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Novel Trend in Vaccine Research - Daniel Douek
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Osong Public Health and Research Perspectives 2011;2(Suppl 1):S8-S8.
DOI: https://doi.org/10.1016/j.phrp.2011.11.030
Published online: December 31, 2011
Senior Investigator and Chief, NIAID, NIH, USA
Copyright ©2012, Korea Centers for Disease Control and Prevention
This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License () which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
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dd class="first" id="idm140056325378960">Even before the partial success of a preventive HIV vaccine in a recent Phase III clinical trial, there has been an active discovery effort to determine one or more immune correlates of protection in HIV infection. This effort has been hampered by the lack of natural protective immunity against HIV. I will discuss lessons learned from the STEP and RV144 trials and how the Vaccine Research Center is proceeding with the HVTN505 study. I will discuss efforts to elicit broadly neutralizing antibodies and the importance of establishing correlates of immunity from studies in humans.
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