<sec>
<title>Objectives</title>
<p><italic>Staphylococcus aureus</italic> is a nosocomial pathogen that provides a major challenge in the healthcare environment, especially in burns units where patients are particularly susceptible to infections. In this study, we sought to determine molecular types of <italic>S. aureus</italic> isolates collected from burns patients, based on staphylococcal protein A and coagulase gene polymorphisms.</p></sec>
<sec>
<title>Methods</title>
<p>Antibiotic susceptibility testing of 89 <italic>S. aureus</italic> strains isolated from burn wounds of patients was assessed using the Kirby-Bauer disk diffusion method. Strains were characterized by <italic>spa</italic> typing, <italic>coa</italic> typing, and resistance and toxin gene profiling.</p></sec>
<sec>
<title>Results</title>
<p>A total of 12 different <italic>spa</italic> types were identified with the majority being t790 (18%). Panton-Valentine leucocidin encoding genes were identified in <italic>spa</italic> types t044 (5.6%), t852 (2.2%) and t008 (2.2%). The most commonly detected antibiotic resistance gene was <italic>ant (4′)-Ia</italic> (60.7%). Ten different <italic>coa</italic> types were detected and the majority of the tested isolates belonged to <italic>coa</italic> III (47.2%). All the high-level mupirocin-resistant and low-level mupirocin resistant strains belonged to <italic>coa</italic> type III.</p></sec>
<sec>
<title>Conclusion</title>
<p>The present study illustrated that despite the high frequency of <italic>coa</italic> III and <italic>spa</italic> t790 types, the genetic background of <italic>S. aureus</italic> strains in Iranian burns patients was diverse. The findings obtained are valuable in creating awareness of <italic>S. aureus</italic> infections within burns units.</p></sec>
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<sec><title>Objectives</title><p>Integrons are thought to play an important role in the spread of antibiotic resistance. This study investigates class 1 and 2 integron-positive methicillin-resistant coagulase-negative staphylococci strains isolated in Iran and characterizes their patterns of antimicrobial resistance.</p></sec><sec><title>Methods</title><p>Hundred clinical isolates of coagulase-negative staphylococci were characterized for integron content and staphylococcal cassette chromosome <italic>mec</italic> (SCCmec) type.</p></sec><sec><title>Results</title><p>Sixteen isolates carried class 1 (<italic>intI1</italic>) integrons and four isolates carried class 2 (<italic>intI2</italic>) integrons. One resistance gene array was identified among the class 1 integrons (<italic>aadA1</italic> cassette). The distribution of SCCmec types in 50 methicillin-resistant coagulase-negative staphylococci strains showed that SCCmec types III and V dominated among the tested strains.</p></sec><sec><title>Conclusion</title><p>This is the first report of methicillin-resistant coagulase-negative staphylococci strains that carry two mobile genetic elements, including class 1 and 2 integrons and SCCmec, in Iran.</p></sec>
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