In Vivo Stem Cell Imaging Principles and Applications Seongje Hong, Dong-Sung Lee, Geun-Woo Bae, Juhyeong Jeon, Hak Kyun Kim, Siyeon Rhee, Kyung Oh Jung International Journal of Stem Cells.2023; 16(4): 363. CrossRef
Molecular imaging of tumor-associated macrophages in cancer immunotherapy Xiaoying Li, Ruike Wang, Yangnan Zhang, Shuangze Han, Yu Gan, Qi Liang, Xiaoqian Ma, Pengfei Rong, Wei Wang, Wei Li Therapeutic Advances in Medical Oncology.2022;[Epub] CrossRef
In vivo molecular and single cell imaging Seongje Hong, Siyeon Rhee, Kyung Oh Jung BMB Reports.2022; 55(6): 267. CrossRef
Evaluation of the Small-animal Nano Scan PET/CT System using 89Zr Khalid Alzimami, Sitah Alanazi, Magdi Gannam, Ahmad Alanazi, Ibrahim Aljamaz, Suliman Alyanbawi, Basem Alotaibi, Yousif Almalki, Abdelmoneim Sulieman, Salem Sassi Current Medical Imaging Formerly Current Medical I.2021; 17(2): 296. CrossRef
Development of an embedded multimodality imaging platform for onco-pharmacology using a smart anticancer prodrug as an example Florian Raes, Serigne Moussa Badiane, Brigitte Renoux, Sébastien Papot, Stéphanie Lerondel, Alain Le Pape Scientific Reports.2020;[Epub] CrossRef
Noninvasive Tracking of Hematopoietic Stem Cells in a Bone Marrow Transplant Model Fernando A. Oliveira, Mariana P. Nucci, Igor S. Filgueiras, João M. Ferreira, Leopoldo P. Nucci, Javier B. Mamani, Fernando Alvieri, Lucas E. B. Souza, Gabriel N. A. Rego, Andrea T. Kondo, Nelson Hamerschlak, Lionel F. Gamarra Cells.2020; 9(4): 939. CrossRef
Genetically Encoded Reporter Genes for MicroRNA Imaging in Living Cells and Animals Yingzhuang Song, Zhijing Xu, Fu Wang Molecular Therapy - Nucleic Acids.2020; 21: 555. CrossRef
The Molecular Imaging of Natural Killer Cells Mariya Shapovalova, Sean R. Pyper, Branden S. Moriarity, Aaron M. LeBeau Molecular Imaging.2018;[Epub] CrossRef
Molecular Imaging: A Useful Tool for the Development of Natural Killer Cell-Based Immunotherapies Prakash Gangadaran, Byeong-Cheol Ahn Frontiers in Immunology.2017;[Epub] CrossRef
Hepatocellular Carcinoma Cells Carrying a Multimodality Reporter Gene for Fluorescence, Bioluminescence, and Magnetic Resonance Imaging In Vitro and In Vivo Xiaoxiao Qin, Xiaojun Hu, Chun Wu, Mingyue Cai, Zhengran Li, Lina Zhang, Liteng Lin, Wensou Huang, Kangshun Zhu Academic Radiology.2016; 23(11): 1422. CrossRef
Prospects on Time-Domain Diffuse Optical Tomography Based on Time-Correlated Single Photon Counting for Small Animal Imaging Yves Bérubé-Lauzière, Matteo Crotti, Simon Boucher, Seyedrohollah Ettehadi, Julien Pichette, Ivan Rech Journal of Spectroscopy.2016; 2016: 1. CrossRef
DNA nanomaterials for preclinical imaging and drug delivery Dawei Jiang, Christopher G. England, Weibo Cai Journal of Controlled Release.2016; 239: 27. CrossRef
Fluorophore-NanoLuc BRET Reporters Enable Sensitive In Vivo Optical Imaging and Flow Cytometry for Monitoring Tumorigenesis Franz X. Schaub, Md. Shamim Reza, Colin A. Flaveny, Weimin Li, Adele M. Musicant, Sany Hoxha, Min Guo, John L. Cleveland, Antonio L. Amelio Cancer Research.2015; 75(23): 5023. CrossRef
GFP-taggedE. colishows bacterial distribution in mouse organs: pathogen tracking using fluorescence signal Pil-Gu Park, Min-Hee Cho, Gi-eun Rhie, Haeseul Jeong, Hyewon Youn, Kee-Jong Hong Clinical and Experimental Vaccine Research.2012; 1(1): 83. CrossRef