Skip Navigation
Skip to contents

PHRP : Osong Public Health and Research Perspectives



Page Path
HOME > Osong Public Health Res Perspect > Volume 6(1); 2015 > Article
Original Article
Evaluation of the Mechanical Properties and Drug Permeability of Chitosan/Eudragit RL Composite Film
Maryam Kouchaka,b, Somayeh Handalia, Basireh Naseri Boroujenia
Osong Public Health and Research Perspectives 2014;6(1):14-19.
Published online: December 18, 2014

aNanotechnology Research Center, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran

bDepartment of Pharmaceutics, School of Pharmacy, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran

∗Corresponding author.
• Received: September 8, 2014   • Revised: October 12, 2014   • Accepted: October 31, 2014

© 2015 Published by Elsevier B.V. on behalf of Korea Centers for Disease Control and Prevention.

This is an Open Access article distributed under the terms of the CC-BY-NC License (

  • 18 Download
  • 30 Crossref
  • 32 Scopus
  • Objectives
    The aim of this study was to design and evaluate a chitosan-based film that has properties required for successful wound dressing, and can control drug penetration and maintenance time in the location.
  • Methods
    Several formulations of a film containing chitosan (3%) and different concentrations of Eudragit RL (0.5%, 1%, and 1.5%) were prepared using the casting/solvent evaporating technique. Mechanical properties, water vapor transmission rate (WVTR), oxygen permeability, water uptake, and nitrofurazone permeability through the films were investigated.
  • Results
    The study results showed that by increasing the Eudragit RL content of composite films, their thickness and tensile strength were enhanced, while their elongation was decreased. No significant difference was observed between the oxygen permeability, WVTR, and water uptake results of pure chitosan films and different composite films containing Eudragit RL. Nitrofurazone permeability of chitosan films was increased by the inclusion of Eudragit RL in composite films, while by increasing the concentration of Eudragit RL, the permeation rate of drug was decreased.
  • Conclusion
    In conclusion, addition of Eudragit RL can improve mechanical properties of chitosan films without any undesirable effect on their water uptake, oxygen permeability, and WVTR qualities. The permeation rate of drugs through the composite films can be modified by changing Eudragit RL/chitosan ratio.
Severe skin wounds such as burn injury recover through several disease stages, including infectious, necrosis (and agglutination), proliferation, and epidermis formation periods. In the infectious period, the healing process is delayed. Wound dressings are often used to protect wounds from infection and repair them. Rapid healing of wounds is desirable for patients, especially for people suffering from diabetes because they show an extremely slow rate of healing [1–3]. Several dressings are currently used in the treatment of burns, split graft donor sites, and chronic ulcers [4]. Unlike conventional wound dressing, which passively provides wound protection, nowadays new types of wound dressings are used that not only protect the wound from surrounding environments, but also effectively promote the healing process by providing an optimum microenvironment for healing, removing excess of wound exudates, and allowing continuous tissue reconstruction processes [2]. Application of an antibiotic can be effective for suppression of bacteria, but many drugs such as nitrofurazone have high skin permeability that decreases their efficacy and maintenance time in the location. A proper wound dressing can control drug penetration. Currently, natural polymers have become more popular due to their nontoxicity, degradability, biological compatibility, and low cost. Chitosan is one of the most abundant polysaccharides found in skeletal materials of crustacean cuticles of insects, crabs, shrimps, and cell walls of various fungi. It is a cationic biopolymer that is obtained by N-deacetylation of chitin [1,5,6]. Chitosan has received great attention for wound management due to its beneficial intrinsic properties such as hemostasis, wound healing, bacteriostatic properties, exudate absorption, and film-forming ability [7,8]. However, pure chitosan films are brittle and have poor mechanical strength. Hence, addition of other polymers is necessary to obtain films with improved strength and elasticity [2]. Polymers such as polyethylene oxide [9,10], Eudragit [11], and polylactic acid [12] are used for this purpose. Eudragit RL is a water-insoluble derivative of acrylate polymers with widespread use in pharmaceutical dosage forms [11]. Eudragit RS and Eudragit RL are neutral copolymers of poly(ethylacrylate, methyl methacrylate, and trimethylammonioethylmethacrylate chloride). These polymers are pH independent and capable of swelling. The RL type of polymer is more permeable to water than the RS type due to its higher quaternary ammonium concentration (RS: l/40 ammonium/ester; RL: l/20 ammonium/ester) [13].
The aim of the current study was to design a wound dressing containing chitosan and Eudragit RL for controlling the permeation of nitrofurazone cream (Ubichem, Hampshire, England) (as a highly permeable drug model) through it.
Chitosan, with a deacetylation degree of 97% and viscosity grade of <25 cp, was purchased from Primex (Siglufjordur, Iceland), Iceland. Eudragit RL 30D and propylene glycol were obtained from Rohm Pharma (Darmstadt, Germany) and Merck (Haar, Germany), respectively. Nitrofurazone was kindly donated by Najo Co., Tehran, Iran. All other materials used in this study were of analytical reagent grade.
