Figure 1Number and rate of tuberculosis notification in 2001–2010.
Figure 2Study population.
Figure 3Relapse rate of tuberculosis by year (2006–2010).
Figure 4Proportion of relapse of tuberculosis by year (2006–2010).
Table 1General characteristics of the study population.
|
|
Total (no.) |
Men (no.) |
Women (no.) |
p
|
Age (y) |
0–9 |
214 |
113 |
101 |
< 0.0001 |
|
10–19 |
2,443 |
1,490 |
953 |
|
|
20–29 |
8,134 |
4,263 |
3,871 |
|
|
30–39 |
7,299 |
4,510 |
2,789 |
|
|
40–49 |
7,338 |
5,251 |
2,087 |
|
|
50–59 |
5,675 |
4,148 |
1,527 |
|
|
60–69 |
6,293 |
4,236 |
2,057 |
|
|
≥ 70 |
8,038 |
4,197 |
3,841 |
|
Region |
1 |
12,085 |
7,309 |
4,776 |
< 0.0001 |
|
2 |
4,531 |
2,799 |
1,732 |
|
|
3 |
2,155 |
1,364 |
791 |
|
|
4 |
1,854 |
1,186 |
668 |
|
|
5 |
1,386 |
850 |
536 |
|
|
6 |
1,048 |
637 |
411 |
|
|
7 |
681 |
432 |
249 |
|
|
8 |
6,747 |
4,221 |
2,526 |
|
|
9 |
2,130 |
1,206 |
924 |
|
|
10 |
1,265 |
787 |
478 |
|
|
11 |
1,841 |
1,205 |
636 |
|
|
12 |
2,101 |
1,329 |
772 |
|
|
13 |
1,946 |
1,247 |
699 |
|
|
14 |
2,106 |
1,284 |
822 |
|
|
15 |
3,157 |
2,089 |
1,068 |
|
|
16 |
401 |
263 |
138 |
|
Registration |
New |
34,569 |
20,631 |
13,938 |
< 0.0001 |
Type |
Relapse |
5,611 |
4,095 |
1,516 |
|
|
T.A.F. |
283 |
214 |
69 |
|
|
T.A.D. |
654 |
496 |
158 |
|
|
T.I. |
1,812 |
1,125 |
687 |
|
|
Other |
2,505 |
1,647 |
858 |
|
Tuberculosis type |
Sputum smear (+) pul TB |
15,745 |
10,251 |
5,494 |
< 0.0001 |
|
Sputum smear (−) pul TB |
23,437 |
14,773 |
8,700 |
|
|
Extrapulmonary TB |
6,216 |
3,184 |
3,032 |
|
Medication |
Only Group 1 drugs |
43,276 |
26,757 |
16,519 |
< 0.0001 |
|
With Groups 2–5 drugs |
2,158 |
1,451 |
707 |
|
Total |
45,434 |
28,208 |
17,226 |
|
Table 2Relapse rate of tuberculosis by the characteristics of the study population.
|
|
Relapse
|
p
|
No |
Yes |
Sex |
Men |
25,145 |
(89.14) |
3,063 |
(10.86) |
< 0.0001 |
|
Women |
15,918 |
(92.41) |
1,308 |
(7.59) |
|
Age (y) |
0–9 |
207 |
(96.73) |
7 |
(3.27) |
< 0.0001 |
|
10–19 |
2,256 |
(92.35) |
187 |
(7.65) |
|
|
20–29 |
7,417 |
(91.19) |
717 |
(8.81) |
|
|
30–39 |
6,583 |
(90.19) |
716 |
(9.81) |
|
|
40–49 |
6,494 |
(88.50) |
844 |
(11.50) |
|
|
50–59 |
5,092 |
(89.73) |
583 |
(10.27) |
|
|
60–69 |
5,662 |
(89.97) |
631 |
(10.03) |
|
|
≥ 70 |
7,352 |
(91.47) |
686 |
(8.53) |
|
Medical |
Public |
11,412 |
(91.03) |
1,124 |
(8.97) |
0.0004 |
Facilities |
Private |
29,651 |
(90.13) |
3,247 |
(9.87) |
|
Registration |
New |
31,756 |
(91.86) |
2,813 |
(8.14) |
< 0.0001 |
Type |
Relapse |
4,772 |
(85.05) |
839 |
(14.95) |
|
|
