aDepartment of Mycobacteriology and Pulmonary Research, Pasteur Institute of Iran, Tehran, Iran
bDepartment of Virology, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran
cDepartment of Hepatitis and AIDS, Pasteur Institute of Iran, Tehran, Iran
dDepartment of Immunology and Microbiology, Babol University of Medical Sciences, School of Medicine, Babol, Iran
eDepartment of Microbiology and Immunology, Faculty of Medicine, Qom University of Medical Sciences, Qom, Iran
fDepartment of Virology, Iran University of Medical Sciences, Tehran, Iran
Copyright © 2016 Korea Centers for Disease Control and Prevention. Published by Elsevier Korea LLC.
This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
IL28B |
rs12979860 |
|||
---|---|---|---|---|
Variable | CC | CT | TT | p |
HCV genotype (1a/3a) | 10/13 | 35/31 | 6/5 | 0.710 |
Baseline viral load (IU/mL) | 3.3 × 106 ± 1.7 × 106 | 4.6 × 106 ± 2.5 × 106 | 4.5 × 106 ± 2.4 × 106 | 0.127 |
AST (IU/L) | 243.4 ± 240.1 | 253.0 ± 183.3 | 239.7 ± 206.9 | 0.661 |
ALT (IU/L) | 248.8 ± 245.9 | 262.2 ± 217.3 | 251.1 ± 213.3 | 0.689 |
ALP (IU/L) | 586.4 ± 360.7 | 558.7 ± 481.6 | 656.3 ± 356.0 | 0.569 |
SVR | 18 | 34 | 4 | 0.032∗ |
Non-SVR | 5 | 32 | 7 |
Patient features | SVR | Non-SVR | Total | p |
---|---|---|---|---|
No. of patients (%) | 56 | 44 | 100 | — |
HCV genotype | ||||
1a | 18 (35.3) | 33 (64.7) | 51 (100) | < 0.001∗ |
3a | 38 (77.5) | 11 (22.5) | 49 (100) |
Characteristic | p | OR | 95% CI |
---|---|---|---|
HCV genotype | <0.001† | 7.42 | 2.605–21.105 |
Baseline viral load (IU/mL) | 0.327 | 1.00 | 1.000–1.000 |
IL28 (CC)† | 0.067 | 1 | |
IL28(TT) | 0.030b | 7.86 | 1.225–50.511 |
IL28(CT) | 0.048b | 4.08 | 1.010–16.524 |