<sec>
<title>Objectives</title>
<p>The aim of this study was to investigate comorbidities in patients with end-stage renal disease, and to compare health-related quality of life (HRQOL) according to the type, and number of comorbidities.</p></sec>
<sec>
<title>Methods</title>
<p>A total of 250 adults undergoing hemodialysis were recruited at local clinics. HRQOL was measured using the 12-item Medical Outcomes Study Short Form questionnaire. Data were analyzed using descriptive statistics, analysis of variance, and <italic>t</italic> test.</p></sec>
<sec>
<title>Results</title>
<p>Around 70.8% of patients with end stage renal disease had 1 or more comorbidities, and the most common comorbidities were hypertension, diabetes, and cardiovascular disease. HRQOL was significantly different based on the number of comorbidities (F = 9.83, <italic>p</italic> < 0.001). The effect of comorbidities on the scores for mental health domains of the HRQOL questionnaire was not conclusive compared with the scores for the physical domain which were conclusive. Among the comorbidities, diabetes was associated with a lower quality of life.</p></sec>
<sec>
<title>Conclusion</title>
<p>The customized management of diabetic and hypertensive patients is necessary for the early detection and prevention of chronic kidney disease, and slowing the progression of renal disease and managing cardiovascular risk factors is essential.</p></sec>
Citations
Citations to this article as recorded by
Impact of Transcatheter Aortic Valve Replacement Volume on Outcomes in Patients With End-Stage Renal Disease Esteban Aguayo, Oh Jin Kwon, Mitchell Won, Saad Mallick, Troy Coaston, Amulya Vadlakonda, Kevin Tabibian, Yas Sanaiha, Richard J. Shemin, Peyman Benharash The Annals of Thoracic Surgery.2026; 121(3): 589. CrossRef
PaCE CKD: A Multinational Survey of Health-Related Quality of Life in Patients with Chronic Kidney Disease and Caregivers Ricardo Correa-Rotter, Mai-Szu Wu, Richard Hull, Ciro Esposito, Helmut Reichel, Steven Chadban, Juan Jose Garcia Sanchez, Surendra Pentakota, Thames Kularatne, Simon Fifer, Hesham M. Elsayed Advances in Therapy.2026; 43(2): 791. CrossRef
Depression, Anxiety, Stress Symptoms and Health-Related Quality of Life in Hemodialysis Patients: Cross-Sectional Findings from a Romanian Cohort Adriana-Luciana Luca, Felicia Militaru, Cristina Mariana Văduva, Ilie-Robert Dinu, Daniela Teodora Maria, Mădălina Iuliana Mușat, Virginia Maria Rădulescu, Ion Udriștoiu, Eugen Moța Medicina.2026; 62(2): 242. CrossRef
The Effect of Wearable Technologies on Disease Management and Psychosocial Adaptation in Hemodialysis Patients: A Systematic Review Arzu Kavala, Tuğba ŞAHİN Tokatlioğlu Journal of Renal Care.2026;[Epub] CrossRef
Impact of Medical Comorbidities on Respiratory-Related Patient-Reported Outcome Measures in Fibrotic Interstitial Lung Disease Joon Yong Moon, Madison Beenken, Teng Moua Journal of Clinical Medicine.2026; 15(3): 1051. CrossRef
Health-related quality of life in patients on maintenance hemodialysis: Evidence from southern Iran using EQ-5D-5L and KDQOL-SF Hassan Karami, Neda Mohammadi, Maryam Shirvani Shiri, Najmeh Bordbar, Ali Mouseli, Reihaneh Taheri Kondar, Ali Rezvani, Mobina Vatankhah, Donovan Anthony McGrowder PLOS One.2026; 21(2): e0342155. CrossRef
