<b>Objectives</b><br/>This study was conducted to assess the efficacy of nirmatrelvir/ritonavir treatment in patients with coronavirus disease 2019 (COVID-19), particularly those aged 60 years and older. Using real-world data, the period during which the BN.1 Omicron variant was dominant was compared to the period dominated by the BA.5 variant. Methods: In this retrospective cohort study, data were collected regarding 2,665,281 patients infected with severe acute respiratory syndrome coronavirus 2 between July 24, 2022, and March 31, 2023. Propensity score matching was utilized to match patients who received nirmatrelvir/ ritonavir in a 1:4 ratio between BN.1 and BA.5 variant groups. Multivariable logistic regression analysis was employed to assess the effects of nirmatrelvir/ritonavir within these groups. Results: Compared to the prior period, the efficacy of nirmatrelvir/ritonavir did not significantly differ during the interval of Omicron BN.1 variant dominance in the Republic of Korea. Among patients treated with nirmatrelvir/ritonavir, a significantly lower risk of mortality was observed in the BN.1 group (odds ratio [OR], 0.698; 95% confidence interval [CI], 0.557–0.875) compared to the BA.5 group. However, this treatment did not significantly reduce the risk of severe or critical illness, including death, for those in the BN.1 group (OR, 0.856; 95% CI, 0.728–1.007). Conclusion: Nirmatrelvir/ritonavir has maintained its effectiveness against COVID-19, even with the emergence of the BN.1 Omicron subvariant. Consequently, we strongly recommend the administration of nirmatrelvir/ritonavir to patients exhibiting COVID-19-related symptoms, irrespective of the dominant Omicron variant or their vaccination status, to mitigate disease severity and decrease the risk of mortality.
<sec>
<b>Objectives</b>
<p>To evaluate the impact of 3 treatment regimens upon health-related quality of life and work productivity using patient-reported outcomes (PROs) in chronic hepatitis C infected patients: sofosbuvir (SOF) + daclatasvir (DCV); SOF + DCV + ribavirin (RBV); SOF + simeprevir (SMV).</p></sec>
<sec>
<b>Methods</b>
<p>4 questionnaires were used to evaluate PROs before, during and after treatment: Short Form-36 (SF-36), Chronic Liver Disease Questionnaire (CLDQ) - hepatitis C virus (HCV), Work Productivity and Activity Index, Functional Assessment of Chronic Illness Therapy-Fatigue (FACIT-F).</p></sec>
<sec>
<b>Results</b>
<p>Of the global sample of 55 patients included in this study; SOF + DCV (<italic>n</italic> = 10); SOF + DCV + RBV (<italic>n</italic> = 29); SOF + SMV (<italic>n</italic> = 16) all had a statistically significant improvement in SF-36, CLDQ and FACIT-F scores during and post-treatment. No statistically significant differences in the PRO questionnaire values were observed between the distinct treatment regimens. The SOF and SMV patient groups presented higher mean PRO variations during and post-treatment, compared to the other groups: SF-36 functional capacity (16.1); SF-36 mental health (21.4); CLDQ activity (1.8); CLDQ emotional function (1.2); FACIT-F physical well-being (8.0); Total FACIT-F (21.6).</p></sec>
<sec>
<b>Conclusion</b>
<p>Treatment with SOF + DCV, with or without RBV, results in an improved PRO similar to treatment with SOF + SMV in chronic hepatitis C patients.</p></sec>
Citations
Citations to this article as recorded by
Health-related quality of life in people receiving opioid agonist treatment and treatment for hepatitis C virus infection Olav Dalgard, Alain H. Litwin, Oren Shibolet, Jason Grebely, Ronald Nahass, Frederick L. Altice, Brian Conway, Edward J. Gane, Anne F. Luetkemeyer, Cheng-Yuan Peng, David Iser, Isaias Noel Gendrano, Michelle M. Kelly, Barbara A. Haber, Heather Platt, Amy Journal of Addictive Diseases.2023; 41(3): 213. CrossRef