2.1 Film preparation
Films were prepared by casting and solvent evaporation. Chitosan solutions (3%) were prepared by dissolving chitosan in 1.8% acetic acid. Eudragit RL 30D was diluted using distilled water in order to prepare 0.5%, 1.0%, and 1.5% w/v dispersions, which were added to the chitosan solutions at a ratio of 1:4 (v/v). In addition, propylene glycol was added to the mixture as a plasticizer and agitated for 15 minutes at room temperature. The mixture was left to stand until air bubbles disappeared. The resultant mixture was poured onto a dry glass Petri dish and allowed to dry at 40°C for 24 hours. The prepared films were stored in airtight desiccators containing saturated magnesium nitrate solution (50% relative humidity) for further studies. Compositions of different formulations of films are shown in Table 1.
2.2 Mechanical properties
The thickness of the films was measured at five different places by using a micrometer. The mechanical properties of the films were evaluated using a texture analyzer (WDW-5; Berder, China) with a 5 kg load cell. Film specimens (2 × 5 cm2) were positioned between two mounting clamps. The films were pulled by the top clamp at a rate of 10 mm/minute. The tensile strength and elongation at break were calculated using the following equations [14]:
2.3 Oxygen permeability
The test of oxygen permeability through films was carried out by placing the films on top of open 250 mL flasks (test area: 1.075 × 10−3 m2) containing deionized water. The test flasks were placed under constant agitation for 24 hours. The negative control was the closed flask with an airtight cap (preventing oxygen from entering the flask), while the positive control was the open flask (allowing oxygen to enter the flask). The dissolved oxygen was analyzed according to the Winkler's method. Oxygen permeability (g/ was defined as the amount of oxygen penetration through the film during 24 hours [15].
2.4 Water uptake (swelling)
First, pieces of the films (2 × 2 cm2) were dried in an oven at 60°C and weighed accurately. Then, they were immersed in 50 mL buffer phosphate (pH 7.4) at 37°C for 48 hours. The swollen samples were withdrawn from the medium and weighed after the removal of excess surface water by a filter paper. The swelling behavior of the films was assessed as follows:
where Ws and Wi are the swollen film and the initial dry film weights, respectively.
2.5 Water vapor transmission rate
The films were cut and placed in sealed test tubes containing 5 g CaCl2, and were placed in an oven at 60°C. The tubes were stored in a desiccator containing 500 mL saturated solution of NaCl (75% relative humidity). After 0 day, 1 day, 2 days, 3 days, 4 days, and 5 days, weights of tubes were determined. Then graphs of increase in weight with respect to time were plotted, and water vapor transmission rate (WVTR) (g/ was calculated using the following equation:
2.6 Nitrofurazone permeability
Permeability of the model drug across the films was determined using a diffusion cell. The film was mounted in a Franz-type diffusion cell. Nitrofurazone cream (0.2%; 1.2 g) was applied on the film. An aliquot of 3 mL of the sample was withdrawn from the receptor compartment (phosphate buffer, pH 7.4) at a predetermined time and replaced by the same volume of fresh phosphate buffer to keep the volume constant. The concentration of released drug was assayed using a UV spectrophotometer (Biowave II; Biochrom, Cambridge, England) at 377 nm. The rate of drug permeation via skin can be determined using the Fick's first law [equations (5)–(7)]. According to this law, the amount of drug (M) flowing through a unit cross-sectional area (S) of a barrier and appearing in the receptor solution in time t is known as the steady-state flux, J:
where D is the diffusion coefficient of the drug in the barrier, h denotes the diffusional path length or the film thickness, K is the partition coefficient of drug between the film and the receptor medium, C0 stands for the applied drug concentration that was assumed to be constant during the experiment, and P is the permeability coefficient of the drug through the film.
The flux, J, was determined from the slope of the steady-state portion of the amount of drug permeated divided by S versus time. Lag time values were determined from the x-intercept of the linear region at steady state.
2.7 Statistical analysis
All data were expressed as mean ± standard deviation. Statistical analysis of data was performed using one-way analysis of variance. Statistical significance was associated with a probability of p < 0.05. All experiments were carried out in triplicate.
