Introduction

Intestinal parasitic infections were highly prevalent until 1970s in Korea, especially among residents of major river basins of the country. During the past decade, a rapid decrease in the overall prevalence of intestinal parasites has been observed and is attributed mainly by nationwide control programs and health education undertaken by the Korean government along with increases in living conditions and quality of life among people living in Korea. Despite the remarkable decrease in soil-transmitted nematode infections,¹ however, the prevalence of fish-borne trematode infections such as with Clonorchis sinensis and Metagonimus yokogawai has been maintained at relatively high level.

The liver fluke, C. sinensis, is currently the most important parasite infecting humans in Korea. Egg positive rates of C. sinensis in general population were 4.6% in 1971, 1.8% in 1976, 2.6% in 1981, 2.7% in 1986, 2.2% in 1992, 1.4% in 1997, and 2.4% in 2004.² In 1981, the egg positive rates of people living in those river basins differed considerably; 40.2% in Nakdonggang, 30.8% in Yeongsangang, 17.3% in Seomjingang, 15.7% in Hangang, 15.9% in Tamjingang, 12.0% in Geumgang, and 8.0% in Mangyeonggang Rivers.³

The infection of C. sinensis is contracted by eating undercooked fishes that harbour the metacercariae. Contaminated fishes are mainly found from streams and rivers where the freshwater snail Parafossarulus manchouricus thrive. The liver fluke in the biliary passage provokes severe pathologic changes therein, such as bile duct dilatation, ductal wall thickening, ductal inflammation, biliary mucosal hyperplasia, and biliary cirrhosis. The infection with C. sinensis was also found to induce cholangiocarcinoma in experimental hamsters acting as a promoter.⁴ Clonorchiasis has been recognized as one of several factors of cholangiocarcinoma in humans.^5,6

Although some local data are previously available on this issue, no nationwide surveys have been conducted. The present survey on the prevalence and distribution of human clonorchiasis is one of the prerequisites for the government to implement its national control measures.

Materials and Methods

2.1 Surveyed area

Twenty-nine counties (Figure 1 and Table 1) were selected in five major river basins, which were located near or alongside the major rivers of Korea with reference to the nationwide survey in 2004.² The study was undertaken for 1 year from January to December 2007.

2.2 Stool collection and examination

Stool specimens were collected in plastic containers and transferred to the laboratory of National Institute of Health. A total of 31,268 subjects were recruited from villages for stool collection by a random household sampling method to assess the prevalence of parasitic infection. The formalin-ether sedimentation technique was used to examine helminth eggs, larvae, and protozoan cysts. One gram of each faecal sample was fixed with 10% neutral formalin in a 10-mL test tube. The formalin-fixed stool specimen was further processed by the formalin-ether concentration technique and examined for parasites in the laboratory. Parasite-positive individuals were treated with praziquantel and other appropriate anti-parasitic drugs at the end of the study.

Results

3.1 Number of positive cases of total intestinal parasites

Of 31,268 stool samples examined, 2957 (9.5%) were found to contain various intestinal parasite eggs, cysts, or larvae. Eggs of C. sinensis, Heterophyes spp., Echinostoma spp., Trichuris trichiura, Ascaris lumbricoides, Gymnophalloide seoi, and Trichostrongylus orientalis were detected from 2542 (8.1%), 255 (0.8%), 36 (0.1%), 30 (0.1%), 8 (0.03%), 7 (0.02%), and 5 (0.02%) individuals, respectively. Protozoan cysts were detected from 133 (1.3%) individuals for Entamoeba spp. and 50 (0.2%) for Giardia lamblia (Table 2).

3.2 Egg positive cases of C. sinensis by river basin and gender

Infection rates of C. sinensis by river basin, locality, and gender are summarized in Table 3. The overall egg positive rate of C. sinensis was 8.1%. The highest rate was observed in the Nakdonggang River basin, which showed an average infection rate of 12.2%, ranging from 2.8% to 23.1% by counties. Yecheon-gun showed the highest rate at 23.1%, followed by Sangju-si (20.8%). The next highest rate was observed in the Seomjingang River basin with an average infection rate of 9.5%, ranging from 6.8% to 14.4%. The lowest infection rate was observed in the Hangang River basin, which showed an average of 1.0%.

The egg positive rate of C. sinensis was higher in male (10.6%) than in female (6.1%). The highest rate of male residents infected with C. sinensis was observed in the Nakdonggang River basin, which showed an average infection rate of 15.3%, ranging from 3.6% to 28.5%. Male residents living in Yecheon-gun showed the highest infection rate at 28.5%, followed by Sangju-si (22.9%). The next highest rate was observed in the Seomjingang River basin (12.7%), followed by the Yeongsangang (5.1%) and the Geumgang (4.6%) River basins. The overall egg positive rate of female residents was 6.1%. The highest female egg positive rate was also observed in the Nakdonggang River basin with an average of 9.7%, ranging from 1.8% to 19.2%. The next highest rate was in the Seomjingang River basin (6.8%), followed by Yeongsangang (2.1%), Geumgang (1.8%), and Hangang (0.6%) River basins.