Transplantation and Employment Earnings in Kidney Transplant Recipients Daisy Thomas, Calvin Diep, Ella Huszti, Juan Pablo Diaz-Martinez, Duminda Wijeysundera, Christopher D. Witiw, Blayne A. Sayed, Karim S. Ladha JAMA Network Open.2026; 9(2): e2560157. CrossRef
Factors Influencing the Quality of Self-Care among Continuous Ambulatory Peritoneal Dialysis Patients in Central Java, Indonesia: A Cross-Sectional Study Muhamad Syamsul Arif Setiyo Negoro, R Susanti, Yuni Wijayanti, Eram Tunggul Pawenang Korean Journal of Adult Nursing.2026; 38(1): 24. CrossRef
Postoperative Outcomes Among Dialysis Patients Undergoing Surgery for Cervical Spine Trauma Muhammad Zulfiqar, Ved A. Vengsarkar, Elizabeth Driskill, Adam L. Shimer, Stephen D. Lockey Spine.2026; 51(7): 478. CrossRef
Cost-effectiveness analysis of interprofessional collaboration in management of blood pressure in hemodialysis outpatients with end-stage renal disease Peri Peri, Azizah Nasution, Asrul Akmal Shafie, Alwi Thamrin Nasution Pharmacia.2026; 73: 1. CrossRef
Factors influencing the development and implementation of a prehabilitation program for kidney transplant candidates: A mixed-methods contextual analysis Avril J. Haanstra, Yvonne van der Veen, Heleen Maring, Evelien E. Quint, Adelita V. Ranchor, Stefan P. Berger, Stephan J.L. Bakker, Evelyn J. Finnema, Coby Annema International Journal of Nursing Studies Advances.2026; 10: 100558. CrossRef
Arteriovenous fistula creation results in cardiac dysfunction and remodeling in a uremic pig model Jamie Kane, Prabh Gurbaj Singh, Sreenivasulu Kilari, Gaurav Baranwal, Shreya Roy-Chowdhury, Atanu Naskar, Dan Montonye, Esther Lutgens, Ying Wang, Ahmed S. Negm, Jeremy D. Collins, Timmy Lee, Sanjay Misra American Journal of Physiology-Renal Physiology.2026; 330(6): F783. CrossRef
Predictors of waiting time for deceased donor kidney transplantation in Thailand: a competing risks analysis Supasiri Ounjai, Natkamol Chansatitporn, Prasong Kitidumrongsuk, Supanit Nivatvongs, Oytip Nathalang Journal of Hematology and Transfusion Medicine.2026; 36(99): 1. CrossRef
Determinants of Quality of Life Among Hemodialysis Patients: Roles of Associated Comorbidities, Smoking, Climate Change, and Residence Amany Gomaa Atia, Hani Jameel Hamad, Mohamed Ali Elsayed, Huda Badr Abd Elhamed, Hanaa Elsayed Elsayed Mohamed, Shimaa Galal El Sayed, Suraiya Saleem Journal of Nutrition and Metabolism.2026;[Epub] CrossRef
Senolytic Changes in Murine Arteriovenous Fistulas with CKD Jamie Kane, Sreenivasulu Kilari, Alaura Lemieux, Prabh G. Singh, Nathaniel Anderson, Dominik Saul, Tamar Tchkonia, James L. Kirkland, Sanjay Misra Kidney360.2026; 7(7): 1489. CrossRef
Real-world effectiveness and safety of difelikefalin for chronic kidney disease-associated pruritus: a systematic review Rocco Sheldon, Morya Wadodkar, Andrew Gan, Hung-Yeh Chien, Jyoti Baharani Renal Failure.2026;[Epub] CrossRef
Comorbidity in kidney transplant recipients I. T. Murkamilov, I. S. Sabirov, V. V. Fomin Nephrology and Dialysis.2026; 28(3): 343. CrossRef
A Scoping Review of Social Work Roles and Their Reported Impacts Across Chronic Kidney Disease and Kidney Failure Care Remona Ghuman, Joyce Mary, Alison MacLean, Eva Wang, Daniel Doh Health & Social Care in the Community.2026;[Epub] CrossRef