A suitable film for wound dressing should be strong and to some extent flexible [5]. The thickness, tensile strength, and elongation at break of the films are shown in Table 2. These results indicated that the tensile strength of the chitosan films decreased with inclusion of Eudragit RL (p < 0.05). However, by increasing the Eudragit RL content of composite films, the thickness and tensile strength of the films were enhanced, but their elongation was decreased. The films with Eudragit RL 1.5% showed the highest strength and the lowest elongation properties compared with the other films (p < 0.05). It is known that there is an inverse relationship between tensile strength and elongation of biopolymer films [5]. Our results are similar to the findings of Wittaya-areekul et al [15]. They evaluated chitosan–Eudragit RS 30D as wound dressings. According to their results, elongation was reduced by enhancing the concentration of Eudragit RS 30D (0.5%, 1%, and 1.5%).Our findings imply that increasing the density of the films by increasing the total solid content reduced their flexibility. High elasticity of chitosan films makes their handling and application as wound dressings difficult. However, elongation at break reduces with the addition of Eudragit RL. Mechanical properties of the composite films with lower elongation at break and reasonable tensile strength values suggest that they have high potential to be used in medical applications.
Oxygen penetration all of formulation was significantly different with positive and negative controls (p < 0.05) (Figure 1). It can be concluded that oxygen was able to penetrate through all the film formulations. It is believed that the presence of propylene glycol in these films helps in the movement of polymer chains, to allow the passage of oxygen molecules [16–18]. Oxygen penetration did not differ significantly among the composite films. These results are similar to the findings of Wittaya-areekul et al [15]. According to their results, oxygen penetration into the films with various Eudragit RS contents was somewhat similar.
Water uptake values and the WVTRs in different formulations are summarized in Table 3. The water uptake values indicated that all films had water retention capability, and no significant difference was observed between chitosan films and the films containing different concentrations of Eudragit RL. Our finding is contrary to the results of Wittaya-areekul et al [15], which showed the chitosan films had the highest water uptake values, while the presence of Eudragit RS reduced their swelling ability, although no significant difference was observed between the films containing various concentrations of Eudragit RS (0.5%, 1%, and 1.5%). Eudragit RL and Eudragit RS are acrylic and methacrylic acid esters with some hydrophilic properties due to the presence of quaternary ammonium groups. Eudragit RL contains a higher amount of such groups, and hence its water permeability is higher than that of Eudragit RS [19]. Owing to this property, the presence of Eudragit RL (in this concentration range) does not lead to lowering of water uptake by the composite films in comparison with the chitosan films. However, the ability of a film to preserve water is one of the most important aspects in skin tissue engineering, especially for wound healing [20]. Water-uptake capacity of a wound dressing should be considerably high for rapid absorption of exudates [21].
It was reported that permeability of moisture through the film is important for wound dressing, to keep the wound moist and comfortable, to help in the healing process [5]. An ideal dressing must be permeable to the extent that moist exudates under the dressing are maintained, to inhibit excess fluid absorption and evaporation leading to desiccation of the wound bed [14]. The rate of water vapor transmission through all films was partly high. Chitosan has good hydrophilic characteristics. It is well known that the hydrophilic nature of a polymer membrane induces water vapor tendency and increases the WVTR [22]. The results demonstrated that the WVTR was not affected by different concentrations of Eudragit RL or by different thicknesses of films (p > 0.05). As mentioned in the section on mechanical strength, the presence of Eudragit RL in the chitosan films led to decreases of integrity and strength of intermolecular forces in the primary structure of chitosan. This phenomenon can facilitate permeation of water. Besides, it is expected that an increase in the film thickness decreases the WVTR due to an increase in the total solid content. It seems that simultaneous occurrence of these two phenomena led to the same WVTR values in the presence of different concentrations of Eudragit RL 100.
The profile of nitrofurazone permeability of different formulations is shown in Figure 2, and the values of flux (J) and KP are presented in Table 4.
According to the results, permeability of chitosan films increased with the inclusion of Eudragit RL in composite films (p < 0.05). Eudragit RL causes the network of cross-linked chitosan to discontinue and reduces the integrity of the films, facilitating the diffusion of nitrofurazone through the films. Of course by an increase in the concentration of Eudragit RL, the permeation rate of drug through the films is decreased (p < 0.05). This decrease might be a result of the enhancement of the total solid content and thickness of composite films with the higher ratios of Eu:Cs. In this study, chitosan films with the lowest content of Eudragit RL (0.5%) exhibited the highest and most acceptable level of drug release (44.478%) after 24 hours.
This study revealed that Eudragit RL can be incorporated into a chitosan film to improve its mechanical properties, while substantially maintaining vapor penetration, water uptake, and oxygen penetration requirements to provide a good wound-healing environment. The films comprising 3% chitosan and 0.5% Eudragit RL showed the highest amount of drug release after 24 hours, exhibiting potential to be used as wound dressings.
The authors declare no conflicts of interest.
The work was financially supported by Nanotechnology Research Center, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran (grant no. N-40).