T.A.F. |
222 |
(78.45) |
61 |
(21.55) |
|
|
T.A.D. |
490 |
(74.92) |
164 |
(25.08) |
|
|
T.I. |
1,622 |
(89.51) |
190 |
(10.49) |
|
|
Other |
2,201 |
(87.86) |
304 |
(12.14) |
|
TB type |
Sputum smear (+) pul TB |
13,797 |
(87.63) |
1,948 |
(12.37) |
< 0.0001 |
|
Sputum smear (−) pul TB |
21,426 |
(91.28) |
2,047 |
(8.72) |
|
|
Extra–pul TB |
5,840 |
(93.95) |
376 |
(6.05) |
|
Medication |
Only Group 1 drugs |
39,248 |
(90.69) |
4,028 |
(9.31) |
<.0001 |
|
With Groups 2–5 drugs |
1,815 |
(84.11) |
343 |
(15.89) |
|
Region |
1 |
11,139 |
(92.17) |
946 |
(7.83) |
< 0.0001 |
|
2 |
3,896 |
(85.99) |
635 |
(14.01) |
|
|
3 |
1,946 |
(90.30) |
209 |
(9.70) |
|
|
4 |
1,671 |
(90.13) |
183 |
(9.87) |
|
|
5 |
1,290 |
(93.07) |
96 |
(6.93) |
|
|
6 |
943 |
(89.98) |
105 |
(10.02) |
|
|
7 |
617 |
(90.60) |
64 |
(9.40) |
|
|
8 |
6,228 |
(92.31) |
519 |
(7.69) |
|
|
9 |
1,899 |
(89.15) |
231 |
(10.85) |
|
|
10 |
1,156 |
(91.38) |
109 |
(8.62) |
|
|
11 |
1,658 |
(90.06) |
183 |
(9.94) |
|
|
12 |
1,930 |
(91.86) |
171 |
(8.14) |
|
|
13 |
1,690 |
(86.84) |
256 |
(13.16) |
|
|
14 |
1,892 |
(89.84) |
214 |
(10.16) |
|
|
15 |
2,735 |
(86.63) |
422 |
(13.37) |
|
|
16 |
373 |
(93.02) |
28 |
(6.98) |
|
Total |
41,063 |
(90.38) |
4,371 |
(9.62) |
|
Table 3Results of multivariate logistic regression analysis.
|
|
OR (95% CI) |
Sex |
Men |
1.33 (1.24–1.43) |
|
Women |
1 |
Age (y) |
0–9 |
0.43 (0.20–0.93) |
|
10–19 |
1 |
|
20–29 |
1.07 (0.91–1.27) |
|
30–39 |
1.10 (0.93–1.31) |
|
40–49 |
1.20 (1.01–1.42) |
|
50–59 |
1.02 (0.86–1.22) |
|
60–69 |
1.04 (0.87–1.23) |
|
≥70 |
0.90 (0.76–1.07) |
Medical facilities |
Public |
1 |
|
Private |
1.23 (1.14–1.33) |
Registration type |
New |
1 |
|
Relapse |
1.76 (1.61–1.91) |
|
T.A.F. |
2.02 (1.50–2.72) |
|
T.A.D. |
3.18 (2.64–3.83) |
|
T.I. |
1.23 (1.05–1.44) |
|
Other |
1.42 (1.25–1.61) |
Tuberculosis type |
Sputum smear (+) pul TB |
1.42 (1.33–1.52) |
|
Sputum smear (−) pul TB |
1 |
|
Extrapulmonary TB |
0.70 (0.62–0.78) |
Medication |
Only Group 1 drugs |
1 |
|
With Groups 2–5 drugs |
1.32 (1.16–1.50) |
Region |
1 |
1 |
|
2 |
1.85 (1.66–2.06) |
|
3 |
1.19 (1.02–1.42) |
|
4 |
1.20 (1.01–1.42) |
|
5 |
0.85 (0.69–1.06) |
|
6 |
1.23 (0.99–1.52) |
|
7 |
1.20 (0.92–1.57) |
|
8 |
0.98 (0.87–1.10) |
|
9 |
1.42 (1.21–1.65) |
|
10 |
1.06 (0.86–1.30) |
|
11 |
1.29 (1.09–1.53) |
|
12 |
1.06 (0.90–1.26) |
|
13 |
1.71 (1.47–1.99) |
|
14 |
1.28 (1.09–1.50) |
|
15 |
1.66 (1.47–1.88) |
|
16 |
0.85 (0.58–1.26) |
Table 4Results of multivariate logistic regression analysis in public health centers.