3.3 Egg positive cases of C. sinensis by age group

Among the 31,268 cases examined by age group, the positive rate of C. sinensis was highest in the age group between 50 and 59 years (10.4%), followed by the order of 40–49 (8.7%), 60–69 (8.3%), and 70–79 (7.7%) years (Table 4).

Discussion

The present study indicated that the overall prevalence of intestinal parasites was 9.5% and 2957 individuals were infected with 13 species of intestinal parasites. This result, however, is considerably lower than that of 2006, which was observed a 14.3% positive rate in southern endemic areas.⁷

The positive rate of C. sinensis was the highest, covering 85.6% of all positive cases. The egg positive rate of C. sinensis (8.1%) decreased slightly compared with the result of 2006 investigation. In the nationwide surveys in 1997 and 2004, C. sinensis positive rates were 1.4% and 2.4%, respectively, and these results suggested that C. sinensis are prevalent along major river basins. The present study was mainly focused on residents of villages where clonorchiasis has been endemic or suspected. Thus, it is the main reason for the higher egg positive rate of C. sinensis of the present study (8.1%) than that (2.4%) of 2004.

Clonorchiasis has been regarded as a persisting helminthiasis and has largely disappeared throughout the country.¹ In 2006, the total egg positive rate of C. sinensis was 11.1% among residents living in the river basins of South Korea. The egg positive rates observed in the river basins of Nakdonggang, Seomjingang, Yeongsangang, and Geumgang were 17.1%, 11.2%, 5.5%, and 4.6%, respectively. In 2007, the total egg positive rate of C. sinensis was 8.1% (Table 3). The positive rates observed in the river basins of Nakdonggang, Seomjingang, Yeongsangang, Geumgang, and Hangang were 12.2%, 9.5%, 3.3%, 3.1% and 1.0%, respectively (Table 3). Especially, the river basins of Nakdonggang and Seomjingang Rivers still appear to be endemic.

The average egg positive rate of C. sinensis among male was 10.6%, which ranged from 0.2% to 28.5% by river basin areas, whereas the average positive rate among female was 6.1% with a range from 0.2% to 19.2% (Table 3). Infection rates of male and female residents showed between 3.0% and 2.8% decrease compared with results of 2006.

The egg positive rate increased as age increased, reaching a maximum of 10.4% in the age group of 50–59- years (Table 3), followed by 40–49 (8.4%), 60–69 (8.3%), 70–79 (7.7%), and older than 80 (6.5%) years. The infection status of C. sinensis among Koreans by age in this study showed the same peak at the 50- to 59-year-old group as compared with the result in 2006.³ This result appears to be the typical pattern of C. sinensis infection, showing a peak at the age group of 40–49 or 50–59 years,⁷ which is then rapidly decreased afterwards. Because the life span of C. sinensis is known to be up to 30 years, the infection peak in the age group of 50s is comprehended as an accumulation effect of reinfection or superinfection with age because epidemiologic studies indicate that humans do not develop any resistance to reinfection or superinfection by the parasites.⁴ However, the egg positive rate decreased after the peak, in spite of the cumulative effect in the age group of 60s or more. This decreasing phenomenon in senior groups has been commonly observed in previous investigations^4,7–9 and may suggest the possibility of shorter lifespan of residents with clonorchiasis than those of uninfected ones at the endemic areas.¹⁰ This decrease of 27% compared with the previous year appears to be an outcome of low endemicity by praziquantel medication. The clonorchiasis in the endemic area of South Korea is under continuous anthelminthic intervention, and the intervention makes the decrease in positive rate.¹¹ Our data have been updated the status of clonorchiasis in endemic area of Korea as reduced egg positive rate and lower intensity of infection compared with previous reports.^3,8,9,11,12

In conclusion, the result of this study revealed little decrease in positive rate of C. sinensis compared with the result of southern endemic areas of Korea in 2006. Therefore, continuous and repeated praziquantel medication is necessary in the endemic in Korea.