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License ( which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

  • 1. Queiroz A.A.A., Ferraz H.G., Abraham G.A.. Development of new hydroactive dressings based on chitosan membranes: characterization and in vivo behavior. 2003 Jan. Wiley Periodicals, Inc; Hoboken: 64(1):147–54.
  • 2. Wittaya-areekul S., Prahsarn C.. Development and in vitro evaluation of chitosan–polysaccharides composite wound dressings. Int J Pharm 313(1-2). 2006 Apr;123−128. PMID: 16488564.ArticlePubMed
  • 3. Rodrigues L.B., Leite H.F., Yoshida M.I.. In vitro release and characterization of chitosan film as dexamethasone carrier. Int J Pharm 368(1-2). 2009 Feb;1−6. PMID: 18955123.ArticlePubMed
  • 4. Kim J.O., Park J.K., Kim J.H.. Development of polyvinyl alcohol–sodium alginate gel-matrix-based wound dressing system containing nitrofurazone. Int J Pharm 359(1-2). 2008 Jul;79−86. PMID: 18440737.ArticlePubMed
  • 5. Sasikala L., Durai B., Rathinamoorthy R.. Manuka honey loaded chitosan hydrogel films for wound dressing applications. Int J Pharm Tech Res 5(4). 2013;1774−1785.
  • 6. Krkic N., Lazic V., Petrovic L.. Properties of chitosan-laminated collagen film. Food Technol Biotechnol 50(4). 2012 Nov;483−489.
  • 7. Alsarra I.A.. Chitosan topical gel formulation in the management of burn wounds. Int J Biol Macromol 45(1). 2009 Jul;16−21. PMID: 19447254.ArticlePubMed
  • 8. Wang Q., Dong Z., Du Y.. Controlled release of ciprofloxacin hydrochloride from chitosan/polyethylene glycol blend films. Carbohydr Polym 69(2). 2007 Jun;336−343.Article
  • 9. Zivanovic S., Li J., Davidson P.M.. Physical, mechanical and antibacterial properties of chitosan PEO blend films. Biomacromolecules 8(5). 2007 May;1505−1510. PMID: 17388625.ArticlePubMed
  • 10. Djokic J.D., Kojovic A., Stojanovic D.. Processing and nanomechanical properties of chitosan/poly(ethylene oxide) blend films. J Serb Chem Soc 77(12). 2012;1723−1733.Article
  • 11. Sadeghi F., Shahabi M., Afrasiabi Garekani H.. Comparison of physicomechanical properties of films prepared from organic solution and aqueous dispersion of Eudragit RL. Daru 19(2). 2011;100−106. PMID: 22615646.PubMedPMC
  • 12. Suyatma N.E., Copinet A., Tighzert L.. Mechanical and barrier properties of biodegradable films made from chitosan and poly (lactic acid) blends. J Polym Environ 12(1). 2004 Jan;1−2.Article
  • 13. Filippis P.D., Zingone G., Gibellini M.. Dissolution rates of different drugs from solid dispersions with Eudragit RS. Eur J Pharm Sci 3(5). 1995 Oct;265−271.Article
