<sec>
<title>Objectives</title>
<p>This study aimed to investigate the immunological and bacterial profiles in pregnant women of Bafang-Cameroon.</p></sec>
<sec>
<title>Methods</title>
<p>Stool and midstream urine were cultured using specific culture media. The disk diffusion method was used for the antimicrobial susceptibility test. T-cell lymphocyte counts (CD3, CD4 and CD8), white blood cell counts, sensitive C-reactive protein, and interleukin-6, were measured by flow cytometry, optical detection, and the enzyme-linked immunosorbent assay solid phase direct sandwich method.</p></sec>
<sec>
<title>Results</title>
<p>Out of 700 participants, 71.43% were pregnant, and 28.57% were non-pregnant women. The mean age was 29.40 ± 8.27 and 27.41 ± 6.55 years in non-pregnant and pregnant women, respectively. CD4 T-cells were not significantly lower in pregnant women compared with non-pregnant women. There were 43.65% and 56.35% bacteria isolates obtained from urine and stool samples, respectively. Bacteria were mostly isolated in patients with a CD4 T-cell count between 461 and 806 cells/μL. Isolates of <italic>Klebsiella pneumoniae</italic> and <italic>Enterobacter aerogenes</italic> showed 100% resistance in non-pregnant women, however all isolated bacteria were shown to be multidrug resistant in pregnant women. <italic>Salmonella sp</italic>. (24.3%) and <italic>Escherichia coli</italic> (21.51%) showed an increase in multidrug resistant phenotypes in pregnant women.</p></sec>
<sec>
<title>Conclusion</title>
<p>This study demonstrated that routine bacteriological analysis during pregnancy is necessary for their follow-up care.</p></sec>
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