Testosterone deficiency in men with end stage renal disease and kidney transplantation: a narrative review Nicholas A. Deebel, Ashley N. Matthew, Justin Loloi, Ari P. Bernstein, Nannan Thirumavalavan, Ranjith Ramasamy International Journal of Impotence Research.2025; 37(4): 271. CrossRef
Predisposing, enabling, and need factors influencing health-related quality of life among people with metabolic syndrome Olajide A. Adekunle, Yun S. Wang, Ismaeel Yunusa, Marc L. Fleming, Enrique Seoane-Vazquez, Lawrence M. Brown Journal of the American Pharmacists Association.2025; 65(1): 102255. CrossRef
Correlations Between Spirituality, Anxiety, and Depression in Hemodialysis Patients in Saudi Arabia: A Cross-Sectional Study Ahmad M. Rayani, Michael W. Smart, Salman M. Alreshidi, Yazan D. Al-Mrayat, Mirna Fawaz, Abdulaziz M. Alodhailah, Ebtsam A. Abou Hashish, Hamad G. Dailah, Mashael F. Dewan, Ali Alhaiti, Mohammad Rababa Journal of Religion and Health.2025; 64(4): 2558. CrossRef
A continuous glucose monitoring device as a valuable tool for supporting diabetes care in haemodialysis patients: A qualitative interview study Sisse Heiden Laursen, Inger Vestergaard Kristensen, Hanne Ravn Larsen, Peter Vestergaard, Morten Hasselstrøm Jensen, Ole Kristian Hejlesen Nordic Journal of Nursing Research.2025;[Epub] CrossRef
Factors Associated with Re-attendance at Emergency Departments Among Older Adults: A Cross-Sectional Analytical Study Saengdao Janda, Juree Sansuk INQUIRY: The Journal of Health Care Organization, .2025;[Epub] CrossRef
Lifestyle Activities and their Impact on Patients Undergoing Hemodialysis in a National Guard Hospital in Saudi Arabia: A Cross-sectional Study Rasha Ahmed Fouad, Norah Hassan Alali, Madawi Abdullah Altulayhan, Bayan Abdullah Albasti, Njoud Khalid Saad Alobaid, Norah Adel Alhafith, May Yousef Abdulelah, Haneen Abdullah Almulhem, Manar Yasser Alyousef, Loga Priya Kaliyaperumal, Ghadah AlShaikh Mub Journal of Nursing Science and Professional Practi.2025; 2(2): 75. CrossRef
Exploring the quality of life of end-stage kidney disease patients in Khartoum State, Sudan: a multicenter cross-sectional study Hiba Ali Elzaki Hajomer, Osama Ahmed Elkhidir, Sara Elawad, Ahmed Balla M. Ahmed, Shaima Omer Mohamed Elawad, Mohamed H. Elbadawi, Wael Atif Fadl Elhassan, Rafa Awad Gasimelseed Mohamed, Kamil Merghani Ali, Tahani Amin Mahmoud, Sarra Mohamed Kheir BMC Nephrology.2025;[Epub] CrossRef
Necrotising Pneumonia in an Immunocompromised Patient with End-stage Renal Disease: A Case Study Mohamed Musthafa, Karthykeyan Natarajan National Journal of Emergency Medicine SEMI.2025; 3(2): 53. CrossRef
Hematological-based immuno-inflammatory indices in dialysis-dependent chronic kidney disease patients: a single-center study Shimaa Abdelmoneem, Ayman Fathy Arafa, Maha E.A. Shoieb, Ahmed Embaby, Manal M. Easa, Samia Hussein, Wesam M.R. Ashour, Batoul A. Hegazy, Elsayed Anany Metwally The Egyptian Journal of Haematology.2025; 50(3): 648. CrossRef
Experiences of Loss, Grief and Support Needs of Adults on Haemodialysis and Families: A Qualitative Explorative Study Jette Marcussen, Rikke Madsen, Ann Bonner, Jette Rude Nielsen, Hanne Agerskov Journal of Renal Care.2025;[Epub] CrossRef
Real-world safety of difelikefalin for chronic kidney disease–associated pruritus: initial insights from a European managed access programme Joerg Latus, Gert Mayer, Carlos Narvaez, Marius Manu, Sara Jesus, Despina Ruessmann, Lucio Manenti Clinical Kidney Journal.2025;[Epub] CrossRef