  • 14. Khan T.A., Peh K.K., Ch'ng H.S.. Mechanical, bioadhesive strength and biological evaluations of chitosan films for wound dressing. J Pharm Pharm Sci 3(3). 2000 Sep–Dec;303−311. PMID: 11177648.PubMed
  • 15. Wittaya-areekul S., Prahsarn C., Sungthongjeen S.. Development and in vitro evaluation of chitosan–Eudragit RS 30D composite wound dressings. AAPS PharmSci Tech 7(1). 2006 Mar;E30. ArticlePDF
  • 16. Vásconez M.B., Flores S.K., Campos C.A.. Antimicrobial activity and physical properties of chitosan–tapioca starch based edible films and coatings. Food Res Int 42(7). 2009 Aug;762−769.Article
  • 17. Gutiérrez-Rocca J., McGinity J.W.. Influence of water soluble and insoluble plasticizers on the physical and mechanical properties of acrylic resin copolymers. Int J Pharm 103(3). 1994 Mar;293−301.Article
  • 18. Lecomte F., Siepmann J., Walther M.. Polymer blends used for the aqueous coating of solid dosage forms: importance of the type of plasticizer. J Control Release 99(1). 2004 Sep;1−13. PMID: 15342176.ArticlePubMed
  • 19. Omari D.M., Sallam A., Abd-Elbary A.. Lactic acid induced modifications in films of Eudragit RL and RS aqueous dispersions. Int J Pharm 274(1-2). 2004 Apr;85−96. PMID: 15072785.ArticlePubMed
  • 20. Li X., Kong X., Shi S.. Biodegradable MPEG-g-chitosan and methoxy poly(ethylene glycol)-b-poly(ε-caprolactone) composite films: Part 1. Preparation and characterization. Carbohydr Polym 79(2). 2010 Jan;429−436.Article
  • 21. Pandima Devi M., Sekar M., Chamundeswari M.. A novel wound dressing material—fibrin–chitosan–sodium alginate composite sheet. Bull Mater Sci 35(7). 2012 Dec;1157−1163.Article
  • 22. Wei H., Li-Fang F., Bai X.. An investigation into the characteristic of kitosan/kollicoat SR30D film for colonic drug delivery. Eur J Pharm Biopharm 72(1). 2009 May;266−274. PMID: 19028578.ArticlePubMed
Figure 1
OP through different formulations (mean ± SD, n = 3). OP = oxygen permeability; SD = standard deviation.
Figure 2
Profile of nitrofurazone permeability of different formulations.
Table 1
Compositions of different formulation of films (v/v ratio).
Formula Chitosan (3%) Eudragit RL Propylene glycol
Cs 4 0 0.1
Cs Eu 0.5 4 1 (0.5%) 0.1
Cs Eu 1 4 1 (1%) 0.1
Cs Eu 1.5 4 1 (1.5%) 0.1
Table 2
Mechanical properties of Cs films (mean ± SD, n = 3).
Formula Thickness (μm) Tensile strength (MPa) Elongation (%)
Cs 94 ± 11.40 25 ± 4.25 20.873 ± 0.69
Cs Eu 0.5 104 ± 11.40 10.73 ± 1.54 12.18 ± 0.99
Cs Eu 1 130 ± 15.81 14.36 ± 0.80 9.634 ± 0.19
Cs Eu 1.5 156 ± 8.94 17.31 ± 2.56 7.93 ± 0.40