Impact of sofosbuvir and daclastavir on health-related quality of life in patients co-infected with hepatitis C and human immunodeficiency virus Evy Yunihastuti, Fhadilla Amelia, Arini Ika Hapsari, Bramantya Wicaksana, Veritea Natali, Alvina Widhani, Andri Sanityoso Sulaiman, Teguh Harjono Karjadi Health and Quality of Life Outcomes.2021;[Epub] CrossRef
Health-related quality of life and fatigue in patients with chronic hepatitis C with therapy with direct-acting antivirals agents interferon-free Raíssa Neves Fagundes, Lincoln Eduardo Villela Vieira de Castro Ferreira, Fábio Heleno de Lima Pace, Yury E. Khudyakov PLOS ONE.2020; 15(8): e0237005. CrossRef
Efficacy and safety of sofosbuvir-based pangenotypic direct-acting antiviral agents for chronic hepatitis C patients without genotype determination Juan Li, Dong-Bo Wu, Wei Jiang, Xue-Bin Chen, Gui-Bao Xiao, Yong-Hong Wang, Meng-Lan Wang, Ya-Chao Tao, En-Qiang Chen Medicine.2020; 99(43): e22726. CrossRef
<sec><b>Objectives</b><p>Rhinoviruses (RVs) cause common cold and are associated with exacerbation of chronic inflammatory respiratory diseases. Until now, no clinically effective antiviral chemotherapeutic agents to treat diseases caused by human rhinoviruses (HRVs) have been reported. We assessed the anti-HRV3 activity of sakuranetin isolated from <italic>Sorbus commixta</italic> Hedl. in human epithelioid carcinoma cervix (HeLa) cells, to evaluate its anti-rhinoviral potential in the clinical setting.</p></sec><sec><b>Methods</b><p>Antiviral activity and cytotoxicity as well as the effect of sakuranetin on HRV3-induced cytopathic effects (CPEs) were evaluated using the sulforhodamine B (SRB) method using CPE reduction. The morphology of HRV3-infected cells was studied using a light microscope.</p></sec><sec><b>Results</b><p>Sakuranetin actively inhibited HRV3 replication and exhibited antiviral activity of more than 67% without cytotoxicity in HeLa cells, at 100 μg/mL. Ribavirin showed anti-HRV3 activity similar to that of sakuranetin. Treatment of HRV-infected HeLa cells with sakuranetin visibly reduced CPEs.</p></sec><sec><b>Conclusion</b><p>The inhibition of HRV production by sakuranetin is mainly due to its general antioxidant activity through inhibition of viral adsorption. Therefore, the antiviral activity of sakuranetin should be further investigated to elucidate its mode of action and prevent HRV3-mediated diseases in pathological conditions.</p></sec>
Citations
Citations to this article as recorded by
Standardized Eucalyptus maculata (Corymbia maculata) Resin Extract: Metabolomic Profiling, In Vitro and In Silico Study of Anti‐HSV Activity Samar M. Bassam, Ibrahim A. Abdelwahab, Mohamed Teleb, Dalia E. Ali Chemistry & Biodiversity.2025;[Epub] CrossRef
Interaction of sakuranetin with unsaturated lipids forming Langmuir monolayers at the air-water interface: A biomembrane model Matheus Lima de Souza, André Campos Machado, Henrique Barbosa, João Henrique Ghilardi Lago, Luciano Caseli Colloids and Surfaces B: Biointerfaces.2024; 234: 113747. CrossRef
Biofortified Rice Provides Rich Sakuranetin in Endosperm Yao Zhao, Jitao Hu, Zhongjing Zhou, Linying Li, Xueying Zhang, Yuqing He, Chi Zhang, Junmin Wang, Gaojie Hong Rice.2024;[Epub] CrossRef
Antiviral activity of the water extract and ethanol extract of Sorbus commixta against influenza A virus in vitro Yewon Kim, Sanghyun Lee, Chulwoo Kim, Sun-Woo Yoon, Sejin Jeon, Mi-Na Kweon, Baik-Lin Seong, Sang-Uk Seo, Yo Han Jang Heliyon.2024; 10(20): e39049. CrossRef
Sakuranetin and its therapeutic potentials – a comprehensive review Md. Junaid, Bristy Basak, Yeasmin Akter, Syeda Samira Afrose, Afsana Nahrin, Rashiduzzaman Emran, Md. Shahinozzaman, Shinkichi Tawata Zeitschrift für Naturforschung C.2023; 78(1-2): 27. CrossRef
Comparative metabolomics of flavonoids in twenty vegetables reveal their nutritional diversity and potential health benefits Han Tao, Yao Zhao, Linying Li, Yuqing He, Xueying Zhang, Ying Zhu, Gaojie Hong Food Research International.2023; 164: 112384. CrossRef