Article information

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

References

• 1. Hong S.T., Chai J.Y., Choi M.H.. A successful experience of soil-transmitted helminth control in the Republic of Korea. Korean J Parasitol 44:2006;177−185. PMID: 16969055.ArticlePubMedPMC
• 2. Prevalence of Intestinal Parasitic Infections in Korea. The 7th Report.
• 3. Seo B.S., Lee S.H., Cho S.Y.. An epidemiologic study on clonorchiasis and metagonimiasis in riverside areas in Korea. Korean J Parasitol 19:1981;137−150.Article
• 4. Lee J.H., Yang H.M., Bak U.B., Rim H.J.. Promoting role of Clonorchis sinensis infection on induction of cholangiocarcinoma during two-step carcinogenesis. Korean J Parasitol 32:1994;13−18. PMID: 8167103.ArticlePubMed
• 5. Shim H.S., Lim B.J., Kim M.J.. Mucinous cholangiocarcinoma associated with Clonorchis sinensis infestation: a case report. Korean J Hepatol 10:2004;223−227. PMID: 15385717.PubMed
• 6. Choi D., Lim J.H., Lee K.T.. Cholangiocarcinoma and Clonorchis sinensis infection: a case-control study in Korea. J Hepatol 44:2006;1066−1073. PMID: 16480786.ArticlePubMed
• 7. Cho S.H., Lee K.Y., Lee B.C.. Prevalence of clonorchiasis in southern endemic areas of Korea in 2006. Korean J Parasitol 46:2008;133−137. PMID: 18830051.ArticlePubMedPMC
• 8. Kim B.J., Ock M.S., Kim I.S., Yeo U.B.. Infection status of Clonorchis sinensis in residents of Hamyang-gun, Gyeongsangnam-do, Korea. Korean J Parasitol 40:2002;191−193. PMID: 12509104.ArticlePubMedPMC
• 9. Lee G.S., Cho I.S., Lee Y.H.. Epidemiological study of clonorchiasis and metagonimiasis along the Geum-gang (river) in Okcheon-gun (county), Korea. Korean J Parasitol 40:2002;9−16. PMID: 11949215.ArticlePubMedPMC
• 10. Hong S.T.. Clonorchis sinensis. (Chapter 35). Edited by Miliotis M.D., Bier J.W.: International Handbook of Foodborne Pathogens. 2003. Marcel Dekker, Inc.; USA: pp 581−592.
• 11. Hong S.T., Rim H.J., Min D.Y.. Control of clonorchiasis by repeated treatments with praziquantel. Korean J Parasitol 39:2001;285−292. PMID: 11775328.ArticlePubMedPMC
• 12. Rim H.J.. Clonorchiasis: an update. J Helminthol 79:2007;269−281. PMID: 16153321.Article

Figure 1

The surveyed areas and five major rivers located in Korea.

Table 1

The subject of investigation according to localities and sex.

Locality (river basin)		No. of residents examined
		Total*	Male	Female
Hangang	1	1,029	477	550
	2	988	453	535
	Subtotal	2,017	930	1,085
Guemgang	3	1,038	480	558
	4	868	390	478
	5	1,120	532	588
	6	1,056	528	528
	7	1,076	467	609
	Subtotal	5,158	2,397	2,761
Seomjingang	8	1,213	547	666
	9	2,424	1,120	1,304
	10	1,193	545	648
	11	1,072	508	563
	12	922	411	511
	Subtotal	6,824	3,131	3,692
Youngsangang	13	1,256	468	788
	14	1,098	426	672
	15	1,009	397	612
	16	1,049	503	546
	Subtotal	4,412	1,794	2,618
Nakdonggang	17	836	349	486
	18	919	430	489
	19	1,001	359	642
	20	1,002	334	668
	21	936	414	522
	22	1,175	515	660
	23	1,165	589	575
	24	880	371	509
	25	1,172	670	502
	26	695	302	393
	27	953	397	556
	28	1,163	526	637
	29	960	421	539
	Subtotal	12,857	5,677	7,178
Total		31,268	13,929	17,334

^∗ Sex unidentified: five.

Table 2

Positive cases of intestinal helminths and protozoa according to locality and parasites species