SD = standard deviation.

Table 3
Value of water uptake and WVTR in different formulations.
Formula Water uptake 48 h (%) WVTR (g/m2 d)
Cs 108.18 ± 1.61 205.63 ± 9.90
Cs Eu 0.5 112.74 ± 0.90 201.30 ± 0.00
Cs Eu 1 111.56 ± 2.77 205.63 ± 9.92
Cs Eu 1.5 116.70 ± 2.39 214.29 ± 6.5

WVTR = water vapor transmission rate.

Table 4
Values of flux (J), permeability coefficient (P), and drug release for each formulation after 24 hours (R24).
Formula J (mg/cm2 h) P (cm/h) R24 (%)
Cs 0.004 ± 0.0004 0.0019 ± 0.0002 19.874 ± 3.125
Cs Eu 0.5 0.022 ± 0.0001 0.0112 ± 0.000 44.478 ± 0.333
Cs Eu 1 0.009 ± 0.0001 0.0044 ± 0.000 27.435 ± 0.331
Cs Eu 1.5 0.008 ± 0.0001 0.0038 ± 0.000 26.125 ± 0.159

Figure & Data



    Citations to this article as recorded by  
    • Production Of Tetracycline Hydrochloride-Collagen-Doped Chitosan Nanofiber Scaffolds And Investigation Of Their Antibacterial Properties
      İbrahim ALTUN, İsmail TİYEK, Eda ALTUN, İdris ALTUN
      International Journal of Life Sciences and Biotech.2023; 6(1): 37.     CrossRef
    • Designing and Evaluating pH-Responsive Electrospun Eudragit® L-100/Hydroxypropyl Methyl Cellulose Composite Mats for Release of Propolis as a Novel Wound Dressing
      Mahdieh Abdi, Parvin Zakeri-Milani, Marjan Ghorbani
      Journal of Polymers and the Environment.2023; 31(7): 3215.     CrossRef
    • Synthesis and characterization of citric acid crosslinked carboxymethyl tamarind gum-polyvinyl alcohol hydrogel films
      Kailas Krishnat Mali, Vishwajeet Sampatrao Ghorpade, Remeth Jacky Dias, Shashikant C. Dhawale
      International Journal of Biological Macromolecules.2023; 236: 123969.     CrossRef
    • Freestanding region-responsive bilayer for functional packaging of ingestible devices
      Michael A. Straker, Joshua A. Levy, Justin M. Stine, Vivian Borbash, Luke A. Beardslee, Reza Ghodssi
      Microsystems & Nanoengineering.2023;[Epub]     CrossRef
    • Osteoblast and bacterial cell response on RGD peptide‐functionalized chitosan coatings electrophoretically deposited from different suspensions on Ti13Nb13Zr alloy
      Łukasz Pawłowski, Szymon Mania, Adrianna Banach‐Kopeć, Michał Bartmański, Anna Ronowska, Kacper Jurak, Aleksandra Mielewczyk‐Gryń, Natalia Karska, Sylwia Rodziewicz‐Motowidło, Andrzej Zieliński
      Journal of Biomedical Materials Research Part B: A.2023; 111(10): 1800.     CrossRef
    • Simvastatin-loaded alginate bilayer membranes for wound dressing applications
      Rubens T. Monteiro, Thamyres F. Da Silva, RaimundoN.F. Moreira Filho, Niédja F. Vasconcelos, KarinaA.B. Nogueira, Raquel Petrilli, Fabia K. Andrade, Rodrigo S. Vieira
      Journal of Drug Delivery Science and Technology.2023; 86: 104701.     CrossRef
    • Novel Temperature Responsive Films Impregnated with Silver Nano Particles (Ag-NPs) as Potential Dressings for Wounds
      Joginder Singh Paneysar, Stephen Barton, Premlata Ambre, Evans Coutinho
      Journal of Pharmaceutical Sciences.2022; 111(3): 810.     CrossRef
    • pH modulating agar dressing for chronic wounds
      Suhela Tyeb, Nitesh Kumar, Gorbel B, Ashok Kumar, Vivek Verma
      Soft Materials.2022; 20(4): 379.     CrossRef