Rice Phytoalexins: Half a Century of Amazing Discoveries; Part I: Distribution, Biosynthesis, Chemical Synthesis, and Biological Activities Alessio Valletta, Lorenzo Maria Iozia, Laura Fattorini, Francesca Leonelli Plants.2023; 12(2): 260. CrossRef
Ethanolamine phospholipids at the air-water interface as cell membranes models of microorganisms to study the nanotoxicology of sakuranetin Guilherme Henrique da Cruz Ramos Pires, Henrique Barbosa, Roberto Baptista Pereira Almeida, João Henrique Ghilardi Lago, Luciano Caseli Thin Solid Films.2023; 770: 139768. CrossRef
Antiviral Activity of Flavonoids Against Non-polio Enteroviruses Hwa-Jung Choi Journal of Bacteriology and Virology.2023; 53(1): 29. CrossRef
Novel anti‑hepatitis B virus flavonoids sakuranetin and velutin fromRhus retinorrhoea Sarfaraz Ahmed, Mohammad Parvez, Mohammed Al‑Dosari, Mazin Abdelwahid, Tawfeq Alhowiriny, Adnan Al‑Rehaily Molecular Medicine Reports.2023;[Epub] CrossRef
Antiviral Activity of Flavonoids from Geopropolis of the Brazilian Jandaira Bee against Zika and Dengue Viruses Poliana Gomes da Silva, Elton José Ferreira Chaves, Tania Maria Sarmento Silva, Gerd Bruno Rocha, Willyenne Marília Dantas, Ronaldo Nascimento de Oliveira, Lindomar José Pena Pharmaceutics.2023; 15(10): 2494. CrossRef
Metabolic engineering in Streptomyces albidoflavus for the biosynthesis of the methylated flavonoids sakuranetin, acacetin, and genkwanin Álvaro Pérez-Valero, Suhui Ye, Patricia Magadán-Corpas, Claudio J. Villar, Felipe Lombó Microbial Cell Factories.2023;[Epub] CrossRef
Antiviral Activity of Quercetin-3-Glucoside Against Non-Polio Enterovirus Hwa-Jung Choi Journal of Bacteriology and Virology.2022; 52(1): 20. CrossRef
Sakuranetin interacting with cell membranes models: Surface chemistry combined with molecular simulation Guilherme Henrique da Cruz Ramos Pires, Vitor Torres Freire, Rafael Guimarães Pereira, Leonardo José Amaral de Siqueira, Eric Umehara, João Henrique Ghilardi Lago, Luciano Caseli Colloids and Surfaces B: Biointerfaces.2022; 216: 112546. CrossRef
Production of (2S)-sakuranetin from (2S)-naringenin in Escherichia coli by strengthening methylation process and cell resistance Qiumeng Sun, Song Gao, Shiqin Yu, Pu Zheng, Jingwen Zhou Synthetic and Systems Biotechnology.2022; 7(4): 1117. CrossRef
Sakuranetin State of the Art: Physical Properties, Biological Effects, and Biotechnological Trends Leonardo Ribeiro Bernardo, Anna Rafaela Cavalcante Braga Industrial Biotechnology.2022; 18(6): 341. CrossRef
Stevia Genus: Phytochemistry and Biological Activities Update Jimena Borgo, Laura C. Laurella, Florencia Martini, Cesar A. N. Catalán, Valeria P. Sülsen Molecules.2021; 26(9): 2733. CrossRef
Phytochemistry and teratogenic potential of Mimosa tenuiflora (willd.) poir. (Fabaceae) in ruminants: A systematic review José Jailson Lima Bezerra, Anderson Angel Vieira Pinheiro, Ricardo Barbosa Lucena Toxicon.2021; 195: 78. CrossRef
DO WE KNOW RHINOVIRUSES AND THEIR CLINICAL IMPACT? Irina Georgieva, Asya Stoyanova, Svetla Angelova, Savina Stoitsova, Silvia Voleva, Neli Korsun, Lubomira Nikolaeva-Glomb PROBLEMS of Infectious and Parasitic Diseases.2021; 49(1): 5. CrossRef
Flavonoids as Antiviral Agents for Enterovirus A71 (EV-A71) Salima Lalani, Chit Laa Poh Viruses.2020; 12(2): 184. CrossRef
A Review on Sources and Pharmacological Aspects of Sakuranetin Monika Stompor Nutrients.2020; 12(2): 513. CrossRef
Ethnopharmacologically important but underestimated genus Sorbus: a comprehensive review Agnieszka Sołtys, Agnieszka Galanty, Irma Podolak Phytochemistry Reviews.2020; 19(2): 491. CrossRef
The Sorbus spp.—Underutilised Plants for Foods and Nutraceuticals: Review on Polyphenolic Phytochemicals and Antioxidant Potential Viive Sarv, Petras Rimantas Venskutonis, Rajeev Bhat Antioxidants.2020; 9(9): 813. CrossRef
Suppression of influenza B virus replication by sakuranetin and mode of its action Dur‐Han Kwon, Jeong‐Hun Ji, Soon‐Ho Yim, Byoung‐Soo Kim, Hwa‐Jung Choi Phytotherapy Research.2018; 32(12): 2475. CrossRef