|
|
OR (95% CI) |
Sex |
Men |
1.32 (1.14–1.52) |
|
Women |
1 |
Age (y) |
0–9 |
3.22 (0.32–32.27) |
|
10–19 |
1 |
|
20–29 |
1.02 (0.78–1.35) |
|
30–39 |
0.99 (0.75–1.32) |
|
40–49 |
0.96 (0.73–1.28) |
|
50–59 |
0.98 (0.73–1.33) |
|
60–69 |
1.02 (0.76–1.38) |
|
≥ 70 |
0.81 (0.60–1.09) |
Registration type |
New |
1 |
|
Relapse |
1.87 (1.60–2.18) |
|
T.A.F. |
3.35 (0.47–23.82) |
|
T.A.D. |
2.32 (1.64–3.29) |
|
T.I. |
1.09 (0.81–1.47) |
|
Other |
1.30 (0.85–1.98) |
Tuberculosis type |
Sputum smear (+) pul TB |
1.66 (1.45–1.88) |
|
Sputum smear (−) pul TB |
1 |
|
Extrapulmonary TB |
0.81 (0.45–1.48) |
Outcome |
Cure |
1 |
|
Complete |
1.39 (0.92–2.11) |
|
Failure |
10.26 (5.95–17.68) |
|
Default |
3.77 (3.03–4.68) |
|
Transfer out |
1.42 (1.17–1.73) |
|
Other |
2.41 (1.80–3.25) |
Region |
1 |
1 |
|
2 |
1.23 (0.96–1.58) |
|
3 |
1.25 (0.89–1.75) |
|
4 |
0.77 (0.54–1.09) |
|
5 |
1.63 (1.03–2.57) |
|
6 |
1.40 (0.94–2.09) |
|
7 |
0.73 (0.40–1.31) |
|
8 |
1.03 (0.84–1.28) |
|
9 |
1.18 (0.84–1.68) |
|
10 |
0.99 (0.68–1.45) |
|
11 |
1.44 (1.05–1.97) |
|
12 |
0.90 (0.62–1.30) |
|
13 |
1.47 (1.10–1.96) |
|
14 |
1.35 (1.02–1.79) |
|
15 |
1.77 (1.35–2.32) |
|
16 |
0.57 (0.30–1.09) |
Table 5Relapse rate of tuberculosis in public health centers.
|
|
Relapse
|
p
|
No |
Yes |
|
Sex |
Men |
7,511 |
(90.0) |
839 |
(10.0) |
< 0.0001 |
|
Women |
3,901 |
(93.2) |
285 |
(6.8) |
|
Age (y) |
0–9 |
4 |
(80.0) |
1 |
(20.0) |
0.002 |
|
10–19 |
1,115 |
(93.5) |
78 |
(6.5) |
|
|
20–29 |
2,377 |
(91.6) |
218 |
(8.4) |
|
|
30–39 |
1,855 |
(90.7) |
190 |
(9.3) |
|
|
40–49 |
1,762 |
(89.8) |
200 |
(10.2) |
|
|
50–59 |
1,195 |
(89.7) |
138 |
(10.3) |
|
|
60–69 |
1,411 |
(90.0) |
156 |
(10.0) |
|
|
≥ 70 |
1,693 |
(92.2) |
143 |
(7.8) |
|
Registration |
New |
8,684 |
(92.5) |
705 |
(7.5) |
< 0.0001 |
Type |
Relapse |
1,655 |
(85.1) |
289 |
(14.9) |
|
|
T.A.F |
3 |
(60.0) |
2 |
(40.0) |
|
|
T.A.D |
178 |
(78.8) |
48 |
(21.2) |
|
|
T.I |
677 |
(92.6) |
54 |
(7.4) |
|
|
Other |
215 |
(89.2) |
26 |
(10.8) |
|
TB type |
Sputum smear (+) pul TB |
4,585 |
(88.2) |
616 |
(11.8) |
< 0.0001 |
|
Sputum smear (−) pul TB |
6,615 |
(93.0) |
496 |
(7.0) |
|
|
Extrapulmonary TB |
212 |
(94.6) |
12 |
(5.4) |
|
Outcome |
Cure |
9,366 |
(92.7) |
735 |
(7.3) |
< 0.0001 |
|
Complete |
217 |
(88.9) |
27 |
(11.1) |
|
|
Failure |
28 |
(50.0) |
28 |
(50.0) |
|
|
Default |
428 |
(76.0) |
135 |
(24.0) |
|
|
Transfer out |
1,083 |
(88.6) |
139 |
(11.4) |
|
|
Other |
290 |
(82.9) |
60 |
(17.1) |
|
Region |
1 |
2,109 |
(91.54) |
195 |
(8.46) |
0.0002 |
|
2 |
967 |
(89.37) |
115 |
(10.63) |
|
|
3 |
430 |
(89.77) |
49 |
(10.23) |
|
|
4 |
606 |
(93.66) |
41 |
(6.34) |
|
|
5 |
212 |
(89.83) |
24 |
(10.17) |
|
|
6 |
277 |
(89.35) |
33 |
(10.65) |
|
|
7 |
223 |
(94.49) |
13 |
(5.51) |
|
|
8 |
2,422 |
(92.09) |
208 |
(7.91) |
|
|
9 |
468 |
(90.87) |
47 |
(9.13) |
|
|
10 |
438 |
(92.41) |
36 |
(7.59) |
|
|
11 |
539 |
(89.68) |
62 |
(10.32) |
|
|
12 |
491 |
(92.99) |
37 |
(7.01) |
|
|
13 |
667 |
(89.65) |
77 |
(10.35) |
|
|
14 |
716 |
(89.50) |
84 |
(10.50) |
|
|
15 |
655 |
(87.68) |
92 |
(12.32) |
|
|
16 |
192 |
(94.58) |
11 |
(5.42) |
|
Total |
11,412 |
(91.0) |
1,124 |
(9.0) |
|