    • A new approach for the management of Escherichia coli and Klebsiella pneumonia by using cefixime-based bionanocomposite films
      Badriyah Shadid Alotaibi, Akram Ashames, Manal Buabeid, Momina Masood, Sadullah Mir, Ghulam Murtaza
      Journal of Experimental Nanoscience.2022; 17(1): 389.     CrossRef
    • Enhanced Healing Activity of Manuka Honey and Nitrofurazone Composite in Full-Thickness Burn Wounds in the Rabbit Model
      Muhammad Fakhar-e-Alam Kulyar, Khurram Ashfaq, Amjad Islam Aqib, Kun Duan, Muhammad Asif, Zeeshan Ahmad Bhutta, Muhammad Shoaib, Samina Shabbir, Shah Nawaz, Muhammad Aamir Naseer, Iqra Sarwar, Muhammad Akhtar, Ayesha Safdar Chaudhry, Riaz Hussain, Hafiz I
      Frontiers in Veterinary Science.2022;[Epub]     CrossRef
    • Effect of clinoptilolite on structure and drug release behavior of chitosan/thyme oil γ‐Cyclodextrin inclusion compound hydrogels
      Sara Moradi, Abolfazl Barati, Alan E. Tonelli, Hamid Hamedi
      Journal of Applied Polymer Science.2021;[Epub]     CrossRef
    • Development of functional pectin edible films with fillers obtained from red cabbage and beetroot
      Carlos M. Otálora González, Maria D. De’Nobili, Ana M. Rojas, María F. Basanta, Lía N. Gerschenson
      International Journal of Food Science & Technology.2021; 56(8): 3662.     CrossRef
    • Recent Updates on Biopolymers based Wound Dressings
      Sonia Arora, Manju Nagpal, Malkiet Kaur
      Asian Journal of Chemistry.2021; 33(7): 1457.     CrossRef
    • N-acylhydrazone Derivative-Loaded Cellulose Acetate Films: Thermoanalytical, Spectroscopic, Mechanical and Morphological Characterization
      Amaro César Lima de Assis, Lívia Maria Coelho de Carvalho Moreira, Beatriz Patrício Rocha, Milena Raissa Bezerra Pereira, Demis Ferreira de Melo, Ricardo Olímpio de Moura, Eduardo Pereira de Azevedo, João Augusto Oshiro-Junior, Bolívar Ponciano Goulart de
      Polymers.2021; 13(14): 2345.     CrossRef
    • Hydroxy citric acid cross-linked chitosan/guar gum/poly(vinyl alcohol) active films for food packaging applications
      Veena G. Bhat, Shivayogi S. Narasagoudr, Saraswati P. Masti, Ravindra B. Chougale, Yogesh Shanbhag
      International Journal of Biological Macromolecules.2021; 177: 166.     CrossRef
    • Chitosan-based hydrogels loading with thyme oil cyclodextrin inclusion compounds: From preparation to characterization
      Sara Moradi, Aboulfazl Barati, Alan E. Tonelli, Hamid Hamedi
      European Polymer Journal.2020; 122: 109303.     CrossRef
    • Effect of Pullulan as Additive to the Synthetic Polymeric Coating Blend Eudragit® NM-L55 on the Properties of the Resulting Films
      Pirijanka Sriganaranjan, Claudia S. Leopold
      Journal of Pharmaceutical Sciences.2020; 109(7): 2166.     CrossRef
    • Electrophoretic Deposition and Characterization of Chitosan/Eudragit E 100 Coatings on Titanium Substrate
      Łukasz Pawłowski, Michał Bartmański, Gabriel Strugała, Aleksandra Mielewczyk-Gryń, Magdalena Jażdżewska, Andrzej Zieliński
      Coatings.2020; 10(7): 607.     CrossRef
    • Vancomycin-functionalized Eudragit-based nanofibers: Tunable drug release and wound healing efficacy