Human rhinoviruses and enteroviruses (family Picornaviridae) infect millions of people worldwide each year, but little is known about effective therapeutical treatment for the infection caused by these viruses. We sought to determine whether or not <i>Zanthoxylum</i> (Rutaceae) species can exhibit antiviral activity against picornaviruses. The leaf parts of four <i>Zanthoxylum</i> species were extracted with methanol, and the extracts were investigated for their antiviral activity against picornaviruses using cytopathic effects by cytopathic effect reduction. Leaf extracts of <i>Zanthoxylum piperitum</i> among four <i>Zanthoxylum</i> species were found to possess only broad-spectrum antipicornavirus activity against human rhninovirus 2 with a 50% inhibitory concentration (IC<sub>50</sub>) value of 59.48 μg/mL, human rhinovirus 3 with an IC<sub>50</sub> value of 39.94 μg/mL, coxsackie A16 virus with an IC<sub>50</sub> value of 45.80 μg/mL, coxsackie B3 virus with an IC<sub>50</sub> value of 68.53 μg/mL, coxsackie B4 virus with an IC<sub>50</sub> value of 93.58 μg/mL, and enterovirus 71 virus with an IC<sub>50</sub> value of 4.48 μg/mL. However, ribavirin did not possess antiviral activity against human rhinovirus 3 and four enteroviruses. Therefore, leaves of <i>Z. piperitum</i> showed broad-spectrum antipicornavirus activity, and may be useful as a candidate for studying picornavirus agents and development of pharmaceuticals.
Citations
Citations to this article as recorded by
LC-MS/MS profiling of Zanthoxylum piperitum (L.) DC. leaves cultivated in Egypt, isolation of its bioactive components, and interrelationships with anti-ulcerative activities: in vitro and in vivo approaches, molecular docking, and dynamics studies Nermin S. El Tayeb, Nermin A. Younis, Samar M. Mouneir, Kawkab A. Ahmed, Ahmed A. Al‐Karmalawy, Radwan Alnajjar, Azza R. Abdel-monem, Nesrin M. Fayek Journal of Ethnopharmacology.2025; 350: 119984. CrossRef
A mini review on the prospects of Fagara zanthoxyloides extract based composites: a remedy for COVID-19 and associated replica? Abiodun Oladipo, Onome Ejeromedoghene, Ademola Adebayo, Olakunle Ogunyemi, George Egejuru Physical Sciences Reviews.2024; 9(2): 1065. CrossRef
Polyherbal Syrup for Coronavirus Infection: Formulation and Evaluation Kranthi Kumar Kotta, Sunil Kumar Kadiri, Sampath Ayyappa Gouru Coronaviruses.2024;[Epub] CrossRef
Multiplicative Effects of Essential Oils and Other Active Components on Skin Tissue and Skin Cancers Hyeong Jae Kim, Jeong Hee Hong International Journal of Molecular Sciences.2024; 25(10): 5397. CrossRef
Simultaneous Analysis of Bergapten and Schinifoline in Zanthoxylum schinifolium Seeds Using HPLC and UPLC-MS/MS Systems Chang-Seob Seo Foods.2023; 12(7): 1355. CrossRef
A REVIEW ON ANTIVIRAL PLANTS EFFECTIVE AGAINST DIFFERENT VIRUS TYPES Falah Saleh Mohammed, İmran Uysal, Mustafa Sevindik Prospects in Pharmaceutical Sciences.2023; 21(2): 1. CrossRef
Cytotoxicity and Genotoxicity Evaluation of Zanthoxylum rhoifolium Lam and In Silico Studies of Its Alkaloids Rufine Azonsivo, Kelly Cristina Oliveira de Albuquerque, Ana Laura Gadelha Castro, Juliana Correa-Barbosa, Helena Joseane Raiol de Souza, Andryo Orfi de Almada-Vilhena, Gleison Gonçalves Ferreira, Anderson Albuquerque de Souza, Andrey Moacir do Rosario Ma Molecules.2023; 28(14): 5336. CrossRef
Six Express Sequence Tag–Simple Sequence Repeat Primers Reveal Genetic Diversity in the Cultivars of Three Zanthoxylum Species Yangchuan Deng, Zhoujian He, Yanlin Li, Meng Ye, Li Xiang Current Issues in Molecular Biology.2023; 45(9): 7183. CrossRef
In silicoinvestigation of spice molecules as potent inhibitor of SARS-CoV-2 Janmejaya Rout, Bikash Chandra Swain, Umakanta Tripathy Journal of Biomolecular Structure and Dynamics.2022; 40(2): 860. CrossRef
In silico, in vitro screening of plant extracts for anti-SARS-CoV-2 activity and evaluation of their acute and sub-acute toxicity Damle Latha, Damle Hrishikesh, Ganju Shiban, C Chandrashekar, BR Bharath Phytomedicine Plus.2022; 2(2): 100233. CrossRef