Locality (river basin)		No. of Examined	No. of Positive (%)	Helminth							Protozoa		Others*
				Cs (%)	Het	Ech	Gs	Al	Tt	To	Am	Gl
Hangang	1	1,029	21 (2.0)	19 (1.8)	1	0	0	0	0	0	0	2	0
	2	988	12 (1.2)	2 (0.2)	1	0	0	1	0	0	4	1	3
	Subtotal	2,017	33 (1.6)	21 (1.0)	2	0	0	1	0	0	4	3	3
Geumgang	3	1,038	9 (0.9)	3 (0.3)	0	0	0	0	1	0	3	1	1
	4	868	45 (5.2)	41 (4.7)	0	0	0	0	2	0	1	1	1
	5	1,120	37 (3.3)	30 (2.7)	0	0	0	0	3	0	4	1	0
	6	1,056	58 (5.5)	48 (4.5)	0	0	0	0	4	0	3	3	0
	7	1,076	45 (4.2)	37 (3.4)	5	0	0	1	1	0	0	0	1
	Subtotal	5,158	194 (3.8)	159 (3.1)	5	0	0	1	11	0	11	6	3
Seomjingang	8	1,213	96 (7.9)	83 (6.8)	5	0	0	0	0	0	7	2	3
	9	2,424	284 (11.7)	247 (10.2)	43	1	0	0	0	0	11	3	2
	10	1,193	124 (10.4)	111 (9.3)	4	0	0	0	1	2	7	2	0
	11	1,072	109 (10.2)	77 (7.2)	16	0	1	2	0	0	14	5	0
	12	922	182 (19.7)	133 (14.4)	50	0	0	0	0	0	11	2	0
	Subtotal	6,824	795 (11.7)	651 (9.5)	118	1	1	2	1	2	50	14	5
Youngsangang	13	1,256	101 (8.0)	40 (3.2)	37	33	0	0	1	0	7	1	0
	14	1,098	58 (5.3)	44 (4.0)	3	1	2	0	1	0	8	2	0
	15	1,009	41 (4.1)	30 (3.0)	10	0	1	0	0	0	5	1	0
	16	1,049	56 (5.3)	31 (3.0)	7	0	1	0	3	1	12	3	0
	Subtotal	4,412	256 (5.8)	145 (3.3)	57	34	4	0	5	1	32	7	0
Nakdonggang	17	836	109 (13.0)	99 (11.8)	10	0	0	0	0	0	0	0	0
	18	919	141 (15.3)	141 (15.3)	5	0	0	0	0	0	0	0	0
	19	1,001	63 (6.3)	59 (5.9)	4	0	0	0	0	0	0	0	0
	20	1,002	80 (8.0)	73 (7.3)	5	0	0	0	2	0	0	0	0
	21	936	149 (15.9)	142 (15.2)	1	0	1	0	2	0	2	1	0
	22	1,175	150 (12.8)	138 (11.7)	4	0	0	0	1	1	4	4	0
	23	1,165	154 (13.2)	145 (12.4)	6	0	0	0	1	0	2	6	0
	24	880	101 (11.5)	98 (11.1)	3	0	0	0	0	0	0	0	0
	25	1,172	57 (4.9)	33 (2.8)	0	0	1	2	1	0	19	0	1
	26	695	103 (14.8)	94 (13.5)	14	0	0	0	2	0	0	0	0
	27	953	211 (22.1)	198 (20.8)	3	1	0	0	3	1	2	7	1
	28	1,163	131 (11.3)	124 (10.7)	10	0	0	0	1	0	3	0	0
	29	960	230 (24.0)	222 (23.1)	8	0	0	2	0	0	4	2	2
	Subtotal	12,857	1,679 (13.1)	1,566 (12.2)	73	1	2	4	13	2	36	20	4
Total		31,268	2,957 (9.5)	2,542 (8.1)	255	36	7	8	30	5	133	50	15

Cs, Clonorchis sinensis; Het, Heterophyes spp.; Ech, Echinostoma spp.; Gs, Gymnophalloides seoi; Al, Ascaris lumbricoides; Tt, Trichuris trichiura; To, Trichostrongylus orientalis; Am, Entamoeba spp.; Gl, Giardia lamblia.

^∗ Hook worm, Diphyllobothrium latum, Enterobius vermicularis, Paragonimus westermani

Table 3

Positive rates of C. sinensis according to localities and gender.

Locality (river basin)		Total∗		Male		Female
		No. of Examined	No. of Positive (%)	No. of Examined	No. of Positive (%)	No. of Examined	No. of Positive (%)
Hangang	1	1,029	19 (1.8)	477	13 (2.7)	550	6 (1.1)
	2	988	2 (0.2)	453	1 (0.2)	535	1 (0.2)
	Subtotal	2,017	21 (1.0)	930	14 (1.5)	1,085	7 (0.6)
Guemgang	3	1,038	3 (0.3)	480	2 (0.4)	558	1 (0.2)
	4	868	41 (4.7)	390	23 (5.9)	478	18 (3.8)
	5	1,120	30 (2.7)	532	24 (4.5)	588	6 (1)
	6	1,056	48 (4.5)	528	33 (6.3)	528	15 (2.8)
	7	1,076	37 (3.4)	467	28 (6)	609	9 (1.5)
	Subtotal	5,158	159 (3.1)	2,397	110 (4.6)	2,761	49 (1.8)
Seomjingang	8	1,213	83 (6.8)	547	61 (11.2)	666	22 (3.3)
	9	2,424	247 (10.2)	1,120	149 (13.3)	1,304	98 (7.5)
	10	1,193	111 (9.3)	545	71 (13)	648	40 (6.2)
	11	1,072	77 (7.2)	508	40 (7.9)	563	36 (6.4)
	12	922	133 (14.4)	411	77 (18.7)	511	56 (11)
	Subtotal	6,824	651 (9.5)	3,131	398 (12.7)	3,692	252 (6.8)
Youngsangang	13	1,256	40 (3.2)	468	24 (5.1)	788	16 (2)
	14	1,098	44 (4.0)	426	28 (6.6)	672	16 (2.4)
	15	1,009	30 (3.0)	397	16 (4)	612	14 (2.3)
	16	1,049	31 (3.0)	503	23 (4.6)	546	8 (1.5)
	Subtotal	4,412	145 (3.3)	1,794	91 (5.1)	2,618	54 (2.1)
Nakdonggang	17	836	99 (11.8)	349	49 (14)	486	50 (10.3)
	18	919	141 (15.3)	430	73 (17)	489	68 (13.9)
	19	1,001	59 (5.9)	359	31 (8.6)	642	28 (4.4)
	20	1,002	73 (7.3)	334	36 (10.8)	668	37 (5.5)
	21	936	142 (15.2)	414	74 (17.9)	522	68 (13)
	22	1,175	138 (11.7)	515	81 (15.7)	660	57 (8.6)
	23	1,165	145 (12.4)	589	97 (16.5)	575	48 (8.3)
	24	880	98 (11.1)	371	56 (15.1)	509	42 (8.3)
	25	1,172	33 (2.8)	670	24 (3.6)	502	9 (1.8)
	26	695	94 (13.5)	302	58 (19.2)	393	36 (9.2)
	27	953	198 (20.8)	397	91 (22.9)	556	107 (19.2)
	28	1,163	124 (10.7)	526	78 (14.8)	637	46 (7.2)
	29	960	222 (23.1)	421	120 (28.5)	539	102 (18.9)
	Subtotal	12,857	1,566 (12.2)	5,677	868 (15.3)	7,178	698 (9.7)
Total		31,268	2,542 (8.1)	13,929	1,481 (10.6)	17,334	1,060 (6.1)