Comparison of Cardiorenal Syndrome and Heart Failure: A Preliminary Study of Clinical, Cognitive, and Emotional Aspects Maria Pagano, Anna Anselmo, Giuseppe Micali, Fabio Mauro Giambò, Francesco Speciale, Daniela Costanzo, Piercataldo D’Aleo, Antonio Duca, Alessia Bramanti, Marina Garofano, Placido Bramanti, Francesco Corallo, Irene Cappadona NeuroSci.2025; 6(4): 129. CrossRef
Association between heart failure and arteriovenous access patency in patients with end-stage renal disease on hemodialysis Andrea T. Fisher, Bianca Mulaney-Topkar, Brian M. Sheehan, Manuel Garcia-Toca, Ehab Sorial, Michael D. Sgroi Journal of Vascular Surgery.2024; 79(5): 1187. CrossRef
Left-Sided Pneumothorax in a Potential Kidney Transplant Recipient—A Surprise in the Surgical Ward: Case Report Zuzanna Jakubowska, Małgorzata Kępska-Dzilińska, Paweł Żebrowski, Michał Macech, Sławomir Nazarewski, Zbigniew Gałązka, Jolanta Małyszko Transplantation Proceedings.2024; 56(4): 992. CrossRef
Efficacy of Benson's Relaxation Technique on Stress and Pain Among Patients Undergoing Maintenance Hemodialysis: A Systematic Review Haya Ibrahim Ali Abu Maloh, Kim Lam Soh, Seng Choi Chong, Siti Irma Fadhilah Ismail, Kim Geok Soh, Dima Ibrahim Abu Maloh, Mohannad Eid AbuRuz SAGE Open Nursing.2024;[Epub] CrossRef
Psychometric and structural properties of the traditional Chinese version of the sleep condition indicator for patients undergoing hemodialysis Yu-Han Chang, Hsun-Hua Lee, Yi-Shu Liao, Ta-Wei Guu, Shu-Liu Guo, Faizul Hasan, Ya-Wen Jan, Hsin‑Chien Lee, Hsiao-Yean Chiu Sleep and Breathing.2024; 28(5): 2197. CrossRef
A Comparative Study of the Epidemiology and Risk Factors of Chronic Kidney Disease Among Rural and Urban Residents in Peshawar, Pakistan Junaid Ali, Shahin Shah, Muhammad Nadeem, Abroo Mahmood, Umair Ahmad Cureus.2024;[Epub] CrossRef
Eicosapentaenoic acid supplementation alleviates pruritus, enhances skin moisture, and mitigates depression in maintenance hemodialysis patients Ya-ling Lin, Chia-Liang Wang, Tsay-I Chiang Frontiers in Nephrology.2024;[Epub] CrossRef
Health-related quality of life in Indonesian hypertension outpatients in Western, Central, and Eastern Indonesia measured with the Bahasa Indonesia version of EQ-5D-5L Bustanul Arifin, Elly Wahyudin, Iman Setiawan, Yuliet, Veni Hadju, Eva Niamuzisilawati, Makiyatul Munawwaroh, Fredrick Dermawan Purba, Listia Discover Medicine.2024;[Epub] CrossRef
Occupational therapy for individuals with chronic kidney disease undergoing renal rehabilitation: A literature review Nikolaos Gerosideris, Symeon-Dimitrios Daskalou, Christina Ouzouni, Pinelopi Vlotinou, Ioanna-Giannoula Katsouri Brazilian Journal of Science.2024; 3(10): 16. CrossRef
Association of systemic immune-inflammation index with all-cause and cardio-cerebrovascular mortality in individuals with diabetic kidney disease: evidence from NHANES 1999-2018 Manhuai Zhang, Siyang Ye, Jianbo Li, Meng Zhang, Li Tan, Yiqin Wang, Peichen Xie, Huajing Peng, Suchun Li, Sixiu Chen, Qiong Wen, Kam Wa Chan, Sydney C. W. Tang, Bin Li, Wei Chen Frontiers in Endocrinology.2024;[Epub] CrossRef
Quality of Life in End-Stage Renal Disease Patients Undergoing Hemodialysis and Its Affecting Factors in a Hemodialysis Unit of General Hospital Denpasar Agustina Nila Yuliawati, Pande Made Desy Ratnasari, Ni Luh Putu Satria Maharani Borneo Journal of Pharmacy.2023; 6(3): 320. CrossRef