Composition, mechanisms of tingling paresthesia, and health benefits of Sichuan pepper: A review of recent progress Ngouana Moffo A. Ivane, Suleiman A. Haruna, Marcillinus Zekrumah, Fopa Kue Roméo Elysé, Mohamed Osman Hassan, Sulafa B.H. Hashim, Haroon Elrasheid Tahir, Di Zhang Trends in Food Science & Technology.2022; 126: 1. CrossRef
Zanthoxylum Species: A Review of Traditional Uses, Phytochemistry and Pharmacology in Relation to Cancer, Infectious Diseases and Sickle Cell Anemia Innocent Uzochukwu Okagu, Joseph Chinedum Ndefo, Emmanuel Chigozie Aham, Chibuike. C. Udenigwe Frontiers in Pharmacology.2021;[Epub] CrossRef
Chemical profiles and screening of potential α-glucosidase inhibitors from Sichuan pepper using ultra-filtration combined with UHPLC-Q-TOF Weili Li, Yao Wu, Yushu Liu, Yong Tang, Zhenming Che, Tao Wu Industrial Crops and Products.2020; 143: 111874. CrossRef
Compostos químicos isolados de extratos e óleos essenciais do gênero Zanthoxylum Linnaeus (Rutaceae) e seu potencial antimicrobiano Daniel Eugenio Saraiva Filho, Josenir Barreto de Sousa, Hélcio Silva dos Santos, Raquel Oliveira dos Santos Fontenelle Hoehnea.2020;[Epub] CrossRef
Chemical composition, sensory properties and application of Sichuan pepper (Zanthoxylum genus) Yue Ji, Shiming Li, Chi-Tang Ho Food Science and Human Wellness.2019; 8(2): 115. CrossRef
Immunomodulatory properties of quercetin-3-O-α-L-rhamnopyranoside from Rapanea melanophloeos against influenza a virus Parvaneh Mehrbod, Muna Ali Abdalla, Fatemeh Fotouhi, Masoumeh Heidarzadeh, Abimbola O. Aro, Jacobus N. Eloff, Lyndy J. McGaw, Folorunso O. Fasina BMC Complementary and Alternative Medicine.2018;[Epub] CrossRef
Anti-allergic Inflammatory Effects of the Essential Oil From Fruits of Zanthoxylum coreanum Nakai Rui Hong Guo, Jung Up Park, Se Jin Jo, Jae Hun Ahn, Jong Hwan Park, Ji Yoon Yang, Sung Suk Lee, Mi Jin Park, Young Ran Kim Frontiers in Pharmacology.2018;[Epub] CrossRef
Inhibitory Effects of Essential Oil from Zanthoxylum coreanum Nakai on Melanin Production: Protection Against Re-Pigmentation after Laser Treatment Ye-Na Kim, Mi-Jin Park, Zhenlong Zheng, Sung-Suk Lee, Kwang Ho Yoo, Heesu Kim Medical Lasers.2018; 7(2): 62. CrossRef
Antiviral effect of compounds derived from Angelica archangelica L. on Herpes simplex virus-1 and Coxsackievirus B3 infections Barbara Rajtar, Krystyna Skalicka-Woźniak, Łukasz Świątek, Agnieszka Stec, Anastazja Boguszewska, Małgorzata Polz-Dacewicz Food and Chemical Toxicology.2017; 109: 1026. CrossRef
<b>Objectives</b><br/>
Coxsackievirus A group 16 strain (CVA16) is one of the predominant causative agents of hand, foot, and mouth disease (HFMD).<br/><b>Methods</b><br/>
Using a specimen from a male patient with HFMD, we isolated and performed sequencing of the Korean CVA16 strain and compared it with a G10 reference strain. Also, we were investigated the effects of medicinal plant extract on the cytopathic effects (CPE) by CPE reduction assay against Korean CVA16.<br/><b>Results</b><br/>
Phylogenetic analysis showed that the Korean CVA16 isolate belonged to cluster B-1 and was closely related to the strain PM-15765-00 isolated in Malaysia in 2000. The Korean CVA16 isolate showed 73.2% nucleotide identity to the G10 prototype strain and 98.7% nucleotide identity to PM-15765-00. Next, we assessed whether the Korean CVA16 isolate could be used for <i>in vitro</i> screening of antiviral agents to treat HFMD infection. Vero cells infected with the Korean CVA16 isolate showed a cytopathic effect 2 days after the infection, and the treatment of cells with <i>Cornus officinalis</i>, <i>Acer triflorum</i>, <i>Pulsatilla koreana</i>, and <i>Clematis heracleifolia</i> var. <i>davidiana</i> Hemsl extracts exhibited strong antiviral activity against CVA16.<br/><b>Conclusion</b><br/>
Collectively, our work provides potential candidates for the development of vaccine and novel drugs to treat the CVA16 strain isolated from a Korean patient.