^∗ Sex unidentified: five

Table 4

Positive rates of C. sinensis according to localities and age groups

				Age group (yr)
Locality (river basin)		Total		1–19		20–29		30–39		40–49		50–59		60–69		70–79		Over 80		Unknown
		No. of Examined	No. of Positive (%)	No. of Examined	No. of Positive (%)	No. of Examined	No. of Positive (%)	No. of Examined	No. of Positive (%)	No. of Examined	No. of Positive (%)	No. of Examined	No. of Positive (%)	No. of Examined	No. of Positive (%)	No. of Examined	No. of Positive (%)	No. of Examined	No. of Positive (%)	No. of Examined	No. of Positive (%)
Hangang	1	1,029	19 (1.8)	65	0 (0.0)	18	0 (0.0)	44	0 (0.0)	167	5 (3.0)	249	6 (2.4)	244	3 (1.2)	153	1 (0.7)	28	2 (7.1)	61	2 (3.3)
	2	988	2 (0.2)	39	0 (0.0)	19	0 (0.0)	46	122	122	0 (0.0)	192	1 (0.5)	324	0 (0.0)	198	1 (0.5)	42	0 (0.0)	6	0 (0.0)
	Subtotal	2,017	21 (1.0)	104	0 (0.0)	37	0 (0.0)	90	0 (0.0)	289	5 (1.7)	441	7 (1.6)	568	3 (0.5)	351	2 (0.6)	70	2 (2.9)	67	2 (3.0)
Guemgang	3	1,038	3 (0.3)	10	0 (0.0)	15	0 (0.0)	42	0 (0.0)	122	1 (0.8)	194	0 (0.0)	275	1 (0.4)	295	1 (0.3)	69	0 (0.0)	16	0 (0.0)
	4	868	41 (4.7)	91	0 (0.0)	39	1 (2.6)	46	2 (4.3)	116	8 (6.9)	137	12 (8.8)	205	11 (5.4)	188	7 (3.7)	35	0 (0.0)	11	0 (0.0)
	5	1,120	30 (2.7)	0	0 (0.0)	33	1 (3.0)	62	2 (3.2)	114	5 (4.4)	250	9 (3.6)	320	5 (1.6)	287	8 (2.8)	46	0 (0.0)	8	0 (0.0)
	6	1,056	48 (4.5)	78	0 (0.0)	24	0 (0.0)	55	0 (0.0)	161	5 (3.1)	257	13 (5.1)	233	22 (9.4)	165	6 (3.6)	34	2 (5.9)	49	0 (0.0)
	7	1,076	37 (3.4)	94	0 (0.0)	14	0 (0.0)	38	3 (7.9)	124	7 (5.6)	179	12 (6.7)	311	10 (3.2)	244	4 (1.6)	72	1 (1.4)	0	0 (0.0)
	Subtotal	5,158	159 (3.1)	273	0 (0.0)	125	2 (1.6)	243	7 (2.9)	637	26 (4.1)	1,017	46 (4.5)	1,344	49 (3.6)	1,179	26 (2.2)	256	3 (1.2)	84	0 (0.0)
Seomjingang	8	1,213	83 (6.8)	48	1 (2.1)	13	1 (7.7)	50	1 (2.0)	136	10 (7.4)	194	17 (8.8)	349	25 (7.2)	340	23 (6.8)	81	5 (6.2)	2	0 (0.0)
	9	2,424	247 (10.2)	37	1 (2.7)	31	1 (3.2)	81	6 (7.4)	304	25 (8.2)	421	47 (11.2)	750	79 (10.5)	617	67 (10.9)	135	13 (9.6)	48	8 (16.7)
	10	1,193	111 (9.3)	2	0 (0.0)	9	1 (11.1)	31	2 (6.5)	95	13 (13.7)	213	26 (12.2)	365	31 (8.5)	383	33 (8.6)	82	5 (6.1)	13	0 (0.0)
	11	1,072	77 (7.2)	74	1 (1.4)	44	1 (2.3)	56	6 (10.7)	125	13 (10.4)	215	15 (7.0)	274	23 (8.4)	209	14 (6.7)	44	1 (2.3)	31	3 (9.7)
	12	922	133 (14.4)	26	4 (15.4)	12	2 (16.7)	36	6 (16.7)	94	16 (17.0)	156	28 (17.9)	267	37 (13.9)	269	35 (13.0)	62	5 (8.1)	0	0 (0.0)
	Subtotal	6,824	651 (9.5)	187	7 (3.7)	109	6 (5.5)	254	21 (8.3)	754	77 (10.2)	1,199	133 (11.1)	2,005	195 (9.7)	1,818	172 (9.5)	404	29 (7.2)	94	11 (11.7)
