<sec><title>Objectives</title><p>Rhinoviruses (RVs) cause common cold and are associated with exacerbation of chronic inflammatory respiratory diseases. Until now, no clinically effective antiviral chemotherapeutic agents to treat diseases caused by human rhinoviruses (HRVs) have been reported. We assessed the anti-HRV3 activity of sakuranetin isolated from <italic>Sorbus commixta</italic> Hedl. in human epithelioid carcinoma cervix (HeLa) cells, to evaluate its anti-rhinoviral potential in the clinical setting.</p></sec><sec><title>Methods</title><p>Antiviral activity and cytotoxicity as well as the effect of sakuranetin on HRV3-induced cytopathic effects (CPEs) were evaluated using the sulforhodamine B (SRB) method using CPE reduction. The morphology of HRV3-infected cells was studied using a light microscope.</p></sec><sec><title>Results</title><p>Sakuranetin actively inhibited HRV3 replication and exhibited antiviral activity of more than 67% without cytotoxicity in HeLa cells, at 100 μg/mL. Ribavirin showed anti-HRV3 activity similar to that of sakuranetin. Treatment of HRV-infected HeLa cells with sakuranetin visibly reduced CPEs.</p></sec><sec><title>Conclusion</title><p>The inhibition of HRV production by sakuranetin is mainly due to its general antioxidant activity through inhibition of viral adsorption. Therefore, the antiviral activity of sakuranetin should be further investigated to elucidate its mode of action and prevent HRV3-mediated diseases in pathological conditions.</p></sec>
Citations
Citations to this article as recorded by
OsPHR2 and OsMYC2 coordinate phosphate starvation-induced sakuranetin biosynthesis for enhanced rice blast resistance Linying Li, Zelong Xu, Yuqing He, Yao Zhao, Xueying Zhang, Chi Zhang, Chunlan Peng, YiYi Hong, Lanlan Wang, Xijiao Song, Gaojie Hong Plant Physiology.2026;[Epub] CrossRef
Standardized Eucalyptus maculata (Corymbia maculata) Resin Extract: Metabolomic Profiling, In Vitro and In Silico Study of Anti‐HSV Activity Samar M. Bassam, Ibrahim A. Abdelwahab, Mohamed Teleb, Dalia E. Ali Chemistry & Biodiversity.2025;[Epub] CrossRef
Etrog Citron (Citrus medica) as a Novel Source of Antiviral Agents: Overview of Its Bioactive Phytochemicals and Delivery Approaches Arik Dahan, Ludmila Yarmolinsky, Faina Nakonechny, Olga Semenova, Boris Khalfin, Sigal Fleisher-Berkovich, Shimon Ben-Shabat Pharmaceutics.2025; 17(9): 1173. CrossRef
Interaction of sakuranetin with unsaturated lipids forming Langmuir monolayers at the air-water interface: A biomembrane model Matheus Lima de Souza, André Campos Machado, Henrique Barbosa, João Henrique Ghilardi Lago, Luciano Caseli Colloids and Surfaces B: Biointerfaces.2024; 234: 113747. CrossRef
Biofortified Rice Provides Rich Sakuranetin in Endosperm Yao Zhao, Jitao Hu, Zhongjing Zhou, Linying Li, Xueying Zhang, Yuqing He, Chi Zhang, Junmin Wang, Gaojie Hong Rice.2024;[Epub] CrossRef
Antiviral activity of the water extract and ethanol extract of Sorbus commixta against influenza A virus in vitro Yewon Kim, Sanghyun Lee, Chulwoo Kim, Sun-Woo Yoon, Sejin Jeon, Mi-Na Kweon, Baik-Lin Seong, Sang-Uk Seo, Yo Han Jang Heliyon.2024; 10(20): e39049. CrossRef
Sakuranetin and its therapeutic potentials – a comprehensive review Md. Junaid, Bristy Basak, Yeasmin Akter, Syeda Samira Afrose, Afsana Nahrin, Rashiduzzaman Emran, Md. Shahinozzaman, Shinkichi Tawata Zeitschrift für Naturforschung C.2023; 78(1-2): 27. CrossRef
Comparative metabolomics of flavonoids in twenty vegetables reveal their nutritional diversity and potential health benefits Han Tao, Yao Zhao, Linying Li, Yuqing He, Xueying Zhang, Ying Zhu, Gaojie Hong Food Research International.2023; 164: 112384. CrossRef
Rice Phytoalexins: Half a Century of Amazing Discoveries; Part I: Distribution, Biosynthesis, Chemical Synthesis, and Biological Activities Alessio Valletta, Lorenzo Maria Iozia, Laura Fattorini, Francesca Leonelli Plants.2023; 12(2): 260. CrossRef