Citations
Citations to this article as recorded by
Recent Advances in Anti-Coxsackievirus A16 Viral Drug Research Xiaolan Yuan, Ziwei Liu, Li Wan, Wei Liu, Yan Huang, Shuang Cao Future Medicinal Chemistry.2023; 15(1): 97. CrossRef
A Review with Updated Perspectives on the Antiviral Potentials of Traditional Medicinal Plants and Their Prospects in Antiviral Therapy Nur Fadlin Saifulazmi, Emelda Rosseleena Rohani, Sarahani Harun, Hamidun Bunawan, Hamizah Shahirah Hamezah, Nor Azlan Nor Muhammad, Kamalrul Azlan Azizan, Qamar Uddin Ahmed, Sharida Fakurazi, Ahmed Mediani, Murni Nazira Sarian Life.2022; 12(8): 1287. CrossRef
Medicinal plants: Treasure for antiviral drug discovery Sofi Imtiyaz Ali, Wajid Mohammad Sheikh, Muzafar Ahmad Rather, Venugopalan Venkatesalu, Showkeen Muzamil Bashir, Showkat Ul Nabi Phytotherapy Research.2021; 35(7): 3447. CrossRef
Seasonal Distribution and Meteorological Factors Associated with Hand, Foot, and Mouth Disease among Children in Xi’an, Northwestern China Tianci Guo, Jifeng Liu, Junjiang Chen, Yao Bai, Yong Long, Baozhong Chen, Shuxuan Song, Zhongjun Shao, Kun Liu The American Journal of Tropical Medicine and Hygi.2020; 102(6): 1253. CrossRef
Short-term effects of meteorological factors and air pollution on childhood hand-foot-mouth disease in Guilin, China Guoqi Yu, Yonghong Li, Jiansheng Cai, Dongmei Yu, Jiexia Tang, Wenwen Zhai, Yi Wei, Shiyi Chen, Quanhui Chen, Jian Qin Science of The Total Environment.2019; 646: 460. CrossRef
The effect of temperature on childhood hand, foot and mouth disease in Guangdong Province, China, 2010–2013: a multicity study Zece Xu, Wenqi Hu, Kedi Jiao, Ci Ren, Baofa Jiang, Wei Ma BMC Infectious Diseases.2019;[Epub] CrossRef
Surveillance, epidemiology, and pathogen spectrum of hand, foot, and mouth disease in mainland of China from 2008 to 2017 Tianjiao Ji, Taoli Han, Xiaojuan Tan, Shuangli Zhu, Dongmei Yan, Qian Yang, Yang Song, Aili Cui, Yan Zhang, Naiying Mao, Songtao Xu, Zhen Zhu, Dandan Niu, Yong Zhang, Wenbo Xu Biosafety and Health.2019; 1(1): 32. CrossRef
A potential therapeutic neutralization monoclonal antibody specifically against multi-coxsackievirus A16 strains challenge Ruixiao Du, Qunying Mao, Yalin Hu, Shuhui Lang, Shiyang Sun, Kelei Li, Fan Gao, Lianlian Bian, Ce Yang, Bopei Cui, Longfa Xu, Tong Cheng, Zhenglun Liang Human Vaccines & Immunotherapeutics.2019; 15(10): 2343. CrossRef
Corni Fructus: a review of chemical constituents and pharmacological activities Yu Dong, Zhe-Ling Feng, Hu-Biao Chen, Fu-Sheng Wang, Jia-Hong Lu Chinese Medicine.2018;[Epub] CrossRef
Inhibition of Murine Norovirus and Feline Calicivirus by Edible Herbal Extracts Dong Joo Seo, Changsun Choi Food and Environmental Virology.2017; 9(1): 35. CrossRef
Antiviral activity of herbal extracts against the hepatitis A virus Dong Joo Seo, Minhwa Lee, Su Been Jeon, Hyunkyung Park, Suntak Jeong, Bog-Hieu Lee, Changsun Choi Food Control.2017; 72: 9. CrossRef
A novel Enterovirus 96 circulating in China causes hand, foot, and mouth disease Yi Xu, Yisuo Sun, Jinmin Ma, Shuru Zhou, Wei Fang, Jiawei Ye, Limei Tan, Jingkai Ji, Dan Luo, Liqiang Li, Jiandong Li, Chunxiao Fang, Na Pei, Shuo Shi, Xin Liu, Hui Jiang, Sitang Gong, Xun Xu Virus Genes.2017; 53(3): 352. CrossRef