The Effect of Chronic Kidney Disease or End-stage Kidney Disease on Perioperative Outcomes and Healthcare Utilization in Patients Undergoing Bariatric Surgery Yung Lee, Léa Tessier, Audrey Jong, Adelia Padoan, Yasith Samarasinghe, Tyler McKechnie, Amber O. Molnar, Michael Walsh, Aristithes Doumouras, Jerry Dang, Matthew Kroh, Dennis Hong Obesity Surgery.2023; 33(5): 1476. CrossRef
Navigating through the haemostatic paradox in kidney failure: A practical overview Jessica Caruana, Nicoletta Riva, Kevin Vella, Andrew Davenport, Alexander Gatt British Journal of Haematology.2023; 202(2): 230. CrossRef
IgA nephropathy in adults with epidermolysis bullosa Manrup K Hunjan, Ajoy Bardhan, Natasha Harper, Dario Leonardo Balacco, Gerald Langman, Vijay Suresh, Adrian Heagerty Clinical and Experimental Dermatology.2023; 48(8): 920. CrossRef
Comorbid Conditions in Kidney Transplantation: Outcome Analysis at King Abdulaziz Medical City Abdulrahman R Al Tamimi, Bader A Aljaafri, Fahad Alhamad, Sultan Alhoshan, Awatif Rashidi, Basayel Dawsari, Ziad A Aljaafri Cureus.2023;[Epub] CrossRef
Duration of Hemodialysis and its Impact on Quality of Life Bushra Akram, Hafiz Shafique Ahmad, Muhammad Tahsin Akhtar, Ahmad Bilal, Khizra Iqbal Pakistan Journal of Health Sciences.2023; : 31. CrossRef
Health Literacy and Change in Health-Related Quality of Life in Dialysed Patients Ivana Skoumalova, Andrea Madarasova Geckova, Jaroslav Rosenberger, Maria Majernikova, Peter Kolarcik, Daniel Klein, Andrea F. de Winter, Jitse P. van Dijk, Sijmen A. Reijneveld International Journal of Environmental Research an.2022; 19(2): 620. CrossRef
Physical Activity and Health-Related Quality of Life of Patients on Hemodialysis with Comorbidities: A Cross-Sectional Study Yu-Hui Wu, Yu-Juei Hsu, Wen-Chii Tzeng International Journal of Environmental Research an.2022; 19(2): 811. CrossRef
Disease Knowledge, Self-Efficacy, and Quality of Life in Patient With Hypertensive Nephropathy Yen-Yen Chen, Mei-Chen Lee, Shu-Fang Vivienne Wu, Yueh-Min Liu, Hui-Mei Chen Clinical Nursing Research.2022; 31(6): 1179. CrossRef
The mediating effect of self‐efficacy in the relationship between mental health and quality of life in patients with hypertensive nephrology Mei‐Chen Lee, Yen‐Yen Chen, Chun‐Yi Tai, Shu‐Fang Vivienne Wu Journal of Advanced Nursing.2022; 78(9): 2827. CrossRef
The relationship between grip strength with health-related quality of life and mortality in hemodialysis patients Clara S. A. Sugizaki, Hellen C. N. Rodrigues, Jéssica F. M. Ivo, Ana T. V. S. Freitas, Maria L. F. Stringhini, Sérgio A. R. Paiva, Marcos F. Minicucci, Maria R. G. Peixoto, Nara A. Costa Nutrire.2022;[Epub] CrossRef
Factors Affecting Quality of Life in Hemodialysis Patients Ade Yonata, Nurul Islamy, Achmad Taruna, Lukman Pura International Journal of General Medicine.2022; Volume 15: 7173. CrossRef
Health related quality of life of patients undergoing in-centre hemodialysis in Rwanda: a cross sectional study Gloria Shumbusho, Celestin Hategeka, Marianne Vidler, Jules Kabahizi, Marla McKnight BMC Nephrology.2022;[Epub] CrossRef
The Short Form-6 Dimension (SF-6D) Validity and Reliability in Hemodialysis Patients Anisa Zulfa Fatihah, Tri Murti Andayani, Nanang Munif Yasin JURNAL FARMASI DAN ILMU KEFARMASIAN INDONESIA.2021; 8(2): 150. CrossRef
First
Prev
