Osong Public Health and Research Perspectives

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In Vitro Antiviral Activity of Sakuranetin against Human Rhinovirus 3: Hwa-Jung Choi; Osong Public Health Res Perspect. 2017;8(6):415-420. Published online December 31, 2017; DOI: https://doi.org/10.24171/j.phrp.2017.8.6.09

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Objectives

Rhinoviruses (RVs) cause common cold and are associated with exacerbation of chronic inflammatory respiratory diseases. Until now, no clinically effective antiviral chemotherapeutic agents to treat diseases caused by human rhinoviruses (HRVs) have been reported. We assessed the anti-HRV3 activity of sakuranetin isolated from Sorbus commixta Hedl. in human epithelioid carcinoma cervix (HeLa) cells, to evaluate its anti-rhinoviral potential in the clinical setting.

Methods

Antiviral activity and cytotoxicity as well as the effect of sakuranetin on HRV3-induced cytopathic effects (CPEs) were evaluated using the sulforhodamine B (SRB) method using CPE reduction. The morphology of HRV3-infected cells was studied using a light microscope.

Results

Sakuranetin actively inhibited HRV3 replication and exhibited antiviral activity of more than 67% without cytotoxicity in HeLa cells, at 100 μg/mL. Ribavirin showed anti-HRV3 activity similar to that of sakuranetin. Treatment of HRV-infected HeLa cells with sakuranetin visibly reduced CPEs.

Conclusion

The inhibition of HRV production by sakuranetin is mainly due to its general antioxidant activity through inhibition of viral adsorption. Therefore, the antiviral activity of sakuranetin should be further investigated to elucidate its mode of action and prevent HRV3-mediated diseases in pathological conditions.

Citations

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Evaluation of Antiviral Activity of Zanthoxylum Species Against Picornaviruses: Hwa-Jung Choi; Osong Public Health Res Perspect. 2016;7(6):400-403. Published online December 31, 2016; DOI: https://doi.org/10.1016/j.phrp.2016.11.003

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Abstract PDF

Human rhinoviruses and enteroviruses (family Picornaviridae) infect millions of people worldwide each year, but little is known about effective therapeutical treatment for the infection caused by these viruses. We sought to determine whether or not Zanthoxylum (Rutaceae) species can exhibit antiviral activity against picornaviruses. The leaf parts of four Zanthoxylum species were extracted with methanol, and the extracts were investigated for their antiviral activity against picornaviruses using cytopathic effects by cytopathic effect reduction. Leaf extracts of Zanthoxylum piperitum among four Zanthoxylum species were found to possess only broad-spectrum antipicornavirus activity against human rhninovirus 2 with a 50% inhibitory concentration (IC₅₀) value of 59.48 μg/mL, human rhinovirus 3 with an IC₅₀ value of 39.94 μg/mL, coxsackie A16 virus with an IC₅₀ value of 45.80 μg/mL, coxsackie B3 virus with an IC₅₀ value of 68.53 μg/mL, coxsackie B4 virus with an IC₅₀ value of 93.58 μg/mL, and enterovirus 71 virus with an IC₅₀ value of 4.48 μg/mL. However, ribavirin did not possess antiviral activity against human rhinovirus 3 and four enteroviruses. Therefore, leaves of Z. piperitum showed broad-spectrum antipicornavirus activity, and may be useful as a candidate for studying picornavirus agents and development of pharmaceuticals.

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