      Lamiaa M. Abdel-Rahman, Hoda M. Eltaher, Kamilia Abdelraouf, Mohammed Bahey-El-Din, Cherine Ismail, El-Refaie S. Kenawy, Labiba K. El-Khordagui
      Journal of Drug Delivery Science and Technology.2020; 58: 101812.     CrossRef
    • Sarı Kantaron (Hypericum perforatum) katkılı kitosan ve jelatin esaslı yara örtücü filmlerinin üretimi ve karakterizasyonu
      İlknur Küçük, Nigar Yıldırım
      Gazi Üniversitesi Mühendislik Mimarlık Fakültesi D.2019; 35(1): 127.     CrossRef
    • Design, Development, and Characterization of Imiquimod-Loaded Chitosan Films for Topical Delivery
      Buddhadev Layek, Saif S. Rahman Nirzhor, Sneha Rathi, Karunya K. Kandimalla, Timothy S. Wiedmann, Swayam Prabha
      AAPS PharmSciTech.2019;[Epub]     CrossRef
    • Preparation and characterization of chitosan based hydrogels containing cyclodextrin inclusion compounds or nanoemulsions of thyme oil
      Sara Moradi, Abolfazl Barati, Ehsan Salehi, Alan E Tonelli, Hamid Hamedi
      Polymer International.2019; 68(11): 1891.     CrossRef
    • Mechanical Properties of Pectin/Eudragit Blend Films
      Yupaporn Sampaopan, Jirapornchai Suksaeree
      Key Engineering Materials.2019; 819: 3.     CrossRef
    • Investigation of effect of anti-angiogenic green tea extract on the mechanical, physical and wound healing property of 2D wheat starch-sodium alginate biocomposite film
      Zubin Shah, Clara Fernandes, Divya Suares
      Journal of Drug Delivery Science and Technology.2019; 52: 255.     CrossRef
    • Characterization and in vitro Biocompatibility of Binary Mixtures of Chitosan and Polyurethanes Synthesized from Chemically Modified Castor Oil, as Materials for Medical Use
      Fabián R. Arévalo, Sonia A. Osorio, Nathaly A. Valcárcel, Jeimmy C. Ibarra, Manuel F. Valero
      Polymers from Renewable Resources.2018; 9(1): 23.     CrossRef
    • Flexible agar-sericin hydrogel film dressing for chronic wounds
      Suhela Tyeb, Nitesh Kumar, Ashok Kumar, Vivek Verma
      Carbohydrate Polymers.2018; 200: 572.     CrossRef
    • The Role of Combined Penetration Enhancers in Nasal Microspheres on In Vivo Drug Bioavailability
      Giovanna Rassu, Luca Ferraro, Barbara Pavan, Paolo Giunchedi, Elisabetta Gavini, Alessandro Dalpiaz
      Pharmaceutics.2018; 10(4): 206.     CrossRef
    • The Drop-in-Drop Encapsulation in Chitosan and Sodium Alginate as a Method of Prolonging the Quality of Linseed Oil
      Szymon Mania, Robert Tylingo, Anna Michałowska
      Polymers.2018; 10(12): 1355.     CrossRef
    • Effect of Eudragit S100 nanoparticles and alginate chitosan encapsulation on the viability of Lactobacillus acidophilus and Lactobacillus rhamnosus
      Fereshteh Ansari, Hadi Pourjafar, Vahid Jodat, Javad Sahebi, Amir Ataei
      AMB Express.2017;[Epub]     CrossRef
    • Preparation and characterisation of atorvastatin and curcumin‐loaded chitosan nanoformulations for oral delivery in atherosclerosis
      Varuna Kumara J.B., Sistla Ramakrishna, Basavaraj Madhusudhan
      IET Nanobiotechnology.2017; 11(1): 96.     CrossRef

    • PubReader PubReader
    • Cite
      export Copy
    • XML DownloadXML Download

    PHRP : Osong Public Health and Research Perspectives