Youngsangang	13	1,256	40 (3.2)	36	0 (0.0)	28	0 (0.0)	28	1 (3.6)	134	5 (3.7)	240	8 (3.3)	435	16 (3.7)	296	9 (3.0)	58	1 (1.7)	1	0 (0.0)
	14	1,098	44 (4.0)	11	0 (0.0)	14	0 (0.0)	25	1 (4.0)	88	2 (2.3)	216	12 (5.6)	390	16 (4.1)	289	11 (3.8)	65	2 (3.1)	0	0 (0.0)
	15	1,009	30 (3.0)	4	0 (0.0)	14	0 (0.0)	39	0 (0.0)	91	1 (1.1)	154	9 (5.8)	278	7 (2.5)	303	10 (3.3)	82	1 (1.2)	44	2 (4.5)
	16	1,049	31 (3.0)	9	0 (0.0)	9	0 (0.0)	38	1 (2.6)	115	1 (0.9)	223	10 (4.5)	361	14 (3.9)	252	4 (1.6)	41	1 (2.4)	1	0 (0.0)
	Subtotal	4,412	145 (3.3)	60	0 (0.0)	65	0 (0.0)	130	3 (2.3)	428	9 (2.1)	833	39 (4.7)	1,464	53 (3.6)	1,140	34 (3.0)	246	5 (2.0)	46	2 (4.3)
Nakdonggang	17	836	89 (10.6)	1	0 (0.0)	4	0 (0.0)	23	3 (13.0)	71	5 (7.0)	146	18 (12.3)	391	55 (14.1)	182	7 (3.8)	16	1 (6.3)	2	0 (0.0)
	18	919	141 (15.3)	69	1 (1.4)	4	0 (0.0)	24	4 (16.7)	91	19 (20.9)	160	31 (19.4)	316	55 (17.4)	210	28 (13.3)	35	3 (8.6)	10	0 (0.0)
	19	1,001	59 (5.9)	0	0 (0.0)	0	0 (0.0)	5	0 (0.0)	58	5 (8.6)	164	11 (6.7)	422	23 (5.5)	317	18 (5.7)	35	2 (5.7)	0	0 (0.0)
	20	1,002	73 (7.3)	0	0 (0.0)	2	0 (0.0)	14	0 (0.0)	66	7 (10.6)	126	15 (11.9)	350	25 (7.1)	389	23 (5.9)	55	3 (5.5)	0	0 (0.0)
	21	936	142 (15.2)	18	1 (5.6)	11	0 (0.0)	34	4 (11.8)	97	14 (14.4)	205	41 (20.0)	282	37 (13.1)	239	37 (15.5)	34	3 (8.8)	16	5 (31.3)
	22	1,175	137 (11.7)	9	0 (0.0)	8	2 (25.0)	18	0 (0.0)	75	9 (12.0)	202	41 (20.3)	398	41 (10.3)	378	35 (9.3)	54	6 (11.1)	33	3 (9.1)
	23	1,165	145 (12.4)	24	2 (8.3)	22	2 (9.1)	37	1 (2.7)	147	26 (17.7)	309	56 (18.1)	346	33 (9.5)	248	22 (8.9)	30	3 (10.0)	2	0 (0.0)
	24	880	98 (11.1)	15	0 (0.0)	9	0 (0.0)	41	3 (7.3)	110	13 (11.8)	216	31 (14.4)	276	30 (10.9)	171	20 (11.7)	17	0 (0.0)	25	1 (4.0)
	25	1,172	33 (2.8)	0	0 (0.0)	15	0 (0.0)	85	0 (0.0)	202	5 (2.5)	298	14 (4.7)	307	7 (2.3)	207	7 (3.4)	57	0 (0.0)	1	0 (0.0)
	26	695	94 (13.5)	17	0 (0.0)	29	5 (17.2)	40	4 (10.0)	60	11 (18.3)	127	26 (20.5)	180	21 (11.7)	188	21 (11.2)	52	6 (11.5)	3	0 (0.0)
	27	953	198 (20.8)	62	4 (6.5)	25	3 (12.0)	31	3 (9.7)	103	13 (12.6)	168	42 (25.0)	271	68 (25.1)	227	49 (21.6)	60	15 (25.0)	6	1 (16.7)
	28	1,163	124 (10.7)	12	0 (0.0)	27	0 (0.0)	43	2 (4.7)	120	12 (10.0)	210	23 (11.0)	330	41 (12.4)	311	38 (12.2)	74	6 (8.1)	36	2 (5.6)
	29	960	222 (23.1)	3	0 (0.0)	6	1 (16.7)	20	1 (5.0)	125	31 (24.8)	203	54 (26.6)	258	54 (20.9)	278	66 (23.7)	67	15 (22.4)	0	0 (0.0)
	Subtotal	12,857	1,555 (12.1)	230	8 (3.5)	162	13 (8.0)	415	25 (6.0)	1,325	170 (12.8)	2,534	403 (15.9)	4,127	490 (11.9)	3,345	371 (11.1)	586	63 (10.8)	134	12 (9.0)
Total		31,268	2,531 (8.1)	854	15 (1.8)	498	21 (4.2)	1,132	56 (4.9)	3,433	287 (8.4)	6,024	628 (10.4)	9,508	790 (8.3)	7,833	605 (7.7)	1,562	102 (6.5)	425	27 (6.4)

