Objectives
This study was performed to evaluate the prevalence of medication adherence and its determinants among Moroccan patients with type 2 diabetes mellitus. Methods: A multicenter cross-sectional survey was conducted from February to June 2024, involving 584 patients from the Casablanca-Settat and Rabat-Sale-Kenitra regions of Morocco. Medication adherence was assessed using the general medication adherence scale. Associations between independent variables and adherence were analyzed using chi-square tests and multivariate logistic regression. Results: Medication adherence was observed in 96.2% of participants. Multivariate analysis revealed significantly lower medication adherence among patients using 2 or more oral antidiabetic drugs (adjusted odds ratio [aOR], 0.026; 95% confidence interval [CI], 0.001–0.642; p=0.026) and those with a diabetes duration of 11 to 15 years (aOR, 0.037; 95% CI, 0.001–0.956; p=0.047). Conclusion: Despite a high overall adherence rate, patients on dual or polytherapy and those with longer disease duration exhibited lower adherence in multivariate analysis. Targeted interventions are needed to improve adherence in these high-risk groups.