Characterization of VP1 sequence of Coxsackievirus A16 isolates by Bayesian evolutionary method Guolian Zhao, Xun Zhang, Changmin Wang, Guoqing Wang, Fan Li Virology Journal.2016;[Epub] CrossRef
Traditional uses, phytochemistry, and pharmacology of the genus Acer (maple): A review Wu Bi, Ying Gao, Jie Shen, Chunnian He, Haibo Liu, Yong Peng, Chunhong Zhang, Peigen Xiao Journal of Ethnopharmacology.2016; 189: 31. CrossRef
Epidemiological Research on Hand, Foot, and Mouth Disease in Mainland China Zhi-Chao Zhuang, Zeng-Qiang Kou, Yong-Juan Bai, Xiang Cong, Li-Hong Wang, Chun Li, Li Zhao, Xue-Jie Yu, Zhi-Yu Wang, Hong-Ling Wen Viruses.2015; 7(12): 6400. CrossRef
<b>Objectives</b><br/>
We characterized and assessed public health measures, including intensive vaccination and antiviral treatment, implemented during the 2009 influenza pandemic in the Republic of Korea.<br/><b>Methods</b><br/>
A mathematical model for the 2009 influenza pandemic is formulated. The transmission rate, the vaccination rate, the antiviral treatment rate, and the hospitalized rate are estimated using the least-squares method for the 2009 data of the incidence curves of the infected, vaccinated, treated, and hospitalized.<br/><b>Results</b><br/>
The cumulative number of infected cases has reduced significantly following the implementation of the intensive vaccination and antiviral treatment. In particular, the intensive vaccination was the most critical factor that prevented severe outbreak.<br/><b>Conclusion</b><br/>
We have found that the total infected proportion would increase by approximately six times under the half of vaccination rates.
Citations
Citations to this article as recorded by
Modeling influenza transmission dynamics with media coverage data of the 2009 H1N1 outbreak in Korea Yunhwan Kim, Ana Vivas Barber, Sunmi Lee, Roberto Barrio PLOS ONE.2020; 15(6): e0232580. CrossRef
Doing Mathematics with Aftermath of Pandemic Influenza 2009 Hae-Wol Cho, Chaeshin Chu Osong Public Health and Research Perspectives.2015; 6(1): 1. CrossRef
<b>Objectives</b><br/>
It is critical to implement effective multiple countermeasures to mitigate or retain the spread of pandemic influenza. We propose a mathematical pandemic influenza model to assess the effectiveness of multiple countermeasures implemented in 2009.<br/><b>Methods</b><br/>
Age-specific parameters, including the transmission rate, the proportion of asymptomatic individuals, the vaccination rate, the social distancing rate, and the antiviral treatment rate are estimated using the least-square method calibrated to the incidence data.<br/><b>Results</b><br/>
The multiple interventions (intensive vaccination, social distancing, antivrial treatment) were successfully implemented resulting in the dramatic reduction in the total number of incidence.<br/><b>Conclusion</b><br/>
The model output is sensitive to age-specific parameters and this leads to the fact that a more elaborate age group model should be developed and extensive further studies must be followed.