Figure & Data

References

Citations

Citations to this article as recorded by  

• Infection characteristics of Metagonimus species (Digenea: Heterophyidae) metacercariae in fish from major rivers of Korea
  Woon-Mok Sohn
  Parasites, Hosts and Diseases.2024; 62(1): 1.     CrossRef
• Global prevalence of 4 neglected foodborne trematodes targeted for control by WHO: A scoping review to highlight the gaps
  Rachel Tidman, Kaushi S. T. Kanankege, Mathieu Bangert, Bernadette Abela-Ridder, Paul R. Torgerson
  PLOS Neglected Tropical Diseases.2023; 17(3): e0011073.     CrossRef
• Infection Characteristics of Clonorchis sinensis Metacercariae in Fish from Republic of Korea
  Woon-Mok Sohn
  The Korean Journal of Parasitology.2022; 60(2): 79.     CrossRef
• High Endemicity with Clonorchis sinensis Metacercariae in Fish from Yongjeon-cheon (Stream) in Cheongsong-gun, Gyeongsangbuk-do, Korea
  Woon-Mok Sohn, Byoung-Kuk Na, Shin-Hyeong Cho, Hee Il Lee, Myoung-Ro Lee, Jung-Won Ju, Gou Ok Kim
  The Korean Journal of Parasitology.2021; 59(1): 97.     CrossRef
• Survey of Zoonotic Trematode Metacercariae in Fish from Water Systems of Geum-gang (River) in Republic of Korea
  Woon-Mok Sohn, Byoung-Kuk Na, Shin-Hyeong Cho, Cheon-Hyeon Kim, Min-Ah Hwang, Kyeong-Woo No, Jai-Dong Kim
  The Korean Journal of Parasitology.2021; 59(1): 23.     CrossRef
• Risk Factors for Clonorchis sinensis Infection in Residents of Binyang, Guangxi: A Cross-Sectional and Logistic Analysis Study
  Meng Xu, Yanyan Jiang, Jianhai Yin, Shengkui Cao, Yujuan Shen, Jianping Cao
  Frontiers in Public Health.2021;[Epub]     CrossRef
• Prevalence and Infection Intensity of Zoonotic Trematode Metacercariae in Fish from Soyang-cheon (Stream), in Wanju-gun, Jeollabuk-do, Korea
  Woon-Mok Sohn, Byoung-Kuk Na, Shin-Hyeong Cho, Jung-Won Ju, Cheon-Hyeon Kim, Min-Ah Hwang, Kyeong-Woo No, Jong-Ho Park
  The Korean Journal of Parasitology.2021; 59(3): 265.     CrossRef
• Survey of Zoonotic Trematode Metacercariae in Fish from Irrigation Canal of Togyo-jeosuji (Reservoir) in Cheorwon-gun, Gangwon-do, Republic of Korea
  Woon-Mok Sohn, Byoung-Kuk Na, Shin-Hyeong Cho, Hee Il Lee, Jung-Won Ju, Myoung-Ro Lee, Eun-Joo Lim, Sung Yong Son, Eunmi Ko, Jaeseok Choi
  The Korean Journal of Parasitology.2021; 59(4): 427.     CrossRef
• Endemicity of Zoonotic Trematode Metacercariae in Fish from Deokcheon-gang (River) in Sancheong-gun, Gyeongsangnam-do, Republic of Korea
  Woon-Mok Sohn, Byoung-Kuk Na, Shin-Hyeong Cho, Hee Il Lee, Jung-Won Ju, Myoung-Ro Lee, Jeong-Gil Park, Jihee Ahn
  The Korean Journal of Parasitology.2021; 59(5): 523.     CrossRef
• Prevalence of Clonorchis sinensis infection in fish in South‐East Asia: A systematic review and meta‐analysis
  Ying Zhang, Qing‐Long Gong, Qing‐Bo Lv, Yang‐Yuan Qiu, Yan‐Chun Wang, Hong‐Yu Qiu, Xin‐Rui Guo, Jun‐Feng Gao, Qiao‐Cheng Chang, Chun‐Ren Wang
  Journal of Fish Diseases.2020; 43(11): 1409.     CrossRef
• Infection Status with Clonorchis sinensis Metacercariae in Fish from Yangcheon (Stream) in Sancheong-gun, Gyeongsangnam-do, Korea
