Objectives
In Indo China, carrots have been reported to regulate the functions of the stomach and intestines. The objective of the present investigation was to unravel the therapeutic potential of 50% ethanol extract from Daucus carota roots (EDC) on antisecretory, gastroprotective, and in vitro antacid capacity using experimental rats. Methods
Assessment of EDC antisecretory and in vivo antacid capacities was carried out using a pyloric ligation induced ulcer model. The gastroprotective effect was assessed with an absolute ethanol induced ulcer model. The integrity of gastric mucosa was evaluated using the estimation of glutathione and gastric mucus level and with histopathological examination of gastric mucosal cells. The in-vitro antacid capacity was evaluated using a titration method. The effect of the extract on the liver was assessed by measuring serum biochemical parameters. Results
The EDC significantly (p < 0.01–0.001) reduced gastric lesions in both models. Furthermore, the EDC also significantly (p < 0.05–0.001) reduced the volume of gastric content whereas the total acidity was significantly (p < 0.05–0.001) reduced with the doses of 100 mg/kg and 200 mg/kg EDC. Moreover, the mucus content and glutathione level increased significantly (p < 0.05) in the absolute alcohol-induced ulcer. The EDC also showed in-vitro antacid capacity. Histopathological studies further confirmed the potential of EDC by inhibiting congestion, edema, hemorrhage, and necrosis in gastric mucosa. Conclusion
The EDC exerted antisecretory, gastroprotective, and in vitro antacid potential. These activities could be attributed due to the presence of glycosides, phenolics, tannins, alkaloids, and flavonoids.
Citations
Citations to this article as recorded by
Plants and their Bioactive Compounds as a Possible Treatment for Traumatic Brain Injury-Induced Multi-Organ Dysfunction Syndrome Manisha Thakur, Neeru Vasudeva, Sunil Sharma, Ashok Kumar Datusalia CNS & Neurological Disorders - Drug Targets.2023; 22(9): 1313. CrossRef
Gastroprotective evaluation of Medicago sativa L. (Fabaceae) on diabetic rats Phool Chandra, Mohammad Kaleem, Neetu Sachan, Rashmi Pathak, Ashwag S. Alanazi, Nawaf A. Alsaif, Sary Alsanea, Bader Alsuwayt, Mohammed M. Alanazi, Atul Kabra Saudi Pharmaceutical Journal.2023; 31(11): 101815. CrossRef
ВИВЧЕННЯ ХІМІЧНОГО СКЛАДУ ТА БІОЛОГІЧНОЇ АКТИВНОСТІ МОРКВИ ПОСІВНОЇ (DAUCUS CAROTA L. VAR. SATIVUS). ОГЛЯД ЛІТЕРАТУРИ Л. П. Морозова ПРОДОВОЛЬЧІ РЕСУРСИ.2023; 11(20): 72. CrossRef
Isolation of Thymol from Trachyspermum ammi Fruits for Treatment of Diabetes and Diabetic Neuropathy in STZ-Induced Rats Neetu Sachan, Nikita Saraswat, Phool Chandra, Mohammad Khalid, Atul Kabra, Riaz Ullah BioMed Research International.2022; 2022: 1. CrossRef
Antioxidant and Gastroprotective Activity of Suaeda fruticosa Forssk. Ex J.F.Gmel Afsheen Ayaz, QurratUlAin Jamil, Musaddique Hussain, Fayyaz Anjum, Adeel Sarfraz, Taha Alqahtani, Nadia Hussain, Reem M. Gahtani, Ayed A. Dera, Hanan M. Alharbi, Shahid M. Iqbal Molecules.2022; 27(14): 4368. CrossRef
Hydromethanolic Crude Extract of the Leaf of Urtica simensis Hochst. ex. A. Rich. (Urticaceae) Acquires Appreciable Antiulcer Effect: Validation for In Vivo Antiulcer Activity Woretaw Sisay, Yared Andargie, Mulugeta Molla, Alefe Norahun, Mozaniel Oliveira Evidence-Based Complementary and Alternative Medic.2021; 2021: 1. CrossRef
The influence of a simulated digest of an equine dietary feed additive G's formula on contractile activity of gastric smooth muscle in vitro Jennifer L. MacNicol, Coral Murrant, Wendy Pearson Journal of Animal Physiology and Animal Nutrition.2020; 104(6): 1919. CrossRef
Evaluation of the Anti-Ulcer Activity of Hydromethanolic Crude Extract and Solvent Fractions of the Root of Rumex nepalensis in Rats
Standardization Using Analytical Techniques (UV, NMR, FTIR, HPLC, Mass) and Pharmacognostic Evaluation of the Roots of Selinum vaginatum: A Rare Himalayan Plant of the Rohtang Region Nikita Saraswat, Neetu Sachan, Phool Chandra Current Biotechnology .2020; 9(2): 89. CrossRef
Cytoprotective, antioxidant and anti-inflammatory mechanism related to antiulcer activity of Cissampelos sympodialis Eichl. in animal models Igor Rafael Praxedes De Sales, Rodrigo De Oliveira Formiga, Flávia Danniele Frota Machado, Raphaela Francelino Nascimento, Matheus Marley Bezerra Pessoa, Monique Emanuela Frutuoso Xavier Barros, Giciane Carvalho Vieira, Francisco Allysson Assis Ferreira G Journal of Ethnopharmacology.2018; 222: 190. CrossRef
Antiulcer properties of fruits and vegetables: A mechanism based perspective Choudhary Harsha, Kishore Banik, Devivasha Bordoloi, Ajaikumar B. Kunnumakkara Food and Chemical Toxicology.2017; 108: 104. CrossRef
Glutathione sulfotransferase inhibition activity of a self-fermented beverage,Kanji Abida Latif, Khalid Hussain, Naureen Shehzadi, Muhammad Islam, Muhammad Tanveer Khan, Rukhsana Anwar, Humaira Majeed Khan, Nadeem Irfan Bukhari Pharmaceutical Biology.2017; 55(1): 547. CrossRef
Mild Hypothermia Protects Pigs’ Gastric Mucosa After Cardiopulmonary Resuscitation via Inhibiting Interleukin 6 (IL-6) Production Yan Wang, Jian Song, Yuhong Liu, Yaqiang Li, Zhengxin Liu Medical Science Monitor.2016; 22: 3523. CrossRef