<b>Objectives</b><br/>
To monitor antiviral drug resistance among seasonal influenza viruses isolated in Korea during the 2008-2009 influenza season, we examined influenza isolates collected through Korea Influenza Surveillance Scheme for antiviral drug susceptibility.<br/><b>Methods</b><br/>
For genetic analysis of antiviral drug resistance, the matrix (M2) and neuraminidase (NA) genes of each isolate were amplified by reverse transcription-polymerase chain reaction and followed by nucleotide sequencing. For phylogenetic analyses, the sequences of hemagglutinin (HA) and NA genes of each isolate were aligned using multiple alignment program. For phenotypic analysis of antiviral drug resistance, drug susceptibilities against M2 inhibitor (amantadine) and NA inhibitors (oseltavimir and zanamivir) were determined by virus yield reduction assay and fluorometric NA inhibition assay, respectively.<br/><b>Results</b><br/>
In Korea, the resistant influenza viruses against oseltamivir were first detected in sealsonal influenza A(H1N1) viruses on Week 48 of 2008. Since then, the number of oseltamivir-resistant A(H1N1) viruses was continuously increased and had reached the highest peak on Week 52 of 2008. 533 (99.8%) of 534 A(H1N1) viruses were resistant to oseltamivir and all of them harbored the H275Y mutation in the NA gene during the 2008-2009 season. The oseltamivir resistance identified by sequencing was confirmed by NA inhibition assay. Genetic analysis based on HA gene of the resistant A(H1N1) viruses revealed that the viruses were identified as A/Brisbane/10/2007-like strain which was vaccine strain for the 2008-2009 season.<br/><b>Conclusions</b><br/>
The oseltamivir-resistant A(H1N1) viruses were first emerged in Europe in November 2007 and then circulated globally. One year later, the oseltamivir-resistant A(H1N1) viruses were first detected in Korea in November 2008 and continued circulating until the Week 7 of 2009 during the 2008-2009 season. Considering the pandemic preparedness, it should be continued to monitor the emergence and the characterization of antiviral drug resistant influenza viruses.
Citations
Citations to this article as recorded by
Pharmacokinetics and safety of a novel influenza treatment (baloxavir marboxil) in Korean subjects compared with Japanese subjects Yun Kim, Sangwon Lee, Yohan Kim, In‐Jin Jang, SeungHwan Lee Clinical and Translational Science.2022; 15(2): 422. CrossRef
2018–2019 antiviral drug sensitivity of the influenza virus strains isolated from various regions of Kazakhstan T. I. Glebova, N. G. Klivleyeva, G. V. Lukmanova, N. T. Saktaganov, A. M. Baimukhametova Russian Journal of Infection and Immunity.2021; 11(6): 1159. CrossRef
Assessment of Intensive Vaccination and Antiviral Treatment in 2009 Influenza Pandemic in Korea Chaeshin Chu, Sunmi Lee Osong Public Health and Research Perspectives.2015; 6(1): 47. CrossRef
Doing Mathematics with Aftermath of Pandemic Influenza 2009 Hae-Wol Cho, Chaeshin Chu Osong Public Health and Research Perspectives.2015; 6(1): 1. CrossRef
Antiviral treatment of influenza in South Korea Young June Choe, Hyunju Lee, Hoan Jong Lee, Eun Hwa Choi Expert Review of Anti-infective Therapy.2015; 13(6): 741. CrossRef
Synthesis and anti-influenza virus activity of 4-oxo- or thioxo-4,5-dihydrofuro[3,4-c]pyridin-3(1H)-ones Ye Jin Jang, Raghavendra Achary, Hye Won Lee, Hyo Jin Lee, Chong-Kyo Lee, Soo Bong Han, Young-Sik Jung, Nam Sook Kang, Pilho Kim, Meehyein Kim Antiviral Research.2014; 107: 66. CrossRef
Was the Mass Vaccination Effective During the Influenza Pandemic 2009–2010 in Korea? Hae-Wol Cho, Chaeshin Chu Osong Public Health and Research Perspectives.2013; 4(4): 177. CrossRef
How to Manage a Public Health Crisis and Bioterrorism in Korea Hae-Wol Cho, Chaeshin Chu Osong Public Health and Research Perspectives.2013; 4(5): 223. CrossRef
Generation and Characterization of Recombinant Influenza A(H1N1) Viruses Resistant to Neuraminidase Inhibitors WooYoung Choi, Jin-Young Shin, Hwan-Eui Jeong, Mi-Jin Jeong, Su-Jin Kim, Joo-Yeon Lee, Chun Kang Osong Public Health and Research Perspectives.2013; 4(6): 323. CrossRef
Occurrence and characterization of oseltamivir-resistant influenza virus in children between 2007-2008 and 2008-2009 seasons Seoung Geun Kim, Yoon Ha Hwang, Yung Hae Shin, Sung Won Kim, Woo Sik Jung, Sung Mi Kim, Jae Min Oh, Na Young Lee, Mun Ju Kim, Kyung Soon Cho, Yeon Gyeong Park, Sang Kee Min, Chang Kyu Lee, Jun Sub Kim, Chun Kang, Joo Yeon Lee, Man Kyu Huh, Chang Hoon Kim Korean Journal of Pediatrics.2013; 56(4): 165. CrossRef
First
Prev