Ethanolamine phospholipids at the air-water interface as cell membranes models of microorganisms to study the nanotoxicology of sakuranetin Guilherme Henrique da Cruz Ramos Pires, Henrique Barbosa, Roberto Baptista Pereira Almeida, João Henrique Ghilardi Lago, Luciano Caseli Thin Solid Films.2023; 770: 139768. CrossRef
Antiviral Activity of Flavonoids Against Non-polio Enteroviruses Hwa-Jung Choi Journal of Bacteriology and Virology.2023; 53(1): 29. CrossRef
Novel anti‑hepatitis B virus flavonoids sakuranetin and velutin fromRhus retinorrhoea Sarfaraz Ahmed, Mohammad Parvez, Mohammed Al‑Dosari, Mazin Abdelwahid, Tawfeq Alhowiriny, Adnan Al‑Rehaily Molecular Medicine Reports.2023;[Epub] CrossRef
Antiviral Activity of Flavonoids from Geopropolis of the Brazilian Jandaira Bee against Zika and Dengue Viruses Poliana Gomes da Silva, Elton José Ferreira Chaves, Tania Maria Sarmento Silva, Gerd Bruno Rocha, Willyenne Marília Dantas, Ronaldo Nascimento de Oliveira, Lindomar José Pena Pharmaceutics.2023; 15(10): 2494. CrossRef
Metabolic engineering in Streptomyces albidoflavus for the biosynthesis of the methylated flavonoids sakuranetin, acacetin, and genkwanin Álvaro Pérez-Valero, Suhui Ye, Patricia Magadán-Corpas, Claudio J. Villar, Felipe Lombó Microbial Cell Factories.2023;[Epub] CrossRef
Antiviral Activity of Quercetin-3-Glucoside Against Non-Polio Enterovirus Hwa-Jung Choi Journal of Bacteriology and Virology.2022; 52(1): 20. CrossRef
Sakuranetin interacting with cell membranes models: Surface chemistry combined with molecular simulation Guilherme Henrique da Cruz Ramos Pires, Vitor Torres Freire, Rafael Guimarães Pereira, Leonardo José Amaral de Siqueira, Eric Umehara, João Henrique Ghilardi Lago, Luciano Caseli Colloids and Surfaces B: Biointerfaces.2022; 216: 112546. CrossRef
Production of (2S)-sakuranetin from (2S)-naringenin in Escherichia coli by strengthening methylation process and cell resistance Qiumeng Sun, Song Gao, Shiqin Yu, Pu Zheng, Jingwen Zhou Synthetic and Systems Biotechnology.2022; 7(4): 1117. CrossRef
Sakuranetin State of the Art: Physical Properties, Biological Effects, and Biotechnological Trends Leonardo Ribeiro Bernardo, Anna Rafaela Cavalcante Braga Industrial Biotechnology.2022; 18(6): 341. CrossRef
Stevia Genus: Phytochemistry and Biological Activities Update Jimena Borgo, Laura C. Laurella, Florencia Martini, Cesar A. N. Catalán, Valeria P. Sülsen Molecules.2021; 26(9): 2733. CrossRef
Phytochemistry and teratogenic potential of Mimosa tenuiflora (willd.) poir. (Fabaceae) in ruminants: A systematic review José Jailson Lima Bezerra, Anderson Angel Vieira Pinheiro, Ricardo Barbosa Lucena Toxicon.2021; 195: 78. CrossRef
DO WE KNOW RHINOVIRUSES AND THEIR CLINICAL IMPACT? Irina Georgieva, Asya Stoyanova, Svetla Angelova, Savina Stoitsova, Silvia Voleva, Neli Korsun, Lubomira Nikolaeva-Glomb PROBLEMS of Infectious and Parasitic Diseases.2021; 49(1): 5. CrossRef
Flavonoids as Antiviral Agents for Enterovirus A71 (EV-A71) Salima Lalani, Chit Laa Poh Viruses.2020; 12(2): 184. CrossRef
A Review on Sources and Pharmacological Aspects of Sakuranetin Monika Stompor Nutrients.2020; 12(2): 513. CrossRef
Ethnopharmacologically important but underestimated genus Sorbus: a comprehensive review Agnieszka Sołtys, Agnieszka Galanty, Irma Podolak Phytochemistry Reviews.2020; 19(2): 491. CrossRef
The Sorbus spp.—Underutilised Plants for Foods and Nutraceuticals: Review on Polyphenolic Phytochemicals and Antioxidant Potential Viive Sarv, Petras Rimantas Venskutonis, Rajeev Bhat Antioxidants.2020; 9(9): 813. CrossRef
Suppression of influenzaBvirus replication by sakuranetin and mode of its action Dur‐Han Kwon, Jeong‐Hun Ji, Soon‐Ho Yim, Byoung‐Soo Kim, Hwa‐Jung Choi Phytotherapy Research.2018; 32(12): 2475. CrossRef
First
Prev