  Woon-Mok Sohn, Byoung-Kuk Na, Shin-Hyeong Cho, Jung-Won Ju
  The Korean Journal of Parasitology.2019; 57(2): 145.     CrossRef
• Prevalence, Species Distribution, and Related Factors of Fish-Borne Trematode Infection in Ninh Binh Province, Vietnam
  Anh Kieu Thi Tran, Hoa Thuy Doan, Anh Ngoc Do, Van Thi Nguyen, Su Xuan Hoang, Huong Thu Thi Le, Hoa Thi Hoang, Nam Hoang Le, Quyen Bao Thi Le, Tran-Anh Le
  BioMed Research International.2019; 2019: 1.     CrossRef
• Infection Status with Digenetic Trematode Metacercariae in Fishes from Coastal Lakes in Gangwon-do, Republic of Korea
  Woon-Mok Sohn, Byoung-Kuk Na, Shin-Hyeong Cho, Soon-Won Lee
  The Korean Journal of Parasitology.2019; 57(6): 681.     CrossRef
• Recombinant adenylate kinase 3 from liver fluke Clonorchis sinensis for histochemical analysis and serodiagnosis of clonorchiasis
  Soon Bin Kwon, Paul Kim, Hae Sun Woo, Tae Yun Kim, Ju Yeong Kim, Hye Min Lee, Yun Soo Jang, Eun-Min Kim, Tai-Soon Yong, Baik Lin Seong
  Parasitology.2018; 145(12): 1531.     CrossRef
• Prevalence and Intensity of Clonorchis sinensis Metacercariae in Freshwater Fish from Wicheon Stream in Gunwi-gun, Gyeongsangbuk-do, Korea
  Woon-Mok Sohn, Byoung-Kuk Na, Shin-Hyeong Cho, Jung-Won Ju, Dong-Chul Son
  The Korean Journal of Parasitology.2018; 56(1): 41.     CrossRef
• Epidemiological and Clinical Parameters Features of Patients with Clonorchiasis in the Geum River Basin, Republic of Korea
  Hee-Eun Shin, Myoung-Ro Lee, Jung-Won Ju, Byong-Suk Jeong, Mi-Yeoun Park, Keoung-Sook Lee, Shin-Hyeong Cho
  Interdisciplinary Perspectives on Infectious Disea.2017; 2017: 1.     CrossRef
• A new method for estimating the prevalence of clonorchiasis in Korea
  Jin-Young Jeong, Jin Yong Lee, Byung-Suk Chung, Younghyun Choi, Allison Baer Alley, Hyun Joo Kim
  Medicine.2017; 96(13): e6536.     CrossRef
• Prevalence of Clonorchis sinensis Infection among Residents along 5 Major Rivers in the Republic of Korea
  Young-Il Jeong, Hee-Eun Shin, Sang-Eun Lee, Hyeng-Il Cheun, Jung-Won Ju, Jung-Yeon Kim, Mi Yeoun Park, Shin-Hyeong Cho
  The Korean Journal of Parasitology.2016; 54(2): 215.     CrossRef
• Trematode Metacercariae in Freshwater Fish from Water Systems of Hantangang and Imjingang in Republic of Korea
  Woon-Mok Sohn, Byoung-Kuk Na, Shin-Hyeong Cho, Soon-Won Lee, Seung-Bong Choi, Won-Seok Seok
  The Korean Journal of Parasitology.2015; 53(3): 289.     CrossRef
• Prevalence and Risk Factors of Clonorchiasis among Residents of Riverside Areas in Muju-gun, Jeollabuk-do, Korea
  Do-Soon Park, Sung-Jin Na, Shin Hyeong Cho, Kyung Ja June, Young-Chae Cho, Young-Ha Lee
  The Korean Journal of Parasitology.2014; 52(4): 391.     CrossRef
• Prevalence and Risk Factors of Clonorchiasis among the Populations Served by Primary Healthcare Posts along Five Major Rivers in South Korea
  Kyung Ja June, Shin Hyeong Cho, Won Ja Lee, Chunmi Kim, Kyung-Soon Park
  Osong Public Health and Research Perspectives.2013; 4(1): 21.     CrossRef